West Ham have beaten Tottenham twice this season and could do with a hat-trick of wins over their London rivals to appease disgruntled fans.
Manager Sam Allardyce again attracted the ire of West Ham's supporters during a 1-0 Premier League defeat at West Brom last weekend.
Saido Berahino scored the only goal of the game as the Upton Park outfit were consigned to a fourth consecutive loss, prompting some travelling fans to call for the former Newcastle United boss to be sacked.
The experienced Allardyce took the criticism on the chin, stating that it was "part of the job", but with his side five points above the relegation zone, he will be eager to secure at least a draw in their last home game of the season against Tim Sherwood's side on Saturday.
While relegation looks highly unlikely for West Ham, if they can stop the rot in this weekend's derby then they will be all-but assured of safety.
West Ham have happy memories of their clashes with Tottenham this season, having won 3-0 at White Hart Lane in the top flight back in October and then 2-1 at the same ground in the League Cup in December.
And under-fire manager Allardyce would revel in another victory over a side that look set to be playing in the UEFA Europa League again next season.
He said: "It would be absolutely fantastic to beat them at home, having beaten them in the Capital One Cup and in the league.
"At this moment in time, our concerns are: one, we were one of the best clean sheets in the league eight or nine games ago and we haven't kept one since then.
"That's been our demise that has caused us a few problems. Two: and it's been the case all season, that the chances created have always been there, but our conversion rate when you look at the stats hasn't been good enough."
Allardyce has been accustomed to questions over his future and Sherwood, his opposite number, has also been probed about his job for some time despite only being appointed in December.
Ajax coach Frank de Boer claimed this week that he is a target for Tottenham, with head coach Sherwood widely expected to be relieved of his duties at the end of the season.
Sherwood has spoken of his disappointment at the continued speculation over his future, but vowed to carry on regardless and he will fancy his chances of heaping more misery on West Ham as Tottenham are in fine form.
A 1-0 win at Stoke City last time out made it three wins from their last four Premier League games and are now just three points behind fifth-placed Everton.
Sherwood will be unable to call upon Andros Townsend after the England winger sustained an ankle injury that will rule him out of the FIFA World Cup, but Jan Vertonghen and Etienne Capoue could return.
On-loan striker Marco Borriello (calf) is West Ham's only absentee.
|Coach: S. Allardyce|
for A. Carroll 84'
for K. Nolan 88'
|Digne at home in Barcelona and ready to help win trophies|
|Defoe´s finishing is ´absurd´ - Bilic|
|Stekelenburg grounded despite penalty heroics|
|Thiago Silva can be our Pirlo - Juve CEO hints at move for PSG defender|
|Koscielny calls for ´tough´ Arsenal|
|Birthday boy Wenger: Result will determine celebrations|
|MLS fines Drogba for Impact snub|
|Klopp backs Sturridge to bounce back|
|Conte: Chelsea still scarred from last season|
|Giggs: United decline was not inevitable|
|Falcao nets as brilliant Monaco hit Montpellier for six|
|Guardiola pleads patience for injury ravaged Kompany|
|No hard feelings as Mourinho focuses on Chelsea task|
|Guardiola: I don´t want City to play like Barcelona|
|Valencia fans´ Alcacer anger normal - Luis Enrique|
|Neymar: Playing for Barca is easy now|
|EPFL terminates agreement with UEFA|
|Aguero keeps Argentina spot, Messi returns|
|Donnarumma eyes Milan captaincy|
|Napoli fans banned from Juve trip|
|Mertesacker hails ´hungry´ hat-trick hero Ozil|
|Suarez says Barcelona renewal talks ´really advanced´|
|Lack of European football can aid Liverpool´s title bid - Pulis|
|European breaks do not benefit Chelsea - Conte|
|Pardew backs Leicester to ´come through´ tough start|
|Pochettino one of ´the very best´ coaches, says Howe|
|Puel backs Manchester City for Premier League title|
|Abramovich and I were not friends - Mourinho|
|It was not mutual consent, I was sacked by Chelsea - Mourinho|
|Brazil recall Douglas Costa, Marcelo and Casemiro for Argentina clash|
|Luis Enrique: If Messi is at his best, nobody knows how to stop him|
|Ramos deserves more than he earns - Perez|
|Neymar renewal proves Barcelona team spirit, says Luis Enrique|
