Juventus climbed above Napoli and to within one point of Serie A leaders Roma with a 3-0 victory over Rafa Benitez's men on Sunday.
Fernando Llorente's second-minute strike set the hosts on their way to a sixth consecutive home win, with Andrea Pirlo's sublime free-kick and a stunning Paul Pogba volley wrapping up the points after the break.
Angelo Ogbonna's late sending off took some shine off Juve's fourth league win on the bounce, but the defending champions now have the summit in their sights after moving into second.
For the visitors, the result ended their five-match winning run in all competitions as they failed to capitalise on Roma's draw with Sassuolo.
Juventus made two changes from the midweek draw against Real Madrid in the UEFA Champions League, while Napoli made three after beating Marseille in the same competition.
Both teams had won their three previous games but it was Antonio Conte's men who made the decisive start.
Pogba's bouncing shot was tipped behind by Pepe Reina and from the short corner, Arturo Vidal's shot was flicked on to Llorente by Carlos Tevez and the Spaniard made no mistake from close range after only two minutes.
It would have been two but for a tremendous save by Reina. Pirlo's deep cross was headed across by Pogba towards Leonardo Bonucci six yards out but his point-blank header was somehow saved by the goalkeeper and Napoli scrambled clear.
More than 20 minutes passed before Napoli registered a shot on target but Lorenzo Insigne's effort on the turn was easy for Gianluigi Buffon.
Insigne almost provided an equaliser after 32 minutes when he found space in the area but his left-foot drive whistled past the post, while Reina had to be alert to thwart Llorente's near-post header.
The back and forth contest almost swung in favour of Benitez’s team just before the break and again it was Insigne who provided the danger with a dipping long-range strike that landed on the roof of the net.
The early exchanges of the second half were dominated by Napoli and the impressive Insigne once again provided the main threat. His curling free-kick after 50 minutes had to be tipped wide by Buffon.
Napoli had only failed to score once in the league all season and Marek Hamsik went close after 63 minutes but lashed into the side netting from inside the area.
Pirlo added the second with typical finesse, the midfielder's inch-perfect free-kick flying into the top corner from 25 yards.
And the impressive Pogba got on the scoresheet after 80 minutes with a spectacular 30-yard volley.
Ogbonna's obstruction of Dries Mertens saw him dismissed for a second booking with seven minutes left, but Juventus were home and dry by then.
|Wigan to investigate pitch invasion after win over Manchester City|
|Drogba ´couldn´t be more proud´ as son signs for Guingamp|
|Stones making no excuses for shock Wigan defeat|
|Bellugi scathing of Inter form and transfer policy|
|Rakitic: I´ve not seen Messi in the gym this often|
|Besiktas face Bayern test, Messi seeks to end drought - Champions League in Opta numbers|
|Sevilla v Manchester United: Montella and Mourinho unified in pursuit of identity|
|Jose Morais: The Mourinho acolyte bringing Barcelona to Barnsley|
|Rakitic: More to Chelsea than just Hazard|
|Klopp tactics behind my form – Salah|
|Young: Man United can win Champions League|
|Messi is best but ´not invincible´, says Pedro|
|It´s a red card – Guardiola accepts Delph sending off amid City´s Wigan woe|
|Aguero lashes out at fan as tempers flare after Wigan stun Man City|
|Grigg revels in dousing Manchester City´s fire|
|Wigan Athletic 1 Manchester City 0: Grigg ends Guardiola´s quadruple dream|
|Messi the best but don´t forget Suarez, says Chelsea boss Conte|
|I need a great game – Hazard aiming for Messi heights|
