Atletico Madrid's La Liga title hopes suffered a huge blow on Sunday as they slipped to a shock 2-0 defeat at Levante.
With Barcelona only able to draw with Getafe on Saturday, Diego Simeone's had the chance to open up a six-point lead at the top of the table, but saw their winless run at Levante extended to six.
After going six games in all competitions without conceding a goal, Atletico found themselves behind early on when Filipe Luis diverted a corner into his own net.
The visitors pushed for an equaliser but found a resolute Levante side in their way, goalkeeper Keylor Navas pulling off a string of fine saves, and David Barral popped up to double the hosts' lead, blowing the title race wide open.
Real Madrid now appear favourites for the title - a 33rd Liga crown will be confirmed if Carlo Ancelotti's men win their remaining games and Atletico fail to pick up three points at Barca on the final day, with the Catalan giants also still in with a shout.
Atletico's fate remains in their own hands - two wins from their final two games will secure the league - but they will have to lift themselves from a desperately disappointing day.
The game was only seven minutes old when the hosts took the lead, through the unfortunate Filipe.
Papakouli Diop swung a corner in from the right, which was missed by a group of Atletico defenders at the front post and inadvertently turned home by the Brazil international's chest.
Atletico should have been level in the 14th minute only for Raul Garcia to see his close-range shot saved by Navas and David Villa sky the rebound over the crossbar.
Mohamed Sissoko and Diego Costa were perhaps lucky to stay on the pitch just after the half-hour when they clashed, referee Jose Gonzalez taking no action despite the Atletico forward appearing to push his head into the Mali international.
Navas was called into action once more before the break, saving Toby Alderweireld's low shot at his near post, Simeone introducing Adrian Lopez and Arda Turan at the break in the search of goals.
The pair made a swift impact on the game, Adrian seeing a shot blocked and the Turkey international heading over.
Atletico's frustration continued to build and only excellent defending from Loukas Vyntra denied Filipe from making amends just after the hour.
Costa was next to go close but he was unable to divert a Diego cross on goal, and moments later Alderweireld saw Navas claw another long-range effort out.
After such resilient defending, the hosts broke on the counter-attack and doubled their lead as Victor found Barral, who held off a challenge and fired low past Thibaut Courtois.
When Adrian was able to beat Navas with 13 minutes remaining, he too was left frustrated as the ball clipped the post on its way wide.
Simeone's side looked to have ran out of ideas and they were unable to muster any further openings, as Levante mathematically secured their top-flight status and provided a huge boost to Atletico's title rivals.
|7||David Barral||60' 69'|
|Coach: Joaquín Caparrós|
for M. Sissoko 59'
for Rubén García 71'
for David Barral 80'
|Poland boss praises Lewandowski after Euro 2016 exit|
|Fonte: United will regret missing out on Sanches|
|Santos: Portugal should have had a penalty|
|Ranieri: English football is not in crisis|
|Ronaldo dreaming of Euro 2016 glory|
|Nawalka: Poland should be proud of Euro 2016 exploits|
|Santos: Goalless Ronaldo was immense for Portugal|
|No player out of reach for Chinese Super League - chief|
|Fearless Sanches had no nerves in dramatic shootout|
|Portugal through despite Ronaldo off-night|
|´Very happy´ Neymar drops contract hint|
|Poland 1 Portugal 1 (aet, 3-5 pens): Heartbreak for Blaszczykowski as Santos´ men sneak into the sem|
|Del Bosque to resign from Spain role|
|Giggs can be a manager in his own right, insists Round|
|Euro 2016 Diary: Wails for Bale, a grumpy water carrier and the inevitable return of Will Grigg|
|Manchester United agree Galatasaray friendly|
|Hazard must bloom into bona-fide superstar as Eden project comes full circle|
|Hazard excited by ´world class´ Ibrahimovic in the Premier League|
|Hazard determined to make his mark on Lille return|
|Special One and Zlatan: United´s match made in heaven or gamble from hell?|
|Vertonghen to miss rest of Euro 2016 due to torn ankle ligaments|
|Conte has helped me a lot, admits grateful De Sciglio|
|Juve pay tribute to departing Caceres|
|Williams banking on ´band of brothers´ to stop Hazard|
|No lack of desire with England - Lampard|
|Germany v Italy: Kroos calls on Khedira knowledge for Azzurri test|
