Leaders Botafogo can move a step closer to qualification from Copa Libertadores' Group 2 when they play host to rivals Union Espanola.
Botafogo, Brazil's Campeonato Carioca champions in 2013, and Chilean outfit Union Espanola will meet at the Estadio Jornalista Mario Filho on Wednesday with just one point separating both teams after four matchdays.
Eduardo Hungaro's men have collected seven points from their opening four games, while Union Espanola have six points thus far.
Although both teams are not assured progression, with Independiente del Valle (five) and San Lorenzo (five) still in with a shout.
Botafogo are unbeaten at home in the Copa Libertadores this season but their recent run of form in all competitions has Union Espanola full of confidence heading into matchday five.
The Brazilian outfit edged Independiente del Valle two weeks ago but that is the team's only win in eight previous outings, while Union Espanola have tasted defeat just once in their last eight games.
In Group 5, leaders Universidad de Chile welcome Cruzeiro to the Estadio Nacional Julio Martinez Pradanos on Thursday.
Universidad de Chile have won two consecutive games since they were trounced 5-1 by Cruzeiro on matchday two.
Ricardo Goulart starred with a hat-trick that day and Universidad de Chile will be out to avoid a repeat of that disastrous performance.
Uruguay's Defensor Sporting can close the gap on their Chilean opponents when they play host to Peruvian outfit Real Garcilaso, who sit bottom of the group, on Tuesday.
In Group 4, cellar dwellers Santa Fe face an uphill task when Brazilian giants Atletico Mineiro visit Colombia on Thursday.
Since losing to Mineiro on the opening matchday, Santa Fe have lost and drawn to Venezuela's Zamora in reverse fixtures to fall three points adrift of the qualifying spots.
Ecuador Primera A leaders Emelec will be aiming to bounce back from their league defeat to El Nacional when they go head-to-head against Brazil's Flamengo in Group 7 action on Wednesday.
Meanwhile, Brazilian club Gremio can leapfrog Newell's Old Boys into top spot in Group 6 with victory over Atletico Nacional of Colombia on Wednesday.
|Coach: Eduardo Hungaro|
for Henrique 66'
for Marcelo Mattos 78'
for Júlio César 90+2'
|Macedonia 0 Australia 0: Stalemate in Skopje|
|Del Bosque not out for Netherlands revenge|
|Burton Albion 1 Stevenage 1: Both teams score at wrong end in draw|
|Pekerman: I have no say on Falcao´s Manchester United future|
|Buffon has studied England new boy Kane|
|Conte urges patience from Italy fans|
|Johnson tasked with keeping Cheltenham up|
|Rooney not keen on Serie A switch|
|Kane to make first England start|
|Colombia 3 Kuwait 1: Spot-on Falcao equals Iguaran record|
|Goal-shy Barkley eyes striker´s role|
|UEFA opens disciplinary proceedings against Montenegro and Russia|
|Draxler and Choupo-Moting back in training|
|Ghana v Mali: Last chance to impress before Giresse return|
|Wilson: Gibraltar getting stronger|
|Mata confident of Spain future|
|Armenia coach Challandes resigns|
|Hiddink rubbishes talk of Dutch negativity|
|Portugal v Cape Verde: Santos set to rotate|
|Loren hails Moyes for Sociedad surge|
|Cruyff brands Netherlands ´a disgrace´|
|Kick It Out backs Barnes over race comments|
|Argentina v Ecuador: Messi remains doubtful for friendly|
|Coates backs Hughes ambition at Stoke|
|Atletico able to call on Saul again|
|Italy v England Preview: Kane set to start after dream debut|
|Zidane would accept Real job|
|Hernandez frustrated by lack of Real opportunities|
|Spartak donate money to 102-year-old fan after robbery|
|Clasie pulls out of Netherlands squad|
|Italy´s Bertolacci out of England friendly|
|Newcastle post record profit as Ashley debt stays the same|
|Al Sadd: We want Xavi to bring tiki-taka|
|Lacazette expected frosty Saint-Etienne reception|
|Barnes: I can´t get back into management because I´m black|
|Rooney praises England aggression|
|Southgate tips Kane for return to U21s|
|Mexico v Paraguay: Goals in order for Copa America aspirants|
|Netherlands - Spain Preview: Wijnaldum rallies behind under-fire Hiddink|
|Peru v Venezuela: Sanvicente wants Venezuelan response|
|Carvalho confident of playing Juventus|
|Neymar demands protection after Medel stamp|
|MLS Review: RSL, Fire secure breakthrough wins|
|Firmino firmly on radar - Dunga|
|O´Neill delighted with second-half display|
|First-half dominance pleases Deschamps|
|Muller criticises Germany profligacy|
|Euro 2016 Qualifying Review: Portugal go top, Gibraltar make history in defeat|
|Liverpool the only English club I could play for - Suarez|
|France 2 Denmark 0: Lacazette off the mark in routine victory|
|Republic of Ireland 1 Poland 1: Long rescues vital point|
|Portugal 2 Serbia 1: Coentrao puts hosts top of Group I|
|Strachan hails ´terrific´ Gibraltar|
|Lafferty back playing with a smile on his face - O´Neill|
|Toure to reveal Ivory Coast future over coming days|
|Georgia 0 Germany 2: Reus and Muller on target for world champions|
|Northern Ireland 2 Finland 1: Lafferty inspires fourth qualifying success|
|Scotland 6 Gibraltar 1: Casciaro´s historic moment outshone by Fletcher´s hat-trick|
|France 2-0 Denmark: Lacazette and Giroud on target|
|Firmino hopeful of Copa America spot|
|Hummels considering options at Dortmund|
|Suarez goalless on Anfield return, but Balotelli nets stunner|
|Casciaro scores first competitive goal for Gibraltar|
|Fleetwood Town 1 Preston North End 1: Ball stunner claims share of derby spoils|
|Italy v England: Judge me on results, says Conte|
|Colombia v Kuwait: Falcao seeking another strong showing|
|Brazil 1 Chile 0: Firmino settles scrappy affair|
|Luxembourg v Turkey: Let´s kick on, urges Terim|
|South Africa 1 Nigeria 1: Zungu strikes late to earn draw|
|Smalling wants long-term United stay|
|South Africa 1-1 Nigeria: Last-gasp Zungu goal cancels out Musa strike|
|Italy call up Santon and Abate for England friendly|
|Switzerland v United States: Klinsmann eyes learning curve|
|Netherlands v Spain: Hiddink has players´ support, says Wijnaldum|
|A-League Review: Sydney end Wellington run, Adelaide suffer injury blows in Jets win|
|Henderson eyes long-term Liverpool future|
|I have nothing to prove - Bale|
|Brazil 1-0 Chile: Firmino gives Selecao battling victory|
|South Korea v New Zealand: All Whites looking to future|
|Japan v Uzbekistan: Hosts eye another win under Halilhodzic|
|MLS Review: Kaka nets in Orlando draw|
|Mexico 1 Ecuador 0: Hernandez, Corona help Herrera´s men to victory|
|Deschamps calls for France response|
|Dunga unfazed by pressure|
|Montenegro fan turns himself in after flare incident|
|Injured Messi not ready - Martino|
|Hodgson: Rooney not close to Charlton|
|Terim proud of Turkey|
|Hiddink happy with point|
|Euro 2016 Qualifying Review: Netherlands and Italy stage late escapes|
|Debutant Eder delighted with Azzurri bow|