Bunyodkor may fail to advance from the AFC Champions League group stages for the first time, while Al Fateh look for their first goal.
Mirjalol Qosimov's Bunyodkor – two-time semi-finalists – sit third in Group B with two points from their opening three games.
The Uzbek champions were eliminated in the round of 16 last year and desperately need a win at Foolad on Tuesday.
"The next match will be the most important for us," Qosimov said of the trip to Iran.
"If we lose or draw we will not have chance to qualify for the next stage."
Bunyodkor will be without suspended captain and centre-back Hayrulla Karimov, while Foolad – who are second – are missing midfielder Shahab Karami.
Also in Group B, Fateh are searching for their first goal in the competition with the Saudi champions in the Champions League for the first time.
They face group leaders El Jaish on Tuesday.
In Group A, leaders Al Jazira will be confident of maintaining top spot ahead of their clash against lowly Esteghlal of Iran on Wednesday.
Al Rayyan desperately need to beat Al Shabab to avoid falling too far behind the top two.
A tight Group D sees Al Sadd top and Al Ahli second, but they are just two points clear of Sepahan.
Al Hilal, bottom of the group, host Al Sadd while Sepahan visit the United Arab Emirates' Al Ahli.
Asamoah Gyan's Al Ain sit top of Group C ahead of their trip to Tractor Sazi, while second-placed Lekhwiya visit Al Ittihad.
Vagner Love, who like Gyan has four goals in the competition so far, will be with his Group E-leading Shandong Luneng team when they host the Pohang Steelers on Wednesday.
Cerezo Osaka will fancy their chances when they visit lowly Buriram United.
Last year's finalists Seoul need a win when they take on Sanfrecce Hiroshima in Group F, which is topped by Beijing Guoan ahead of their trip to Australia to take on Central Coast.
High-flying Guangzhou Evergrande face Jeonbuk Motors in a clash between Group G's top two, while Melbourne Victory will be looking to move into second with a win at Yokohama F Marinos.
Group H sees Guizhou Renhe welcome leaders Ulsan and Western Sydney will be looking to stay second ahead of a trip to Kawasaki Frontale.
|23||Khaled Al Zereiqi|
|5||Mohammed Al Jabri|
|Coach: N. Maâloul|
for Nilmar 63'
for J. Kembo-Ekoko 82'
for Majed Mohammed 87'
|Robinho likely to move, claims agent|
|Drogba completes Chelsea return|
|Kiyotake moves to Hannover|
|Marotta: Juventus eyeing striking additions|
|Bakayoko set for Monaco switch|
|J.League Preview: Vortis out to improve dismal fortunes against Ardija|
|Juve complete Pereyra deal|
|Ranieri named Greece head coach|
|Fiorentina agree Basanta deal|
|Di Natale backs Pereyra´s Juve move|
|Iniesta: Suarez has talent to restore Barca glory|
|Cerci in charge of his future, says Cairo|
|West Ham target new striker|
|Pardew hopeful over De Jong|
|Rodgers expects new Gerrard deal|
|Jones: United embracing Van Gaal methods|
|Henry: Time had come to sell Suarez|
|Brunt eyes new West Brom deal|
|Arsenal´s World Cup winners to miss league opener|
|Modric hails Rodriguez, Kroos signings|
|Cech does not want bench role|
|Inzaghi blames fatigue for Milan loss|
|Real´s time to shine, says Ancelotti|
|Real Salt Lake 3 Montreal Impact 1: Garcia stars in Utah|
|Downing: Carroll injury a ´big blow´|
|Irvine: I have not seen Ideye play live|
|Olympiacos triumph in Toronto|
|Giggs likens Van Gaal to Ferguson|
|Copa do Brasil Review: Corinthians among trio on the verge of progression|
|Blanc: World Cup stars will move on|
|Pinto steps down as Costa Rica coach|
|Mourinho planning Drogba swoop|
|UEFA Europa League Review: Rosenborg complete comeback to see off Sligo|
|Mathieu out to enjoy Barcelona move|
|Mandzukic not Diego Costa´s replacement|
|Eliseu returns to Portugal with Benfica|
|Sanabria makes Roma switch|
|Carroll to miss start of season|
|Vidal: I´m not going to Manchester|
|Xavi staying at Barcelona|
|Hannover complete Gulselam signing|
|Astori loaned to Roma, Cagliari confirm|
|Nigeria to talk with Keshi over return|
|Gamberini makes Chievo move|
|Besic poised to complete Everton move|
|Marseille move Montpellier fixture from Stade Velodrome|
|CSL Preview: Harbin eye Luneng scalp, Guangzhou face Hena|
|Guardiola preaches patience with Lewandowski|
|Lampard joins New York City|
|Blanc coy on Di Maria speculation|
