Liverpool came from behind to beat nine-man Newcastle United 2-1, but it was not enough to see them claim a first league title since 1990.
Brendan Rodgers' men went into the final Premier League match of the season on Sunday knowing that a win, combined with rivals Manchester City losing at home to West Ham, would see Liverpool crowned champions and end a 24-year wait.
As it transpired, City put the title out of their reach with a 2-0 victory at the Etihad Stadium, but even with the disappointed news filtering through to Anfield, Liverpool managed to sign off with a hard-earned victory.
Martin Skrtel, a regular source of goals in important matches for Rodgers' side throughout the campaign, put through his own net on this occasion, turning Yoan Gouffran's centre past Simon Mignolet in front of a shell-shocked Kop after 20 minutes.
It looked as though the hosts were going to be frustrated, until two almost identical goals from set-pieces midway through the second half from Daniel Agger and Daniel Sturridge changed the game.
The visitors then saw Shola Ameobi sent off for dissent in the aftermath of Sturridge's winner, as Newcastle's dismal second half of the season ended with an eighth defeat in the last 10 league outings and was further compounded when Paul Dummett also saw red late on.
The hosts worked an opening in the 11th minute as Raheem Sterling got in behind the Newcastle backline, but Mathieu Debuchy recovered smartly to poke the ball away from the forward in the nick of time.
Liverpool thought they had gone in front in the 18th minute when Luis Suarez took a quick free-kick, bending a superb finish over the head of Tim Krul from wide on the right, but referee Phil Dowd brought play back as he was talking to a Newcastle player when the set-piece was taken.
Newcastle stunned the Anfield faithful by taking the lead two minutes later, Skrtel slicing Gouffran's cross from the left inside the far post off his right shin.
Agger, recalled to the side in place of Mamadou Sakho, ought to have equalised in the 24th minute, but the Denmark international sent a free header straight at Krul after meeting a Steven Gerrard corner from the right.
Gouffran could have extended the visitors' lead soon afterwards when played clear on goal by Ameobi's accurate throughball, but Mignolet rushed from his line to make a fine one-on-one stop from the Frenchman.
Suarez was a constant threat, evading the attentions of three Newcastle defenders in the 34th minute, but the finish did not match the approach play as he sent a weak shot into the arms of Krul from the edge of the area.
Sturridge wasted another glorious opportunity five minutes before the break as Jordan Henderson, back after a three-match suspension, got to the byline and delivered a perfect cross for the England forward, who headed wide of goal unmarked from eight yards out.
After a quiet start to the second period, Liverpool turned things around with two goals in as many minutes shortly after the hour.
Agger first stretched to prod home a Gerrard free-kick at the back post before Sturridge tapped in at the far post after yet another fine delivery from the Liverpool captain.
Ameobi was sent off by Dowd, receiving two yellow cards seemingly for dissent as Newcastle prepared to kick off after Sturridge's strike.
Substitute Dummett, only introduced in the 81st minute, was then given his marching orders three minutes from time for a rash challenge on Suarez as Liverpool ended a fine campaign with a win, albeit ultimately just falling short of champions City.
|Coach: B. Rodgers|
for J. Flanagan 46'
for J. Allen 59'
for D. Sturridge 80'
|Mashaba wants lessons to be learnt after AFCON exit|
|Mourinho refuses to wade into Costa incidents after Chelsea win|
|Football League Review: Bent double sends Derby second, Rotherham triumph|
|Chelsea 1 Liverpool 0 (aet, agg 2-1): Ivanovic settles action-packed League Cup semi-final|
|Milan 0 Lazio 1: Inzaghi future plunged into further doubt|
|Neymar dreaming of ending Brazil´s home hoodoo|
|South Africa 1 Ghana 2: Late Ayew winner seals qualification|
|Senegal 0 Algeria 2: Mahrez and Bentaleb dump Senegal out|
|Bocchetti poised to join Milan on loan|
|De Rossi suffers calf injury|
|Montano accuses Oldham of double standards after Evans saga|
|Bojan out for the season with ruptured cruciate|
