Pablo Daniel Osvaldo's last-gasp goal helped Juventus surpass the Serie A points record as they overcame Roma 1-0 at the Stadio Olimpico.
The champions moved on to 99 points, beating the tally set by Inter in 2006-07, as Antonio Conte's men stand on the edge of reaching triple figures.
Juve need to avoid defeat against Cagliari on the final day to achieve that feat, though they will hope to do so in less dramatic circumstances than Sunday.
Paul Pogba struck the post just before the break and Gervinho wasted a gilt-edged one-on-one, though Giorgio Chiellini could have been dismissed for an elbow on Miralem Pjanic in the second half.
However, in the fourth minute of stoppage time former Roma man Osvaldo steered home his first Serie A goal of the season from the bench, ending Roma's unbeaten record on their own patch this term.
Roma's title challenge had ended with a desperate 4-1 reverse at Catania last week, leaving Juve to wrap up their third consecutive Scudetto and the result served as a reminder of their dominance.
The kick-off time at the Stadio Olimpico was brought forward by three hours following trouble in the capital before last week's Coppa Italia final.
It did little to dampen the atmosphere inside Roma's home ground as the supporters got behind their team, who started on the front foot but saw Francesco Totti and Mattia Destro fire off target.
Any fears that the game would be treated as a dead rubber were dispelled inside the opening half, which was played at a frenetic pace.
The visitors spurned an excellent chance to take the lead with 15 minutes gone when Carlos Tevez worked room for a shot inside the box but scuffed tamely wide.
Just a minute later at the other end, Vasilis Torosidis was denied his second league goal of the season after being adjudged to have handled the ball over the line.
Top scorer Destro wasted an opening when a heavy touch allowed Marco Storari to save, while Roma debutant Lukasz Skorupski made two good stops from Fernando Llorente as the contest became increasingly open.
Indeed, Juve's defence was wide open six minutes before the break when Gervinho raced through on goal, but he was thwarted by the onrushing Storari.
The woodwork came to Roma's rescue on the stroke of half-time, Pogba's powerful drive striking Skorupski's left upright.
Chiellini was fortunate to avoid sanction when he appeared to elbow Pjanic in a defensive wall for Andrea Pirlo's ultimately wasted free-kick around the hour mark.
Pjanic, who signed a new four-year deal before the game, took matters into his own hands and was booked for a blatant foul on Chiellini a minute later.
Skorupski was forced into an athletic save from Stephan Lichtsteiner and Storari produced a fine double save to deny Radja Nainggolan and substitute Alessandro Florenzi.
But, as the clock ticked down, Lichtsteiner's cut-back was turned into the corner by Osvaldo - Roma's top scorer last season - to spark jubilant celebrations among the travelling support and move Juve to the brink of history.
|16||D. De Rossi|
|Coach: R. Garcia|
for D. De Rossi 55'
for M. Benatia 71'
for M. Destro 80'
|Begiristain confident despite tough group for City|
|West Ham 0 Astra 1 (1-2 agg): Romanian minnows embarrass Hammers again|
|Hammers sign Swiss midfielder Fernandes|
|Humble Ronaldo hails team-mates following UEFA award|
|Krul joins Ajax on loan after signing new Newcastle deal|
|Leicester underdogs again in Champions League - Ranieri|
|Bale gunning for Champions League glory in Cardiff|
|Juventus additions strengthen Champions League bid - Marotta|
|Tuchel relishing ´classic´ Madrid Champions League encounter|
|Changed Burnley determined to survive|
|Ronaldo named UEFA Best Player in Europe for second time|
|Champions League draw in full|
|Guardiola handed Barca return with City in Champions League|
|Guidolin calls on Swansea to avenge Leicester thrashings|
|Eduardo completes Chelsea switch|
|Not easy to see Higuain at Juve - Cannavaro|
|Puel insists Fonte focused on Southampton|
|Ranieri knows Leicester are wanted men in Champions League|
|Puel backs Forster to take England chance|
|Cannavaro questions Juve´s European credentials after Pogba exit|
|Milan: Romagnoli not for sale, despite Chelsea bid|
|´Nobody more exciting than Michail Antonio´ - West Ham chairman|
|Pochettino prioritising transfers over new deals|
|Bravo completes Manchester City switch|
|No Barcelona bid for Mariano, insist Sevilla|
|Rashford drops down to England Under-21 squad|
