Superstar forward Lionel Messi will be reduced to the role of spectator as Argentina take on Germany in a rematch of the World Cup final.
The South Americans meet Joachim Low's men this week less than two months after their 1-0 defeat to Germany at the World Cup showpiece in Rio de Janeiro.
Wednesday's clash serves as the perfect opportunity for new Argentina coach Gerardo Martino to make a strong first impression as they build towards next year's Copa America.
Martino was appointed following the resignation of Alejandro Sabella after the World Cup, but faces the most difficult of tasks if he is to get his tenure off to a winning start.
And Martino and Argentina's hopes of victory in Dusseldorf have been hit by the absence of Messi, who played under the 51-year-old at Barcelona last season and will be out of action due to a hamstring strain.
The 27-year-old has been withdrawn from the squad as a precaution and is not the only the key player unavailable to Martino.
Indeed, Rodrigo Palacio (ankle), Maxi Rodriguez (hamstring) and Ezequiel Garay (leg), all of whom contested the World Cup final, are on the sidelines, while forward Ezequiel Lavezzi is a doubt due to a back problem.
Germany will also be without an array of players that contested the gripping final at the Maracana, with former captain Philipp Lahm, defender Per Mertesacker and all-time leading goalscorer Miroslav Klose all retiring from international football after sealing a fourth world title for their country.
In addition, midfielder Bastian Schweinsteiger and defender Shkodran Mustafi were not considered fit enough to be named in the squad for the game at the Esprit Arena.
Arsenal midfielder Mesut Ozil is also a doubt through injury for Germany, although the hosts will be able to welcome back Marco Reus after the Borussia Dortmund star missed the World Cup due to an ankle ligament problem.
While much will be made of the quick renewal of acquaintances between the two sides, for Germany the game is little more than a prelude to their qualification campaign for UEFA Euro 2016, which they begin on Sunday against Scotland.
And goalkeeper Manuel Neuer is keen for Germany to build momentum ahead of that game.
"We have to hit the ground running," Neuer said.
"We have to have a good match against Argentina to prepare for Scotland because the team will be slightly different.
"It is very important for us to start our qualifiers with a win over Scotland on Sunday."
|Coach: J. Löw|
for J. Draxler 33'
for M. Neuer 46'
for M. Gómez 57'
for A. Schürrle 57'
for T. Kroos 71'
for B. Höwedes 77'
|I´m glad Rochdale haven´t made the news - Hughes|
|Getafe 2 Celta Vigo 1: Hosts come from behind for first win in 10|
|Real hit back at media reports over transfer dealings|
|Rochdale 1 Stoke City 4: Joy and angst for Bojan as Premier League side progress|
|Turkish Super Lig Review: Kuyt at the double in Fenerbahce win, Besiktas back on track|
|Senegal v Algeria: Morale is high, insists Gourcuff|
|Cassano leaves beleaguered Parma|
|Copa del Rey Preview: Atleti look to overturn Barca advantage, Espanyol wary|
|Atletico Madrid v Barcelona: Griezmann targets second-leg fightback|
|Sheffield United v Tottenham: Clough expects fired-up Spurs for second leg|
|Cape Verde 0 Zambia 0: Stalemate sends both sides out|
|Democratic Republic of Congo 1 Tunisia 1: Both teams qualify for quarter-finals|
|FA Cup fifth round: Middlesbrough handed Arsenal test|
|South Africa v Ghana: Must-win game for Mashaba´s men|
|Parma v Juventus: Serie A leaders strong favourites to reach semi-finals|
|Van Praag planning to stand for FIFA presidency|
|Inter snap up Brozovic|
|Van Persie unsure of long-term United future|
|Broken metatarsal rules El Shaarawy out for at least six weeks|
|FIFA: No disciplinary proceedings against Real|
|No Plan B if Guardiola goes - Rummenigge|
|Millwall take Hooiveld on loan|
|Chile v United States: Klinsmann has high hopes for young stars|
