Barcelona and Atletico Madrid will put their Liga title chase to one side when they meet in the UEFA Champions League on Tuesday.
The sides currently occupy the top two spots in the Spanish top flight - Atleti are one point clear of second-placed Barca - and clash this week in the first leg of their quarter-final tie at Camp Nou.
There has been no previous meeting between the clubs in continental football, but their three domestic fixtures this season point to this being a hotly contested encounter.
Barca edged the Supercopa de Espana on away goals after both legs ended all square in August, while the Liga meeting in January ended goalless.
Despite their proximity in La Liga, Barca head into the last-eight tie with far greater experience of Europe's premier club competition.
Barca will be looking to extend their record of having contested the semi-finals in the last six seasons, while Atleti are in the quarter-finals for the first time since 1997 and have not reached the last four for 40 years.
Current Atleti coach Diego Simeone was in the side that lost 4-3 on aggregate to Ajax in the quarter-finals 17 years ago.
The men from the Spanish capital have not won at Camp Nou since a 3-1 league victory in 2006, when Fernando Torres - now of fellow quarter-finalists Chelsea - netted a brace.
That said, Barcelona do not have the best of records against Spanish opponents over two legs in continental competition, losing five of their nine ties, but have lost just one of their last 26 European home ties.
Barcelona knocked out Manchester City to reach this stage, while Atleti disposed of Milan.
On an individual level, Lionel Messi is four goals short of Raul's Champions League goalscoring record of 71 and is bang in form, finding the net nine times in his last five appearances in all competitions.
Atleti have taken many by surprise with their sensational form this season, with Simeone keen to maintain the feel-good factor at the club.
"We are enjoying the situation day by day, minute by minute, training session by training session and game by game," he said after Saturday's 2-1 win at Athletic Bilbao.
"That is how we feel strong and we will continue like that because we don't want to get away from that line of thinking."
The hosts will be without goalkeeper Victor Valdes, who is likely to have played his last match for Barcelona after being ruled out for the season with a knee injury.
Javier Manquillo (neck) remains sidelined for Atleti, while Raul Garcia is ruled out through suspension.
|Coach: G. Martino|
for Piqué 12'
for Fàbregas 68'
|Tottenham v Partizan: Pochettino´s men look to seal qualification|
|Messi breaks Champions League scoring record|
|Wolfsburg v Everton: Distin buoyed by good run|
|Allegri expects improved away display|
|Rodgers: First goal crucial for Liverpool confidence|
|CSKA Moscow 1 Roma 1: Late leveller keeps Russians in the hunt|
|Ancelotti not worried about record|
|BATE 0 Porto 3: Belarusians knocked out but go into the record books|
|Klopp looking forward to Champions League distraction|
|Parish urges Warnock to stop ref rage|
|UEFA Europa League Preview: Celtic and Inter seek home wins to advance|
|Diame could make Hull return on Saturday|
|QPR lose Sandro to knee injury|
|Juanmi fractures arm|
|Wilshere out for ´a while´ - Wenger|
|Wenger hits back at Usmanov|
|De Jong back in training for Newcastle|
|Chelsea ´head and shoulders´ above rest - Giggs|
|Stevens returns to Stuttgart|
|Cheltenham sack Yates|
|Giggs open to United exit to further career|
|Sampaoli relaxed after Copa America draw|
|Pekerman eyes Copa America revenge|
|Time for City to produce - Nasri|
|Copa Sudamericana Preview: River search for form ahead of Superclasico|
|K. League Preview: Cup winners Seongnam eye safety|
|Argentine Primera Division Review: Racing Club beat River Plate to go top|
|Guardiola: Desperate City are dangerous|
|Paraguayan Division Profesional Review: Libertad back on top as Cerro Porteno slip up|
|Brazil to meet Colombia at Copa America|
|Koeman backs ´great´ Forster|
|Lambert delighted with makeshift Villa defence|
|Koeman remains confident of top-four finish|
|Granada 0 Almeria 0: Visitors hold on to move out of bottom three|
|Genoa 1 Palermo 1: Hosts rue Pinilla miss in lively draw|
|Aston Villa 1 Southampton 1: Saints spoil Lambert´s 100th game|
|No let-up from Bayern - Guardiola|
|Turkish Super Lig Review: Besiktas and Fenerbahce gridlocked, Yanal makes winning start|
|Basel v Real Madrid: Ancelotti approaching winning record|
|Russian Premier League Review: Zenit extend advantage, Torpedo win marred|
