Charlie Austin's 93rd-minute penalty denied 10-man West Ham a hard-earned Premier League point as Southampton escaped with a 3-2 win at St Mary's on Saturday.
Javier Hernandez looked to have secured a fantastic draw with a brace either side of half-time after the Saints surged two goals ahead, but Pablo Zabaleta's push on Maya Yoshida enabled substitute Austin to snatch all three points with effectively the last kick of the match.
Southampton had earlier opened up a two-goal lead as Manolo Gabbiadini found a way past Joe Hart after 11 minutes. The Hammers then lost Marko Arnautovic to a straight red card for catching Jack Stephens with his arm before Dusan Tadic made it 2-0 from the spot.
However, Hernandez appeared to be Slaven Bilic's saviour by cutting the deficit before half-time and then added an equaliser with around 16 minutes remaining, opening his account in thrilling fashion following his close-season move from Bayer Leverkusen.
But Austin stepped off the bench to roll in a late winner from the spot and give Mauricio Pellegrino a first league victory as Saints boss.
Bilic handed a first start to 18-year-old Declan Rice as he rung the changes following the 4-0 defeat at Manchester United, although his plans suffered a setback when Winston Reid sustained a calf injury in the warm-up.
Michail Antonio made his return from a lengthy hamstring injury and the winger looked lively from the outset, teeing up Arnautovic for a good early chance before heading a corner into the arms of Fraser Forster.
West Ham's encouraging start quickly came to an end, though, as Nathan Redmond put a smart pass into space for Gabbiadini, who raced into the area and swept a clean left-foot finish across Hart.
Arnautovic should have done better again when Hernandez whipped an enticing ball in behind the defence, but the Austrian's stooping header was well smothered by Forster.
Tempers began to flare with Mario Lemina at the centre of a couple of heated exchanges, catching Arnautovic with a stray arm before receiving an unpunished studs-up challenge from Mark Noble. The tension proved too much for Arnautovic as the winger caught Saints defender Stephens in the face with his arm and was promptly shown a straight red card – just as he was against the same opposition while at Stoke City last season.
His petulance was compounded within five minutes as former Saints defender Jose Fonte dragged down Steven Davis in the area, allowing Tadic to fire the spot-kick through Hart's legs.
There was still time for the Hammers to pull one back on the stroke of half-time with Hernandez punishing Forster for failing to hold Antonio's half-volley.
Gabbiadini exploded back into life on the hour as his long-range attempt crashed against the crossbar, while Tadic was also denied a second by Hart's sharp near-post save.
Those near-misses appeared costly when Hernandez again showed his poacher's instinct, tucking away at point-blank range after Forster pushed Diafra Sakho's effort against the bar.
A stunned Southampton only recovered in the closing moments, with Redmond shooting against the crossbar before Austin was gifted the chance to seal a dramatic victory.
Key Opta stats:
- Charlie Austin has been directly involved in three goals in his last two Premier League games versus West Ham (two goals, one assist).
- Manolo Gabbiadini's goal ended a run of nine hours and 15 minutes without a Premier League goal at St. Mary's for Southampton.
- Since the start of 2015-16, West Ham have conceded more goals from the penalty spot than any other Premier League team (13).
- Dusan Tadic, who made his 100th Premier League appearance, scored his first goal in 13 games.
- Javier Hernandez scored his first Premier League goals since April 2014 vs Newcastle (1,232 days ago) – all 39 of his goals in the English top-flight have come inside the box.
|Marcelino laughs off injury after hurting hamstring celebrating|
|Milan shouldn´t be losing to weaker teams – Fassone slams Montella´s men|
|MLS Review: Sporting KC, Portland keep pressure on|
|Wenger unwilling to sacrifice any potential trophy|
|Kane worth more than £100m – Noble|
|Klopp: I could write a book on defending|
|Ederson wishes Mane well after recovering from horror tackle|
|Morata shining as Chelsea´s leading man after Juve, Madrid frustration|
|Guardiola balks at Chelsea or United fearing in-form Manchester City|
|CAF Champions League Review: Etoile Sahel see off Al Ahli Tripoli to reach semi-finals|
|Brighton winner was a foul, claims frustrated Benitez|
|Spalletti: Unbeaten Inter must go beyond their limits|
|Brighton and Hove Albion 1 Newcastle United 0: Hemed the hero in second home win|
|Better late than never - Matuidi delighted with start to life at Juventus|
|Inter 1 Genoa 0: Late D´Ambrosio header snatches victory for Spalletti´s side|
|Delph a willing deputy for injured City left-back Mendy|
