Ten-man Real Madrid scored in a record 30th consecutive UEFA Champions League game as they beat Galatasaray 4-1 to qualify for the last 16.
Carlo Ancelotti's side shrugged off the first-half dismissal of Sergio Ramos, the 17th red card of his Real career, with goals from Gareth Bale, Alvaro Arbeloa, Angel di Maria and Isco eclipsing Umut Bulut's strike.
Ramos' match was ended for a foul on Bulut after just 26 minutes, although the Turkey international appeared to make the most of minimal contact when he was through on goal.
Bale rifled in a long-range free-kick eight minutes before the interval, only for Bulut to level almost immediately.
However, Arbeloa provided a collector's item of a goal in the second half, finding the net for the first time since November 2010, Di Maria added the third and Isco completed the scoring nine minutes from time to wrap up Group B's top spot for the hosts.
Real were without Cristiano Ronaldo (thigh), who was nonetheless the centre of attention in the build-up as the Real fans showed their support for the forward's bid to be crowned FIFA Ballon d'Or winner by displaying banners and wearing masks of the Portuguese's face.
Coach Carlo Ancelotti also rested Xabi Alonso, Karim Benzema and Alvaro Morata, with Jese Rodriguez selected up front and Casemiro handed his debut in the competition.
Opposite number Roberto Mancini, who was not in charge when the Turkish side were humbled 6-1 in the reverse fixture, left Burak Yilmaz and Wesley Sneijder on the bench.
Real should have taken the lead inside the opening four minutes when Bale was sent racing clear by Isco, but the Welshman side-footed wide with only the goalkeeper to beat.
The home side threatened again six minutes later as Marcelo cut in from the left and tried to pick out Rodriguez, but Selcuk Inan's desperate challenge denied the Spaniard a shooting opportunity.
Inan also had the visitors' first sight of goal but flashed an ambitious long-range shot over the bar from a tight angle in a rare Galatasaray attack.
But the momentum threatened to shift when Ramos, who was the last man, was given his marching orders after making the slightest of contact with a goal-bound Bulut.
Jese had to make way in the tactical reshuffle as Nacho was introduced, but Bale put the 10 men ahead eight minutes before half-time with a dipping 25-yard free-kick that looked to have deceived Eray Iscan.
The lead was short-lived, however, as Bulut collected Didier Drogba's pass before coolly slotting past Iker Casillas two minutes later.
Real went back ahead six minutes after the restart, Di Maria swinging in a low cross from the left to find the most unlikely of scorers in Arbeloa, who tucked home with surprising confidence amid suspicions of offside.
Arbeloa's spell in the spotlight did not end there and he was booked for diving in the 55th minute, before turning provider for Di Maria with 63 minutes gone.
Casillas produced a stunning save from Drogba's header before Isco added the fourth with a clever turn and finish in the box and there there was no way back for Mancini's men, who must now beat Juventus in the final group game to qualify.
|Valverde: Barcelona away goal not definitive for progression|
|Muller & Robben bemoan poor first half despite Bayern rout|
|Chelsea close to a perfect game against Barcelona - Conte|
|Defending for 90 minutes at Barcelona a ´suicide mission´ - Fabregas|
|Championship Review: Villa miss chance to move into promotion places|
|Messi ends his Chelsea hoodoo|
|Chelsea 1 Barcelona 1: Messi breaks Blues hoodoo to leave tie in the balance|
|Bayern Munich 5 Besiktas 0: Two-goal Muller inspires emphatic win after Vida red|
|De Vrij confirms intention to leave Lazio on free transfer|
|Sanchez move down to Champions League frustration at Arsenal - Mourinho|
|Mourinho suggests Pogba is fit to face Sevilla|
|AFC Champions League Review: Hulk & Oscar lead Shanghai, Jeonbuk Motors hit six|
|Cech expects Ospina to start for Arsenal in EFL Cup final|
|Gueye signs new Everton deal until 2022|
|FA charges Man City and Wigan for failing to control players|
|Aguero faces no action over Wigan fan incident|
|Las Palmas get green light to sign Viera replacement amid Nasri talk|
|FA issues West Ham with anti-doping charge|
|Florenzi a doubt to face Shakhtar, confirms Roma´s Di Francesco|
|Maybe we ´lock him up or tie him up´ – Montella ponders how to stop Sanchez|
|Pogba and Ibrahimovic train with Man Utd ahead of Sevilla tie|
|Zidane hints at resting Ronaldo for Real Madrid´s trip to Leganes|
|Modric adds to Real Madrid injury worries|
|Wolfsburg turn to Labbadia in fight for Bundesliga survival|
|Wigan to investigate pitch invasion after win over Manchester City|
|Drogba ´couldn´t be more proud´ as son signs for Guingamp|
|Stones making no excuses for shock Wigan defeat|
|Bellugi scathing of Inter form and transfer policy|
|Rakitic: I´ve not seen Messi in the gym this often|
|Besiktas face Bayern test, Messi seeks to end drought - Champions League in Opta numbers|
|Sevilla v Manchester United: Montella and Mourinho unified in pursuit of identity|
|Jose Morais: The Mourinho acolyte bringing Barcelona to Barnsley|
|Rakitic: More to Chelsea than just Hazard|
|Klopp tactics behind my form – Salah|
|Young: Man United can win Champions League|
|Messi is best but ´not invincible´, says Pedro|
|It´s a red card – Guardiola accepts Delph sending off amid City´s Wigan woe|
|Aguero lashes out at fan as tempers flare after Wigan stun Man City|
|Grigg revels in dousing Manchester City´s fire|
|Wigan Athletic 1 Manchester City 0: Grigg ends Guardiola´s quadruple dream|
|Messi the best but don´t forget Suarez, says Chelsea boss Conte|
|I need a great game – Hazard aiming for Messi heights|
|AFC Champions League Review: El-Arabi´s brace seals Al Wahda´s fate|
|Barcelona boss Valverde tells Chelsea: History counts|
|Schmidt departs as Wolfsburg face relegation fight|
|Madrid, Barca & PSG are Champions League favourites, says Heynckes|
|Former football coach Bennell sentenced to 31 years|
|Hummels wary of ´top European team´ as Bayern prepare for Besiktas|
|WATCH: ´Crazy´ Evra drives to West Ham training in London cab|
|Barca clash a chance for Chelsea ´to do things right´, proclaims Rudiger|
|Lucas claims Tottenham can win Champions League|
|Barcelona tie will not decide Conte´s Chelsea future, says Deco|
|Lewandowski won´t be distracted by Real Madrid rumours|
|Man Utd must not underestimate Sevilla - Navas|
|Iniesta will not be made welcome at Stamford Bridge, warns Azpilicueta|
|Ballack sees ´a big difference´ between Bundesliga and Premier League|
|Betis boss would have preferred to face Madrid´s BBC|
|Chelsea v Barcelona: Messi´s blues against the Blues|
|James leaving Madrid was the best thing, says father|
|He´s looking good – Zidane thrilled with Ronaldo|
|It needs to take 30 seconds – Matic wants quicker VAR|
|Gattuso: My job is to be the players´ nightmare until season´s end|
|I wasn´t good enough – Guardiola reveals Wigan rejection|
|Brazilian derby between Vitoria and Bahia abandoned after red-card frenzy|
|It was crazy, but I like that - Zidane revels in eight-goal Betis thriller|