Inter can move a step closer to sealing European qualification with victory over Lazio at San Siro on Saturday.
Both sides are pushing for a place in the UEFA Europa League next season, with Inter occupying fifth spot in Serie A with just two games remaining.
Lazio, meanwhile, are in with a chance of claiming the expected additional qualifying position after Napoli and Fiorentina - placed third and fourth in the table - contested the Coppa Italia final.
Inter failed to challenge for the title in Walter Mazzarri's first season in charge, but have consistently been in the top five throughout the campaign.
Edy Reja's Lazio have spent the majority of their season in mid-table, but they missed a chance to move up to joint sixth and close the gap on Inter to two points when they needed a stoppage-time goal from Stefano Mauri to draw 3-3 with Verona.
However, the Rome club remain just four points adrift of Mazzarri's men - meaning a win at San Siro would give them a real chance of snatching fifth place.
Recent history is on Lazio's side too, as they have won the last four meetings between the teams.
Inter go into the fixture looking to shake off the disappointment of losing to city rivals Milan last weekend, and forward Rodrigo Palacio has called on them to get back to winning ways and all but seal their Europa League berth.
"First and foremost it's important to beat Lazio so that we get into Europe, there are a host of clubs close behind us, so we have to win," he told Inter's official website.
"It's fundamental (we qualify for Europe). That's the objective we set ourselves. There are two tough games left to play now and we need to play well in them to achieve our objective."
Lazio travel to Milan in good form having lost just one of their last six Serie A matches, and will have fond memories of the corresponding fixture last season, which they won 3-1 almost exactly a year ago.
Reja will be without midfielder Senad Lulic after his dismissal against Verona, while Helder Postiga (knee), Emiliano Alfaro (knee) and Ederson (hamstring) are also missing.
Striker Miroslav Klose did return in Monday's draw from the bench, though, and he could start.
Inter midfielder Esteban Cambiasso serves a one-match suspension after his booking against Milan, while Juan Jesus (knee) and McDonald Mariga (muscle) are Mazzarri's only injury concerns ahead of a game that will mark club legend Javier Zanetti's final San Siro appearance.
|Lampard welcomes ´perfect´ NYCFC challenge|
|Shamrock Rovers 3 Progres Niederkorn 0: Waters at the double|
|Gerrard keen to emulate ´hero´ Beckham at Galaxy|
|UEFA Champions League Review: Red Imps make history, TNS breeze through|
|Ameobi extends Newcastle deal and heads for Cardiff|
|U.S. women celebrate World Cup victory with LA rally|
|Atletico agree Vietto deal|
|Silva appointed Olympiacos head coach|
|Presidential candidates unsure of Turan´s Barca switch|
|Toure keen to bounce back from ´disappointing´ campaign|
|El Salvador v Canada: Floro targets Gold Cup learning curve|
|Juve complete Zaza swoop|
|Costa Rica v Jamaica: Borges confident Wanchope´s men are ready|
|Marseille snare Sarr|
|Italy coach Conte to stand trial in match-fixing case|
|Castan keen to repay Roma´s faith|
|Rami thrilled to reunite with ´best coach´ Emery at Sevilla|
|Lusitans v West Ham: Tomkins seeks to silence minnows|
|Kagawa shines as Dortmund hit six in Japan|
|Alonso tips Gerrard for Galaxy glory|
|Firmino seeks self-improvement with Liverpool|
|Buffon bids farewell to Pirlo|
|Sterling named Europe´s ´most valuable´ young player|
|Casillas´ agent reveals Porto offer|
|Southampton bring in Martina|
|Dundee United accept Celtic´s Ciftci bid|
|McArthur pens new Palace deal|
|Bartomeu rules out Barca move for Pogba this year|
|Spurs have to be better now - Bentaleb|
|Milner expects central role|
|Micronesia thrashed again, this time 46-0|
|Marchisio: I cannot be Pirlo´s heir|
|Inter aiming for Champions League return - Icardi|
|UEFA Europa League Preview: Brondby and Slovan to protect handsome leads|
|Bentaleb pens new long-term deal at Tottenham|
|Barca agree Turan deal|
|FIFA bans Mayne-Nicholls|
|United States v Honduras: Klinsmann demands improvement ahead of Gold Cup opener|
|CONCACAF institutes extensive reforms in wake of FIFA corruption scandal|
|Mauri completes Milan move|
|City sign Turkey striker|
|Women´s World Cup final draws huge US TV ratings|
|My first Chelsea team better than current crop - Drogba|
|Bertrand set for lay-off after knee surgery|
|New five-year Juve deal for Marchisio|
|Allegri extends Juve contract|
|Koeman reiterates Alderweireld interest|
|Valencia bag Bakkali|
|New York City FC complete Pirlo capture|
|Panama v Haiti: Collat ready to challenge the best of CONCACAF|
|UEFA Champions League Preview: Harrison eyes TNS progression|
|FIFA sanctions Yemen for fielding ineligible player|
|Toulouse rubbish Ben Yedder exit reports|
|Mourinho ´knows what he´s doing´ with Falcao signing|
|Watford shell out club-record fee for Capoue|
|Braafheid signs Lazio extension|
|Nani finalises Fenerbahce move|
|Liverpool confirm O´Driscoll appointment|
|Liverpool have to start better - Lucas|
|USA simply too good - Sasaki|
|Portland Timbers 1 San Jose Earthquakes 0: Jewsbury wins it in stoppage time|
|No move yet for Van Persie|
|Lloyd wins Golden Ball, Silver Boot awards|
|Mascherano: I never grabbed Banega|
|Dunga requested Brazil not appeal Neymar´s suspension|
|United States 5 Japan 2: Lloyd stars with hat-trick|
|Fiorentina deny Inter criticism|
|Nani relishing Fenerbahce opportunity|