Superstar forward Lionel Messi will be reduced to the role of spectator as Argentina take on Germany in a rematch of the World Cup final.
The South Americans meet Joachim Low's men this week less than two months after their 1-0 defeat to Germany at the World Cup showpiece in Rio de Janeiro.
Wednesday's clash serves as the perfect opportunity for new Argentina coach Gerardo Martino to make a strong first impression as they build towards next year's Copa America.
Martino was appointed following the resignation of Alejandro Sabella after the World Cup, but faces the most difficult of tasks if he is to get his tenure off to a winning start.
And Martino and Argentina's hopes of victory in Dusseldorf have been hit by the absence of Messi, who played under the 51-year-old at Barcelona last season and will be out of action due to a hamstring strain.
The 27-year-old has been withdrawn from the squad as a precaution and is not the only the key player unavailable to Martino.
Indeed, Rodrigo Palacio (ankle), Maxi Rodriguez (hamstring) and Ezequiel Garay (leg), all of whom contested the World Cup final, are on the sidelines, while forward Ezequiel Lavezzi is a doubt due to a back problem.
Germany will also be without an array of players that contested the gripping final at the Maracana, with former captain Philipp Lahm, defender Per Mertesacker and all-time leading goalscorer Miroslav Klose all retiring from international football after sealing a fourth world title for their country.
In addition, midfielder Bastian Schweinsteiger and defender Shkodran Mustafi were not considered fit enough to be named in the squad for the game at the Esprit Arena.
Arsenal midfielder Mesut Ozil is also a doubt through injury for Germany, although the hosts will be able to welcome back Marco Reus after the Borussia Dortmund star missed the World Cup due to an ankle ligament problem.
While much will be made of the quick renewal of acquaintances between the two sides, for Germany the game is little more than a prelude to their qualification campaign for UEFA Euro 2016, which they begin on Sunday against Scotland.
And goalkeeper Manuel Neuer is keen for Germany to build momentum ahead of that game.
"We have to hit the ground running," Neuer said.
"We have to have a good match against Argentina to prepare for Scotland because the team will be slightly different.
"It is very important for us to start our qualifiers with a win over Scotland on Sunday."
|Coach: J. Löw|
for J. Draxler 33'
for M. Neuer 46'
for M. Gómez 57'
for A. Schürrle 57'
for T. Kroos 71'
for B. Höwedes 77'
|Newcastle complete Mbemba swoop|
|Blackpool protest incurs FA fine|
|Scottish Premiership Preview: Dons seek to run Celtic closer|
|Paris Saint-Germain v Lyon: Ibrahimovic ready for season opener|
|Wolfsburg v Bayern Munich: De Bruyne centre of attention|
|Real Madrid 0 Milan 0 (10-9 on pens): Real lift second International Champions Cup|
|De Bruyne a doubt for Supercup clash|
|Reine-Adelaide needs time to blossom, says Walcott|
|Rodgers will not rush Ibe development|
|Napoli not interested in selling Higuain - De Laurentiis|
|Wilson agrees Bournemouth extension|
|Messi makes early Barcelona return|
|Ibrahimovic: My next move will be a very big surprise|
|Van Aanholt backs Lens to shine|
|Besiktas complete loan move for Gomez|
|McClaren: No decision on Coloccini future|
|Kane, Kaka hail goalkeeper Rimando|
|Chung eager to become FIFA president|
|Yedlin open to loan move|
|Tigres not scared of River trip - Ferretti|
|MLS Preview: Wright-Phillips, Lampard set to debut|
|´A draw is good for us´ - River´s Gallardo confident of Libertadores success|
|Di Maria poised for PSG switch - Blanc|
|Franjic: Bring on Bangladesh, Tajikistan|
|Van Gaal bemoans De Gea situation|
|MLS All-Stars 2 Tottenham 1: Kane stunner can´t spare Spurs|
|Manchester United 0 Paris Saint-Germain 2: Van Gaal´s defensive frailties exposed|
|Tigres UANL 0 River Plate 0: Visitors lose Gallardo in Copa Libertadores final first leg|
|Penedo parts ways with Galaxy|
|Benitez backs Mihajlovic, Milan to succeed|
|Barnetta joins Union in MLS|
|Allegri critical of Morata´s attitude|
|Franjic targets more A-League glory with City|
|Beto undaunted by Super Cup clash against Barca|
|Advocaat upbeat despite another Sunderland flop|