|Coleman welcomes pressure of ´biggest game since 1958´|
|Ibrahimovic claims he will join Manchester United|
|Sevilla receive ´big offer´ for Krychowiak|
|Bartra seeks to justify Dortmund´s trust|
|Montella vows to bring the good times back to AC Milan|
|Bournemouth bring in striker Mousset|
|Barca confirm Umtiti fee agreed|
|Puel takes charge at Southampton|
|Hulk completes €55.8m Shanghai SIPG switch|
|Bruce focused on Hull and pursuing transfer targets|
|Sinclair agrees Watford move|
|Janssen wants AZ to accept Spurs offer|
|Bartomeu claims five-year Neymar deal imminent|
|Reluctant father figure Evra defends Pogba|
|Boateng declares himself fit to face Italy|
|73 goals, 44 assists: The stats that show why Man Utd want Ibrahimovic and Mkhitaryan|
|Conte has made Italy proud again – Vieri|
|Evra pledges to respect Iceland after England shock|
|Vrba leaves Czech Republic for Anzhi|
|Bernstein backs Allardyce for England job|
|Rodgers rejects England talk|
|Klose lauds ´unbelievable´ Italy|
|Muller confident Italy´s defence can be breached|
|´Lineker does not know what he is talking about´ - Raiola defends Pogba|
|Morrison opts to stay with West Brom|
|Kempes expects Messi to return to international football|
|´Leave Messi alone!´ - Maradona|
|Evra suffers training injury|
|Iceland´s Viking chant terrified England - Shilton|
|Ballack doubts Italy can repeat Spain performance|
|Caparros hoping Del Bosque continues as Spain coach|
|Falcao targeting Ligue 1 top scorer award|
|Maradona: England continue to be over-hyped|
|Santos: You talk about Ronaldo because he is great|
|James Rodriguez is an ´average player´ - Stoichkov|
|Mooy moves from Melbourne to Manchester City|
|Copa America champions Chile set to face Euro 2016 winner|
|Guardiola ´relaxed´ ahead of renewing Mourinho rivalry|
|Simeone on post-Champions League final comments: I spoke heatedly|
|Skrtel pins blame on friend after Klopp ´d***´ slur|
|Euro 2016 Diary: Medals for Irish fans and Blaszczykowski inspires Wimbledon triumph|
|Bale is slightly better than Hazard, admits Lukaku|
|Argentina make Simeone approach, jokes Atleti president|
|Mamelodi Sundowns 2 Enyimba 1: Arendse nets winner in Group B clash|
|Wilmots confirms Batshuayi medical ahead of expected Chelsea switch|
|Santos insists no favourite in Portugal-Poland tie despite Ronaldo presence|
|Celtic is the best place for me to be, insists Dembele|
|Lagerback: I don´t think I will take a job like England|
|Umtiti has ´exclusive agreement´ to join Barcelona|
|Milik putting Ronaldo worship to one side for 90 minutes|
|Only losers make excuses, insists Florenzi|
|Nawalka: We must not focus solely on Ronaldo|
|Hamsik: Bayern offer reports are nonsense|
|Injured De Rossi a major doubt to face Germany|
|Wales will not be a stepping stone for Belgium - Bale|
|Lyon add Nkoulou as Barcelona close in on Umtiti|
|Neymar, Rafinha and Douglas Costa named in Brazil´s Olympics squad|
|Goalless Lewandowski should look to Ronaldo for inspiration|
|Mane has cost Liverpool far too much - Thompson|
|Bilic not interested in England job, says Gold|
|Hummels hopes Gomez can break through impressive Italy defence|
|Gerrard: England gripped by a ´culture of fear´|
|Bournemouth sign Chelsea´s Ake on season-long loan|
|Iceland emulating Leicester City would delight Hallgrimsson|
|Chelsea could still sign Pato permanently, says agent|
|Wales v Belgium: Wilmots will not man-mark Bale in quarter-final clash|
|Genoa seal Ocampos capture|
|Fuchs retires from Austria duty|
|Bundesliga fixtures: Bayern begin title defence against Werder Bremen|
|Bordeaux complete Toulalan signing|
|Suarez confident Messi will return for Argentina|
|´England players did not know what to do´ - Lineker critical of Hodgson|
|Dybala turned down ´€80m Barcelona move´|
|Emery a big loss for Sevilla, says Baptista|
|Valencia: ICC derby more than a friendly|
|Defoe: Allardyce ready for England|
|Wales defend celebrations after England´s Euro 2016 elimination|
|Rooney: Next England manager doesn´t have to be English|
|Mascherano set for Barca stay|
|Carragher suggests Klinsmann as England boss, dismisses Shearer|
|Glik confirms Monaco move|
|Australia to face Japan in Melbourne|
|Galliani: Montella gives Milan a fresh start|
|We must take care of Messi - Argentina president|
|England players ´babies´ and soft - Carragher|
|Higuain unlikely to renew Napoli contract - agent|
|Hart: Tough job for next England boss|
|Nani to join Valencia, confirms Fener president|
|Glenn: Man, woman or caretaker for England|
|Skrtel´s Fenerbahce move ´almost done´|
|Al Ahly 1 ASEC Mimosas 2: Jol´s men beaten again|