Atletico Madrid's La Liga title hopes suffered a huge blow on Sunday as they slipped to a shock 2-0 defeat at Levante.
With Barcelona only able to draw with Getafe on Saturday, Diego Simeone's had the chance to open up a six-point lead at the top of the table, but saw their winless run at Levante extended to six.
After going six games in all competitions without conceding a goal, Atletico found themselves behind early on when Filipe Luis diverted a corner into his own net.
The visitors pushed for an equaliser but found a resolute Levante side in their way, goalkeeper Keylor Navas pulling off a string of fine saves, and David Barral popped up to double the hosts' lead, blowing the title race wide open.
Real Madrid now appear favourites for the title - a 33rd Liga crown will be confirmed if Carlo Ancelotti's men win their remaining games and Atletico fail to pick up three points at Barca on the final day, with the Catalan giants also still in with a shout.
Atletico's fate remains in their own hands - two wins from their final two games will secure the league - but they will have to lift themselves from a desperately disappointing day.
The game was only seven minutes old when the hosts took the lead, through the unfortunate Filipe.
Papakouli Diop swung a corner in from the right, which was missed by a group of Atletico defenders at the front post and inadvertently turned home by the Brazil international's chest.
Atletico should have been level in the 14th minute only for Raul Garcia to see his close-range shot saved by Navas and David Villa sky the rebound over the crossbar.
Mohamed Sissoko and Diego Costa were perhaps lucky to stay on the pitch just after the half-hour when they clashed, referee Jose Gonzalez taking no action despite the Atletico forward appearing to push his head into the Mali international.
Navas was called into action once more before the break, saving Toby Alderweireld's low shot at his near post, Simeone introducing Adrian Lopez and Arda Turan at the break in the search of goals.
The pair made a swift impact on the game, Adrian seeing a shot blocked and the Turkey international heading over.
Atletico's frustration continued to build and only excellent defending from Loukas Vyntra denied Filipe from making amends just after the hour.
Costa was next to go close but he was unable to divert a Diego cross on goal, and moments later Alderweireld saw Navas claw another long-range effort out.
After such resilient defending, the hosts broke on the counter-attack and doubled their lead as Victor found Barral, who held off a challenge and fired low past Thibaut Courtois.
When Adrian was able to beat Navas with 13 minutes remaining, he too was left frustrated as the ball clipped the post on its way wide.
Simeone's side looked to have ran out of ideas and they were unable to muster any further openings, as Levante mathematically secured their top-flight status and provided a huge boost to Atletico's title rivals.
|7||David Barral||60' 69'|
|Coach: Joaquín Caparrós|
for M. Sissoko 59'
for Rubén García 71'
for David Barral 80'
|Ligue 1 Review: Title chasers´ slip-ups go unpunished|
|La Liga Review: Real and Atletico suffer frustrating draws|
|Primeira Liga Review: Porto´s Tello dents Sporting´s title hopes|
|Monaco 0 PSG 0: Champions miss chance to go top|
|Real Madrid 1 Villarreal 1: Moreno leveller ensures stalemate|
|Simeone satisfied with Sevilla point|
|Henry: Chelsea can win a trophy treble this season|
|Mancini frustrated by ´hesitant´ Inter|
|Sevilla 0 Atletico Madrid 0: Simeone´s men in fiery draw|
|Pochettino upbeat despite League Cup defeat|
|Inter 0 Fiorentina 1: Montella´s men end San Siro wait|
|Bundesliga Review: Wolfsburg edge eight-goal thriller, Monchengladbach win|
|Mourinho revels in ´beautiful´ League Cup success|
|Eredivisie Review: PSV lose home record as Ajax close the gap|
|Terry thrilled by ´massive´ League Cup final win|
|Chelsea 2 Tottenham 0: Mourinho´s men seal League Cup success|
|Coquelin sustains broken nose|
|Wenger hails Giroud character after Everton goal|
|Everton not getting what they deserve - Martinez|
|Coutinho is coming of age at Anfield - Rodgers|
|Football League Preview: Wolves in the hunt for back-to-back promotions|
