Javier Zanetti bid farewell to San Siro in style as two goals from Rodrigo Palacio helped Inter to a confident 4-1 Serie A win over Lazio.
Both sides came into the clash needing points in their quests for European qualification, but all the attention was on the most decorated player in Inter's history.
Fourty-year-old Zanetti, who is Argentina's most-capped player with 145 outings, has lifted 16 trophies with the club since joining from Banfield in 1995, but his 857th appearance for Inter had to wait until the second half.
Initially the hosts appeared to be in trouble as Giuseppe Biava put Lazio ahead in the second minute, but Inter battled back and ultimately went into the break 3-1 up thanks to two goals from Palacio and Mauro Icardi's strike.
Zanetti was introduced to much fanfare just after the break and although Lazio crafted numerous opportunities in the second period, Hernanes sealed the result against his former club with a stunning effort from range.
Victory means Inter are all but guaranteed a spot in the UEFA Europa League, with defeat for Lazio ending their hopes of a top-six finish.
With an expectant home crowd displaying banners of thanks for Zanetti, coach Walter Mazzarri was greeted with a frosty reception from the home faithful as word of the Argentinian's absence from the XI spread.
And things got even worse for him in just the second minute as Lorik Cana headed Bruno Pereirinha's free-kick back across goal for Biava to prod in.
Lazio barely held the lead for five minutes, however, as Palacio raced on to Mateo Kovacic's defence-splitting throughball and deftly poked a clever finish past Etrit Berisha.
Proceedings quietened down after a frantic start, but Kovacic produced another moment of magic in the 34th minute, delivering a delightful outside-of-the-foot pass to Icardi, who coolly slotted home from inside the area.
Inter doubled their advantage just three minutes later.
Yuto Nagatomo's left-wing cross evaded the Lazio defence and Palacio duly stroked the ball beyond Berisha's reach.
The second half endured a muted start as the inevitable arrival of Zanetti was anticipated and Mazzarri finally unleashed his captain in the 52nd minute, drawing a thunderous ovation from the crowd.
Lazio were in no mood to stand around and appreciate the retiring midfielder, however.
Samir Handanovic denied Biava a second with an acrobatic save to his right, before Balde Keita inexcusably sliced a half-volley well over the crossbar from 14 yards.
Lazio's pressure continued into the final stages, but any threat of an unlikely comeback was thwarted with 11 minutes to go as Hernanes rifled in an unstoppable left-footed effort from 20 yards.
Zanetti was the game's final focus as he consoled a supporter who had run onto the pitch and approached him - an act met with applause from all sides of San Siro as the emotional fan was escorted from the field.
|8||R. Palacio||7' 30' 37'|
|Coach: W. Mazzarri|
for Jonathan 52'
for R. Palacio 64'
for Z. Kuzmanović 74'
|Smith likens Postecoglou to Klopp|
|Hart backs Sterling to shine at Euro 2016|
|Giovinco happy in MLS despite Euro 2016 snub|
|Balotelli set for Liverpool return, confirms Berlusconi|
|Atletico must win Champions League - Cerezo|
|Arbeloa: Mourinho didn´t get enough recognition at Madrid|
|Mijatovic: Bale can save Madrid´s season in Champions League final|
|Gallas expects Conte to revive Chelsea|
|Deschamps ´annoyed, but not worried´ by Varane´s absence|
|´Impossible´ to see MSN leaving Barcelona - Bartomeu|
|Thiago pledges future to Bayern|
|AFC Champions League Review: Urawa pay the penalty as Seoul advance|
|Uruguay v Trinidad and Tobago: Sanchez skips final to help Suarez-less La Celeste|
|Benitez ´convinced´ he can win trophies at Newcastle|
|Nigeria v Mali: Moses among many absentees for Super Eagles|
|Benitez to stay at Newcastle|
|Kramaric leaves Leicester for Hoffenheim permanently|
|Neustadter gets green light for Russia Euro 2016 selection|
|Chile v Jamaica: Copa plans crystallize in Vina del Mar|
|Ledley making progress in bid to prove Euro 2016 fitness|
|Gotze returns to Germany training|
|Ronaldo: Madrid would be smart to give me a new deal|
|Varane disappointed by Euros absence|
|Republic of Ireland v Netherlands: O´Neill wants confident display|
|Ronaldo shakes off injury in Real Madrid training|
|Atletico star Griezmann ´listening to different clubs´|
|United States - Ecuador Preview: Klinsmann pins hopes on Yedlin as Copa preparations continue|
|Gold tells Middlesbrough to ´dream on´ over Antonio|
|Schweinsteiger wants Mourinho to spice up Manchester derby|
