Millwall boss Ian Holloway has labelled Tuesday's clash with fellow strugglers Birmingham City the most important game of his life.
Holloway has won just two of his 13 league games in charge at the New Den since replacing Steve Lomas in January, and saw his side beaten 2-1 at Leeds United on Saturday.
Third-bottom Millwall now face a home match against Birmingham in midweek, with the Midlanders sitting five points and two places above them in the Championship.
The other sides involved in the relegation scrap all face daunting matches against teams in the top seven on Tuesday, with Yeovil Town visiting leaders Leicester City, Barnsley travelling to Reading and Charlton Athletic playing out-of-form Nottingham Forest.
And Holloway is under no illusions as to the importance of Millwall beating a Birmingham side who have taken just a point from their last five league outings and lost 2-1 at home to Reading on Saturday.
"The Birmingham game is a massive one for us now. We have to try and drag them into it," the former Crystal Palace manager said.
"It's a must win. I've never had a more important game in my life."
At the other end of the table, second-placed Burnley - fresh from their 3-0 win at Charlton on Saturday - could heighten fears of relegation at Doncaster Rovers, who travel to Turf Moor after a morale-boosting 1-0 victory over Yorkshire rivals Sheffield Wednesday.
Sean Dyche's men remain 10 points clear of third-placed Derby County with nine games to go, and will look to extend their unbeaten run to 15 league games.
Doncaster's win over Wednesday saw them climb above Birmingham and put eight points between themselves and the bottom three, but with a tough run-in including matches against Leicester, Derby and Reading after their trip to Burnley, Paul Dickov's side are not yet certain to survive.
Derby boss Steve McClaren, meanwhile, will hope Saturday's 5-0 thumping of local rivals Forest - his side's first win in five outings - will act as a catalyst for a late-season push to catch Burnley, beginning at ninth-placed Ipswich Town.
Play-off rivals QPR and Wigan Athletic will go head-to-head at Loftus Road, and the visitors know victory over Harry Redknapp's men will move them just a point behind their opponents.
Brighton and Hove Albion, who lost ground in the race for the play-offs with a 2-0 defeat to Ipswich at the weekend, travel to Hillsborough to face a Wednesday side keen to put their loss to Doncaster behind them.
Elsewhere, Bolton Wanderers and Blackpool meet at the Reebok Stadium, while Huddersfield Town entertain Middlesbrough, Blackburn Rovers travel to Watford and Leeds are Bournemouth's visitors at Dean Court.
|Pulis rounds on ´cheating´ Sanchez amid Rodriguez penalty row|
|Ramsey: Arsenal must make Emirates a fortress|
|Arsenal 2 West Brom 0: Lacazette double enough for Gunners as Barry breaks Premier League record|
|No Real Madrid doubts over Cristiano Ronaldo, insists Carvajal|
|Nineteen years and counting – Barry´s record-breaking Premier League career in Opta numbers|
|Barry to break Giggs´ Premier League appearance record|
|Zidane has faith in Real Madrid style|
|Suso pens AC Milan extension until 2022|
|Real Madrid injuries will make no difference, says Bosz|
|A waste of time - Klopp baffled by media questions ahead of Champions League tie|
|Football Association backs Glenn over Sampson sacking|
|Juventus to appeal against fine, Agnelli ban issued by FIGC|
|Aguero and Jesus partnership delights Guardiola|
|Deulofeu, Semedo return for Barcelona but Alcacer dropped for Sporting CP clash|
|Guardiola uneasy over lofty Manchester City comparisons|
|FIFA ´applying common sense´ with expected poppy ban U-turn|
|Walker: It was a nightmare facing Aguero|
|Promes a doubt for Spartak´s Liverpool clash|
|Dortmund meet Madrid again as Besiktas look to end drought - Champions League in Opta numbers|
|Villarreal promote coach Calleja to first-team duties|
|Napoli striker Milik set for long lay-off after knee surgery|
|Mourinho avoids FA punishment after being sent off at Southampton|
|Draxler predicts a ´spectacle´ when PSG face Bayern|
|Tevez challenged to prove his worth by Shanghai Shenhua|
|Bielsa has backing of Lille owner despite poor run|
|Shakhtar will attack Man City, predicts Fernandinho|
|Burki hopes Dortmund crowd can be key against Madrid|
|Kroos returns for Madrid´s trip to Dortmund|
|Chelsea boss Conte: For sure, I will return to Italy|
|Neymar and Mbappe need time to settle at PSG, says Ancelotti|
|Mathieu hits out at Barcelona treatment|
|Villarreal sack Escriba after Getafe humbling|
|Lukaku and Raiola repeat calls for offensive chant to stop|
|De Bruyne keen on new Manchester City deal|
|Marcelino laughs off injury after hurting hamstring celebrating|
|Milan shouldn´t be losing to weaker teams – Fassone slams Montella´s men|
|MLS Review: Sporting KC, Portland keep pressure on|
|Wenger unwilling to sacrifice any potential trophy|
|Kane worth more than £100m – Noble|
|Klopp: I could write a book on defending|
|Ederson wishes Mane well after recovering from horror tackle|
|Morata shining as Chelsea´s leading man after Juve, Madrid frustration|
|Guardiola balks at Chelsea or United fearing in-form Manchester City|
|CAF Champions League Review: Etoile Sahel see off Al Ahli Tripoli to reach semi-finals|
|Brighton winner was a foul, claims frustrated Benitez|
|Spalletti: Unbeaten Inter must go beyond their limits|
|Brighton and Hove Albion 1 Newcastle United 0: Hemed the hero in second home win|
|Better late than never - Matuidi delighted with start to life at Juventus|
|Inter 1 Genoa 0: Late D´Ambrosio header snatches victory for Spalletti´s side|
|Delph a willing deputy for injured City left-back Mendy|
|Howedes ruled out for four weeks|
|Milan lacked determination and quality in Samp defeat - Montella|
|Sheffield Wednesday 2 Sheffield United 4: Clarke at the double in derby win|
|Uruguayan Primera Division fixtures cancelled amid referee strike|
|Mendy hoping to follow successful City season with World Cup triumph|
|Sampdoria 2 AC Milan 0: Duvan Zapata claims family bragging rights|
|Dybala backs dropped Higuain to rediscover clinical touch|
|21st century boy - Lyon youngster Geubbels makes Ligue 1 history|
|Napoli fear more knee surgery for Milik|
|Spalletti promises reaction from smarting Inter|
|Montella backs ´fired up´ AC Milan to ´raise the bar´|
|Meunier: PSG don´t have Neymar dependency|
|Pogba could have surgery on hamstring injury – surgeon|
|MLS Review: Shield-chasing Toronto beaten again, Union extinguish Fire|
|Allegri: Higuain needs to rediscover form after Juve axing|
|Juventus great Nedved comes out of retirement|
|I´ll be back! Schwarzenegger visits Barcelona|
|Are you on loan from Man City? Messi quizzes Girona´s Maffeo|
|CAF Champions League Review: Holders Sundowns out on penalties|
|Alba lauds Valverde´s impact at in-form Barcelona|
|Pjanic: Things will only get better for Juventus|
|Bosz points to collective effort despite Aubameyang & Philipp heroics|