Atletico Madrid's La Liga title hopes suffered a huge blow on Sunday as they slipped to a shock 2-0 defeat at Levante.
With Barcelona only able to draw with Getafe on Saturday, Diego Simeone's had the chance to open up a six-point lead at the top of the table, but saw their winless run at Levante extended to six.
After going six games in all competitions without conceding a goal, Atletico found themselves behind early on when Filipe Luis diverted a corner into his own net.
The visitors pushed for an equaliser but found a resolute Levante side in their way, goalkeeper Keylor Navas pulling off a string of fine saves, and David Barral popped up to double the hosts' lead, blowing the title race wide open.
Real Madrid now appear favourites for the title - a 33rd Liga crown will be confirmed if Carlo Ancelotti's men win their remaining games and Atletico fail to pick up three points at Barca on the final day, with the Catalan giants also still in with a shout.
Atletico's fate remains in their own hands - two wins from their final two games will secure the league - but they will have to lift themselves from a desperately disappointing day.
The game was only seven minutes old when the hosts took the lead, through the unfortunate Filipe.
Papakouli Diop swung a corner in from the right, which was missed by a group of Atletico defenders at the front post and inadvertently turned home by the Brazil international's chest.
Atletico should have been level in the 14th minute only for Raul Garcia to see his close-range shot saved by Navas and David Villa sky the rebound over the crossbar.
Mohamed Sissoko and Diego Costa were perhaps lucky to stay on the pitch just after the half-hour when they clashed, referee Jose Gonzalez taking no action despite the Atletico forward appearing to push his head into the Mali international.
Navas was called into action once more before the break, saving Toby Alderweireld's low shot at his near post, Simeone introducing Adrian Lopez and Arda Turan at the break in the search of goals.
The pair made a swift impact on the game, Adrian seeing a shot blocked and the Turkey international heading over.
Atletico's frustration continued to build and only excellent defending from Loukas Vyntra denied Filipe from making amends just after the hour.
Costa was next to go close but he was unable to divert a Diego cross on goal, and moments later Alderweireld saw Navas claw another long-range effort out.
After such resilient defending, the hosts broke on the counter-attack and doubled their lead as Victor found Barral, who held off a challenge and fired low past Thibaut Courtois.
When Adrian was able to beat Navas with 13 minutes remaining, he too was left frustrated as the ball clipped the post on its way wide.
Simeone's side looked to have ran out of ideas and they were unable to muster any further openings, as Levante mathematically secured their top-flight status and provided a huge boost to Atletico's title rivals.
|7||David Barral||60' 69'|
|Coach: Joaquín Caparrós|
for M. Sissoko 59'
for Rubén García 71'
for David Barral 80'
|Allardyce confirms Rooney retains England captaincy|
|Hart to join Torino – agent|
|Sanches withdrawn from Portugal squad|
|Sporting CP issue Adrien Silva clarification amid Leicester links|
|Watford confirm Okaka signing|
|Manchester City outcast Zuculini seals Rayo Vallecano loan switch|
|Dembele offers something different - Deschamps|
|Sunderland would just love to get rid of me - Lens|
|No Casillas in Spain squad represents a ´new era´, says Ramos|
|Zenit defender Criscito could return to Italy, claims agent|
|Barcelona reveal Messi hamstring injury|
|Modric named new Croatia captain|
|Napoli announce Rog signing|
|De Boer is building something at Inter - Morratti|
|Keane eyes coaching career after international retirement|
|Bravo left out of Chile squad for family reasons|
|West Brom announce Chadli signing|
|Former Dodgers owner set for Marseille purchase|
|Ferdinand: I reached out to Wenger|
|Holgate has big quality for a young player - Koeman|