|Bravo mistakes will be on the front page - Guardiola|
|I would sign Modric as Scholes´ successor - Giggs|
|At last! Neymar signs new Barcelona contract|
|Ronaldo injury helped Portugal to Euro 2016 success, says Abidal|
|Ronaldo injury helped Portugal to Euro 2016 success, says Abidal|
|Rummenigge blasts Premier League clubs for ´kidnapping´|
|Prandelli awed by Messi but ´dreaming big´ against Barcelona|
|Guardiola fumes at Aguero rumours after Barcelona omission|
|Conte: Mourinho deserves maximum respect|
|Moses happy for Conte chance after Mourinho struggle|
|Garcia dreaming of glory with lowly Marseille|
|Dawson back as Phelan expects Hull reaction|
|Conte declares Terry fit to face Mourinho´s United|
|Pardew: Why would I leave Palace for England?|
|Montella wants San Siro to strike fear into Juventus|
|Guardiola criticism ´political´, says Del Bosque|
|Ancelotti ready to unleash rampant Robben once more|
|Chelsea in a good position - Mourinho|
|Tuchel heartened by Reus return|
|Allegri wary of AC Milan after Inter ´whack´|
|Koeman hopes for Barkley ´wake-up call´|
|Melbourne City 2 Perth Glory 3: Keogh hat-tricks decider thriller|
|Dybala delighted to stay at Juve after rejected offer|
|Hughes eager to test Hull fragility|
|Carrasco extends Atletico contract|
|Moyes: I am under pressure - just like Guardiola|
|Wenger talks up Arsenal´s title credentials|
|Fuchs signs new Leicester contract|
|Guardiola doesn´t communicate - Benatia|
|Magical Messi from another planet, says awestruck Digne|
|Wenger pleased to see Ozil on goal trail as talks continue|
|Evra hails old rival Suarez as ´the best number 9´|
|Ranieri: I feel like a hybrid car|
|Falcao returns for Monaco|
|De Bruyne defends Guardiola tactics|
|Del Bosque: I rejected €10m offer from China|
|CONCACAF Champions League Review: Pumas, Dallas reach QFs|
|Alli like ´wild horse´ - Pochettino|
|Nani hails ´special´ Messi|
|Serious knee injury sidelines Hull´s Odubajo for six months|
|Mkhitaryan edging closer to comeback - Mourinho|
|Klopp: United game good prep for West Brom|
|Pogba praises Rooney after resounding win|
|Under-fire De Boer driven by reaching knockout stages|
|Pogba no longer Premier League´s ´worst´ player, mocks Mourinho|
|Austria Vienna spoil Totti milestone|
|Manchester United 4 Fenerbahce 1: Van Persie nets on return as Pogba stars|
|Puel rues unfortunate Inter defeat|
|Inter 1 Southampton 0: Candreva seals fortunate win for Inter|
|Buffon rules out club management after retirement|
|Mazzarri ´very happy´ about Holebas-Capoue row|
|Non-European city could host Champions League final - UEFA|
|Bradley calls for players to reconnect with fans|
|Pochettino lauds ´fantastic´ Howe|
|Frankfurt´s Russ eyeing return after tumour disease all-clear|
|Karanka insists Middlesbrough will not sit back against Arsenal|
|Atletico Madrid cannot sign players in January after FIFA deal|
|Koeman calls for greater Lukaku support|
|Suarez: Two goals at the Bernabeu were my best|
|Pochettino delivers mixed news on injury front|
|Karius has Klopp´s confidence|
|Suarez hopes to finish his career at Barcelona|
|Burnley suffer Defour injury blow|
|Marseille confirm Garcia appointment|
|No concerns for Ranieri as Vardy, Morgan and King miss training|
|Tony Pulis is Tony Pulis - Klopp not expecting surprises from West Brom|
|Garcia´s Roma contract terminated amid Marseille reports|
|Injured Pique ruled out for three weeks|
|Moyes the builder will fix Sunderland, says chief exec Bain|
|Walcott impressed by the ´new, aggressive´ Ozil|
|Bilic eyes Ayew injury boost|
|Bonaventura on Icardi saga: I´ll wait until I´ve won something before writing a book!|
|Van Persie: I may still be at Man Utd if Ferguson was in charge|
|Emery wants more from PSG despite victory|
|Muller: Bayern enjoyed PSV rout|
|Barcelona lose Alba and Pique to injury|
|Nolito: Messi made the difference|
|CONCACAF Champions League Review: Pachuca edge through, Timbers out|
|Ozil has ´taste´ for goals - Wenger|
|Renard, Morocco prepared for AFCON test|
|Guardiola: Barca loss not my worst|
|Luis Enrique hails ´decisive´ Messi|
|Pulisic, Green & Morris´ youth movement delight USMNT legend Jones|
|Clinical Barca point the way for Sterling and City|
|Sarri: Napoli making life hard for ourselves|
|That´s life for goalkeepers - Ter Stegen on Bravo woe|
|Schubert delighted with mature Gladbach display|
|Gunes not getting carried away after Besiktas upset Napoli|
|Lucas praises PSG response to stuttering start|
|Luis Enrique happy to rule in game of errors|
|Vitoria: Benfica face three more finals|