Barcelona and Atletico Madrid will put their Liga title chase to one side when they meet in the UEFA Champions League on Tuesday.
The sides currently occupy the top two spots in the Spanish top flight - Atleti are one point clear of second-placed Barca - and clash this week in the first leg of their quarter-final tie at Camp Nou.
There has been no previous meeting between the clubs in continental football, but their three domestic fixtures this season point to this being a hotly contested encounter.
Barca edged the Supercopa de Espana on away goals after both legs ended all square in August, while the Liga meeting in January ended goalless.
Despite their proximity in La Liga, Barca head into the last-eight tie with far greater experience of Europe's premier club competition.
Barca will be looking to extend their record of having contested the semi-finals in the last six seasons, while Atleti are in the quarter-finals for the first time since 1997 and have not reached the last four for 40 years.
Current Atleti coach Diego Simeone was in the side that lost 4-3 on aggregate to Ajax in the quarter-finals 17 years ago.
The men from the Spanish capital have not won at Camp Nou since a 3-1 league victory in 2006, when Fernando Torres - now of fellow quarter-finalists Chelsea - netted a brace.
That said, Barcelona do not have the best of records against Spanish opponents over two legs in continental competition, losing five of their nine ties, but have lost just one of their last 26 European home ties.
Barcelona knocked out Manchester City to reach this stage, while Atleti disposed of Milan.
On an individual level, Lionel Messi is four goals short of Raul's Champions League goalscoring record of 71 and is bang in form, finding the net nine times in his last five appearances in all competitions.
Atleti have taken many by surprise with their sensational form this season, with Simeone keen to maintain the feel-good factor at the club.
"We are enjoying the situation day by day, minute by minute, training session by training session and game by game," he said after Saturday's 2-1 win at Athletic Bilbao.
"That is how we feel strong and we will continue like that because we don't want to get away from that line of thinking."
The hosts will be without goalkeeper Victor Valdes, who is likely to have played his last match for Barcelona after being ruled out for the season with a knee injury.
Javier Manquillo (neck) remains sidelined for Atleti, while Raul Garcia is ruled out through suspension.
|Coach: G. Martino|
for Piqué 12'
for Fàbregas 68'
|Bilic: Cup run will help in Premier League|
|Pjaca out for up to three weeks|
|Trophies still the focus for Guardiola|
|Mignolet wants ´fair´ Karius battle|
|Ancelotti impressed by motivated Bayern|
|West Ham ´unreservedly condemn´ crowd trouble|
|Allegri praises strike duo after win over Sampdoria|
|De Boer praises two-goal Icardi after vital win|
|Chelsea were ´unlucky´ with missed chances, insists Conte|
|Mourinho: I´ve never had fans like these|
|Nacho´s goal better than my Champions League final volley - Zidane|
|Borussia Dortmund 1 Union Berlin 1 (aet, 3-0 pens): Weidenfeller shootout heroics seal progress|
|Bilic: Crowd trouble distracts from great West Ham win|
|Kompany told me he couldn´t play anymore - Guardiola|
|Liverpool and Manchester United handed home quarter-finals|
|Inter 2 Torino 1: Icardi double alleviates pressure on De Boer|
|Manchester United 1 Manchester City 0: Mata extends Guardiola´s winless run|
|West Ham 2 Chelsea 1: Crowd trouble tarnishes Hammers´ route to quarter-finals|
|Cultural Leonesa 1 Real Madrid 7: Morata and Asensio star in BBC´s absence|
|Bayern Munich 3 Augsburg 1: Green´s first goal sends holders through|
|Juventus 4 Sampdoria 1: Rapid start sets champions on their way|
|Crafty Suarez is world´s best striker - Godin|
|Mancini: Balotelli has wasted years but can bounce back|
|Rami rejected ´risky´ PSG move|
|Neymar would have cost PSG €430m, claims father|
|Sacchi warns Bayern players over Ancelotti temper|
|Valencia ´pleased´ with RFEF bottle ruling|
|Mourinho apologises to Utd fans for Chelsea thrashing|
|Barcelona lash out at ´totally reprehensible´ RFEF comments|
