Liverpool came from behind to beat nine-man Newcastle United 2-1, but it was not enough to see them claim a first league title since 1990.
Brendan Rodgers' men went into the final Premier League match of the season on Sunday knowing that a win, combined with rivals Manchester City losing at home to West Ham, would see Liverpool crowned champions and end a 24-year wait.
As it transpired, City put the title out of their reach with a 2-0 victory at the Etihad Stadium, but even with the disappointed news filtering through to Anfield, Liverpool managed to sign off with a hard-earned victory.
Martin Skrtel, a regular source of goals in important matches for Rodgers' side throughout the campaign, put through his own net on this occasion, turning Yoan Gouffran's centre past Simon Mignolet in front of a shell-shocked Kop after 20 minutes.
It looked as though the hosts were going to be frustrated, until two almost identical goals from set-pieces midway through the second half from Daniel Agger and Daniel Sturridge changed the game.
The visitors then saw Shola Ameobi sent off for dissent in the aftermath of Sturridge's winner, as Newcastle's dismal second half of the season ended with an eighth defeat in the last 10 league outings and was further compounded when Paul Dummett also saw red late on.
The hosts worked an opening in the 11th minute as Raheem Sterling got in behind the Newcastle backline, but Mathieu Debuchy recovered smartly to poke the ball away from the forward in the nick of time.
Liverpool thought they had gone in front in the 18th minute when Luis Suarez took a quick free-kick, bending a superb finish over the head of Tim Krul from wide on the right, but referee Phil Dowd brought play back as he was talking to a Newcastle player when the set-piece was taken.
Newcastle stunned the Anfield faithful by taking the lead two minutes later, Skrtel slicing Gouffran's cross from the left inside the far post off his right shin.
Agger, recalled to the side in place of Mamadou Sakho, ought to have equalised in the 24th minute, but the Denmark international sent a free header straight at Krul after meeting a Steven Gerrard corner from the right.
Gouffran could have extended the visitors' lead soon afterwards when played clear on goal by Ameobi's accurate throughball, but Mignolet rushed from his line to make a fine one-on-one stop from the Frenchman.
Suarez was a constant threat, evading the attentions of three Newcastle defenders in the 34th minute, but the finish did not match the approach play as he sent a weak shot into the arms of Krul from the edge of the area.
Sturridge wasted another glorious opportunity five minutes before the break as Jordan Henderson, back after a three-match suspension, got to the byline and delivered a perfect cross for the England forward, who headed wide of goal unmarked from eight yards out.
After a quiet start to the second period, Liverpool turned things around with two goals in as many minutes shortly after the hour.
Agger first stretched to prod home a Gerrard free-kick at the back post before Sturridge tapped in at the far post after yet another fine delivery from the Liverpool captain.
Ameobi was sent off by Dowd, receiving two yellow cards seemingly for dissent as Newcastle prepared to kick off after Sturridge's strike.
Substitute Dummett, only introduced in the 81st minute, was then given his marching orders three minutes from time for a rash challenge on Suarez as Liverpool ended a fine campaign with a win, albeit ultimately just falling short of champions City.
|Coach: B. Rodgers|
for J. Flanagan 46'
for J. Allen 59'
for D. Sturridge 80'
|´I don´t care about age´ - Klopp committed to promoting youngsters|
|Koeman: Ibrahimovic was fantastic at 19|
|Pulis not letting court decision tarnish Palace memories|
|Carroll to make West Ham return against Arsenal|
|Real Madrid must win LaLiga and end Barca dominance - Roberto Carlos|
|Barcelona v Real Madrid: Zidane´s men eye LaLiga supremacy|
|Costa discipline issues in the past - Conte|
|A-League review: Melbourne Victory held by Perth Glory|
|I deserve criticism if Dortmund´s players do - Tuchel|
|Emery wants Cavani to dethrone Ibrahimovic|
|Martial is happy again, says Mourinho|
|Guardiola wary of Costa and Pedro|
|Messi, Ronaldo and Griezmann to battle it out for FIFA award|
|Conte reveals admiration for Guardiola philosophy|
|Mourinho: Schweinsteiger can stay at Man Utd|
|Conte: It is a pity Chelsea sold De Bruyne|
|Carrasco now competing with Griezmann and Gameiro - Simeone|
|Luis Enrique: Clasico not decisive in title race|
|Barcelona have no weaknesses - Zidane|
|Zidane: Ronaldo´s hunger for success key for Real Madrid|
|Barcelona midfielder Iniesta back for Clasico|
|Higuain does not need Dybala to score - Allegri|
|Summerbee: Chelsea blew it with De Bruyne|
|Ranieri, Zidane and Santos up for FIFA coach award|
|Chelsea paid me £50,000 to prevent child abuse revelations - Johnson|
|Vertonghen signs new Tottenham deal|
|Klopp hopeful on Lallana and Firmino|
|Ozil: Arsenal can win Champions League with a bit of luck|
|Sturridge exit a non-story, says Klopp|
