Atletico Madrid aim to stride towards one of La Liga's most unforeseen conquests as a thrilling title race enters its penultimate round.
Atleti lead Barcelona, whom they visit on the final day, by three points at the summit, with Real Madrid a further point back in third.
The trio, who all failed to win in the same round of fixtures for the first time this season last weekend, kick off simultaneously on Sunday: Atleti at home to Malaga, Barca away to relegation-threatened Elche, and Real at mid-table Celta Vigo.
And Diego Simeone, whose side could lay their hands on the trophy should Barca fail to pick up three points, believes the whole country wants to see David outlast two Goliaths and lift the trophy at the end of the season.
"It’s not easy to break the stranglehold of two such powerful teams," said the Atleti boss. "Fans of teams all across Spain are behind us."
Malaga do not have the best of records at Vicente Calderon in the league, though two victories in the past four campaigns could give the hosts cause for concern.
Elche are unbeaten in front of their own supporters in 2014, but their last win over Barca came way back in 1974.
Lionel Messi will certainly be up for the fixture, however, as he lurks three goals behind Cristiano Ronaldo on the Liga scoring charts.
With little chance of winning the title, Real coach Carlo Ancelotti may choose to rest key players with one eye on the UEFA Champions League final.
Victory for Atleti would rule their city rivals out of the chase for the league crown.
Athletic Bilbao and Real Sociedad have secured UEFA Champions League and UEFA Europa League football respectively, so their Basque Derby will be all about bragging rights.
Antoine Griezmann and Carlos Vela, who has scored in his past three appearances, have dazzled for Sociedad this season, but in Aymeric Laporte, Bilbao have one of the most coveted young defenders in Europe.
Sociedad have won their last three derbies by two-goal margins, but Bilbao enter the latest pursuing a fifth win in six matches.
The relegation battle will recommence with Granada and Almeria, both hovering narrowly above the bottom three, doing battle, and third-bottom Getafe at home to fifth-placed Sevilla.
Real Valladolid and Osasuna know they must seize their opportunities to boost their survival hopes - they are away to relegated Betis and a desperately out-of-sorts Espanyol respectively.
The round begins with two matches of little importance on Saturday, with seventh-placed Villarreal hosting Rayo Vallecano and Valencia away at Levante.
|Zidane lauds talented Mbappe as Madrid circle Monaco star|
|Everton, Zenit and PSV learn Europa League opponents as Galatasaray suffer shock exit|
|Africa Cup of Nations expanded and moved to June and July|
|Cillessen happy at Barcelona and denies Crystal Palace links|
|RFEF president Villar held in custody amid corruption case|
|Bonucci aims to follow AC Milan legends Baresi, Costacurta, Maldini|
|DFB punishes Borussia Dortmund over crowd disorder|
|Neymar not for sale - Bartomeu gives FFP warning to PSG|
|Griffiths given Champions League ban over Linfield incident|
|Real Madrid places up for grabs - Bale|
|BREAKING NEWS: Hernandez set to join West Ham from Leverkusen|
|Bernardeschi misses Fiorentina training camp amid Juventus move reports|
|Monaco warn clubs over illegal Mbappe approaches|
|Hughton ´very hopeful´ over Knockaert injury|
|Morata perfect for Premier League but Lukaku has advantage - Karanka|
|Whelan ends nine-year Stoke City stay by joining Aston Villa|
|Hoeness tells Sammer to ´say little´ about Bayern|
|Altidore´s girlfriend: Only I can grab Jozy´s nipples!|
|Perisic to play on Inter tour as Manchester United bid stalls|
|Defrel reunited with Di Francesco at Roma|
|Bonucci and Ramos best in the world, says Milan boss Montella|
|Injured Thiago out of Bayern pre-season tour|
|Klopp helped me a lot - Liverpool captain Henderson reflects on injury woe|
|Rashford: Lukaku partnership could fire Man Utd to glory|
|De Sciglio completes €12m Juventus switch|
|Insigne eyes Scudetto success... and the tattoo to match|
|Mourinho: Manchester United can´t compete with clubs who buy and buy and buy|
|Lewandowski happy to see Aubameyang stay at Dortmund|
|Morata: Conte has shown the most faith in me|
|Neymar signing ´would be good´ for PSG, says Silva|
|Chelsea eyeing all titles this season - Kante|
|Neymar could make PSG Champions League contenders - Emery|
|MLS Review: Red Bulls put five past Earthquakes, Sounders rally from 3-0 down|
|PSG target Neymar and Barca arrive in New York|
|Morata says goodbye to Real Madrid ahead of Chelsea move|
|Mourinho unfazed by Morata´s Chelsea move|
|United States 2 El Salvador 0: Hosts advance to Gold Cup semis|
|Roma 1 Paris Saint-Germain 1 (3-5 pens): Alves makes debut in win|
|Rummenigge names Sanches price as he doubts Milan can meet Bayern demands|
|Messi a machine built for football – Xavi|
|Costa Rica 1 Panama 0: Godoy own goal the difference|
|Kompany: Man Utd star Lukaku believes he´s best in the world|
|Mourinho: Guardiola rivalry has eased|
|Lennon steps up Everton return with goal in Twente friendly|
|Morata ´very happy´ as Chelsea move nears|
|Verratti drops agent for Raiola after ´prisoner´ comments|
|Celtic 4 Linfield 0 (6-0 agg): Plain sailing as Sinclair scores twice|
|He´d still be running now if we didn´t take him off! - Klopp impressed by Salah energy|
|Sammer not convinced by ´limited´ James|
|Morata ready to be Chelsea´s main man? Spain star compared to Costa and Lukaku|
|Aguero going nowhere as Guardiola cools Sanchez talk|
|Manchester derby gets worker bee emoji in tribute to terror victims|
|Chelsea agree terms with Madrid on Morata deal|
|Barkley set to miss season opener after surgery|
|Southampton goalkeeper Forster signs new long-term contract|
|Guardiola confirms Manchester City´s Danilo interest|
|Adrian sends Sullivan reminder after West Ham chairman´s gushing Hart comments|
|Liverpool 2 Crystal Palace 0: Solanke and Origi on target in Hong Kong|
|Murphy completes move to boyhood club Newcastle|
|Bayern Munich 1 Arsenal 1 (2-3 pens): Cech and Martinez the heroes in shoot-out win|
|Szczesny completes €12.2m Juventus move|
|AC Milan did not respect Dortmund over Aubameyang, says Watzke|
|Great in the air, will Crouch be a hit on-air?|
|Atletico guarded over Costa bid|
|Del Piero backs Juventus to respond to Bonucci loss|
|Jakupovic joins Hull exodus to seal Leicester deal|
|Mourinho unsatisfied with Manchester United transfer business|
|Barcelona have been sleeping, warns Xavi|
|De Sciglio finalising Juventus move|
|Roma eye Mahrez as Salah replacement|
|€75m? No way! Leipzig reject huge bid for Liverpool target Keita|
|Matic closer to Manchester United move after Chelsea tour snub|
|Lukaku: Mourinho has already made me a better player|
|Mourinho wants 15 more years at United|
|Wijnaldum confident Liverpool can challenge for title|
|Conte´s non-extension the latest twist in Chelsea´s stuttering close-season|
|Hammered at Arsenal and destroying Man United - five key games in Chelsea´s title triumph|
|Masterful tactics, signing Kante and Moses´ reinvention: How Antonio Conte won Chelsea the Premier L|