Atletico Madrid's La Liga title hopes suffered a huge blow on Sunday as they slipped to a shock 2-0 defeat at Levante.
With Barcelona only able to draw with Getafe on Saturday, Diego Simeone's had the chance to open up a six-point lead at the top of the table, but saw their winless run at Levante extended to six.
After going six games in all competitions without conceding a goal, Atletico found themselves behind early on when Filipe Luis diverted a corner into his own net.
The visitors pushed for an equaliser but found a resolute Levante side in their way, goalkeeper Keylor Navas pulling off a string of fine saves, and David Barral popped up to double the hosts' lead, blowing the title race wide open.
Real Madrid now appear favourites for the title - a 33rd Liga crown will be confirmed if Carlo Ancelotti's men win their remaining games and Atletico fail to pick up three points at Barca on the final day, with the Catalan giants also still in with a shout.
Atletico's fate remains in their own hands - two wins from their final two games will secure the league - but they will have to lift themselves from a desperately disappointing day.
The game was only seven minutes old when the hosts took the lead, through the unfortunate Filipe.
Papakouli Diop swung a corner in from the right, which was missed by a group of Atletico defenders at the front post and inadvertently turned home by the Brazil international's chest.
Atletico should have been level in the 14th minute only for Raul Garcia to see his close-range shot saved by Navas and David Villa sky the rebound over the crossbar.
Mohamed Sissoko and Diego Costa were perhaps lucky to stay on the pitch just after the half-hour when they clashed, referee Jose Gonzalez taking no action despite the Atletico forward appearing to push his head into the Mali international.
Navas was called into action once more before the break, saving Toby Alderweireld's low shot at his near post, Simeone introducing Adrian Lopez and Arda Turan at the break in the search of goals.
The pair made a swift impact on the game, Adrian seeing a shot blocked and the Turkey international heading over.
Atletico's frustration continued to build and only excellent defending from Loukas Vyntra denied Filipe from making amends just after the hour.
Costa was next to go close but he was unable to divert a Diego cross on goal, and moments later Alderweireld saw Navas claw another long-range effort out.
After such resilient defending, the hosts broke on the counter-attack and doubled their lead as Victor found Barral, who held off a challenge and fired low past Thibaut Courtois.
When Adrian was able to beat Navas with 13 minutes remaining, he too was left frustrated as the ball clipped the post on its way wide.
Simeone's side looked to have ran out of ideas and they were unable to muster any further openings, as Levante mathematically secured their top-flight status and provided a huge boost to Atletico's title rivals.
|7||David Barral||60' 69'|
|Coach: Joaquín Caparrós|
for M. Sissoko 59'
for Rubén García 71'
for David Barral 80'
|Pochettino delighted with in-form Son|
|Vietto undeterred by wasteful showing|
|Tuchel: Dortmund can still get better|
|Resilient Leicester display pleases Morgan|
|Glenn reflects on ´painful´ call to dismiss ´distraught´ Allardyce|
|Borussia Dortmund 2 Real Madrid 2: Late Schurrle strike salvages draw|
|Monaco 1 Bayer Leverkusen 1: Glik stunner snatches a point|
|Dinamo Zagreb 0 Juventus 4: Pjanic pilots comfortable victory|
|CSKA Moscow 0 Tottenham 1: In-form Son hits late winner|
|Copenhagen 4 Club Brugge 0: Delaney stunner helps Danish champions canter to victory|
|Sporting CP 2 Legia Warsaw 0: Magiera´s first game ends in defeat|
|Sevilla 1 Lyon 0: Ben Yedder seals win for Europa League holders|
|Leicester City 1 Porto 0: Slimani continues to haunt old foes|
|Shearer: Allardyce has made England a laughing stock|
|Howe, Pardew and Wenger among the contenders to succeed Allardyce|
|Emery´s PSG struggles give Ludogorets hope|
|Allardyce offers ´wholehearted apology´ for England shame|
|Lahm: ´Extraordinary´ Griezmann different to Lewandowski|
