Bunyodkor may fail to advance from the AFC Champions League group stages for the first time, while Al Fateh look for their first goal.
Mirjalol Qosimov's Bunyodkor – two-time semi-finalists – sit third in Group B with two points from their opening three games.
The Uzbek champions were eliminated in the round of 16 last year and desperately need a win at Foolad on Tuesday.
"The next match will be the most important for us," Qosimov said of the trip to Iran.
"If we lose or draw we will not have chance to qualify for the next stage."
Bunyodkor will be without suspended captain and centre-back Hayrulla Karimov, while Foolad – who are second – are missing midfielder Shahab Karami.
Also in Group B, Fateh are searching for their first goal in the competition with the Saudi champions in the Champions League for the first time.
They face group leaders El Jaish on Tuesday.
In Group A, leaders Al Jazira will be confident of maintaining top spot ahead of their clash against lowly Esteghlal of Iran on Wednesday.
Al Rayyan desperately need to beat Al Shabab to avoid falling too far behind the top two.
A tight Group D sees Al Sadd top and Al Ahli second, but they are just two points clear of Sepahan.
Al Hilal, bottom of the group, host Al Sadd while Sepahan visit the United Arab Emirates' Al Ahli.
Asamoah Gyan's Al Ain sit top of Group C ahead of their trip to Tractor Sazi, while second-placed Lekhwiya visit Al Ittihad.
Vagner Love, who like Gyan has four goals in the competition so far, will be with his Group E-leading Shandong Luneng team when they host the Pohang Steelers on Wednesday.
Cerezo Osaka will fancy their chances when they visit lowly Buriram United.
Last year's finalists Seoul need a win when they take on Sanfrecce Hiroshima in Group F, which is topped by Beijing Guoan ahead of their trip to Australia to take on Central Coast.
High-flying Guangzhou Evergrande face Jeonbuk Motors in a clash between Group G's top two, while Melbourne Victory will be looking to move into second with a win at Yokohama F Marinos.
Group H sees Guizhou Renhe welcome leaders Ulsan and Western Sydney will be looking to stay second ahead of a trip to Kawasaki Frontale.
|23||Khaled Al Zereiqi|
|5||Mohammed Al Jabri|
|Coach: N. Maâloul|
for Nilmar 63'
for J. Kembo-Ekoko 82'
for Majed Mohammed 87'
|Vitoria Guimaraes 3 Penafiel 0: Mensah brace inspires victory|
|Blanc has no worries despite Evian stalemate|
|Bayern Munich 2 Wolfsburg 1:Pep´s men kick off with a win|
|Heracles 0 Cambuur 1: Last-gasp defeat for pointless Heracles|
|Evian 0 Paris Saint-Germain 0: Cabaye sees red as champions frustrated|
|Al Hilal Omdurman 2 Zamalek 1: Al Madina ensures hosts of victory|
|McLeish returns to management with Genk|
|Mackay defends Bevan over controversy|
|Milan dealt blow in search for Balotelli replacement|
|Sunderland v Manchester United: Van Persie returns in much-needed boost|
|Depay agrees PSV contract extension|
|Barcelona v Elche: Confidence flows as Luis Enrique era dawns|
|N´Diaye leaves Sunderland for Betis|
|Dortmund can challenge Bayern - Hitzfeld|
|Van Gaal ´enchanted´ by Rojo|
|Tottenham v QPR: Redknapp returns to White Hart Lane|
|Hughes unaware of Palacios interest|
|Hull City v Stoke City: Visitors keen to spoil party|
|Hannover seal Briand deal|
|Emery braced for Fazio departure|
|Rodgers coy on Balotelli speculation|
|Xavi out to feel ´useful´ at Barca|
|Cardiff call for Bevan resignation|
|Mourinho: Club takes priority over players|
|Pellegrini ready for crucial Liverpool clash|
|Retirement not on Buffon´s radar|
|Swansea loan Carroll from Spurs|
|Taylor wants Liberty to become a fortress|
|Celtic enter Scepovic race|
|Samaras signs two-year deal at Albion|
|We cannot be complacent - Marcelino|
|Redknapp: Mackay should get second chance|
|LMA apologise for initial Mackay statement|
|Neymar a doubt for Elche clash|
|Alves confident of Enrique evolution|
|Ferdinand dreaming of England job|