|Debuchy out for up to six weeks|
|Pardew ready to turn around slumping Palace|
|Arsenal will not sign Cazorla replacement - Wenger|
|Courtois not getting carried away over Chelsea form|
|CAS to rule on Blatter case on Monday|
|Ozil refuses to rule out Real Madrid return|
|Sterling: I am keeping away from certain stuff I was doing last year|
|Leverkusen´s Volland out until 2017|
|Aloisi rules out Roar swoop for Keane|
|Pele reflects on ´sad moment´ of Chapecoense tragedy|
|Southgate urges downtime responsibility from England|
|Ranieri: Leicester signings not to blame for poor form|
|Sky is the limit for ´special´ Donnarumma, says Hart|
|Southgate drops Rashford Euro U21s hint|
|Chapecoense will rebuild with the world´s support, says vice-president|
|Toure can win Premier League for Manchester City - Hart|
|Only a matter of time until Balotelli gets Italy call - Zola|
|Ter Stegen can become new Valdes at Barca - Zambrotta|
|´Exceptional´ Costa just like Drogba, says Zola|
|Ronaldinho could play for Chapecoense|
|Garcia extends Manchester City deal|
|Injured Cazorla to miss another three months|
|Schmeichel has a gentle handshake, not like Wasilewski! - Ranieri|
|Lloris to follow Kane and pen new Spurs deal|
|Puel: I replaced Koeman to give Southampton youngsters a chance|
|Barcelona could have signed Ronaldo for €17million before Real Madrid move|
|Ancelotti keen for Lahm to carry on playing|
|Leipzig will last the pace in title race, says Ancelotti|
|If Bayern lose I´ll cry and miss El Clasico! - Ancelotti|
|No Europe could give Conte edge over Guardiola - Summerbee|
|Southgate keeps Rooney as captain but calls for leaders to emerge|
|Real Madrid dominate FIFA FIFPro World11 nominations|
|Sigurdsson: Kane will be Spurs´ main man for years to come|
|Ronaldo can beat Messi to next two Ballons d´Or - even if he loses the Clasico|
|No break clause in Southgate´s England contract|
|Kane signs new contract with Tottenham|
|Phelan hopeful on Hernandez and Maloney for Boro trip|
|Pioli not entertaining Messi to Inter possibility|
|Conte doing a remarkable job at Chelsea - Zola|
|Nesta amazed by ´special´ Totti|
|Elneny sick in Saints loss - Wenger|
|Atletico Nacional supporters pay tribute to Chapecoense air crash victims|
|Enzo Zidane targets more opportunities after ´special´ debut goal|
|Mkhitaryan excited by United display|
|Toronto FC 5 Montreal Impact 2 (aet, 7-5 agg): Hosts storm to maiden MLS Cup berth|
|Emotional Cavani brings up 100 amid Chapecoense tributes|
|Barca did not take Hercules lightly, insists Luis Enrique|
|Emery feels PSG are slowly making progress|
|Barcelona do not need to be scared, insists Rafinha|
|Simeone wants consistency from Gaitan|
|Wenger blasts sloppy Arsenal after Southampton loss|
|Hercules 1 Barcelona 1: Debutant Alena prevents embarrassing defeat|
|Mourinho: Half-time pep talk was catalyst for United win|
|Cavani hits 100-goal mark for PSG|
|In El Clasico there are no favourites - Deco|
|Manchester United and Liverpool kept apart in EFL Cup draw|
|Chapecoense asked to continue in Brasileiro to honour plane crash dead|
|Paris Saint-Germain 2 Angers 0: Cavani nets landmark goal in routine win|
|Guijuelo 0 Atletico Madrid 6: Carrasco scores twice in rout|
|Manchester United 4 West Ham 1: Mourinho ban no problem for dominant hosts|
|Arsenal 0 Southampton 2: Gunners lose first game in 20 as Saints march on|
|Zidane ´proud as a father and manager´ for son Enzo|
|Cuca to leave champions Palmeiras|
|Real Madrid 6 Cultural Leonesa 1 (13-2 agg): Zidane´s son nets on debut in Copa cruise ahead of Clas|
|Mascherano: Messi is three players in one|
|Speaking to Arsenal players did not feel right - Wilshere|
|Saint-Etienne don jerseys with Chapecoense badge|
|Watzke backs Tuchel over Dortmund criticism|
|Southgate sees Lallana as crucial to tactical plans|
|Ribery: Bayern must hold on to Robben|
|Beckham: I believe in Mourinho|
|Mourinho to serve one-match touchline ban|
|Messi, Suarez and Neymar world´s best - Coutinho|
|Khedira: Time for Juventus to step up|
|Southgate confirmed as England manager|
|´Our fans would never forgive us´ - Bayern won´t sell Muller to Manchester United|
|Alonso open to new Bayern Munich contract|
|Poulsen: Don´t compare Leipzig to Leicester|
|Mathieu out of Clasico with calf injury|
|West Ham´s Sakho out for six weeks|
|Hoeness warns ´outstanding´ Lahm against early retirement|
|Kompany determined to end injury heartache - Summerbee|
|Inter dreaming of signing Messi|
|Zidane and Luis Enrique tangled in El Clasico´s identity politics|
|Bilic: Mourinho kicked the bottle too well!|
|Alonso: I wish we had Ronaldo at Bayern|
|Beckham´s franchise would be welcome in MLS - Nesta|
|Emery confirms Barca approach for Marquinhos|
|Tite, Zidane pay respects to crash victims|
|Chapecoense pay tribute to ´eternal champions´|
|Amor banned for Phoenix clash|
|Benitez laments missed opportunities|
|Colombian plane crash toll revised to 71|
|Klopp tries not to spark Woodburn blaze|
|Wenger to field ´mixed´ side against Southampton|
|Lucas: It was hard to play after Chapecoense tragedy|