David Moyes will aim to quieten talk over his Manchester United future by denting Manchester City's title hopes at Old Trafford on Tuesday.
Victories over Olympiacos and West Ham, the former overturning a 2-0 UEFA Champions League last-16 deficit to secure United's progression, have served to dampen criticism of the Scot.
However, Moyes knows murmurings could intensify if seventh-placed United again come up short at home against a bitter rival following the recent 3-0 home loss to Liverpool.
While the Old Trafford faithful will be far from satisfied by another game in which their sole aim is to hinder a rival's Premier League title aspirations, a triumph would be a feather in the cap of the United boss.
"We'll go into our next game confident and ready to get a result," said a bullish Moyes after Saturday's 2-0 win at Upton Park.
For City, the game carries similar significance at the start of what will likely prove a season-defining run of fixtures.
Currently six points behind leaders Chelsea with three games in hand, Manuel Pellegrini's men head to their neighbours brimming with confidence after a 5-0 drubbing of Fulham at the weekend.
But City will be aware, too, that the derby precedes trips to Arsenal and Liverpool, which sandwich a tricky home game against Southampton.
Pellegrini will not be able to call on the services of key striker Sergio Aguero, who is another week away from fitness as he continues his rehabilitation from a hamstring injury.
However, Edin Dzeko looks set to be fit after being taken ill before the Fulham game and Stevan Jovetic should also be available having returned from injury for the final eight minutes on Saturday.
"I think that this team doesn't depend just on one striker," said Pellegrini. "Maybe in the last week we had some problems with Aguero and Jovetic.
"Now Jovetic is coming back and I hope Aguero will be next week with the team. If they don't score there are other players that will do it."
Chief among the supporting cast is Yaya Toure, who boasts 16 Premier League goals this term following his hat-trick against Fulham.
Moyes will, therefore, be buoyed to have Rio Ferdinand available having been forced to deploy Michael Carrick at centre-back versus West Ham.
Ferdinand was rested at the weekend, but United will again be without Nemanja Vidic, who serves the second of his two-game ban.
At the other end, Moyes will surely deploy Juan Mata behind Wayne Rooney again as Robin van Persie continues to be sidelined.
City, boosted by the return of captain Vincent Kompany from a ban, head to United following four successive Premier League clean sheets and bidding for a third straight victory at Old Trafford in a row.
Pellegrini's men were also 4-1 winners when the sides met back in September at the Etihad Stadium.
|Coach: D. Moyes|
for T. Cleverley 46'
for M. Fellaini 66'
for D. Welbeck 76'
|Puel pleased with ´good point´ in Israel|
|Mourinho not ´over the moon´ with United wins|
|Southampton investigating Eric Black allegations|
|Rodgers: Celtic would challenge at the top in England|
|Ibrahimovic expects more from United|
|Manchester United 1 Zorya 0: Ibrahimovic header earns Mourinho´s men narrow win|
|De Boer blasts Inter for lack of focus|
|Zarate reveals message to ill wife after goalscoring return|
|Raffael suffers fresh injury setback|
|Hapoel Be´er Sheva 0 Southampton 0: Saints´ winning run comes to an end|
|Sparta Prague 3 Inter 1: De Boer´s side humbled in Europa League again|
|Police to review corruption allegations after Telegraph sting|
|Brady hails Wenger as ´possibly the best ever´ Gunners boss|
|Yacob signs new West Brom deal|
|Guidolin prioritising Swansea improvement over his future|
|Sakho outburst has been dealt with – Klopp|
|Bilic sorry for Allardyce in ´very sad´ week for English football|
|Laporte saga nears conclusion as defender earns France call-up|
|Everton are exceeding expectations – Koeman|
|Wenger could be tempted by an international offer, says ex-assistant|
|No excuses for Liverpool this time, says Klopp|
|Rashford left out of England Under-21 squad|
|Boro must pick up where they left off - Karanka|
|Matuidi could still join Juventus, says Raiola|
|Pardew anticipates battle of the Belgians|
|Legia Warsaw to face Real Madrid behind closed doors|
|England job would be the pinnacle - Pardew|
|Wright sacked by Barnsley|
|Bilic defends West Ham team night out|
|Ramsey withdrawal was Arsenal´s call - Coleman|
|LMA demand ´immediate full disclosure´ of corruption evidence|