|Norwich City 2 Ipswich Town 0: Neil´s men go third with derby triumph|
|Southampton v Crystal Palace: Fonte focusing on big picture|
|Arsenal 2 Everton 0: Giroud strikes to silence doubters|
|Dynamo Dresden v Borussia Dortmund: Hummels eager to build on derby win|
|Rodgers tips hat to relentless Liverpool|
|City facing uphill challenge to retain title - Pellegrini|
|Celtic 4 Aberdeen 0: Champions dominate top-of-the-table clash|
|Lallana hails ´massive´ win as Liverpool´s top-four charge continues|
|Hull City v Sunderland: Cattermole allowing no excuses against ´bogey team´|
|Liverpool 2 Manchester City 1: Coutinho dents City´s title hopes|
|Sunderland to appeal Brown red card|
|Aston Villa v West Brom: Sherwood looking for confidence boost|
|Allegri not taking risks on Vidal and Pogba|
|Pardew defends Jedinak over Sakho elbow|
|Heldt apologises after Schalke´s derby humbling|
|Milan must give that bit extra - Bocchetti|
|Rooney: Brown red must be rescinded|
|Monk hails Swansea´s versatility|
|Melbourne Victory 2 Wellington Phoenix 3: Hosts miss chance to go top|
|Rodgers: Top-four finish would be bigger than last season´s effort|
|Batman and Robin ´a bit of fun´ - Reus|
|Rakitic feeling better after ending goal drought|
|Copa Libertadores Preview: Well-rested Cruzeiro ready for Universitario|
|Fournier fuming after Lyon loss|
|DFB Pokal Preview: Gladbach visit rusty Offenbach|
|Mourinho: Tottenham approached me|
|Primeira Liga Review: Birthday boys Benfica hit Estoril for six|
|Inzaghi finds positives in lacklustre display|
|Eredivisie Review: AZ move third, Propper fires Vitesse to victory|
|Chievo 0 Milan 0: Pressure back on Inzaghi|
|Bundesliga Review: Derby win for Dortmund superheroes, Leverkusen go fourth|
|Ligue 1 Review: Lyon loss leaves door open for PSG|
|Bueno nets perfect hat-trick in four-goal spree for Rayo|
|Carver impressed with Newcastle´s fighting spirit|
|Van Gaal explains Di Maria decision|
|Luis Enrique angered by Granada pitch|
|Sherwood confident of Villa survival|
|Referee East says ´no mistaken identity´ as Poyet pledges to look again|
|League One Review: Robertson and Johnson off to winning starts, Bristol City go eight clear|
|Bruce angered by missed decision|
|Berahino can be ´top class´ - Pulis|
|Grateful Gutierrez thanks ´special´ fans|
|Monk targets Swansea points record|
|Klopp´s ´perfect´ afternoon|
|Victory soured by Ireland injury, says Hughes|
|Championship Review: Middlesbrough´s opportunity missed as Derby are defeated|
|Koeman: I am realistic on Champions League|
|League Two Review: Burton beaten again, Hartlepool gain welcome lift|
|´Triple punishment´ rule could be scrapped|
|Scottish Premiership Review: Inverness slip up as strugglers prosper|
|Mancini wary of Fiorentina quality|
|Hearts attack hits double figures in Scotland|
|West Brom 1 Southampton 0: Berahino wins it, then limps off|
|Manchester United 2 Sunderland 0: Rooney at the double amid red card controversy|
|Newcastle United 1 Aston Villa 0: Cisse strike downs visitors|
|Stoke City 1 Hull City 0: Super sub Crouch secures win|
|Granada 1 Barcelona 3: Suarez inspires routine win|
|Burnley 0 Swansea City 1: Trippier own goal proves decisive|
|Borussia Dortmund 3 Schalke 0: Late show seals dominant derby win|
|Referee Dowd fails to make it through West Brom, Saints clash|
|Allardyce ´shocked´ after home loss|
|Pardew lauds Murray after ´mixed afternoon´ for striker|
|West Ham 1 Crystal Palace 3: Pardew enjoys more away-day success|
|Blanc: PSG prepared for confident Monaco|
|Ancelotti: Isco place is non-negotiable|
|Pellegrini out to end dismal record at Anfield|
|Roma v Juventus: Matri eyes glory in title tussle|
|Martinez wary of wounded Arsenal|
|A-League Review: Spectacular Sydney derby the highlight|
|Perez to testify in corruption case|
|Bentaleb determined to avoid European hangover|
|Liverpool cannot dwell on Europa exit, says Rodgers|
|Marquinhos welcomes Manchester United interest|
|Tottenham must be ´nearly perfect´ to beat Chelsea - Pochettino|
|Bielsa: I take responsibility|
|League Cup final ´most important´ for Mourinho|
|Rodgers unsure if European exit will be a blessing|
|Vitoria Guimaraes 1 Maritimo 0: Hosts end winless run|