Milan welcome a buoyant Sassuolo to San Siro needing a miracle to secure their place in the UEFA Europa League places this season.
Clarence Seedorf's hopes of guiding Milan to European football look all but lost after they were beaten 2-1 by Atalanta last time out.
Franco Brienza scored deep into injury time on Sunday to snatch three points for the hosts and deal Milan a major blow in their quest for Europe.
Milan must now beat 16th-placed Sassuolo and will likely need both Torino and Parma to lose on the final day of the Serie A campaign - they take on Fiorentina and Livorno respectively.
Their season finale comes amid strong rumours that Seedorf, appointed as Massimiliano Allegri's replacement in January, will be sacked in the close-season despite making a reasonably positive start to his managerial career.
Even qualification for Europe's second-tier club competition is unlikely to do much to strengthen his position but the Dutchman is eager to finish the campaign on a high - whether it proved to be his final match in charge or not.
"We'll be hoping to do well in the last match," he said after the defeat to Atalanta.
"There's some disappointment for the loss and for how we lost. Now we have to wait and see. Our destiny wasn't completely in our hands even before and it's less so now."
Midfielder Kaka added: "We need to win next Sunday for our pride and to close the season well."
While the pressure is on Milan going into their final game of the season, Sassuolo can relax knowing they have already secured their top-flight status.
Eusebio Di Francesco has helped the club to Serie A safety after their first season in the league, having taken 10 points from their last five games, and will look for a repeat of their dramatic 4-3 win over Milan early this year.
If this does prove to be Seedorf's final game in charge, there would be a certain symmetry to it all, as the seven-goal thriller in January was the final straw for Milan in Allegri's reign.
Domenico Berardi scored four times that day at the Stadio Citta del Tricolore and, even if they fail to do the double over Milan, Di Francesco feels their season has already been a success.
"This safety is worth a Scudetto for us, so achieving it a round early is nothing short of miraculous," he said.
Seedorf has no fresh injury concerns and could hand a debut to 15-year-old Hachim Mastour. Should he play, he would edge out Paolo Maldini to become the youngest player to feature for the club.
|5||P. Mexès||32' 68'|
|2||M. De Sciglio||89'|
|34||N. de Jong||27'|
|Coach: C. Seedorf|
for S. Muntari 59'
for K. Constant 63'
for Kaká 73'
|Blatter formally submits bid to remain FIFA president|
|Puncheon predicts ´great times´ for Palace|
|Donadoni has no plans to leave Parma and criticises Cassano|
|Mangala: My first season at City could have been better|
|UAE v Iraq: Rare podium finish on offer|
|Ryan spurred on by Australia´s 2011 heartbreak|
|Montella will not sell Cuadrado cheap|
|Mali, Guinea furious with tie-breaking procedure|
|Luis Enrique defends Neymar´s behaviour|
|Gabi: Referee lacked personality|
|Chile 3 USA 2: Gonzalez´s brace extends Americans´ pain|
|Franjic cleared of serious injury|
|Our progression was deserved - Pochettino|
|Ivory Coast´s tournament starts now - Renard|
|Allegri rejects Juve criticism|
|Atletico´s Arda Turan escapes red card after throwing boot at assistant referee|
|Atletico Madrid 2 Barcelona 3 (agg 2-4): Neymar double secures semi-final spot|
|Parma 0 Juventus 1: Morata late show wins it for visitors|
|Sheffield United 2 Tottenham 2 (agg 2-3): Pochettino books Wembley final|
|Ecuador dismiss Vizuete|
|Championship Preview: Middlesbrough out to continue run, Bournemouth seek response|
|Guinea 1 Mali 1: Lots to decide Group D runners-up|
|Cameroon 0 Ivory Coast 1: Gradel strike sends Renard´s men through|
|Lots to be drawn to decide AFCON qualifiers|