|Jacob leaves Marseille amid rumours of Zubizarreta appointment|
|Lavezzi added to Argentina squad as Dybala drops out|
|Del Bosque: Mourinho had a point on Conte|
|N´Zonzi in talks over Sevilla extension|
|Allardyce successor ´will not be a mercenary´ - Glenn|
|Aubameyang like a rocket, Lewandowski perfect - Riedle|
|RFEF fines Valencia, warns Barca over bottle incident|
|Wenger tells Iwobi to improve his finishing|
|Barcelona without Mathieu for three weeks|
|Kimmich draws inspiration from Xavi|
|Vazquez signs new Madrid deal|
|Higuain the best striker in the world - Nedved|
|Wolfsburg regret De Bruyne, Perisic sales|
|Parejo slams Neymar for ´inciting´ Valencia fans|
|Gundogan predicts ´very lively´ Manchester derby|
|Luis Enrique satisfied with Supercopa workout|
|Messi could join Newell´s after World Cup - Maxi Rodriguez|
|Ibrahimovic wants United to be the boss of City|
|Schmidt on the bus as Lotte book ticket for next round|
|Pogba still adapting to Premier League, says Mourinho|
|Southgate hails influence of demoted Rooney|
|Lille ready to heap more pressure on PSG as Corchia dreams big|
|I´m among top 20 LaLiga coaches, jokes Luis Enrique|
|Brattan earns Socceroos call-up|
|Pochettino pleased with Janssen|
|Klopp never questioned Sturridge quality|
|Barcelona downed by Espanyol in Supercopa|
|Heavy Milan defeat ´just a bump in the road´ - Montella|
|Pochettino wanted Liverpool debutant sent off|
|Klopp happy to entertain as Liverpool youngsters earn their spurs|
|Leverkusen dumped out by 10-man minnows|
|Wenger praises Oxlade-Chamberlain work ethic|
|Wenger praises Oxlade-Chamberlain work ethic|
|Tuchel unaffected by Real Madrid rumours|
|I would like to pick Toure, believe me - Guardiola|
|Genoa 3 AC Milan 0: Unbeaten run comes crashing to an end as Paletta sees red|
|Liverpool 2 Tottenham 1: Sturridge at the double to book quarter-final spot|
|Arsenal 2 Reading 0: Oxlade-Chamberlain brace secures safe passage|
|Football world mourns Carlos Alberto|
|81 per cent win ratio and more goals than Bayern Munich - Two years of Messi, Suarez and Neymar|
|Ridgewell reportedly arrested for drink driving|
|Verratti not leaving PSG - agent|
|Costa competition benefitting Batshuayi, says Conte|
|Pele hails ´friend and brother´ Carlos Alberto|
|Bailly confirms two-month lay-off|
|How Carlos Alberto established his legacy as one of the greats|
|Allegri hints at Marchisio return|
|Lewandowski has not renewed with Bayern - agent|
|Carlos Alberto: Capita´s World Cup triumph in numbers|
|Hull´s Snodgrass out for a month|
|Keita reveals Arsenal, Manchester City, Liverpool snub|
|Mikel not giving up on Chelsea career|
|Former Brazil captain Carlos Alberto dies|
|Guardiola wants to help ´special player´ Aguero|
|Roma welcome back Strootman, Rudiger for Sassuolo clash|
|Wolves confirm Zenga dismissal|
|Bruce lauds Rooney as a world ´great´|
|Raiola made €27m on Pogba move, reveals Juventus director|
|Dortmund injury woes worsen with Aubameyang|
|De Bruyne out of Manchester derby|
|Conte: I always show respect to opponents|
|FIFA fines RFEF over Madrid, Atletico breaches|
|Pedro backs Conte amid Mourinho spat|
|Big clubs would fight for Edwards if he was Brazilian - Pochettino|
|They boo Ronaldo, they booed me as well - Zidane|
|De Boer fed up of sacking talk|
|Neuer: Bayern have no room for error|
|Bilic praises Conte´s ´aggressive´ demeanour|
|Di Maria will bounce back - Motta|
|EFL opens investigation into Watford over ´forged´ bank letter|
|Hummels admits RB Leipzig a serious threat for Bayern|
|Pedro reveals Barcelona talks|
|De Bruyne: I have no problem with Mourinho|
|Casillas: I have not retired from Spain duty|
|Raul backs under-fire Ronaldo for Ballon d´Or glory|
|Mourinho and United must lower expectations - Xavi|
|Hands off! Milan CEO insists Donnarumma will stay|
|Glory coach Lowe accepts ban|
|Scolari extends contract with Guangzhou Evergrande|
|Guardiola eliminated City doubts - De Bruyne|
|Klopp lauds Ings for ´perfect´ response|
|Wenger: Perez needs to take chance|
|Boys to men: Mourinho challenges United players|
|Kompany committed to bargain with City medics|
|´Insipid´ Hazard overlooked for Ballon d´Or|