Milan welcome a buoyant Sassuolo to San Siro needing a miracle to secure their place in the UEFA Europa League places this season.
Clarence Seedorf's hopes of guiding Milan to European football look all but lost after they were beaten 2-1 by Atalanta last time out.
Franco Brienza scored deep into injury time on Sunday to snatch three points for the hosts and deal Milan a major blow in their quest for Europe.
Milan must now beat 16th-placed Sassuolo and will likely need both Torino and Parma to lose on the final day of the Serie A campaign - they take on Fiorentina and Livorno respectively.
Their season finale comes amid strong rumours that Seedorf, appointed as Massimiliano Allegri's replacement in January, will be sacked in the close-season despite making a reasonably positive start to his managerial career.
Even qualification for Europe's second-tier club competition is unlikely to do much to strengthen his position but the Dutchman is eager to finish the campaign on a high - whether it proved to be his final match in charge or not.
"We'll be hoping to do well in the last match," he said after the defeat to Atalanta.
"There's some disappointment for the loss and for how we lost. Now we have to wait and see. Our destiny wasn't completely in our hands even before and it's less so now."
Midfielder Kaka added: "We need to win next Sunday for our pride and to close the season well."
While the pressure is on Milan going into their final game of the season, Sassuolo can relax knowing they have already secured their top-flight status.
Eusebio Di Francesco has helped the club to Serie A safety after their first season in the league, having taken 10 points from their last five games, and will look for a repeat of their dramatic 4-3 win over Milan early this year.
If this does prove to be Seedorf's final game in charge, there would be a certain symmetry to it all, as the seven-goal thriller in January was the final straw for Milan in Allegri's reign.
Domenico Berardi scored four times that day at the Stadio Citta del Tricolore and, even if they fail to do the double over Milan, Di Francesco feels their season has already been a success.
"This safety is worth a Scudetto for us, so achieving it a round early is nothing short of miraculous," he said.
Seedorf has no fresh injury concerns and could hand a debut to 15-year-old Hachim Mastour. Should he play, he would edge out Paolo Maldini to become the youngest player to feature for the club.
|5||P. Mexès||32' 68'|
|2||M. De Sciglio||89'|
|34||N. de Jong||27'|
|Coach: C. Seedorf|
for S. Muntari 59'
for K. Constant 63'
for Kaká 73'
|Pereyra poised for Juve switch|
|Fabregas eyes trophies at Chelsea|
|Vorm confirms Tottenham transfer|
|Deila: Forster will leave Celtic eventually|
|No pressure for Shaw|
|Van Gaal happy with preparations|
|Diarra aiming for Bordeaux return after West Ham frustration|
|Last season for Montpellier owner Nicollin|
|Monaco: Rodriguez deal too good to ignore|
|Nacional Asuncion 2 Defensor Sporting 0: Hosts surge towards Libertadores final|
|Garcia eyeing Serie A title|
|Father against Vlasic´s move abroad|
|Rodgers welcomes Gerrard´s international retirement|
|Cruzeiro, Atletico Mineiro bid for Robinho|
|Inzaghi not drawn into Balotelli speculation|
|Dunga ´not going to sell a dream´|
|City´s Fofana allegedly racially abused|
|Carroll ruled out of NZ friendlies|
|Rodgers excited by new arrivals|
|Zeljeznicar 2 Metalurg Skopje 2 (agg 2-2): Visitors advance on away goals|
|Gibson returns as Tranmere hold Everton|
|UEFA Champions League Review: Celtic coast through, BATE given scare|
|Gomez and Jones feature in Sunderland win|
|Leicester hit Ilkeston for six|
|Austin fires QPR to narrow victory|
|Guardiola: No trophies and I may be sacked|
|Dortmund held as Immobile makes debut|
|Rodriguez´s dream becomes Real|
