Nkana venture into uncharted waters on Saturday as they face Al Ahly in the group stages of the CAF Confederation Cup.
The Zambian Premier League champions are one of six teams who make up the last eight of the competition having started the season in the CAF Champions League.
A daunting trip to eight-time Champions League winners Al Ahly awaits them in Group B, which also contains Sewe Sport and Etoile du Sahel.
Al Ahly are competing in the Confederation Cup for the first time after suffering the disappointment of elimination from Africa's elite club competition, and coach Fathi Mabrouk is not concerned about their opening game.
"We have a strong team, same with our opponents, but I think it's our pedigree and determination to win that sets us apart," he said.
"The game against Nkana is important. It will set the tone for our campaign.
"They were here last month but I did not have the opportunity to watch them. It's, however, not something to worry us, we know their style."
The visit to Egypt will bring back painful memories for Nkana, who were knocked out of the Champions League by Al Ahly's fierce rivals Zamalek, losing 5-0 in Cairo in March.
With defending champions CS Sfaxien not playing in the competition this season the most recent winners left are Leopards, and the Congolese side, who triumphed in 2012, host Cotonsport in Group A.
Leopards needed penalties to make it into the group stages at the expense of Medeama, and they face their Cameroonian opponents for the first time since 2010.
That was a first-round match in the same competition, with Cotonsport progressing on away goals after the two-legged tie had finished 3-3.
The other game in Group A sees Real Bamako face ASEC Mimosas, the Ivorians one of the two sides who have been in the competition from the start.
ASEC have only conceded three goals in their six games so far in the competition and will hope their mean defence can enable their free-scoring strikers, who have netted12 goals, to secure victory.
Sewe Sport will take part in the group stages for the first time when they host former winners Etoile in Abidjan.
Etoile lifted the trophy in 2006 and were runners-up two seasons later but have concentrated their focus on the Champions League in recent seasons.
The Tunisian side have already beaten Congo's CARA Brazzaville, Supersport United from South Africa and Guinea champions Horoya in the competition and will be confident of starting the group stages with a win.
|MLS Review: Wright-Phillips double inspires Red Bulls to New York derby rout|
|James seeks more game time at Madrid|
|Rooney: I want to be a manager|
|Mignolet welcomes Karius challenge in Liverpool number one battle|
|Batshuayi buoyed by winning vibes at Chelsea|
|Moyes and Sunderland players diverted after plane fault|
|´Loved´ Varane targets long Madrid stay|
|Kostic set for Hamburg medical|
|Leicester crying over Kante sale - Ranieri|
|Schurrle the perfect Mkhitaryan replacement - Tuchel|
|West Ham face anxious wait on Cresswell injury|
|Mourinho will accept criticism from United legends|
|Bertolacci desperate for fresh start after underwhelming first season at Milan|
|Hoops hand Toure one-year deal|
|Origi ready to fight for Liverpool spot|
|Emery wants PSG stay for ´fantastic´ Matuidi|
|No Barcelona offer for Vietto - Cerezo|
|Burnley apologise for racist abuse from supporter|
|Guardiola will not rush Kompany comeback|
|Of course I´ll shake Guardiola´s hand, snaps riled Mourinho|
|Watzke: No more signings for Dortmund|
|Roma expect Manolas to snub Premier League move|
|Adriano set to leave Barcelona for Besiktas|
|Manchester United in worst possible situation - Mourinho|
|Sporting would have to sell stadium to afford Van Persie - Jesus|
|Jonas´ agent confirms Barcelona approach|
|No problem with Mourinho, insists Guardiola ahead of derby in China|
|Toronto´s hat-trick hero Giovinco: I´m back|
|Drogba revels in ´special night´, dedicates hat-trick to family|
|MLS Review: Hat-tricks for Drogba and Giovinco as stars shine|
|Whelan backs Liverpool for top-four finish|
|Pellegrini still waiting for right offer|
|Ronaldo deserves to win Ballon d´Or - Vazquez|
|Phelan wants Hull job|
|Alaba saddened by Gotze exit|
|Morgan: Vardy right to re-sign|
|Maradona ´hurting´ as Higuain closes on Juventus move|
|Moyes watches Sunderland win, Ibe opens account in six-goal Bournemouth thriller|
|Messi cuts short holiday for Barcelona training camp|
|Ranieri still confident of keeping Mahrez|
|Toure to complete Celtic move on Sunday, says Rodgers|
|Vietto sends Simeone a reminder amid Barcelona links|
|Celtic 1 Leicester City 1 (5-6 on penalties): Mahrez magic the highlight as Ranieri´s side triumph i|
|Ribery, Alaba on target in Bayern win|
|Neymar hails Micale ahead of Olympic tilt|
|Ronaldo wants Real Madrid renewal|
|Ochoa joins Granada from Malaga|
|Heidel quashes Meyer to Liverpool as ´nonsense´|
|Scholes challenges Allardyce to change England mentality|
|Tenerife star Crosas investigated for killing endangered shark|
|De Gea: Manchester United can win title under Mourinho|
|Marseille replace Batshuayi with brother Leya Iseka|
|Cristiano Ronaldo: Best season of my career|
|Scholes: Pogba is not worth £100million|
|Gotze has not forgotten how to play football - Riedle|
|Delph learning more than ever under Guardiola|
|Jovetic ´not worried´ about Juventus|
|Allardyce wants Euro 2016 woes to fire his England|
|Giggs not in a rush to take manager´s job|
|Lopetegui: If not for Spain I would be Wolves boss|
|Shaw one of best left-backs in world - Herrera|
|Injured Sanchez to miss Arsenal tour|
|Melbourne Victory 1 Juventus 1 (Melbourne win 4-3 on pens): Thomas inspires Victory as Juve pay pena|
|Janssen: Ajax and PSV were never going to pay as much as Tottenham|
|Bayern to make Munich shooting tributes|
|Wenger wishes luck to old foe Allardyce|
|United defender Varela joins Frankfurt on loan|
|Sunderland appoint Moyes as Allardyce replacement|
|Javi Martinez devastated by Munich shootings|
|Rooney: I´m desperate to play for Mourinho, just like under Ferguson|
|Godin: Champions League the dream, but LaLiga the focus|
|Klopp hails Wijnaldum´s ´football smartness´|
|Klavan ready to fight for starting spot after completing ´dream´ Liverpool move|
|Real Salt Lake 1 San Jose Earthquakes 1: Mulholland salvages point|
|Madeira airport to be named after Cristiano Ronaldo|
|Villar, Ceferin and Van Praag announce UEFA presidential bid|
|Witsel has offers from England and Italy|
|Tuchel will bring out Gotze´s best - Watzke|
|Swansea confirm interest in Liverpool´s Allen|
|Arsenal´s Coquelin: LeBron v Curry is like Messi v Ronaldo|
|Rooney backs Allardyce appointment|
|Bayern and Ancelotti respond to Munich attacks|
|West Brom friendly cancelled over violence concerns|