|Howedes ruled out for four weeks|
|Milan lacked determination and quality in Samp defeat - Montella|
|Sheffield Wednesday 2 Sheffield United 4: Clarke at the double in derby win|
|Uruguayan Primera Division fixtures cancelled amid referee strike|
|Mendy hoping to follow successful City season with World Cup triumph|
|Sampdoria 2 AC Milan 0: Duvan Zapata claims family bragging rights|
|Dybala backs dropped Higuain to rediscover clinical touch|
|21st century boy - Lyon youngster Geubbels makes Ligue 1 history|
|Napoli fear more knee surgery for Milik|
|Spalletti promises reaction from smarting Inter|
|Montella backs ´fired up´ AC Milan to ´raise the bar´|
|Meunier: PSG don´t have Neymar dependency|
|Pogba could have surgery on hamstring injury – surgeon|
|MLS Review: Shield-chasing Toronto beaten again, Union extinguish Fire|
|Allegri: Higuain needs to rediscover form after Juve axing|
|Juventus great Nedved comes out of retirement|
|I´ll be back! Schwarzenegger visits Barcelona|
|Are you on loan from Man City? Messi quizzes Girona´s Maffeo|
|CAF Champions League Review: Holders Sundowns out on penalties|
|Alba lauds Valverde´s impact at in-form Barcelona|
|Pjanic: Things will only get better for Juventus|
|Bosz points to collective effort despite Aubameyang & Philipp heroics|
|Juventus and Napoli make record-breaking Serie A start|
|Atletico have improved despite transfer ban, says Simeone|
|Championship Review: Pacesetters Leeds, Cardiff & Wolves battle to wins|
|Klopp: We are not the Harlem Globetrotters|
|Juventus 4 Torino 0: Dybala stars again in rampant derby victory|
|Girona 0 Barcelona 3: Centurion Suarez seals Catalan derby triumph|
|He´s been brilliant – Henderson delighted with Coutinho contribution|
|Klopp sees flawed performance at Leicester as typical of Liverpool|
|Benteke knee injury piles more woe on Palace|
|Emery angry at failure to give PSG ´very clear´ penalty|
|Llorente agrees new four-year Real Madrid deal|
|Ronaldo relaxed despite goalscoring woes, says Zidane|
|Dyche demands rule change after Van La Parra dive|
|Borussia Dortmund 6 Borussia Monchengladbach 1: Aubameyang hat-trick inspires Dortmund rout|
|Sane´s simple stuff delights Guardiola after poor pre-season|
|Leicester City 2 Liverpool 3: Classy Coutinho helps to halt Reds slump|
|Manchester United to take action after Lukaku chants resurface|
|Clement shoulders blame as Swansea´s home woes continue|
|18 shots, zero goals - why Cristiano Ronaldo is LaLiga´s most frustrated player|
|Like Barca without Messi or Madrid without Ronaldo – Verratti insists Neymar-less PSG are still grea|
|Chelsea star Morata must continue scintillating form – Conte|
|Mourinho hails ´amazing´ Manchester United fans despite reprisal of Lukaku song|
|Caixinha stands by ´loud and clear´ Old Firm row with Brown|
|Relieved Koeman hails ´incredible´ Niasse|
|The boys were not sharp – Mourinho concedes United had to go defensive at Southampton|
|Montpellier 0 Paris Saint-Germain 0: 100 per cent record ends in Neymar´s absence|
|Five-star Manchester City on best top-flight goal run since 1950s|
|Swansea 1 Watford 2: Late Richarlison strike secures victory for Silva´s side|
|Deportivo Alaves 1 Real Madrid 2: Ceballos off the mark as champions bounce back|
|Burnley 0 Huddersfield Town 0: Spoils shared after uninspired arm-wrestle|
|Everton 2 Bournemouth 1: Niasse double relieves pressure on Koeman|
|Manchester City 5 Crystal Palace 0: Guardiola´s men sink strugglers to go top|
|Southampton 0 Manchester United 1: Lukaku strikes again in unconvincing victory|
|Stoke City 0 Chelsea 4: Magic Morata hits hat-trick|
|Kane one of the best, Bilic says|
|Manchester United fans sing Lukaku chant in defiance of warnings|
|I am in love with him! - Pochettino praises derby hero Kane|
|Two-goal Kane surpasses 19 Premier League teams for shots against the woodwork|
|West Ham 2 Tottenham 3: Kane at the double to play derby hero again|
|Pulis regrets comments on Livermore´s West Brom absence|
|Rangers 0 Celtic 2: Rogic and Griffiths maintain Old Firm dominance|
|Atletico Madrid 2 Sevilla 0: Carrasco, Griezmann send Simeone´s side second|
|Ulreich shoulders blame as Bayern colleagues rally around stand-in keeper|
|Go **** yourselves - Wright blasts Arsenal fans after Oxlade-Chamberlain backlash|
|Falcao revels in career-best streak|
|De Bruyne, a drug test and a lot of questions - Mendy reveals origin of Man City move|
|Benevento blame captain Lucioni´s failed doping test on cream|
|Ibrahimovic stamp was an accident – Mings|
|Carroll must stay fit to earn new West Ham deal, says Bilic|
|Mourinho: Every Man United forward deserves to start|
|Salah better than expected at Liverpool – Klopp|
|Wenger: Something will happen to regulate transfer fees|
|Mourinho warns Shaw to work hard to regain Manchester United place|
|Ancelotti slams ´slow´ Bayern after Wolfsburg fightback|