Liverpool came from behind to beat nine-man Newcastle United 2-1, but it was not enough to see them claim a first league title since 1990.
Brendan Rodgers' men went into the final Premier League match of the season on Sunday knowing that a win, combined with rivals Manchester City losing at home to West Ham, would see Liverpool crowned champions and end a 24-year wait.
As it transpired, City put the title out of their reach with a 2-0 victory at the Etihad Stadium, but even with the disappointed news filtering through to Anfield, Liverpool managed to sign off with a hard-earned victory.
Martin Skrtel, a regular source of goals in important matches for Rodgers' side throughout the campaign, put through his own net on this occasion, turning Yoan Gouffran's centre past Simon Mignolet in front of a shell-shocked Kop after 20 minutes.
It looked as though the hosts were going to be frustrated, until two almost identical goals from set-pieces midway through the second half from Daniel Agger and Daniel Sturridge changed the game.
The visitors then saw Shola Ameobi sent off for dissent in the aftermath of Sturridge's winner, as Newcastle's dismal second half of the season ended with an eighth defeat in the last 10 league outings and was further compounded when Paul Dummett also saw red late on.
The hosts worked an opening in the 11th minute as Raheem Sterling got in behind the Newcastle backline, but Mathieu Debuchy recovered smartly to poke the ball away from the forward in the nick of time.
Liverpool thought they had gone in front in the 18th minute when Luis Suarez took a quick free-kick, bending a superb finish over the head of Tim Krul from wide on the right, but referee Phil Dowd brought play back as he was talking to a Newcastle player when the set-piece was taken.
Newcastle stunned the Anfield faithful by taking the lead two minutes later, Skrtel slicing Gouffran's cross from the left inside the far post off his right shin.
Agger, recalled to the side in place of Mamadou Sakho, ought to have equalised in the 24th minute, but the Denmark international sent a free header straight at Krul after meeting a Steven Gerrard corner from the right.
Gouffran could have extended the visitors' lead soon afterwards when played clear on goal by Ameobi's accurate throughball, but Mignolet rushed from his line to make a fine one-on-one stop from the Frenchman.
Suarez was a constant threat, evading the attentions of three Newcastle defenders in the 34th minute, but the finish did not match the approach play as he sent a weak shot into the arms of Krul from the edge of the area.
Sturridge wasted another glorious opportunity five minutes before the break as Jordan Henderson, back after a three-match suspension, got to the byline and delivered a perfect cross for the England forward, who headed wide of goal unmarked from eight yards out.
After a quiet start to the second period, Liverpool turned things around with two goals in as many minutes shortly after the hour.
Agger first stretched to prod home a Gerrard free-kick at the back post before Sturridge tapped in at the far post after yet another fine delivery from the Liverpool captain.
Ameobi was sent off by Dowd, receiving two yellow cards seemingly for dissent as Newcastle prepared to kick off after Sturridge's strike.
Substitute Dummett, only introduced in the 81st minute, was then given his marching orders three minutes from time for a rash challenge on Suarez as Liverpool ended a fine campaign with a win, albeit ultimately just falling short of champions City.
|Coach: B. Rodgers|
for J. Flanagan 46'
for J. Allen 59'
for D. Sturridge 80'
|Bravo: I hope Messi continues playing for Argentina|
|Aguero: Messi not the only player considering retirement|
|I think Messi is just upset, Romero says after captain announces retirement|
|Aguero: This is the worst I have seen Messi|
|Messi set to retire from international football|
|Sanchez: This is the best thing to happen to me|
|Martino: Argentina deserved to beat Chile in final|
|Vidal: This Chile generation is to stand|
|Sanchez crowned Copa´s best as champions Chile sweep awards|
|Argentina 0 Chile 0 (aet, 2-4 on penalties): Defending champs sink Messi and Co. again|
|Taylor ready for Belgium test|
|Portland Timbers 3 Houston Dynamo 2: Valeri late show seals win|
|Euro 2016 Diary: Love blossoms in Paris and last orders for Ireland as Hallgrimsson baits England|
|De Bruyne, Belgium target Euro 2016 final|
|Wilmots: Hazard does his talking with his feet|
|Storck enthusiastic about Hungary future|
|My best Belgium performance - Hazard|
|´It took him long enough!´ - Schweinsteiger hails Boateng´s first Germany goal|
|Courtois: Hungary made an error by coming to play|
|No back-three fears for Spain boss Del Bosque|
|Grigg fired by Euro bench duty|
|Davis: Stranger things have happened than O´Neill to Southampton|
|Gunnarsson insists Iceland do not fear England|
|Brilliant Hazard inspires Belgium´s golden boys|
|Student Morata wants to bring down Juventus masters with Spain|
|Hungary 0 Belgium 4: Hazard inspires Wilmots´ men into quarter-finals|
|Conte demands extraordinary Italy to topple Spain|
|Nolito: No contact with Barca or Man City|
|Alves jets into Turin for Juve medical|
|Low: No sleepless nights over Italy or Spain|
|Kozak: Germany had too much quality|
|Fury gets in the spirit with England fans in Nice|
|Draxler shares the plaudits as Germany move through|
|O´Shea not drawn on Ireland future|