|Iniesta is the best in the world, claims Menotti|
|Irregular heartbeat ends Dempsey´s season|
|Bournemouth ´realistic´ over permanent deal for Wilshere|
|Guardiola warns against complacency|
|Allardyce and England part company after damning video|
|De Bruyne out for up to three weeks - Guardiola|
|Luis Enrique demands fast start at Gladbach|
|Ancelotti wary of Atletico threat|
|Al Ain 3 El Jaish 1: Caio capitalises on late error|
|Ter Stegen happy with solution to Bravo battle|
|Emery: PSG need time to gel|
|Hernandez: It was very difficult at Real Madrid|
|Derby stand down Pearson ahead of Cardiff match|
|Rodgers sympathises with ´poor guy´ Allardyce|
|Opponents are trying to get Ribery send off - Hoeness|
|Martino named Atlanta United head coach|
|Rodgers urges Celtic to have belief against City|
|Rodgers has made same impact as Guardiola - Brown|
|Benfica one of the best in Europe, warns Sarri|
|Menotti: Ronaldo never played in a team like Messi´s|
|Walcott happy to move on from Arsenal struggles|
|Champions League Matchday Two: Bayern hunt Atleti revenge|
|Coquelin facing three weeks out|
|Arsenal transfers beyond reproach, says Wenger|
|Schubert extends Gladbach contract|
|Lewandowski urges Bayern to learn from Atletico defeat|
|Griezmann feared Simeone to PSG was ´a done deal´|
|FA investigating Allardyce claims|
|Valencia keep Voro in charge for Atletico clash|
|One of Serie A´s all-time greats: The numbers behind Totti at 40|
|Toure brands FIFA ´complacent´ after racism taskforce closed|
|Emery expects Ronaldo to stay at Real Madrid|
|Tottenham not scared of Moscow trip - Alderweireld|
|Sessegnon signs with Montpellier|
|Rakitic delighted with form|
|Gameiro: I could have joined Barcelona|
|Stones talks up Celtic quality|
|Liverpool good enough to win title - Houllier|
|Klopp happy with Firmino in central role|
|Watford got bullied all over the pitch - Deeney|
|Nuno keen for Porto to end England misery|
|Legia boss Magiera set for whirlwind debut|
|´Terrific´ Burnley delight Dyche|
|Burnley 2 Watford 0: Landmark goals for Hendrick and Keane seal first win in four|
|Schmidt lauds hitman Hernandez|
|Klopp not banking on Liverpool winning title|
|Kroos plays down Ronaldo rage rumours|
|Confidence coursing through Copenhagen|
|Madrid form draws no concern for Zidane|
|Burki looking forward to ´dream´ Madrid clash|
|Juve and Higuain have work to do - Allegri|
|CSKA boss Slutski wary of Tottenham threat|
|Pochettino: Kane to return within three weeks|
|City youngster Diaz signs three-year deal|
|Aurier vows to ´continue working hard´ for PSG despite prison sentence|
|Tuchel expecting Ronaldo on top form|
|Ter Stegen eyes new Barcelona deal|
|Hazard: No excuse for Arsenal defeat|
|Cisse back in training with Auxerre|
|Hummels resumes training ahead of Atletico clash|
|Facing Barcelona´s MSN not a nightmare, insists Bravo|
|Thiago: Atletico defence best in the world|
|Alonso wants to end career at Bayern Munich|
|Ranieri went to Slimani for Porto advice|
|Draxler: Wolfsburg blocked my exit|
|Samoura defends abolishment of racism task force|
|Sampaoli backs Nasri for France recall|
|Gisdol ´twitching with joy´ at Hamburg presentation|
|Zanetti determined Inter will return to the top|
|Getafe sack Esnaider|
|Bartra happy with playing time at Dortmund|
|Aurier handed two-month prison sentence over police altercation|
|Klopp attributes Lallana´s fine form to hard work|
|Totti´s wife slams ´small man´ Spalletti|
|Guardiola has already done an amazing job at Manchester City - Alonso|
|Referees attacked by hooligans in Bosnia and Herzegovina|
|Griezmann: I am not the anti-Benzema|
|Sterling hails Guardiola´s role in goalscoring form|
|Champions League Matchday Two: Madrid look for first win in Dortmund|
|Smalling confident Rooney will bounce back|
|Vardy fears ´permanent stain against my name´ following casino incident|
|Brave Wilshere will reap rewards of loan move - Howe|
|MLS Review: Sounders surprise Galaxy, Kamara double sinks New England|
|Walcott a special case - Wenger|
|Guardiola striving for more after perfect 10|
|Chelsea risk another mid-table finish, admits Conte|
|Montella feels AC Milan lacked courage|