Real Madrid failed to capitalise on slips by their rivals as Valencia applied further drama to La Liga’s title race with a 2-2 Bernabeu draw.
Following Barcelona’s draw with Getafe on Saturday and a 2-0 defeat for leaders Atletico Madrid at Levante earlier on Sunday, Carlo Ancelotti’s team looked in pole position for the title.
But Valencia had not read that script and goals from Jeremy Mathieu and former Real youth product Daniel Parejo either side of Sergio Ramos’ equaliser looked to have handed Juan Antonio Pizzi’s side a famous triumph.
Visiting goalkeeper Diego Alves was magnificent throughout, routinely thwarting Cristiano Ronaldo, but the Portuguese finally got the better of him in stoppage time to earn a point.
Despite rescuing a draw, it is Real's local rivals Atletico who appear best-placed. Victory in their final two matches - including the much-anticipated season-ending encounter with Barca at Camp Nou - will hand them the title.
For Valencia, the performance provided a tonic to Thursday's last-gasp UEFA Europa League semi-final elimination at the hands of Sevilla.
Real still have La Decima to chase in the UEFA Champions League, but they now require a huge favour from fierce enemies Barca on the final day to take the title.
Ancelotti’s men quickly hit their stride, Ronaldo beginning his game-long duel with Alves as early as the third minute.
As Madrid failed to build on their start, Parejo found himself unmarked on the end of Sofiane Feghouli's wonderful right-wing cross 16 minutes in, but Diego Lopez tipped his header onto the crossbar.
It was Alves' turn to impress again after 26 minutes as Ronaldo stormed past Ricardo Costa, only to see his strike palmed around the post.
Valencia served further warning of their intentions when Paco Alcacer failed to get a decisive touch on Eduardo Vargas' low cross and, after Alves thwarted Ronaldo once more, they claimed a 44th-minute advantage.
Lopez was at full stretch in touching Feghouli's strike over the bar but erred by staying on his line from the resulting corner and Mathieu scored, the ball ultimately finding the net via his shoulder.
Ancelotti sent Angel di Maria on at the interval and the Argentina midfielder's energy immediately boosted the hosts.
After saving from Di Maria, Alves again kept out Ronaldo but, after Raphael Varane spurned a set-piece chance, Real’s pressure finally told.
Ramos was still up from an earlier attack and enjoyed a tap-in when Ronaldo headed across goal in the 59th minute - netting for the fourth time in Real's last three outings.
With the game seemingly at their mercy, Real allowed the action to drift and, following a scrappy passage of play, Valencia poured forwards, Parejo steering clinically into the corner from Feghouli's pass.
Ronaldo sought an instant response from close range but Alves again excelled, and he tormented the FIFA Ballon d'Or winner with another stellar stop from a trademark free-kick.
The Portugal captain's frustrations appeared to have gotten the better of him in the last 10 minutes as he sent a free header wide and had a penalty claim rejected.
But Real's talisman salvaged a point in stoppage time. Ronaldo produced an inventive stabbed volley from Di Maria's left-wing cross, though he should have secured a stunning triumph even deeper into the additional time, heading wide to keep Ancelotti's men second-best in the title race.