|Rami: France were scared of going out|
|Germany 3 Slovakia 0: Spain or Italy await for world champions after comprehensive win|
|Brilliant Boateng gets Germany juggernaut motoring|
|Lagerback hopes England´s attacking struggles will continue|
|Juventus, Napoli and Roma ´all interested in De Sciglio´|
|O´Neill hails coming of age for Ireland´s youngsters|
|England will not disrespect Iceland, says Rooney|
|Deschamps stands firm on team changes|
|Hodgson adamant he is happy with England strikers|
|Evra: We knew it would be difficult|
|Deschamps: We had to dig deep|
|Rooney: Do not question Sterling´s attitude|
|O´Neill: France´s extra rest took its toll|
|France star Payet: It is difficult to stop us|
|Griezmann: Stern words led to second-half fightback|
|Coleman: We felt it was there for us|
|Deschamps defies doubters as France heed call to arms|
|Konko ´in talks´ to join AC Milan|
|Sigurdsson looking forward to dream England clash|
|Cacic: Croatia´s time will come|
|Italy v Spain will be different to Euro 2012 final - Camoranesi|
|France 2 Republic of Ireland 1: Griezmann double rescues hosts|
|Capello: Spain are pure magic|
|Wolfsburg complete Bruma signing|
|Koke: Spain need to bring back ´The Red Fury´|
|Pizzi: Chile can beat Messi and Argentina|
|Schalke swoop for Swiss star Embolo|
|Subotic signals intention to leave Dortmund|
|Howedes eager for France showdown|
|Russia confirm Slutsky resignation|
|Pirlo: Italy out for Spain revenge|
|Vokes consoles McAuley after Wales march on|
|Italy-Spain a battle of world´s best - Llorente|
|Messi one win away from becoming the greatest|
|Play-offs the goal as Baptista settles into life in Orlando|
|Colombia closer to winning titles - Pekerman|
|MLS Review: Kaka scores 100th-minute penalty in thriller, Lampard inspires NYC|
|Portugal ´don´t have a clue how they scored´ – Rakitic|
|Klinsmann: USA should be proud of Copa America display|
|United States 0 Colombia 1: Bacca secures third place at Copa America|
|Corluka: Portugal among worst teams at Euro 2016|
|Sanches happy to be involved as Portugal reach quarters|
|Euro 2016 Diary: Shaqiri rivals Pique for Shakira´s affection, Bale reveals secret weapon|
|Morata: I have nothing to prove to Zidane|
|Di Maria fit for Copa final|
|´You do not always win by playing prettily´ - Santos unconcerned by dour Portugal|
|The best team lost, says disconsolate Cacic|
|Fabianski: Poland must create more for Lewandowski|
|McAuley pride after crushing Wales loss|
|Ronaldo takes one for the team as Portugal emerge from drudgery in Lens|
|Croatia 0 Portugal 1 (aet): Quaresma earns quarter-final berth|
|Hodgson will not beg for FA approval after Euro 2016|
|Emotional Bale glad to share Paris joy with family|
|O´Neill left frustrated by officials following Euro 2016 exit|
|Coleman hails Bale brilliance in Wales win|
|Low relying on Kroos to lead Germany the way|
|Italy v Spain: Thiago denies shirt jinx ahead of Azzurri clash|
|O´Neill: McAuley has been magnificent|
|Szczesny thanks Swiss fans for drink|
|Hector: Slovakia have plenty of quality in attack|
|Morata: Italy defenders have told me to wear a helmet|
|Coleman content with scrappy Wales progression|
|Wales remain and Northern Ireland leave after Paris battle|
|We are free of pressure - Gera|
|´Do I look like I have doubts?´ - Defiant Nawalka defends Lewandowski|
|Wales 1 Northern Ireland 0: McAuley´s woe is Welsh joy|
|No chance Barcelona star Neymar will join Madrid, says his father|
|Witsel happier to face Hungary than Spain|
|Wilmots accepts pressure ahead of Hungary test|
|Slovakia can upset Germany again - Pekarik|
|Shaqiri unhappy with Poland celebrations after Euro 2016 exit|
|Grosicki struggled to watch Poland shootout win|
|Poland need Lewandowski to rediscover ruthless streak|
|Switzerland 1 Poland 1 (aet, 4-5 pens): Xhaka shocker costs Swiss after Shaqiri magic|
|Payet can handle hero status - Deschamps|
|Redmond joins Southampton on five-year deal|
|Sturridge: Sterling unfairly targeted over England performances|
|Wilmots: I want more from smiling De Bruyne|
|Croatia star Perisic unveils latest wacky hairstyle|
|Brazil´s Lucas Lima wants European move|
|Lloris tempers talk of Ireland revenge mission|
|Deschamps refuses to make France ´98 comparisons|
|O´Neill confident Ireland can shock France|
|Chiellini will give Morata a few kicks - Barzagli|
|England v Iceland: Rooney targets early goal|
|Italy´s Candreva ruled out of Spain match|
|Butland ready for pre-season after scan gives goalkeeper all-clear|
|Origi not underestimating Hungary|
|Plans drafted for Old Firm games to be played abroad|
|Boost for Germany as Boateng trains ahead of last 16|
|I never saw Ronaldo look in the mirror! - Ancelotti|
|Fabregas fears Brexit will damage Premier League|
|Roy not keen on Ireland allocation|
|Dyke backs Hodgson for new contract|
|Spain not as aggressive as 2012, claims Ancelotti|
|Ronaldo and Messi need each other – Ancelotti|
|Juve on the same level as Madrid and Barcelona - Dybala|
|Fabregas: Conte´s Italy will be tough|
|Argentina v Chile: New year, same Copa finalists|
|Ronaldo ´cannot be the whole of Portugal´ - Shilton|
|Messi: Neymar is an amazing person|
|Pekerman keen to finish Copa on high note|
|Rakitic: Ronaldo won´t sleep easily|
|Messi: Now is not a time to give nothing|
|Courtois expects to leave Chelsea in future|
|Less rest no problem for Portugal - Joao Mario|
|Euro 2016 Diary: Benteke rap and Nelly the elephant|