Liverpool host Newcastle United to close a superb Premier League campaign but much attention inside Anfield will be trained 30 miles east.
Brendan Rodgers' team head into the final game of the season with a chance of lifting the title for the first time in the Premier League era, but dropped points against Chelsea and - quite remarkably - Crystal Palace over the past fortnight handed the initiative back to leaders Manchester City.
A draw at home to West Ham will be enough for City to claim a second league crown in three years - Manuel Pellegrini's men are two points clear at the summit and 13 better off than Liverpool on goal difference.
The odds are that the recent wave of euphoria at Anfield will be replaced by a sense of what might have been but City's near miss on the final day against lowly QPR two years ago, along with the wildly unpredictable nature of this season's title race, means events at the Etihad Stadium will be monitored keenly.
Irrespective of this weekend's outcome, the swashbuckling nature with which Liverpool chalked up 11 consecutive wins to put them in pole position for a first league crown in 24 years and secure a UEFA Champions League return will be one of the campaign's abiding memories.
By the same token, Chelsea's clinical 2-0 win on Merseyside to check their momentum and the defensive horror-show that turned Monday's handsome 3-0 lead at Palace into a dramatic 3-3 draw look set to be the kind of defining moments the Anfield masses did not have in mind.
Rodgers believes such a contrast in experiences and emotions over this short space of time will stand his squad in good stead.
He told Liverpool's official website: "To be successful, you have to be able to lose. If you look over the years, the great winners have been teams and individuals that have lost but have gone on and became a champion again.
"We've made great strides this season and there's still another game to go.
"If anyone had said to us in August about being top going into the last week of the season (Liverpool led by a point before City beat Aston Villa 4-0 on Wednesday), we would have taken that. We've qualified for the Champions League, but we know there is an awful lot of work here that we want to achieve."
Ex-Sunderland midfielder Jordan Henderson is sure to receive a feisty reception from the visiting supporters when he returns from a three-match ban, but the Newcastle faithful end the season with boss Alan Pardew also in their crosshairs.
Seven wins and a draw in a nine-game spell spanning November and December meant Newcastle had European designs of their own but their form has fallen off completely in recent months.
Last Saturday's 3-0 win to relegate Cardiff City ended a run of six consecutive losses, during which time they scored just once.
Experienced defensive duo Steven Taylor and Fabricio Coloccini committed their futures to the club this week and Pardew has no fresh injury concerns to contend with.
Top scorer Loic Remy, on loan from QPR, is expected to play his last game for Newcastle, with a host of clubs including Arsenal reportedly interested in his signature.
For the hosts, prolific striker Luis Suarez - voted the Professional Footballers' Association's Player of the Year - will set a record for the most goals in a 38-game Premier League season if he finds the net on Sunday.
The Uruguayan has 31 to his name despite missing the opening five league games due to suspension.
|Coach: B. Rodgers|
for J. Flanagan 46'
for J. Allen 59'
for D. Sturridge 80'
|Griezmann will still take penalties - Simeone|
|Simeone proud of ´one of the best´ wins|
|Godin suffers sprained ankle ligament|
|West Ham receive positive news over injured duo|
|Robson: Four wins for Southgate and he´s an England contender|
|Gunes rues Besiktas´ inability to see off Dynamo|
|Sarri: Late goals leave bitter taste|
|Borussia Monchengladbach were exceptional against Barcelona, feels Schubert|
|PSG must be patient, says Emery|
|Celtic are lucky to have Dembele - Rodgers|
|I´m completely focused on Arsenal, insists Wenger amid England talk|
|Hasselbaink denies wrongdoing amid impropriety allegations|
|Ancelotti frustrated by slow, toothless Bayern|
|Barcelona deserved their win - Luis Enrique|
|I want Celtic atmosphere at City – Guardiola|
|Rebrov defends Yarmolenko after ´difficult´ match|
|Rostov draw is two points dropped for PSV, says De Jong|
|Torres eyeing ´magical´ year for Atletico|
|Celtic 3 Manchester City 3: Dembele at the double in six-goal thriller|
|Celtic 3 Manchester City 3: Dembele at the double in six-goal thriller|
|Rostov 2 PSV 2: Propper´s penalty miss costs visitors|
|Besiktas 1 Dynamo Kiev 1: Tsygankov stuns wasteful Turks|
|Napoli 4 Benfica 2: Mertens bags two as Napoli run riot|
|Arsenal 2 Basel 0: Walcott´s capital gains tax Swiss visitors|
|Borussia Monchengladbach 1 Barcelona 2: Pique grabs the winner|
|Atletico Madrid 1 Bayern Munich 0: Carrasco gives Ancelotti first taste of defeat|
|Ludogorets 1 Paris Saint-Germain 3: Cavani inspires comeback win|
|Premier League, FA and EFL to investigate transfer allegations|