|Cameroon v Ivory Coast: Renard defends Yaya Toure|
|Yanga-Mbiwa makes Roma move permanent|
|Guinea v Mali: Quarter-final berth on offer in Mongomo|
|Thohir: Inter not reliant on European football|
|Bremen land Vestergaard|
|Allegri refuses to rule out Cassano move|
|Mexes handed four-game ban after Lazio dismissal|
|Joyce reveals Valdes´ inspirational team-talk|
|CAF announces AFCON venue switches|
|Alcacer commits future to Valencia|
|Postecoglou calls for Aussie ´energy´|
|Everton confirm Eto´o departure to Sampdoria|
|Pochettino to stick with Vorm despite cup error|
|Barcelona are not favourites against Atletico, says Luis Enrique|
|Allegri wary of Parma backlash in Coppa Italia|
|Zidane urges Real to tie Ancelotti down|
|FIFPro: Transfer system failing football|
|Anderlecht condemn Standard´s Defour banner|
|Australia 2 UAE 0: Socceroos ease into home final|
|Barca overhaul youth system|
|FIFPro demands clubs respect contractual obligations|
|Mahmoud targeting World Cup place with Iraq|
|Fabregas wants Chelsea to show winning mentality|
|Rangers borrow £10m from Ashley´s Sports Direct|
|Lyon face anxious wait over Lacazette|
|Undermanned Lazio recall Perea|
|Ki wants South Korea to prove their superiority|
|Ghana´s Gyan wary of South Africa|
|Mashaba urges South Africa to attack|
|Benitez: Napoli deserved to win|
|Pacos de Ferreira 1 Benfica 0: Leaders fail from the spot|
|Serie A Review: Higuain at the double in controversial Napoli win, Udinese see off Empoli|
|I´m glad Rochdale haven´t made the news - Hughes|
|Getafe 2 Celta Vigo 1: Hosts come from behind for first win in 10|
|Real hit back at media reports over transfer dealings|
|Rochdale 1 Stoke City 4: Joy and angst for Bojan as Premier League side progress|
|Turkish Super Lig Review: Kuyt at the double in Fenerbahce win, Besiktas back on track|
|Senegal v Algeria: Morale is high, insists Gourcuff|
|Cassano leaves beleaguered Parma|
|Copa del Rey Preview: Atleti look to overturn Barca advantage, Espanyol wary|
|Atletico Madrid v Barcelona: Griezmann targets second-leg fightback|
|Sheffield United v Tottenham: Clough expects fired-up Spurs for second leg|
|Cape Verde 0 Zambia 0: Stalemate sends both sides out|
|Democratic Republic of Congo 1 Tunisia 1: Both teams qualify for quarter-finals|
|FA Cup fifth round: Middlesbrough handed Arsenal test|
|South Africa v Ghana: Must-win game for Mashaba´s men|
|Parma v Juventus: Serie A leaders strong favourites to reach semi-finals|
|Van Praag planning to stand for FIFA presidency|
|Inter snap up Brozovic|
|Van Persie unsure of long-term United future|
|Broken metatarsal rules El Shaarawy out for at least six weeks|
|FIFA: No disciplinary proceedings against Real|
|No Plan B if Guardiola goes - Rummenigge|
|Millwall take Hooiveld on loan|
|Chile v United States: Klinsmann has high hopes for young stars|
|Carver to lead Newcastle until end of season|
|Shenaishil taking positives from last-four exit|
|Neymar happy with life at Barca and Messi relationship|
|Lucas Silva ready for life at Real|
|Milan ´always with Inzaghi´ - Menez|
|Rodriguez living the dream at Real|
|Stielike expecting Australia in final|
|Mourinho not dwelling on Bradford defeat|
|Schweinsteiger under no pressure to extend Bayern contract|
|Herd heads to Wigan on loan|
|Inter defensive duo suffer hamstring tears|
|UAE coach Ali eyes Asian Cup final|
|Gattuso dreaming of managing Rangers|
|Fiorentina agree return of Gilardino on loan|
|Sakho hits back at critics|
|South Korea 2 Iraq 0: Kim books sixth Asian Cup final place|
|Sturridge could return against Chelsea|
|Zinnbauer backs Drobny as Hamburg first choice|
|Drogba targeting Chelsea stay|
|Postecoglou confident Australia squad can progress|
|UEFA does not have the courage to run against me - Blatter|
|Foster: Anichebe unplayable|
|Australia v UAE: Japan´s absence a boon for Asian Cup hosts|
|Milan v Lazio: Injury-hit visitors aiming for back-to-back wins|
|Trezeguet confirms retirement|
|No ´major problems´ with Nicolas Frey´s head wound|
|Strootman injury not "serious" - Garcia|
|No Paraguay, USA for retiring Riquelme|
|Saint-Etienne did not try to play football - Blanc|
|Primeira Liga Review: Sporting move within one point of Porto|
|La Liga Review: Parejo downs Sevilla, Resino starts with a point|
|Serie A Review: Juve go seven points clear as Roma draw again|