|´My answer would be a big fat no´ - Coleman rules out taking England job|
|Leeds dismiss Cellino sting as ´non-story´|
|Gabigol, Rashford and Sanches among Golden Boy nominees|
|Keane slams Arsenal: Half their players will have gloves on soon|
|´Special´ Man City draw a career highlight, says Gordon|
|Southgate admits England situation is ´not ideal´|
|England should have gone for O´Neill, says Shilton|
|PSG´s powers of recovery impress Cavani|
|Howe ´absolutely committed´ to Bournemouth amid England links|
|Man City proved character against Celtic, says Zabaleta|
|Walcott: Sanchez partnership bodes well for Arsenal´s season|
|MLS Review: DC, Impact on track for play-offs|
|CONCACAF Champions League Review: Tigres, Dallas left waiting|
|Central Sanchez pleases Wenger|
|Barca felt Messi absence - Busquets|
|Martino knew Messi would come out of retirement|
|Shilton never convinced by Allardyce|
|Degenek replaced by Giannou for Socceroos|
|Griezmann will still take penalties - Simeone|
|Simeone proud of ´one of the best´ wins|
|Godin suffers sprained ankle ligament|
|West Ham receive positive news over injured duo|
|Robson: Four wins for Southgate and he´s an England contender|
|Gunes rues Besiktas´ inability to see off Dynamo|
|Sarri: Late goals leave bitter taste|
|Borussia Monchengladbach were exceptional against Barcelona, feels Schubert|
|PSG must be patient, says Emery|
|Celtic are lucky to have Dembele - Rodgers|
|I´m completely focused on Arsenal, insists Wenger amid England talk|
|Hasselbaink denies wrongdoing amid impropriety allegations|
|Ancelotti frustrated by slow, toothless Bayern|
|Barcelona deserved their win - Luis Enrique|
|I want Celtic atmosphere at City – Guardiola|
|Rebrov defends Yarmolenko after ´difficult´ match|
|Rostov draw is two points dropped for PSV, says De Jong|
|Torres eyeing ´magical´ year for Atletico|
|Celtic 3 Manchester City 3: Dembele at the double in six-goal thriller|
|Celtic 3 Manchester City 3: Dembele at the double in six-goal thriller|
|Rostov 2 PSV 2: Propper´s penalty miss costs visitors|
|Besiktas 1 Dynamo Kiev 1: Tsygankov stuns wasteful Turks|
|Napoli 4 Benfica 2: Mertens bags two as Napoli run riot|
|Arsenal 2 Basel 0: Walcott´s capital gains tax Swiss visitors|
|Borussia Monchengladbach 1 Barcelona 2: Pique grabs the winner|
|Atletico Madrid 1 Bayern Munich 0: Carrasco gives Ancelotti first taste of defeat|
|Ludogorets 1 Paris Saint-Germain 3: Cavani inspires comeback win|
|Premier League, FA and EFL to investigate transfer allegations|
|Vardy reveals matchday energy drink and port routine|
|Everton coping without Stones, says Jagielka|
|Sacked Jemez admits to ´great sadness´ at Granada exit after worst start in over 70 years|
|Wenger has so much to offer English football - Schmeichel|
|No truth to England rumours, says Klinsmann|
|Spalletti demands end to damaging Roma ´games´|
|De Boer: Brozovic was punished and forgiven|
|Allardyce paid price for lack of privacy - McClaren|
|Milik can match Lewandowski - Reina|
|LMA ´extremely concerned´ about manager bribe allegations|
|Iwobi: I nearly left Arsenal|
|Mata has found a ´natural habitat´ at United|
|Higuain slowly approaching top form|
|´Stupid´ Allardyce driven by money - Dyke|
|Wijnaldum vows to improve|
|Renato Sanches needs time at Bayern - Hitzfeld|
|Ibrahimovic nurturing United talent - Lingard|
|Mourinho feels sorry for Allardyce|
|United boss primed for ´must-win´ Europa League tie|
|Mourinho keen to protect under-fire Rooney|
|Jeonbuk Motors 4 Seoul 1: Leonardo brace puts hosts in the driving seat|
|Maloney returns to Scotland squad|
|Van Persie: Kids will decide my future|
|Entrapment won on this occasion - Allardyce|
|Ibra-Rashford pairing the answer for United - Neville|
|Tevez hints at imminent retirement|
|England in safe hands with Southgate - Glenn|
|Holman talks up A-League quality|
|CONCACAF Champions League Review: Red Bulls progress, Timbers win|
|Januzaj blow for Sunderland|
|Navas accepts blame for Dortmund equaliser|
|Sporting assistant Raul Jose pleased with win|
|Nuno left to regret slow start as Porto fail on English soil again|
|Vardy rejected Arsenal due to style|
|Simeone: I am not Griezmann´s mentor|
|Schmidt bemoans ´brutal´ Monaco equaliser|
|Ranieri doesn´t trust bookies over England job|
|Genesio worried wastefulness will cost Lyon in long run|
|Preud´homme admits Champions League too much for Club Brugge|
|Telegraph passes findings to FA after further corruption claims|
|Zidane: Draw difficult to accept|