|CAF Confederation Cup Preview: ASEC coach confident, Al Ahly seek qualification|
|Chelsea loan Piazon to Frankfurt|
|Pochettino has high hopes for Lamela|
|Aguirre appointed as Japan coach|
|Swansea swoop for Montero|
|Pozuelo makes Vallecano switch|
|Fred back at Shakhtar, Ismaily to follow|
|CFF investigate Fofana accusations|
|Suarez could make sensational Clasico debut|
|Ribery in line for return, says Guardiola|
|Reus could resume training in two or three weeks - Klopp|
|Roma need another defender, says Garcia|
|Everton on verge of new signings|
|Rodrigo hails Nuno after Valencia switch|
|Delph eager for new Villa deal|
|Ljajic not seeking Roma exit|
|Talks held as players strike in Ecuador|
|Crouch excited by Bojan capture|
|Lambert expects swift recovery for Cole|
|West Ham duo fail to travel|
|United to play 3-4-3, says Van Gaal|
|Lallana, Markovic set to feature against Olympiacos|
|Real want to win every trophy, says Bale|
|San Jose Earthquakes 5 Chicago Fire 1: Hosts break winless streak|
|Chelsea have "outstanding squad" - Costa|
|United make winning start under Van Gaal|
|Rodgers plays down Borini injury concerns|
|Atletico Mineiro 4 Lanus 3 (agg 5-3): Own goals gift Brazilians the win|
|Dunga names Brazil assistants|
|Man City show class in Kansas|
|Villa too good for Dallas|
|Santos cannot meet Robinho´s demands, says vice-president|
|Mourinho happy with goalkeeper situation|
|Borini hurt as Liverpool lose to Roma|
|Palace held to draw by Crew|
|Tottenham down Toronto after Lamela brace|
|San Lorenzo 5 Bolivar 0: Hosts close in on Copa Libertadores final|
|Sunderland forward Scocco joins Newell´s|
|Rodgers: We won´t overpay in transfer market|
|Maccabi Haifa friendly abandoned after pitch invasion|
|USA dynamo Beasley joins Houston|
|UEFA Champions League Review: Steaua ease through as Legia Warsaw hit five|
|Youngsters inspire Sunderland to win at Hartlepool|
|Aluko and Sagbo net as Hull City beat York|
|PSG loan Aurier from Toulouse|
|Emotional Davies thanks Swansea fans|
|Mandzukic makes debut as Atletico win|
|Filipe makes bow in Chelsea draw|
|Bahebeck stars again as PSG beat Nice|
|Conte rubbishes PSG talk|
|Tottenham sign Davies and Vorm as Sigurdsson joins Swansea|
|De Laurentiis vows Napoli will fight for Scudetto|
|Lyon sign Jallet from PSG|
|Rijeka deny racism allegations|
|Suarez has been treated ´like a murderer´, says Aspas|
|Basel secure Samuel swoop|
|Thai Premier League Review: Buriram go top as Muang Thong slip up|
|Dnipro-Copenhagen clash moved to Kiev|
|Tevez never considered Juve exit|
|Djuricic joins Mainz on loan|
|Cavani keen on PSG stay|
|Shaqiri flattered by Juventus link|
|Johnson, Sommer arrive at Monchengladbach|
|J.League Review: Kawasaki close gap on Sagan, Urawa move clear at top|
|Coleman to miss Everton´s Thailand trip|
|Thankful Rueda bids farewell to Ecuador|
|Liga MX Preview: Peralta set for home debut, Leon seek recovery|
|K.League Review: Top two draw blanks, Jeju United close in|
|CAF Champions League Preview: Zamalek primed for crucial game, CS Sfaxien meet ES Tunis|
|Low quashes Germany exit rumours|
|Getafe agree Michel loan|
|Porto bring in Brahimi from Granada|
|Pardew satisfied with attacking signings|
|Pellegrini targets further City signings|
|Sevilla complete Krychowiak deal|
|Eisfeld makes Fulham move|
|Zarate opens account as West Ham stumble|
|I have nothing to prove, says Ince|
|Barcelona seal Mathieu deal|
|United prepared to spend big, claims Woodward|
|Shakhtar to play in Lviv|
|Pereyra poised for Juve switch|
|Fabregas eyes trophies at Chelsea|
|Vorm confirms Tottenham transfer|
|Deila: Forster will leave Celtic eventually|
|No pressure for Shaw|
|Van Gaal happy with preparations|
|Diarra aiming for Bordeaux return after West Ham frustration|
|Last season for Montpellier owner Nicollin|
|Monaco: Rodriguez deal too good to ignore|
|Nacional Asuncion 2 Defensor Sporting 0: Hosts surge towards Libertadores final|
|Garcia eyeing Serie A title|
|Father against Vlasic´s move abroad|
|Rodgers welcomes Gerrard´s international retirement|
|Cruzeiro, Atletico Mineiro bid for Robinho|
|Inzaghi not drawn into Balotelli speculation|
|Dunga ´not going to sell a dream´|
|City´s Fofana allegedly racially abused|
|Carroll ruled out of NZ friendlies|
|Rodgers excited by new arrivals|