|AFC Champions League Review: El-Arabi´s brace seals Al Wahda´s fate|
|Barcelona boss Valverde tells Chelsea: History counts|
|Schmidt departs as Wolfsburg face relegation fight|
|Madrid, Barca & PSG are Champions League favourites, says Heynckes|
|Former football coach Bennell sentenced to 31 years|
|Hummels wary of ´top European team´ as Bayern prepare for Besiktas|
|WATCH: ´Crazy´ Evra drives to West Ham training in London cab|
|Barca clash a chance for Chelsea ´to do things right´, proclaims Rudiger|
|Lucas claims Tottenham can win Champions League|
|Barcelona tie will not decide Conte´s Chelsea future, says Deco|
|Lewandowski won´t be distracted by Real Madrid rumours|
|Man Utd must not underestimate Sevilla - Navas|
|Iniesta will not be made welcome at Stamford Bridge, warns Azpilicueta|
|Ballack sees ´a big difference´ between Bundesliga and Premier League|
|Betis boss would have preferred to face Madrid´s BBC|
|Chelsea v Barcelona: Messi´s blues against the Blues|
|James leaving Madrid was the best thing, says father|
|He´s looking good – Zidane thrilled with Ronaldo|
|It needs to take 30 seconds – Matic wants quicker VAR|
|Gattuso: My job is to be the players´ nightmare until season´s end|
|I wasn´t good enough – Guardiola reveals Wigan rejection|
|Brazilian derby between Vitoria and Bahia abandoned after red-card frenzy|
|It was crazy, but I like that - Zidane revels in eight-goal Betis thriller|
|Asensio credits Zidane for Madrid´s thrilling Betis comeback|
|Zidane hopeful over Marcelo hamstring injury|
|Bonaventura claims Milan can catch Inter|
|Bravo for Claudio! Guardiola to pick keeper at Wembley|
|Mourinho hoping for reinforcements at Sevilla|
|Real Madrid become first side to score 6,000 goals in LaLiga|
|Real Betis 3 Real Madrid 5: Asensio at the double in LaLiga classic|
|AC Milan 1 Sampdoria 0: Bonaventura makes it 10 unbeaten for Rossoneri|
|Schurrle excited to finally link up with Reus and Gotze|
|Real Madrid defender Marcelo suffers hamstring injury|
|Costa fumes referees ´want to give me a card´, but Simeone plays down penalty row|
|Stoger makes Dortmund history with Gladbach win|
|Championship Review: Leeds fight back for point, Norwich & Ipswich share derby spoils|
|Borussia Monchengladbach 0 Borussia Dortmund 1: Burki unbeatable as Reus returns to haunt Foals|
|FA Cup ´magic´ no surprise to Pochettino after Rochdale thriller|
|Rochdale hero Davies: This is every kid´s dream|
|Atletico Madrid will not stop in pursuit of Barcelona, promises Gameiro|
|´Wrong image´ to blame for VAR confusion in Manchester United´s FA Cup win|
|Rochdale 2 Tottenham 2: Davies denies Kane in FA Cup classic|
|Atletico Madrid 2 Athletic Bilbao 0: Gameiro and Costa settle cagey clash|
|Napoli set club record with another Serie A win|
|Napoli 1 SPAL 0: Allan sends hosts top of Serie A again|
|Allegri allays Higuain injury fears|
|Allegri convinced Juve can get past Spurs|
|Everton fear ´long-term´ injury for Mangala|
|If it isn´t Madrid, it´s Paris - Hazard tires of speculation|
|Torino 0 Juventus 1: Champions win derby but lose Higuain|
|Neymar exit made Barcelona stronger - Ter Stegen|
|Injured Higuain forced off against Torino|
|Jesus confident of returning strong after knee injury|
|We had to change hotels – Ovrebo recalls fury after 2009 Chelsea-Barcelona semi-final|
|Spalletti: Inter board will decide my future|
|Fabregas still wary of timeless Iniesta|
|Liverpool´s 30-goal hero Salah: There´s more to come|
|Valverde: Coutinho dropped for the good of Barcelona|
|Ronaldo better than Neymar? No says Xavi|
|Real Madrid hurt you with nothing – Xavi says PSG loss an injustice|
|Conte: Chelsea need perfect game to stop Messi and Barcelona|
|Inter in a fragile moment, says Spalletti|
|Booed Emery praises PSG´s mental strength|