|Carver to lead Newcastle until end of season|
|Shenaishil taking positives from last-four exit|
|Neymar happy with life at Barca and Messi relationship|
|Lucas Silva ready for life at Real|
|Milan ´always with Inzaghi´ - Menez|
|Rodriguez living the dream at Real|
|Stielike expecting Australia in final|
|Mourinho not dwelling on Bradford defeat|
|Schweinsteiger under no pressure to extend Bayern contract|
|Herd heads to Wigan on loan|
|Inter defensive duo suffer hamstring tears|
|UAE coach Ali eyes Asian Cup final|
|Gattuso dreaming of managing Rangers|
|Fiorentina agree return of Gilardino on loan|
|Sakho hits back at critics|
|South Korea 2 Iraq 0: Kim books sixth Asian Cup final place|
|Sturridge could return against Chelsea|
|Zinnbauer backs Drobny as Hamburg first choice|
|Drogba targeting Chelsea stay|
|Postecoglou confident Australia squad can progress|
|UEFA does not have the courage to run against me - Blatter|
|Foster: Anichebe unplayable|
|Australia v UAE: Japan´s absence a boon for Asian Cup hosts|
|Milan v Lazio: Injury-hit visitors aiming for back-to-back wins|
|Trezeguet confirms retirement|
|No ´major problems´ with Nicolas Frey´s head wound|
|Strootman injury not "serious" - Garcia|
|No Paraguay, USA for retiring Riquelme|
|Saint-Etienne did not try to play football - Blanc|
|Primeira Liga Review: Sporting move within one point of Porto|
|La Liga Review: Parejo downs Sevilla, Resino starts with a point|
|Serie A Review: Juve go seven points clear as Roma draw again|
|Ligue 1 Review: Paris Saint-Germain and Lyon make Marseille pay for slip-up|
|Burkina Faso coach puts AFCON exit down to bad luck|
|Saint-Etienne 0 Paris Saint-Germain 1: Ibrahimovic scores in repeat performance|
|Shenaishil optimistic despite Kasim absence|
|Walcott: Goal has been a long time coming|
|DR Congo v Tunisia: Leekens warns against complacency|
|Congo 2 Burkina Faso 1: Thievy helps send 2013 runners-up crashing out|
|Gabon 0 Equatorial Guinea 2: Balboa and Iban put hosts through|
|McCarthy and Distin on road to recovery|
|Gil has hit the ground running - Lambert|
|Eredivisie Review: Ajax and Feyenoord lose ground after dour draw, Eagles secure big win|
|Wenger confirms Gabriel move is imminent|
|Eto´o presented to Sampdoria fans|
|Cape Verde v Zambia: Victory a must for 2012 winners to avoid elimination|
|Brighton and Hove Albion 2 Arsenal 3: Walcott and Ozil among the goals for holders|
|Mancini upbeat despite ´cruel´ late defeat|
|Pogba revelling in rich vein of form|
|Aston Villa 2 Bournemouth 1: Gil helps under-fire Lambert breathe easy|
|Defour dismissed after Standard Liege banner taunt|
|Allardyce relieved with scrappy West Ham win|
|Sturridge ´happy man´ after return to Liverpool training|
|Inter 0 Torino 1: Moretti ends unbeaten run for top-four hopefuls|
|Juventus 2 Chievo 0: Pogba inspires victory as leaders march on|
|Bristol City 0 West Ham 1: Super sub Sakho sinks City|
|Hughes in talks over new Stoke deal|
|Delph signs new contract|
|Chelsea v Liverpool: Mourinho demands League Cup response|
|Football League Preview: Derby eye top two, Cambridge back to reality|
|Nani not giving up on Old Trafford career|
|Perth Glory 3 Melbourne Victory 3: Leaders stage two-goal late comeback|
|Neymar: Barca have no interest in Real results|
|Milan defender Mexes apologises for red card|
|South Korea v Iraq: Strange lead-up for Shenaishil´s men|
|Lazio´s Djordjevic thanks well-wishers ahead of ankle surgery|
|Iran´s Asian Cup appeal dismissed by AFC|
|Cech urges Chelsea to clean up FA Cup exit ´mess´|
|Henderson: Liverpool are up for the cup|
|Edimar wants ´normal´ ban for Real star Ronaldo|
|Pellegrini defends misfiring City strikers|
|Australia ready for UAE - Sainsbury|
|Blanc takes positives from past|
|Inzaghi promises ´something different´ at Milan|
|Mexes sorry for seeing red|
|La Liga Review: Wins for top three|
|Vitoria Guimaraes 2 Gil Vicente 2: Last-gasp penalty salvages point for hosts|