Inter's sporting director Piero Ausilio has confirmed Esteban Cambiasso and Diego Milito are to leave the club at the end of the season.
Both players had been tipped to depart San Siro after coming to the end of their contracts, with Cambiasso recently suggesting that he was not likely to be offered fresh terms.
Inter owner Erick Thohir looks set to splash the cash in the close-season, with Manchester United captain Nemanja Vidic due to arrive, and a host of other big names linked with a switch.
With incoming players likely ahead of next season, Ausilio confirmed the pair are set to leave, although he hinted that Cambiasso could return in a non-playing capacity.
"I speak to Cambiasso every day in an informal manner, as he is a friend," Ausilio explained on ahead of Sunday's trip to Chievo.
"Today there was a difficult moment between him and I, as we talked about the future. Due to reasons of strategy, renewal and an Inter for young players, he will not be confirmed in the squad (for next season).
"We will not propose a new contract. He understood this and sooner or later will return to us."
On Milito, he added: "We said to each other it was preferable to change, he knows that.
"Milito does not represent a problem for us, as he is a professional who loves our club colours.
"I would like to win tomorrow with him as a protagonist. It would be great closure."
The likes of Fernando Torres, Alvaro Morata and Edin Dzeko have all been linked with a move to Inter in recent months and Blackpool's forward Tom Ince became the latest reported target this month.
Ausilio revealed that Ince may replicate his father Paul and play for the club but insisted that it was "not a done deal".
"He's a young player with an expiring contract who is weighing up several offers," he explained.
"It's definitely not a done deal for Ince. It's an intriguing possibility, him coming here in his father's footsteps."
|Kasperczak committed to attacking approach as Tunisia reach AFCON quarters|
|Slimani wants Algeria youngsters to learn from AFCON humiliation|
|Senegal 2 Algeria 2: Slimani at the double as Desert Warriors bow out|
|Zimbabwe 2 Tunisia 4: First-half glut seals progression|
|Adrian: I always wanted to return to Villarreal|
|Togo v DR Congo: Agassa could miss crucial game after vandals hit home|
|Extended Southampton stay on the cards for Sims|
|Bayern hoping for speedy Vidal return|
|Hull sign Markovic on loan from Liverpool|
|Wenger charged with misconduct by FA|
|Deulofeu joins AC Milan - and this time the deal is definitely done!|
|Henderson still playing through pain, reveals Klopp|
|Record-breaking Rooney reveals secret to longevity|
|No ulterior motive behind Van Dijk captaincy call - Puel|
|Carroll ignoring want-away Payet|
|Gerrard´s managerial ambitions ´wonderful news for Liverpool´ - Klopp|
|PSG interested in Guedes, confirms Emery|
|Barca lose Busquets to sprained ankle|
|Pulisic commits to Dortmund until 2020|
|Mason speaking after suffering fractured skull|
|Aubameyang blames poor preparation for Gabon AFCON exit|
|David Beckham returns to PSG|
|Morocco v Ivory Coast: Holders must beat old boss Renard as group reaches thrilling conclusion|
|Djilobodji charged over Fletcher incident|
|Cahill and Terry visit Mason in hospital|
|Allardyce onto second-choice transfer targets|
|Dortmund sign teenager Isak|
|Madrid confirm Modric and Marcelo injury blows|
|Vidal fears longer lay-off, targets return against Arsenal|
|Yaya Toure: Sterling should have dived!|
|Turan wants to see out Barcelona contract despite China talk|
|Impassioned Ibrahimovic attacks Rooney´s critics|
|´He has to lose weight´ – Mihajlovic angry after dropping Maxi Lopez|
|Lack of Liverpool signings frustrates Klopp|
|Suarez: Busquets difficult to replace for Barca|
|Depay impresses Lyon after debut|
|CSL? Rooney committed to United|
|Denis Suarez wants more goals after opening Barca account|
|Simeone bemoans inconsistency but says Atletico are improving|
|Mourinho won´t stand in the way of Rooney and CSL|
|Dzeko on target as Roma stay on Juve´s tail|
|Rakitic ready to cover for injured Busquets|
|Bale and Kane wish Mason well after serious injury|
|Busquets injury less severe than feared - Luis Enrique|
|Mason in stable condition after skull fracture|
|Senegal v Algeria: Misfiring favourites in last-chance saloon|
|PSV provide perfect finish for darts champ Van Gerwen|
|Broos predicts ´something great´ for Cameroon|
|Eibar 0 Barcelona 4: MSN see Barca to victory after Busquets blow|
|Busquets sustains ankle ligament damage in Eibar v Barcelona|
|Cameroon 0 Gabon 0: Aubameyang miss haunts hosts as AFCON campaign ends|
|Guinea-Bissau 0 Burkina Faso 2: Traore on target as Stallions advance|
|Busquets injury at Eibar compounds Barcelona midfield woes|
|Deulofeu lands in Italy ahead of AC Milan move|
|´I made the best decision´ - Conte basks in Costa recall|
|Wenger urges Xhaka not to ´punish´ Arsenal|
|Ex-Bastia man Palmieri questions Balotelli racial abuse claims|
|Costa reaction hailed by Cahill|
|Manchester City must be mentally strong, says embattled Bravo|
|Chelsea 2 Hull City 0: Costa back with a bang for Blues|
|Koke lauds Griezmann ´stroke of genius´ as Atletico snatch draw|
|Pioli questions Ansaldi dismissal|
|´I should have shut up and I apologise´ - Wenger sorry for ref rant|
|Arsenal can be proud of this red-card record|
|Mustafi: Arsenal never give up|
|Higuain: Lazio posed no threat to Juventus|
|Athletic Bilbao 2 Atletico Madrid 2: Griezmann magic rescues point|
|Puel unsure Van Dijk will be fit for Liverpool clash|
|Free-scoring Monaco return to Ligue 1 summit|
|Arsenal 2 Burnley 1: Sanchez snatches thrilling win for 10-man Gunners|
|Palermo 0 Inter 1: Joao Mario strike extends Inter streak|
|Arsenal fans give Alexis Sanchez paws for thought|
|Costa returns to Chelsea XI to face Hull City|
|Inter cannot delude fans about Messi - Ausilio|
|Allegri admits new Juventus formation was a ´mad idea´|
|Leicester boss Ranieri admits to tactical mistakes|
|Zimbabwe v Tunisia: Kasperczek demands ruthlessness with quarter-final spot on the line|
|Southampton 3 Leicester City 0: Saints end losing streak but suffer potential Van Dijk blow|
|Juventus 2 Lazio 0: Dybala and Higuain strikes see leaders return to form|
|Iborra makes a mark at both ends as Sevilla scrape past Osasuna|
|Pogba hails ´brother´ Griezmann as Manchester United speculation continues|
|Costa fight rumour ´not nice´, says Courtois|
|Henry makes emotional Ozil plea: Stay and become an Arsenal legend|
|Welbeck still has huge promise, says Wenger|
|A-League Review: Wanderers finally end home hoodoo|
|Tevez denies he´s highest-paid player after CSL move|
|Napoli capable of greatness - Sarri|
|Montella proud of Milan display against Napoli|
|Ramos tells Madrid fans: We need support|
|Conte: Costa committed to Chelsea|
|Callejon credits ´Maradona effect´ as Napoli down AC Milan|