|Vardy reveals matchday energy drink and port routine|
|Everton coping without Stones, says Jagielka|
|Sacked Jemez admits to ´great sadness´ at Granada exit after worst start in over 70 years|
|Wenger has so much to offer English football - Schmeichel|
|No truth to England rumours, says Klinsmann|
|Spalletti demands end to damaging Roma ´games´|
|De Boer: Brozovic was punished and forgiven|
|Allardyce paid price for lack of privacy - McClaren|
|Milik can match Lewandowski - Reina|
|LMA ´extremely concerned´ about manager bribe allegations|
|Iwobi: I nearly left Arsenal|
|Mata has found a ´natural habitat´ at United|
|Higuain slowly approaching top form|
|´Stupid´ Allardyce driven by money - Dyke|
|Wijnaldum vows to improve|
|Renato Sanches needs time at Bayern - Hitzfeld|
|Ibrahimovic nurturing United talent - Lingard|
|Mourinho feels sorry for Allardyce|
|United boss primed for ´must-win´ Europa League tie|
|Mourinho keen to protect under-fire Rooney|
|Jeonbuk Motors 4 Seoul 1: Leonardo brace puts hosts in the driving seat|
|Maloney returns to Scotland squad|
|Van Persie: Kids will decide my future|
|Entrapment won on this occasion - Allardyce|
|Ibra-Rashford pairing the answer for United - Neville|
|Tevez hints at imminent retirement|
|England in safe hands with Southgate - Glenn|
|Holman talks up A-League quality|
|CONCACAF Champions League Review: Red Bulls progress, Timbers win|
|Januzaj blow for Sunderland|
|Navas accepts blame for Dortmund equaliser|
|Sporting assistant Raul Jose pleased with win|
|Nuno left to regret slow start as Porto fail on English soil again|
|Vardy rejected Arsenal due to style|
|Simeone: I am not Griezmann´s mentor|
|Schmidt bemoans ´brutal´ Monaco equaliser|
|Ranieri doesn´t trust bookies over England job|
|Genesio worried wastefulness will cost Lyon in long run|
|Preud´homme admits Champions League too much for Club Brugge|
|Telegraph passes findings to FA after further corruption claims|
|Zidane: Draw difficult to accept|
|Pochettino delighted with in-form Son|
|Vietto undeterred by wasteful showing|
|Tuchel: Dortmund can still get better|
|Resilient Leicester display pleases Morgan|
|Glenn reflects on ´painful´ call to dismiss ´distraught´ Allardyce|
|Borussia Dortmund 2 Real Madrid 2: Late Schurrle strike salvages draw|
|Monaco 1 Bayer Leverkusen 1: Glik stunner snatches a point|
|Dinamo Zagreb 0 Juventus 4: Pjanic pilots comfortable victory|
|CSKA Moscow 0 Tottenham 1: In-form Son hits late winner|
|Copenhagen 4 Club Brugge 0: Delaney stunner helps Danish champions canter to victory|
|Sporting CP 2 Legia Warsaw 0: Magiera´s first game ends in defeat|
|Sevilla 1 Lyon 0: Ben Yedder seals win for Europa League holders|
|Leicester City 1 Porto 0: Slimani continues to haunt old foes|
|Shearer: Allardyce has made England a laughing stock|
|Howe, Pardew and Wenger among the contenders to succeed Allardyce|
|Emery´s PSG struggles give Ludogorets hope|
|Allardyce offers ´wholehearted apology´ for England shame|
|Lahm: ´Extraordinary´ Griezmann different to Lewandowski|
|Iniesta is the best in the world, claims Menotti|
|Irregular heartbeat ends Dempsey´s season|
|Bournemouth ´realistic´ over permanent deal for Wilshere|
|Guardiola warns against complacency|
|Allardyce and England part company after damning video|
|De Bruyne out for up to three weeks - Guardiola|
|Luis Enrique demands fast start at Gladbach|
|Ancelotti wary of Atletico threat|
|Al Ain 3 El Jaish 1: Caio capitalises on late error|
|Ter Stegen happy with solution to Bravo battle|
|Emery: PSG need time to gel|
|Hernandez: It was very difficult at Real Madrid|
|Derby stand down Pearson ahead of Cardiff match|
|Rodgers sympathises with ´poor guy´ Allardyce|
|Opponents are trying to get Ribery send off - Hoeness|
|Martino named Atlanta United head coach|
|Rodgers urges Celtic to have belief against City|
|Rodgers has made same impact as Guardiola - Brown|
|Benfica one of the best in Europe, warns Sarri|
|Menotti: Ronaldo never played in a team like Messi´s|
|Walcott happy to move on from Arsenal struggles|
|Champions League Matchday Two: Bayern hunt Atleti revenge|
|Coquelin facing three weeks out|
|Arsenal transfers beyond reproach, says Wenger|
|Schubert extends Gladbach contract|
|Lewandowski urges Bayern to learn from Atletico defeat|
|Griezmann feared Simeone to PSG was ´a done deal´|
|FA investigating Allardyce claims|
|Valencia keep Voro in charge for Atletico clash|
|One of Serie A´s all-time greats: The numbers behind Totti at 40|
|Toure brands FIFA ´complacent´ after racism taskforce closed|
|Emery expects Ronaldo to stay at Real Madrid|
|Tottenham not scared of Moscow trip - Alderweireld|
|Sessegnon signs with Montpellier|
|Rakitic delighted with form|
|Gameiro: I could have joined Barcelona|
|Stones talks up Celtic quality|
|Liverpool good enough to win title - Houllier|
|Klopp happy with Firmino in central role|
|Watford got bullied all over the pitch - Deeney|
|Nuno keen for Porto to end England misery|
|Legia boss Magiera set for whirlwind debut|
|´Terrific´ Burnley delight Dyche|