|Garcia: Benatia and Ljajic going nowhere|
|Stoke secure Bojan on four-year deal|
|FA: No World Cup bids for England|
|Kroos commits to Bremen|
|Caulker makes QPR move|
|Forest agree Hunt loan deal with Palace|
|Bartra ready to prove himself at Barca|
|Southampton looking to sell Osvaldo|
|Marveaux loaned to Guingamp|
|Mourinho eyes success on two fronts|
|Sammer encouraged by Lewandowski start|
|PSG punished for abuse of Chelsea fans|
|Dunga unveiled as Brazil coach|
|Shakhtar CEO: Focus is on players´ safety|
|Foster agrees new West Brom deal|
|Real Madrid sign Rodriguez|
|Mustafi eyes Bundesliga switch|
|Klopp laughs off Hummels, Reus speculation|
|Campana makes Sampdoria switch|
|Leicester seal Ulloa deal|
|Morata sidelined for seven weeks with knee injury|
|Riviere on target in comfortable Newcastle win|
|Advocaat set for Serbia role|
|Wisdom joins West Brom on loan|
|Bundesliga to consider vanishing foam|
|Five-man shortlist for Ivory Coast|
|´Personal issues´ keep Gervinho away from Roma tour|
|Jedinak raring to go|
|Borini set for Liverpool stay, claims agent|
|Koeman: No bids for Lovren|
|Livermore: England hopes shouldn´t hinge on club side|
|MLS Preview: Tough tests for Conference leaders, Revolution still struggling|
|Mathieu not Barca material, says Marquez|
|West Brom claim unimpressive win in Sacramento|
|Neymar: Brazil behind Germany, Spain|
|Vietnamese police confirm match-fixing players|
|Lucescu blames Joorabchian for AWOL players|
|Robinho undecided on future|
|Rush: Still years left in Gerrard|
|Tiago re-signs with Atletico|
|Puyol against Spain overhaul|
|Agger considering his Liverpool future|
|Peruvian Primera Division Review: Juan Aurich bounce back, Melgar draw with Inti Gas|
|Bayern deny interest in Cuadrado|
|New signings on show in Hull double-header|
|Hooiveld strike sinks Swindon|
|Costa departs Valencia|
|Morata suffers knee injury in training|
|K.League Preview: Seoul, Sangju aim to close gap to sixth, Ulsan host Jeonbuk|
|Lewandowski off the mark on Bayern bow|
|Gerrard retirement will boost Liverpool - Carragher|
|World Cup bidding report due in September|
|Evra bids emotional farewell to United fans|
|J.League Preview: Ventforet Kofu look to escape drop zone, Sagan Tosu battle Kawasaki Frontale|
|Salah spared military service|
|Garcia would welcome Torres return|
|Livermore understands Ince decision|
|Cole happy to get away from English press|
|Evra seals Juve switch|
|Bayern stay was Kroos´ ´priority´|
|Scuffet: Udinese right place to continue developing|
|Gerrard retires from England duty|
|Ambitious Pochettino targets title|
|Aspas eager to put ´bad season´ behind him|
|Atletico Mineiro v Lanus: Visitors out to recover from first-leg loss|
|UEFA Europa League Preview: Sligo, Inter Baku out to finish shocks|
|Hughes expects Bojan decision soon|
|Cech on the mend - Holland|
|Pardew eager to honour crash victims|
|Prandelli hits back at critics|
|Negredo breaks metatarsal|
|Rooney eager to impress Van Gaal|
|Palacios´ Qatar move falls through|
|Wenger rules out striker signing|
|Six Shakhtar players refuse to return|
|Six Vietnamese footballers arrested for match fixing|
|Copa Libertadores Preview: Nacional Asuncion, San Lorenzo to host first legs|
|Mata hopeful of title|
|Napoli bullish about Scudetto chances|
|Colombian Primera A Review: Patriotas Boyaca, Deportes Tolima start with wins|
|Subotic thrilled to be back|
|Germain: Monaco can replace Rodriguez|
|Sullivan confident of Carroll improvement|
|Callejon staying put|
|DC United 3 Chivas USA 1: DC end Chivas´ winning run|
|Liga MX Review: Goalkeeping howler costs champions Leon, Monterrey move top|
|Chilean Primera Division Review: Huachipato, Santiago Wanderers opening-day winners|
|Brazilian Serie A Review: Internacional rout Flamengo, Cruzeiro win again|
|Prosinecki keen on South Korea job|