|Eredivisie Preview: De Boer warning for Ajax, leaders PSV host Willem II|
|Bundesliga Preview: Leaders Bayern and Wolfsburg kick off Ruckrunde|
|Howard boost for Everton|
|Ligue 1 Preview: Jardim plays down Monaco title hopes ahead of Lyon showdown|
|Costa charged by FA for alleged Can stamp|
|O´Keefe joins Cardiff|
|Dons teenager Alli in demand|
|Gabriel seals Arsenal switch|
|Wolfsburg v Bayern Munich: Guardiola eyes ´big step´ to Bundesliga title|
|Paris Saint-Germain v Rennes: Montanier seeks another upset in French capital|
|Martinez rules out panic buys|
|Gilardino targets Fiorentina goals|
|Milan agree Bocchetti loan|
|League Two Preview: Cambridge and Luton prepare to renew rivalries|
|Ronaldo hit with two-match ban|
|West Brom complete McManaman deal|
|Sullivan hits back in Sakho row|
|Richards: Cuadrado suited to Premier League|
|Figo to challenge for FIFA presidency|
|Inzaghi out to freshen up struggling Milan|
|Wigan agree a fee for Mckay|
|Carver eyes strong finish|
|Bowen cools talk of Stoke swoop for Sandro and Traore|
|Lazio-bound Morrison lands in Rome|
|Mourinho fined £25k for ´campaign´ claims|
|Mainz bring in Castillo|
|Villa: Lambert will not be sacked|
|Monk hopeful of adding new faces|
|Sainsbury ready to replace Franjic|
|Beckenbauer hopeful of Guardiola stay|
|Mourinho hits back at Costa critics|
|Rodriguez grateful for ´fundamental´ Ronaldo support|
|La Liga Preview: Real want revenge against Socieded|
|No Dallas move for Essien|
|Bale rubbishes United link, Ronaldo rift|
|Sahin in ´good shape´ for Bundesliga resumption|
|Rodgers slams Costa´s stamp collection|
|Under-fire Inzaghi urges patience|
|Rodgers: Courtois saved Chelsea|
|Mashaba wants lessons to be learnt after AFCON exit|
|Mourinho refuses to wade into Costa incidents after Chelsea win|
|Football League Review: Bent double sends Derby second, Rotherham triumph|
|Chelsea 1 Liverpool 0 (aet, agg 2-1): Ivanovic settles action-packed League Cup semi-final|
|Milan 0 Lazio 1: Inzaghi future plunged into further doubt|
|Neymar dreaming of ending Brazil´s home hoodoo|
|South Africa 1 Ghana 2: Late Ayew winner seals qualification|
|Senegal 0 Algeria 2: Mahrez and Bentaleb dump Senegal out|
|Bocchetti poised to join Milan on loan|
|De Rossi suffers calf injury|
|Montano accuses Oldham of double standards after Evans saga|
|Bojan out for the season with ruptured cruciate|
|Cameroon v Ivory Coast: Renard defends Yaya Toure|
|Yanga-Mbiwa makes Roma move permanent|
|Guinea v Mali: Quarter-final berth on offer in Mongomo|
|Thohir: Inter not reliant on European football|
|Bremen land Vestergaard|
|Allegri refuses to rule out Cassano move|
|Mexes handed four-game ban after Lazio dismissal|
|Joyce reveals Valdes´ inspirational team-talk|
|CAF announces AFCON venue switches|
|Alcacer commits future to Valencia|
|Postecoglou calls for Aussie ´energy´|
|Everton confirm Eto´o departure to Sampdoria|
|Pochettino to stick with Vorm despite cup error|
|Barcelona are not favourites against Atletico, says Luis Enrique|
|Allegri wary of Parma backlash in Coppa Italia|
|Zidane urges Real to tie Ancelotti down|
|FIFPro: Transfer system failing football|
|Anderlecht condemn Standard´s Defour banner|
|Australia 2 UAE 0: Socceroos ease into home final|
|Barca overhaul youth system|
|FIFPro demands clubs respect contractual obligations|
|Mahmoud targeting World Cup place with Iraq|
|Fabregas wants Chelsea to show winning mentality|
|Rangers borrow £10m from Ashley´s Sports Direct|
|Lyon face anxious wait over Lacazette|
|Undermanned Lazio recall Perea|
|Ki wants South Korea to prove their superiority|
|Ghana´s Gyan wary of South Africa|
|Mashaba urges South Africa to attack|
|Benitez: Napoli deserved to win|
|Pacos de Ferreira 1 Benfica 0: Leaders fail from the spot|
|Serie A Review: Higuain at the double in controversial Napoli win, Udinese see off Empoli|