There was mixed fortunes for the three La Liga title rivals on Wednesday on a day when Victor Valdes' Barcelona career looked to be ended.
Atletico Madrid solidified their place at the top of the table with 1-0 over Granada, while Real Madrid lost 2-1 at Sevilla.
Real's controversial 4-3 Clasico loss to arch-rivals Barcelona at the Bernabeu on Sunday saw them replaced by Atletico at the table's summit and they were unable to bounce back from that defeat.
Cristiano Ronaldo gave them a 14th-minute lead at Estadio Ramon Sanchez Pizjuan, but the deficit was overturned just a few moments later as Carlos Bacca poked the ball past Diego Lopez.
The visitors enjoyed more of the ball than their hosts in the second half, but Bacca's contribution was vital - as he netted his second with 18 minutes left to give Sevilla all three points.
The victory was Sevilla's sixth consecutive triumph in the league, moving them to within six points of fourth-placed Athletic Bilbao, while Real slip three points behind leaders Atletico, who won without playing particularly well.
Atleti struggled to break through Granada in a frustrating first half, but top scorer Diego Costa salvaged all three points after 63 minutes with his 24th Liga goal of the campaign.
Real's defeat means Atleti are a point clear of Barcelona as the title race swings between three teams.
Barcelona moved up to second, above Real, thanks to their 3-0 home win over Celta Vigo, but the victory was marred by a season-ending knee injury to goalkeeper Valdes.
The goalkeeper has already announced his intention to leave at the end of the campaign, meaning that he has played his final game in a Barcelona shirt.
He suffered a torn anterior cruciate ligament after landing awkwardly while collecting a routine ball into the box, and he is now set for surgery that also puts his FIFA World Cup participation with Spain in doubt.
Away from that incident, two goals from Neymar and one from Lionel Messi was more than enough to see off a Celta side coached by Barca legend Luis Enrique.
The day's other game saw Rayo Vallecano take a big leap towards survival as they beat another of the league's relegation contenders, Osasuna, 1-0 at home.
Rayo went into the match a point above their visitors and it looked set to end all-square at Estadio de Vallecas as proceedings entered second-half stoppage time with the scores level.
However, Jose Carlos won a late penalty after a tug from full-back Damia and forward Joaquin Larrivey converted the resulting spot-kick to win it.
|Coach: D. Simeone|
for C. Rodríguez 56'
for A. Turan 60'
for David Villa 70'
|UEFA Champions League Review: Steaua ease through as Legia Warsaw hit five|
|Youngsters inspire Sunderland to win at Hartlepool|
|Aluko and Sagbo net as Hull City beat York|
|PSG loan Aurier from Toulouse|
|Emotional Davies thanks Swansea fans|
|Mandzukic makes debut as Atletico win|
|Filipe makes bow in Chelsea draw|
|Bahebeck stars again as PSG beat Nice|
|Conte rubbishes PSG talk|
|Tottenham sign Davies and Vorm as Sigurdsson joins Swansea|
|De Laurentiis vows Napoli will fight for Scudetto|
|Lyon sign Jallet from PSG|
|Rijeka deny racism allegations|
|Suarez has been treated ´like a murderer´, says Aspas|
|Basel secure Samuel swoop|
|Thai Premier League Review: Buriram go top as Muang Thong slip up|
|Dnipro-Copenhagen clash moved to Kiev|
|Tevez never considered Juve exit|
|Djuricic joins Mainz on loan|
|Cavani keen on PSG stay|
|Shaqiri flattered by Juventus link|
|Johnson, Sommer arrive at Monchengladbach|
|J.League Review: Kawasaki close gap on Sagan, Urawa move clear at top|
|Coleman to miss Everton´s Thailand trip|