|England v Australia: All eyes on Rashford debut|
|Aggressive Premier League better for me - Xhaka|
|Schweinsteiger ´right on schedule´ for Euro 2016|
|Darmian relishing Euros after return from injury|
|Northern Ireland v Belarus: Last chance to impress as O´Neill prepares to trim squad|
|Ventura leaves Torino amid Italy talk, Mihajlovic appointed|
|Sevilla confident of keeping Emery|
|Godin wants Atletico to use 2014 defeat as inspiration|
|Xhaka agrees Arsenal move|
|Idolisation of Ibrahimovic warranted Sweden captaincy - Hamren|
|Scholes hopes Mourinho keeps Giggs at Manchester United|
|Gotze snubbing Liverpool will boost Germany - Bierhoff|
|Bosz honoured by Ajax appointment|
|Ramos highlights Griezmann threat|
|Record-chasing Ronaldo and taming the Wolves - Real Madrid´s route to the Champions League final|
|Donnarumma dreams of being Milan captain|
|Koke: History, not revenge motivating Atletico|
|Costa Rica v Venezuela: Hosts ramp up preparations for maiden Copa America tilt|
|Argentina v Honduras: Messi and co warm up for Copa America|
|USA will win a World Cup, says Donovan|
|Pumas UNAM 2 Independiente del Valle 1 (3-3 agg, 3-5 on penalties): Hosts suffer shoot-out heartbrea|
|Gracia leaves Malaga as Rubin Kazan loom|
|Messi: Argentina deserve to be Copa America champions|
|Dybala included in Argentina´s preliminary Olympics squad|
|Mourinho and United a ´good wedding´ - Ancelotti|
|Klinsmann: Copa America better than Euros|
|Messi: Joining Barcelona not an easy decision|
|Carrico receives four-game ban for homophobic slur|
|Dani Alves wants Atletico to win Champions League|
|McNair out to impress ´world-class´ Mourinho|
|Ranieri: Premier League survival is Leicester´s priority next season|
|Argentina forward Lavezzi suffers hamstring scare|
|Koeman talks ´very positive´, say Southampton|
|Rami replaces injured Varane in France´s Euro 2016 squad|
|Matthaus applauds Gotze for rejecting ´easy solution´ of Liverpool|
|Suarez silenced his doubters - De Boer|
|AFC Champions League Review: Jeonbuk, Shanghai SIPG progress|
|Klopp can take Liverpool right to the top, says McAllister|
|Lindelof happy at Benfica amid Real Madrid, Barcelona links|
|Zidane is perfect on and off the pitch - Lippi|
|Bale: Zidane has brought the best out of Real Madrid|
|Favre takes over as Puel and Nice part ways|
|Liverpool complete Karius deal|
|Van Gaal was treated poorly by United, but Mourinho will be a success - De Boer|
|Dani Alves: I have won more titles than Pele|
|I know who I´m taking - Conte sure on Euro 2016 selection|
|Xavi backs Guardiola to ´change the face of English football´|
|Lucescu appointed Zenit boss|
|Manchester United and Liverpool hit with €40,000 fines|
|Weinzierl: I have nothing to lose at Schalke|
|Rangers complete Barton signing|
|Italy better placed as underdogs ahead of Euro´s - Motta|
|Cantona: I love Mourinho, but he is not Manchester United|
|Ben Arfa wants Lyon move - Aulas|
|David Silva praises Iniesta´s Copa del Rey heroics|
|´It was a little scare´ - Ronaldo plays down injury fears|
|Eder the real deal for Lille|
|Van Gaal treated unfairly during Manchester United spell - Daley Blind|
|Ginola doing ´very well´ after heart surgery|
|Depay rules out Manchester United exit following Van Gaal departure|
|Hojbjerg confirms desire to leave Bayern|
|Ronaldo leaves Madrid training early after knock|
|Abbiati unimpressed with Milan players´ attitude|
|Pepe calls on Madrid to continue making history|
|Ayestaran signs two-year deal with Valencia|
|Montolivo, Antonelli sign new AC Milan contracts|
|Ronaldo ready for UCL final after being rested from practice match|
|Hummels, Sanches deals will not stop Bayern spending - Rummenigge|
|Oblak´s penalty heroics, Griezmann´s Barcelona brace - Atletico Madrid´s route to the Champions Leag|
|Salvio all but confirms Gaitan will join Atletico Madrid|
|Motta warns PSG over Ronaldo, Neymar interest|
|Europa League Mourinho´s best hope for United trophy - Sheringham|
|Injustice if Iniesta never wins a Ballon d´Or - Del Bosque|
|Van Gaal didn´t deserve United sacking - Blind|
|I´ll be happy if we make Euro 2016 semi-finals - Del Bosque|
|Koke: Why would I want to leave Atletico?|
|Fofana could retire aged 25 - Lyon president|
|Sandro set to leave Barcelona|
|Silva plays down injury worries ahead of Euro 2016|
|United would be brave to appoint Mourinho, says Schmeichel|
|Neymar adamant he is happy at Barcelona|
|Wilshere: Arsenal play me out of position|
|Ryan backs former coach Neville|
|Keane talks up Galaxy move for Ronaldo|
|´Free agent´ Diarra wants Mourinho reunion|