|Mourinho not interested in Reus|
|Pellegrini dismisses Messi rumours|
|Anderlecht v Galatasaray: Faint hopes remain alive in Belgium|
|Luis Enrique: Barca must beat APOEL|
|Indian Super League Preview: Materazzi keen to maintain momentum, Goa host Kerala|
|Arsenal v Borussia Dortmund: Klopp visits Emirates amid switch rumours|
|Fer concerned by QPR away form|
|Shakhtar must not underestimate Athletic - Lucescu|
|Indian Super League Review: Chennaiyin well-placed for post-season, Delhi win|
|Atletico Madrid v Olympiacos: Atleti on the brink of last 16|
|Dragons take American football player on trial|
|Di Matteo has no thoughts of Chelsea revenge|
|Vermaelen could require surgery|
|Destiny in Roma´s hands - Garcia|
|Ludogorets v Liverpool: Rodgers demands improvement|
|Malmo v Juventus: Pogba issues rallying cry|
|Blanc demands killer instinct against Ajax|
|Bayer Leverkusen v Monaco: Germans looking to progress|
|Aguero and Jovetic fit to face Bayern|
|Ancelotti reveals contract talks|
|Slutsky targeting Champions League last 16|
|PSV receive Guardado boost|
|Ter Stegen waiting for Barcelona chance|
|Allardyce hopeful Carroll can stay injury-free|
|Arsenal must be ruthless - Arteta|
|Veh resigns from struggling Stuttgart|
|Juventus have ´more quality´ this season, says Pogba|
|Copa America win can restore Brazil´s confidence – Marin|
|Lallana issues rallying cry|
|Fritz confident Bremen can turn things around|
|Bruce backing Hull to stay out of trouble|
|Lambert determined to transform Villa|
|Valdez: Suarez needs ´miracle´ for Copa America|
|Real Madrid heading to Australia for ICC|
|Martinez: Lukaku can become ´best striker in the world´|
|Koeman slams ´crazy´ Christmas fixture list|
|Iniesta, Vermaelen unavailable for Cyprus trip|
|Zenit v Benfica: Pereira, Lima set to return for Portuguese champions|
|Inzaghi sorry for derby stalemate|
|Colombian Primera A Review: Medellin on cusp of final, Santa Fe deny Huila|
|Mancini ´very happy´ with derby draw|
|Peruvian Primera Division Review: Sporting Cristal beaten|
|Liga del Futbol Profesional Boliviano Review: Late Blooming spark sends Oriente second|
|Venezuelan Primera Division Review: Trujillanos stay top, Metropolitanos embarrassed|
|Liga MX Review: Pachuca, Pumas UNAM reach play-offs|
|MLS Review: Wins for Galaxy, Revolution|
|Ecuadorian Primera A Review: Top three fail to score, Olmedo win big|
|Brazilian Serie A Review: Cruzeiro retain title|
|Chilean Primera Division Review: Universidad Chile held, Colo Colo go top|
|Costa Rican Primera Division Review: Cartagines into fourth|
|Uruguayan Primera Division Review: Champions Nacional win again|
|Ligue 1 Review: Marseille come from behind, Nantes extend unbeaten run|
|La Liga Review: Valencia suffer derby defeat, Rayo Vallecano beat Celta Vigo|
|Serie A Review: Mancini´s Inter rescue derby draw|
|Milan 1 Inter 1: Draw for Mancini on return|
|Pochettino wants home comforts|
|Bundesliga Review: Hamburg secure derby win, Stuttgart beaten again|
|Bruce disappointed with Vertonghen reaction|
|Eriksen backing Tottenham to kick on|
|Hull City 1 Tottenham 2: Eriksen snatches late winner after Ramirez sees red|
|Eredivisie Review: De Leeuw denies leaders PSV, Heracles secure timely win|
|Rodgers takes responsibility for Liverpool slump|
|Falcao ready for United return|
|Warnock basks in Palace display|
|Fabregas calls for ruthlessness|
|Crystal Palace 3 Liverpool 1: Rodgers´ men stumble at Palace again|
|Partick Thistle 0 Aberdeen 1: Rooney spot on for visitors|
|Reus blow for Dortmund|
|Mulvey leaves Roar post|
|Shakhtar Donetsk v Athletic Bilbao: Bernard eyes fast start|
|Forster urges Southampton to build|
|Sporting v Maribor: Montero out to continue hot streak|
|Schalke v Chelsea: Chance of revenge for Di Matteo|
|Manchester City v Bayern Munich: Pellegrini putting pressure on himself|
|Mourinho guards against Chelsea complacency|
|Rodriguez urges Real focus|
|Paris Saint-Germain v Ajax: Dutch outfit quietly confident|
|APOEL v Barcelona: Xavi seeks further improvement|
|Gotze basks in Bayern form|
|Tevez wants domestic form replicated in Europe|
|Mixed news on Naismith for Everton|
|Central Coast Mariners 0 Adelaide United 2: Sanchez nets brace for visitors|
|Can full of praise for Gerrard|
|BATE v Porto: Visitors eye top spot|
|CSKA Moscow v Roma: Italians eye qualification|
|Simeone lauds Atletico display|
|Messi the best ever - Luis Enrique|
|Eredivisie Review: Feyenoord make Peersman pay, Ajax beat Heerenveen|
|La Liga Review: Real Madrid, Barcelona win big|