|Thankful Rueda bids farewell to Ecuador|
|Liga MX Preview: Peralta set for home debut, Leon seek recovery|
|K.League Review: Top two draw blanks, Jeju United close in|
|CAF Champions League Preview: Zamalek primed for crucial game, CS Sfaxien meet ES Tunis|
|Low quashes Germany exit rumours|
|Getafe agree Michel loan|
|Porto bring in Brahimi from Granada|
|Pardew satisfied with attacking signings|
|Pellegrini targets further City signings|
|Sevilla complete Krychowiak deal|
|Eisfeld makes Fulham move|
|Zarate opens account as West Ham stumble|
|I have nothing to prove, says Ince|
|Barcelona seal Mathieu deal|
|United prepared to spend big, claims Woodward|
|Shakhtar to play in Lviv|
|Pereyra poised for Juve switch|
|Fabregas eyes trophies at Chelsea|
|Vorm confirms Tottenham transfer|
|Deila: Forster will leave Celtic eventually|
|No pressure for Shaw|
|Van Gaal happy with preparations|
|Diarra aiming for Bordeaux return after West Ham frustration|
|Last season for Montpellier owner Nicollin|
|Monaco: Rodriguez deal too good to ignore|
|Nacional Asuncion 2 Defensor Sporting 0: Hosts surge towards Libertadores final|
|Garcia eyeing Serie A title|
|Father against Vlasic´s move abroad|
|Rodgers welcomes Gerrard´s international retirement|
|Cruzeiro, Atletico Mineiro bid for Robinho|
|Inzaghi not drawn into Balotelli speculation|
|Dunga ´not going to sell a dream´|
|City´s Fofana allegedly racially abused|
|Carroll ruled out of NZ friendlies|
|Rodgers excited by new arrivals|
|Zeljeznicar 2 Metalurg Skopje 2 (agg 2-2): Visitors advance on away goals|
|Gibson returns as Tranmere hold Everton|
|UEFA Champions League Review: Celtic coast through, BATE given scare|
|Gomez and Jones feature in Sunderland win|
|Leicester hit Ilkeston for six|
|Austin fires QPR to narrow victory|
|Guardiola: No trophies and I may be sacked|
|Dortmund held as Immobile makes debut|
|Rodriguez´s dream becomes Real|
|Garcia: Benatia and Ljajic going nowhere|
|Stoke secure Bojan on four-year deal|
|FA: No World Cup bids for England|
|Kroos commits to Bremen|
|Caulker makes QPR move|
|Forest agree Hunt loan deal with Palace|
|Bartra ready to prove himself at Barca|
|Southampton looking to sell Osvaldo|
|Marveaux loaned to Guingamp|
|Mourinho eyes success on two fronts|
|Sammer encouraged by Lewandowski start|
|PSG punished for abuse of Chelsea fans|
|Dunga unveiled as Brazil coach|
|Shakhtar CEO: Focus is on players´ safety|
|Foster agrees new West Brom deal|
|Real Madrid sign Rodriguez|
|Mustafi eyes Bundesliga switch|
|Klopp laughs off Hummels, Reus speculation|
|Campana makes Sampdoria switch|
|Leicester seal Ulloa deal|
|Morata sidelined for seven weeks with knee injury|
|Riviere on target in comfortable Newcastle win|
|Advocaat set for Serbia role|
|Wisdom joins West Brom on loan|
|Bundesliga to consider vanishing foam|
|Five-man shortlist for Ivory Coast|
|´Personal issues´ keep Gervinho away from Roma tour|
|Jedinak raring to go|
|Borini set for Liverpool stay, claims agent|
|Koeman: No bids for Lovren|
|Livermore: England hopes shouldn´t hinge on club side|
|MLS Preview: Tough tests for Conference leaders, Revolution still struggling|
|Mathieu not Barca material, says Marquez|
|West Brom claim unimpressive win in Sacramento|
|Neymar: Brazil behind Germany, Spain|
|Vietnamese police confirm match-fixing players|
|Lucescu blames Joorabchian for AWOL players|
|Robinho undecided on future|
|Rush: Still years left in Gerrard|
|Tiago re-signs with Atletico|
|Puyol against Spain overhaul|
|Agger considering his Liverpool future|
|Peruvian Primera Division Review: Juan Aurich bounce back, Melgar draw with Inti Gas|
|Bayern deny interest in Cuadrado|