|European and EPL clubs circling for Jets|
|Millen ready to lead Palace recruitment|
|Wenger: Wilshere should ignore critics|
|CONCACAF Champions League Review: Herediano start strongly|
|Lambert excited by ´big asset´ Cole|
|Copa Sudamericana Review: Barcelona, Deportivo Capiata in the box seat|
|Brazilian Serie A Review: Luciano inspires Corinthians, Cruzeiro extend lead|
|Blanc: Di Maria transfer difficult|
|Klopp eager to deny Leverkusen|
|Blanc optimistic over Ibrahimovic fitness|
|Tiote will stay - Pardew|
|Bruce laments ´stupid´ McGregor mistake|
|UEFA Europa League Review: Tottenham in late turnaround, Astra shock Lyon|
|League Two Preview: Morecambe, Burton out to continue fast starts|
|Sassuolo 4 Cittadella 1: Second-half rally sees Sassuolo into Coppa fourth round|
|Howard to take US sabbatical|
|Lokeren 1 Hull City 0: McGregor error gifts Belgians victory|
|Rwanda given Wednesday hearing for disqualification appeal|
|Pochettino hails substitutes´ impact|
|Mackay apologises over text message scandal|
|Brandao suspended over Motta incident|
|Borussia Dortmund v Bayer Leverkusen: Klopp expecting tough start|
|QPR complete loan deal for Vargas|
|League One Preview: Fleetwood, Preston face home tests|
|Chelsea v Leicester City: Schurrle expecting Chelsea improvement|
|Southampton v West Brom: Koeman wary of Albion|
|AEL 1 Tottenham 2: Late turnaround gives visitors play-off edge|
|CAF Confederation Cup: Al Ahly, Nkana out to reach last four|
|Swansea City v Burnley: Monk expecting stern examination|
|Bender close to Leverkusen return|
|Morocco will host Club World Cup despite Ebola concerns - FIFA|
|Schneiderlin not allowed to leave, insists Koeman|
|Dyche confident Burnley can strengthen|
|West Brom eye Samaras signing|
|Aston Villa v Newcastle United: Lambert wants more Weimann goals|
|MLS Preview: Sounders look to bounce back at Portland, Johnson banned for DC|
|Klose eyes European football|
|Monk warns Swansea over complacency|
|De Jong set for Newcastle return|
|Crystal Palace v West Ham: No excuses from Millen|
|Pearson looking for Chelsea indication|
|Blanc wants Rabiot to stay|
|Bowyer reveals Hull approach for Rhodes|
|Atletico out to gatecrash Barca, Real party once again|
|Barcelona go back to the future|
|CSL Preview: Beijing Guoan, Dalian Aerbin hit the road|
|Westwood returns to Ireland squad|
|Millen confident on Palace job prospects|
|Pedro struck down by gastroenteritis|
|Championship Preview: Magath preaches patience, Ipswich host East Anglian derby|
|Ribery not ready for Bayern return - Guardiola|
|Ancelotti: Di Maria has asked to leave|
|Moody resigns from Palace post|
|Everton v Arsenal: Martinez denies Everton have advantage|
|Coventry agree Ricoh return|
|Allardyce eyes defensive improvements|
|FA to investigate Cardiff dossier|
|Simeone not expecting to retain title|
|Balotelli bids farewell to Milan team-mates|
|Wenger open to signings after Arteta blow|
|Martinez to wait on Kone, Oviedo before considering late signings|
|Ocampos believes in Jardim´s methods|
|Villas-Boas calls for Zenit focus|
|Jovetic predicts bright future at City|
|Hamren hoping for quick Ibrahimovic recovery|
|Van Gaal retains focus on team ethic|
|Martinez calls for Everton consistency|
|Oxlade-Chamberlain: Arsenal´s best will come|
|Benaglio retires from Swiss duty|
|MLS Review: Galaxy stun Rapids, Sounders held|
|CONCACAF Champions League Review: MLS clubs shine|
|Panama 4 Cuba 0: Hosts finally win|
|K. League Preview: In-form Jeonbuk out to increase advantage|
|Copa Sudamericana Review: Penarol poised to advance, General Diaz on track|
|Liga MX Preview: America target another win|
|J.League Preview: In-form Kashima, Tokyo face tests|
|Fresh faces in Australia squad|
|Copa Argentina Review: River Plate, Estudiantes des Caseros reach quarters|
|Girard rues wasteful Lille|
|Scholes: ´I am scared for United´|
|Patient Inter got just rewards - Mazzarri|
|UEFA Europa League Review: Inter win in Iceland|