Milan welcome a buoyant Sassuolo to San Siro needing a miracle to secure their place in the UEFA Europa League places this season.
Clarence Seedorf's hopes of guiding Milan to European football look all but lost after they were beaten 2-1 by Atalanta last time out.
Franco Brienza scored deep into injury time on Sunday to snatch three points for the hosts and deal Milan a major blow in their quest for Europe.
Milan must now beat 16th-placed Sassuolo and will likely need both Torino and Parma to lose on the final day of the Serie A campaign - they take on Fiorentina and Livorno respectively.
Their season finale comes amid strong rumours that Seedorf, appointed as Massimiliano Allegri's replacement in January, will be sacked in the close-season despite making a reasonably positive start to his managerial career.
Even qualification for Europe's second-tier club competition is unlikely to do much to strengthen his position but the Dutchman is eager to finish the campaign on a high - whether it proved to be his final match in charge or not.
"We'll be hoping to do well in the last match," he said after the defeat to Atalanta.
"There's some disappointment for the loss and for how we lost. Now we have to wait and see. Our destiny wasn't completely in our hands even before and it's less so now."
Midfielder Kaka added: "We need to win next Sunday for our pride and to close the season well."
While the pressure is on Milan going into their final game of the season, Sassuolo can relax knowing they have already secured their top-flight status.
Eusebio Di Francesco has helped the club to Serie A safety after their first season in the league, having taken 10 points from their last five games, and will look for a repeat of their dramatic 4-3 win over Milan early this year.
If this does prove to be Seedorf's final game in charge, there would be a certain symmetry to it all, as the seven-goal thriller in January was the final straw for Milan in Allegri's reign.
Domenico Berardi scored four times that day at the Stadio Citta del Tricolore and, even if they fail to do the double over Milan, Di Francesco feels their season has already been a success.
"This safety is worth a Scudetto for us, so achieving it a round early is nothing short of miraculous," he said.
Seedorf has no fresh injury concerns and could hand a debut to 15-year-old Hachim Mastour. Should he play, he would edge out Paolo Maldini to become the youngest player to feature for the club.
|5||P. Mexès||32' 68'|
|2||M. De Sciglio||89'|
|34||N. de Jong||27'|
|Coach: C. Seedorf|
for S. Muntari 59'
for K. Constant 63'
for Kaká 73'
|Sutton United 0 Arsenal 2: Perez and Walcott break minnows´ stern resolve|
|Walcott brings up 100 goals for Arsenal|
|Simeone will make late Oblak call for Leverkusen clash|
|AFC Champions League Review: In-form El Arabi gives Lekhwiya dream start, Diop saves Al Ahli|
|Fabinho disagrees with Guardiola over favourites tag|
|Guardiola hails Bielsa as best in the world|
|Jardim insists Monaco will not change style for Manchester City clash|
|Clattenburg´s Premier League career not over yet|
|Dortmund could renew Tuchel deal|
|Chicharito return to form boosts Schmidt´s Leverkusen for Atletico test|
|Iniesta sees Verratti as his successor - Matuidi|
|Ramos did not make history at Sevilla like me - Alves questions Real Madrid captain|
|Vertonghen feels Tottenham deserve silverware|
|Agent denies Lucas Perez exit claims|
|Barcelona forward Neymar to stand trial after losing appeal|
|City history can´t compare to United, Liverpool – De Bruyne wants to make Champions League impressio|
|Europa League the priority for United´s Mata as EFL Cup final looms|
|Winning the FA Cup ´may not save Wenger´|
|Falcao perfect for ´killers´ Monaco - Guardiola wary of Champions League threat to Manchester City|
|Ancelotti asked to explain middle finger gesture|