|McClaren praises Newcastle recruit Mitrovic|
|Payet will improve West Ham - Bilic|
|Pulis confirms interest in Lambert|
|Deila expects tough test in Baku|
|Drogba mobbed by Montreal Impact fans|
|UEFA Champions League Review: Ajax spurn two-goal lead at 10-man Rapid|
|Sunderland´s struggles continue as Doncaster cruise to win|
|Mahrez and Nugent on target in Leicester win|
|Mitrovic tastes debut defeat for Newcastle|
|Celtic 1 Qarabag 0: Boyata snatches crucial win|
|Jablonec 0 Copenhagen 1: Verbic cracker gives Danes the edge|
|Norwich sign Wisdom on loan from Liverpool|
|UEFA Europa League Preview: Koeman plays down importance of Vitesse links|
|Schneiderlin keen to learn from experienced duo|
|Mandzukic´s maiden Juventus goal seals win in Poland|
|Fofana completes Bastia loan|
|Deila delighted that Gordon pledges future to Celtic|
|Grenier ruled out for four months|
|Rooney: United squad ready for title challenge|
|Messi and Neymar available for start of season|
|Szczesny seals Roma switch|
|Benitez cools Mourinho war of words|
|Filipe Luis vows to win back Atletico fans|
|Besiktas in negotiations over Gomez switch|
|Kishna seals Lazio switch|
|Diaby completes Marseille move|
|Platini is bad for FIFA - Prince Ali|
|Bilic keen to make further additions|
|Brady makes Norwich move|
|Southampton complete Caulker loan|
|Rummenigge feels Muller ´will never leave´ Bayern|
|Platini to stand in FIFA presidential election|
|Howedes to remain Schalke skipper|
|Albion sign Hull defender Chester|
|Lucescu defends Fred selection amid doping allegations|
|Fabregas still in love with Arsenal|
|Luis Enrique ´happy´ with Barca´s US trip|
|Mourinho optimistic over Cahill and Costa|
|River owe Tigres´ Esqueda - Mercado|
|Van Gaal expecting big season from Shaw|
|Begovic keen to challenge Courtois|
|Mourinho launches attack on Benitez|
|CONMEBOL ´knocked on a lot of doors´ to keep half-spot - president|
|America 0 Benfica 0 (3-4 on penalties): Primeira Liga champions finally win|
|Napoli striker Higuain ´untouchable´ - Gabbiadini|
|Arsenal´s friendly form will boost confidence - Wenger|
|Nagatomo-Melo swap possible, says agent|
|Chelsea 2 Barcelona 2 (4-2 on penalties): Courtois stars for Premier League champions|
|Eriksen calls for ruthless Spurs|
|Pulis praises Berahino attitude|
|Alderweireld confident of top-four finish|
|Villa ready for tough Spurs clash|
|West Ham edge win on Carrow Road anniversary|
|Kozak scores twice as Villa draw at Wolves|
|Stanislas brace leads Bournemouth past Yeovil|
|Watford slip to friendly defeat at Cardiff|
|Lukaku injury sours Everton win at Dundee|
|UEFA Champions League Review: Fenerbahce draw blank as Monaco impress|
|West Brom earn friendly win over Walsall|
|Vardy at the double as Leicester beat Burton|
|Atletico impress in win over Oviedo|
|Herrera sacked by Mexico after ´punch´|
|Gerrard, Keane and Bradley pull out of MLS All-Star squad|
|Marseille reach Diaby agreement|
|Sammer thrilled with Vidal´s winning mentality|
|Platini expected to launch FIFA presidency bid|
|Romanov sacked me over Barca snub - Korobochka|
|Villa complete Crespo capture|
|Wolfsberger v Borussia Dortmund: Bender praises ´fun but exhausting´ training|
|Okaka swaps Sampdoria for Anderlecht|
|Southampton v Vitesse: Fonte excited for ´dream´ sojourn into Europe|
|Bournemouth agree King compensation|
|West Ham v Astra: Kouyate confident West Ham can progress|
|Vidal completes Bayern switch, signs four-year deal|
|Fabregas calls for Champions League improvement|
|BREAKING NEWS: Filipe Luis completes Atletico return|
|Bayern to present Vidal|
|Wenger unfazed by Mourinho´s spending jibe|
|Pellegrini: Sterling will justify price tag|
|Cavani hit with two-match Uruguay ban|
|Bonucci to remain at Juve until 2020|
|No bids for Berahino - West Brom|
|Putin: Blatter deserves a Nobel prize|
|Howe: Swansea a benchmark for Bournemouth|
|New Parma to play in Serie D|
|Mata vows to hit the goal trail at United|
|Drogba ´perfect fit´ for Montreal|
|Berahino ´not yet´ ready for Tottenham - Irvine|
|Romero lauds caring Van Gaal|
|Jese flying at Real under Rafa|
|Sampdoria unwilling to pay €10m for Balotelli|
|Mourinho talks up Arsenal title chances|
|Hull sign Ryan Taylor, Sam Clucas|
|Kane, Pochettino hail MLS All-Star test|
|Di Santo sorry for swift Werder departure|