|Koeman: No Everton interest in Hart|
|Ancelotti has it all - Ballack|
|Nolito eager for Champions League challenge|
|Evra dropped from France squad|
|Oliver Torres agrees Porto return|
|Ancelotti sees no need for Bayern revolution|
|Messi´s Roma goal wins UEFA award|
|Maradona questions Messi U-turn|
|Napoli pledge funds to earthquake victims|
|Hughes confirms Stoke interest in Manchester United defender Jones|
|Bentaleb completes Schalke switch|
|Klopp: Balotelli decision not imminent|
|Manquillo makes Sunderland move|
|Barca complete Cillessen signing|
|Hummels surprised by criticism from Dortmund fans|
|Blatter will accept CAS ruling|
|I do not want Sturridge as a wide player, insists Klopp|
|Schalke close in on Bentaleb and Stambouli|
|Wanted man Sukur denounces coup|
|´Everyone knows my best position´ - Sturridge unhappy at wide role|
|Villa says Alcacer ´knows what to do´ amid Barcelona links|
|Solo ´saddened´ by United States axing|
|Drinkwater signs new Leicester deal|
|Spanish clubs dominate as history beckons for Ancelotti - the Champions League in numbers|
|Lopes sets sights on Lille silverware and Portugal breakthrough|
|´A scholar and a monster´ - Surgeon hails ´unique´ Ronaldo|
|MLS Review: Altidore scores as Toronto move top in east, Galaxy rally|
|CONCACAF Champions League Review: Tigres win, Dallas held|
|Victory lure Rojas back to Melbourne|
|Chaplow suspended two games for verbal abuse, denies homophobia|
|Eduardo farewells Dinamo Zagreb amid Chelsea speculation|
|Zidane shoud give James more respect - Asprilla|
|Solo suspended from USA women´s team for six months|
|Guardiola understands fans unhappiness over Hart situation|
|Burnley and Middlesbrough sent packing from League Cup|
|Coleman baffled by Ramsey´s treatment at Arsenal|
|Six of the best for Gladbach as Rostov rout Ajax|
|Leicester face Chelsea, Northampton host United in League Cup third round|
|Cillessen set to fly out to Barca to complete move|
|Guardiola hails ´legend´ Hart as Bravo wait in the wings|
|Emotional Hart edges towards City exit|
|Manchester City 1 Steaua Bucharest 0 (6-0 agg): City ease through amid Hart-felt goodbyes|
|Ronaldo working hard for Madrid return|
|Pique warns of European Super League dangers|
|AFC Champions League: Damjanovic inspires Seoul, Wanderley puts Al Nasr in charge|
|Rauball re-elected as German league president|
|Cillessen returns for Ajax despite Barcelona talk|
|Surgery for Pereira after De Rossi horror challenge|
|Hart set for City farewell against Steaua|
|CAF Champions League Review: Wydad draw at ZESCO to earn top spot|
|Retiring Keane in Republic of Ireland squad for final time|
|Sion in talks to sign Liverpool outcast Balotelli, claims club president|
|Athletic´s Laporte not distracted by Barcelona visit|
|Keane announces international retirement|
|Clarke named FA chairman|
|Neuer: Schweinsteiger remains one of world´s best|
|Bielsa would call me before coming to Marseille - Passi|
|Watford bring in Janmaat from Newcastle|
|FIFA opens adjudicatory proceedings against disgraced African football officials|
|European Super League could cause ´war´|
|Sampdoria pounce for Praet|
|Zaza agent confirms Napoli talks but rules out loan move|
|No Grigg in Northern Ireland´s World Cup qualifying squad|
|Cahill reflects on ´amazing´ Melbourne City debut|
|Europa League must take priority, Recoba tells Inter|
|Saint-Etienne swoop for Saivet and Veretout|
|Ronaldo: Pepe was the best player at the Euros, not Griezmann|
|Schweinsteiger: Manchester United my last club in Europe|
|Dante sees Nice as a positive move|
|Pique: Barcelona by far the best in Spain|
|Pique backs Stones for success under Pep|
|Coleman dismisses Premier League talk|
|Spurs want Calhanoglu, claims agent|
|Bony an ´option´ for Bilic|
|Leverkusen cannot challenge Bayern, says Ballack|
|Pallotta blasts ´disgusting´ referee after Roma defeat|
|Badstuber taking his time after injury nightmare|
|Conte: Terry return between him and Allardyce|
|We beat Bayern to Dembele - Watzke|
|Wanderers bring back Bulut|
|Moyes rules out Kone exit|
|CONCACAF Champions League Review: Whitecaps, Pachuca win big|
|Bale: I´ll never forget this year|
|Griezmann: I deserve Best Player in Europe Award|
|No surgery for Ayew as West Ham target December return|
|Villarreal did all they could to make it through - Escriba|
|Spalletti rues lack of Roma discipline|
|Conte: Chelsea must learn to kill matches|
|Watford and West Brom crash out of League Cup|
|My longest 90 minutes as a coach - Rodgers|