|Manchester United want to keep Rojo, says agent|
|Low not concerned by captaincy as Germany bid farewell to greats|
|Aguero pulls out of Argentina squad|
|Howedes: Germany must prove themselves all over again|
|Ventura close to tears on first day of Italy training|
|Torino interested in City outcast Hart|
|Adrien Silva hoping to seal ´exceptional´ Leicester switch|
|Boufal joins Southampton from Lille for club-record fee|
|Villa outcast Lescott joins AEK Athens|
|Milner: I´m learning left-back role as fast as I can|
|Allardyce ready for Hart transfer disruption|
|´Door always open´ for Barkley - Allardyce|
|Xhaka like Petit, claims Wenger|
|Coric: I was a medical away from joining Liverpool|
|Pasalic keen to put injury troubles behind him at Milan|
|Guardiola delighted with Sterling form|
|Rooney should retire from England duty - Shearer|
|Hazard can ´decide´ the title - Ivanovic|
|Allardyce hails ´outstanding´ Antonio|
|Belgium can make history - Henry|
|Nice president: Call Balotelli and tell him we need a striker|
|Modric would like to see out career in Madrid|
|Geromel replaces Caio in Brazil squad|
|Mustafi: Ozil convinced me to join Arsenal|
|Pardew confirms ´one or two´ more signings|
|MLS Review: Kaka brace denies NYC top spot, Timbers beat Sounders|
|Mihajlovic: I won´t waste anymore breath on Maksimovic|
|Okon named Central Coast Mariners coach|
|´Special´ Rashford will get chance - Rooney|
|Injury forces Schurrle out of Germany squad|
|Burke snubs Premier League interest to join RB Leipzig|
|Guardiola: Nasri has a future at City, if he wants it|
|Klopp confident ´all will be good´ with Sturridge|
|Emery confident PSG will bounce back|
|Athletic may strengthen squad - Valverde|
|Fabregas dismisses exit rumours, committed to Conte and Chelsea|
|De Boer encouraged as Inter´s wait continues|
|Barca ´strengthened´ by Luis Enrique´s 100th win|
|Fekir to undergo knee operation|
|Monaco 3 Paris Saint-Germain 1: Ligue 1 champions suffer early loss|
|Aguero facing possible Manchester derby ban|
|Athletic Bilbao 0 Barcelona 1: Rakitic strike extends Barca´s strong start|
|West Ham´s Antonio handed first England call-up|
|Guardiola ´so optimistic´ after Man City´s perfect start|
|Inter 1 Palermo 1: Icardi gets De Boer´s men off the mark|
|Credit Guardiola for boost in form, says Sterling|
|Manchester City 3 West Ham 1: Hosts stay perfect under Guardiola|
|Cavani won´t return to Napoli - De Laurentiis|
|Pulis puts 48-hour deadline on Berahino future|
|Zaza awaits ´new adventure´ at West Ham|
|Karanka open to transfer ´surprises´ after strong Middlesbrough start|
|Dost completes Sporting move|
|Allardyce wanted N´Zonzi for England|
|World Cup could be expanded - Infantino|
|West Brom 0 Middlesbrough 0: Booed Berahino benched for dour draw|
|Gyan´s ´destiny´ in England, Sunderland return an option|
|Zidane wanted Pogba and Madrid are weaker without him - Raiola|
|Juventus end Matuidi pursuit|
|´He´s freaking amazing!´ - Balogun hails Dortmund´s Dembele|
|Thohir thrilled as Inter confirm Joao Mario signing|
|Fabinho expects Monaco stay despite Manchester United links|
|Infantino has Blatter wine cellar removed as part of FIFA reform commitment|
|West Ham seal Zaza loan|
|Joao Mario posts heartfelt thanks to Sporting after record-breaking Inter move|
|Aguero: I´m not competing with Ibrahimovic|
|Mihajlovic: Maksimovic is dead to me|
|Risdon replaces Wright for Socceroos|
|MLS Review: DC United in goal-fest, Impact stun Toronto|
|Schmeichel to undergo surgery|
|Milik revels in ´dream´ brace as he ignores Higuain shadow|
|Rossi to join Celta Vigo|
|Ayestaran: Barcelona target Alcacer unable to compete|
|Simeone: Winless Atletico must remain calm|
|Griezmann: Atletico must improve or face relegation fight|
|Sterling ´feels the love´ at City - Guardiola|
|Stones glad he did not end up at Chelsea|
|James impact earns Zidane´s praise|
|Montella bemoans AC Milan´s indiscipline|
|Leganes 0 Atletico Madrid 0: Returning Griezmann fails to inspire turgid visitors|