|Ribery closing in on Bayern Munich return|
|Nani eager for improving Valencia to tackle Real Madrid|
|Rashford eyes Chelsea revenge after huge FA Cup draw|
|Glorious Griezmann and Aguero´s knockout drought - Champions League in Opta numbers|
|Otamendi´s agent talks up Real Madrid switch|
|He has to get used to it – Montella reacts to Bacca boos|
|Low hopes to discover Germany´s Luis Suarez|
|Mourinho unsure if Rooney will recover for EFL Cup final|
|Rami rejects talk of Marseille switch|
|Tarnat tips Manchester City´s Sane to become Germany star|
|I don´t see why he should quit - Begovic tips Terry to continue|
|PSG ´weakened´ without Ibrahimovic, claims Monaco´s Bakayoko|
|Low believes in ´locksmith´ Gotze|
|No pain, no gain for Cristiano Ronaldo|
|Barcelona have no idea how to treat players - Dani Alves slams Camp Nou board|
|Low: Germany´s youngsters must be good enough to beat Messi and Ronaldo|
|Mandorlini replaces Juric at Genoa|
|Liverpool could face ´new´ Leicester – Klopp|
|Corchia excited by Bielsa arrival but Lille future remains uncertain|
|Wenger: I threw up after first loss as coach|
|Conte wants fairytale finish for Terry|
|Iniesta: Barcelona haven´t lost faith in Luis Enrique|
|Mourinho knew Ibrahimovic would be ´massive´ for United|
|Ter Stegen doesn´t understand Barcelona fans whistling|
|´He is doing a fantastic job´ – Bartomeu backs Luis Enrique|
|Guardiola slams ´unacceptable´ Wenger treatment|
|Spalletti: Roma goal machine Dzeko now believes he´s world class|
|Emery refuses to blame referee after PSG are held|
|Montella dedicates AC Milan win to Berlusconi|
|The players don´t need whistles – Luis Enrique hits out at fans|
|Brazilian game called off due to TV dispute|
|Chelsea are already Premier League champions, says United boss Mourinho|
|Barcelona 2 Leganes 1: Late Messi penalty spares Ter Stegen´s blushes|
|Paris Saint-Germain 0 Toulouse 0: Champions spill valuable points|
|AC Milan 2 Fiorentina 1: Deulofeu strike keeps European hopes alive|
|Attitude got Man United through - Mourinho|
|Roma 4 Torino 1: Dzeko strikes again|
|Lincoln face Sutton or Arsenal in FA Cup quarter-finals, Chelsea host Man United|
|Neuer slams Jarstein after brawl|
|Blackburn Rovers 1 Manchester United 2: Substitutes Pogba and Ibrahimovic combine for late winner|
|Inter insist Perisic going nowhere, rule out move for Verratti|
|Borussia Monchengladbach 1 RB Leipzig 2: Forsberg and Werner reignite title bid|
|Training-ground meetings paid dividends - Pochettino|
|I´m trying to find a team - Berbatov open to offers|
|Inspired by Zeman´s return, Pescara hammer Genoa 5-0|
|Gabigol wants to make history after Inter breakthrough|
|Chievo 1 Napoli 3: Sarri´s men bounce back from Champions League disappoitment|
|Alfonso Perez calls for Pique to quit international football over political beliefs|
|Benatia refuses to question Allegri´s decisions|
|Fulham 0 Tottenham 3: Kane hat-trick fires Spurs into quarter-finals|
|Oblak return boosts Atletico ahead of Leverkusen trip|
|Gabigol and Inter ready to feast on success after late winner|
|Bologna 0 Inter 1: Gabigol gets belated lift-off in Serie A|
|Still no Mascherano or Arda for Barcelona|
|Bielsa appointed Lille boss from next season|
|Janssen determined to make the grade at Tottenham|
|Stones missing Kompany influence at Manchester City - Ferdinand|
|Central Coast Mariners 0 Melbourne Victory 3: Muscat´s men cruise to win|
|David Villa sent off after video replay|
|Favre not blaming Balotelli for latest red card|
|´It is my future at stake´ – Isco could leave Real Madrid|
|Smalling desperate for Ibrahimovic stay|
|´He will be here for sure´ - Mourinho rules out Shaw exit|
|Wenger not ready for retirement, wants Arsenal stay|
|Pogba will soon look cheap, claims Manchester United boss Mourinho|
|Casilla defends under-fire Navas|
|Isco ´happy and committed´ at Real Madrid – Zidane|