|Coach: C. Ancelotti|
for Illarramendi 46'
for Isco 72'
for K. Benzema 84'
|Juventus unveil dramatic change to club logo - but not everyone´s a fan|
|´I do not think I will return to coaching´ - Van Gaal set to call it quits|
|Torino 2 AC Milan 2: Bacca caps thrilling comeback as hosts pay the penalty|
|DR Congo 1 Morocco 0: Kabananga pounces on blunder to give 10 men the points|
|´Happy and comfortable´ Sanchez dismisses Arsenal exit talk|
|How much?! West Ham flop Simone Zaza could cost Valencia €20m|
|Mali v Egypt: Salah leads Pharaohs´ bid for AFCON glory|
|Sevilla concede they ´cannot force´ sporting director Monchi to stay|
|Ivory Coast 0 Togo 0: Reigning champions held to opening draw by Adebayor and co.|
|Goalkeeping woes, Stones and tactical confusion - How Guardiola is making life difficult for himself|
|Ozil and Sanchez can be persuaded to stay - Cech|
|Pogba: I rejected Barcelona and Real Madrid|
|Ghana v Uganda: Gyan dreams of first trophy since 1982|
|Chiellini: Juventus a work in progress|
|Robben agrees Bayern renewal until 2018|
|Hazard: Goals do not matter to me|
|Bennell pleads not guilty to eight child sex offences|
|Muller fed up with debate over Bayern role|
|Wenger glad Sanchez is not ´a Costa problem´|
|Flick resigns as DFB´s sporting director|
|Gomis ´can´t wait´ to welcome Payet to Marseille|
|Chinese FA changes foreign player rules after ´irrational´ spending|
|Like father, like son: Justin Kluivert follows in dad´s footsteps|
|´No reason to lose him´ - Marotta rubbishes talk of Allegri exit|
|Courtois: We don´t need Costa|
|Kane: Tottenham players won´t go to China|
|Noble ´angry and disappointed´ with Payet|
|Klopp furious over Matip uncertainty|
|Wenger surprised by tight Premier League|
|´Money is not everything´ - Conte issues warning amid China speculation|
|Fiorentina defeat a ´bad setback´ - Allegri|
|´This will elevate this group of players´ - Sampaoli revels in Sevilla late show|
|WATCH: Rio Ferdinand screams and dances in crazy Man Utd celebration|
|Real Madrid relaxed, admits Zidane after Sevilla defeat|
|Monaco go top of Ligue 1 with stunning Marseille victory|
|Ronaldo equals LaLiga penalty record as Real Madrid lose|
|Sevilla 2 Real Madrid 1: Stunning late comeback ends unbeaten run at 40|
|Fiorentina 2 Juventus 1: Brilliant Viola breathe life into Serie A title race|
|Tunisia 0 Senegal 2: Mane on target as favourites start strongly|
|Mourinho explains Klopp confrontation|
|Klopp delights in Alexander-Arnold display|
|Algeria must cut out mistakes against Tunisia - Leekens|
|Long balls led to Man Utd equaliser, says Klopp|
|´We attacked, Liverpool defended´ – Mourinho insists a point flattered Klopp´s men|
|DR Congo v Morocco: ´Confidence´ the Atlas Lions´ biggest hindrance ahead of AFCON opener|
|Ibrahimovic: Direct tactics worked for United|
|Guardiola rues gap to Chelsea after Goodison mauling|
|Algeria 2 Zimbabwe 2: Mahrez double prevents shock defeat|
|Manchester United 1 Liverpool 1: In-form Ibrahimovic saves hosts|
|Ivory Coast v Togo: AFCON champions hope to tame Le Roy´s ´troublemakers´|
|Guardiola lays City´s mental frailties bare after Goodison rout|
|Koeman hails ´perfect´ Everton after City mauling|
|Nice stalemate gives Monaco chance to go top|
|Guardiola suffers heaviest league loss in Everton thrashing|
|Neymar-esque Zaha is England´s loss – Bolasie|
|Everton 4 Manchester City 0: Koeman leaves old pal Guardiola´s title bid in tatters|
|Matip withdrawn from Liverpool selection over eligibility questions|
|Podolski staying at Galatasaray, insists sporting director|
|Cavani wants PSG stay|
|Torino move feels normal now – Hart|
|Chinese FA changes rule on CSL foreign players - reports|
|Bayern complete swoop for Hoffenheim duo Sule and Rudy|
|Aubameyang: Dortmund not really like Barca, Madrid or Bayern|
|Pogba can chance a game in one second - Herrera|
|Newcastle Jets 2 Perth Glory 2: Keogh´s eighth of season seals draw|
|Klopp: Liverpool ready for Old Trafford test|
|Herrera taunts Liverpool ahead of Old Trafford showdown|
|I had to be 100 per cent to stay at Boca - Tevez|
|No player is bigger than the club - Carroll takes swipe at want-away Payet|
|Icardi: I can always move to China at end of career|
|Mkhitaryan: Klopp convinced me not to join Liverpool|
|Mourinho: Pogba can score every game|
|Cameroon´s profligacy frustrates Broos|