A goal in each half kept Wolves at the top of the League One table and dampened Sheffield United's 125th anniversary celebrations.
James Henry's 13th-minute cross evaded United goalkeeper Mark Howard to give the leaders the advantage and the same player also struck the post before setting up Dave Edwards to secure the points shortly after the interval.
The match kicked off at 1:25pm to commemorate United's landmark, but Nigel Clough's men could not mark the occasion as their eight-game unbeaten run in League One was halted.
Brentford remain a point behind Wolves after coming from a goal down to beat Coventry City 3-1.
The visitors took a sixth-minute lead through Callum Wilson's close-range effort, and Brentford's Alan Judge had a penalty saved before Clayton Donaldson, Marcello Trotta and Alan McCormack chipped in to spare his blushes.
Third-placed Leyton Orient lost ground on the top two as they required Nathan Clarke's deflected half-volley to salvage a 1-1 draw at Walsall.
Rotherham prevailed 1-0 over Peterborough through a Kieran Agard penalty as fifth played sixth at London Road, and Steve Evans' men leapfrogged Preston North End to go fourth - their rivals beaten by the same scoreline at Swindon Town.
Basement boys Notts County secured a morale-boosting 4-1 triumph over Carlisle United, who themselves drop into the bottom four on the back of a chastening reverse.
Hayden Hollis bagged a brace either side of half-time and Ronan Murray had also scored for County, before James Berrett offered Carlisle a route back into the match that Gary Liddle’s 70th-minute overhead kick definitively closed.
Crewe Alexandra profited from Carlisle's misfortune as they climbed out of the bottom four courtesy of a 3-1 win at Gillingham inspired by Chuks Aneke's double.
Oldham similarly eased their relegation fears with a 1-0 victory over Crawley Town, but Tranmere Rovers saw their worries increase.
A second-half comeback could not prevent a 3-2 loss at Port Vale that leaves them fifth-bottom and just a point above the drop zone.
Shrewsbury Town remain in the bottom four but climbed above Stevenage as debutant Shaun Miller came off the bench to fire an injury-time winner to sink Bradford City 2-1.
Graham Westley's side were downed in similarly dramatic circumstances - Dean Lewington scoring the last of three goals in the final 10 minutes as play-off chasing MK Dons prevailed 3-2 in remarkable fashion.
Elsewhere, Colchester United came back from two down to draw 2-2 with Bristol City.
|Inzaghi praises Milan derby officials|
|La Liga Review: Granada frustrate Sevilla, Villarreal´s woes continue|
|Inter should have had a penalty, Mancini fumes|
|Ligue 1 Review: Lyon return top after derby draw|
|Inter 0 Milan 0: Disappointing derby ends in stalemate|
|Primeira Liga Review: Sporting made to battle, Penafiel running out of time|
|Balotelli targets officials in latest social media outburst|
|Bundesliga Review: Werder Bremen edge Nordderby, De Bruyne rescues Wolfsburg|
|Serie A Review: Napoli close on stumbling Roma|
|Pochettino congratulates 30-goal Kane|
|Rodgers questions Liverpool´s mental strength|
|Carver counting on experience after latest defeat|
|Sherwood marvels at Grealish potential|
|Eredivisie Review: Dordrecht relegated as Go Ahead Eagles stun Feyenoord|
|Newcastle United 1 Tottenham 3: Losing streak continues amid fan boycott|
|Kouyate elbow on Silva accidental - Allardyce|
|Aston Villa 2 Liverpool 1: Delph ends Gerrard´s hopes of dream farewell|
|Pellegrini hails City response to derby defeat|
|Silva back home after Kouyate elbow|
|Manchester City 2 West Ham 0: Silva injury sours routine win|
|Bayern Munich v Porto: Neuer rallies Germans for uphill battle|
|Barcelona v Paris Saint-Germain: Marquinhos keeps the faith ahead of Camp Nou test|
|Fer closes in on QPR return|
|Crouch set for surgery|
|Dortmund confirm Tuchel as Klopp replacement|
|Adams leaves relegation-threatened Tranmere|
|Real still unsure over Modric injury|
|Tevez rubbishes Juve exit talk|
|Moyes: I had to fight to keep Rooney at United|
|Perth Glory 3 Melbourne City 1: Maclaren treble the difference|
|Dyche: Burnley are too honest|
|Illarramendi eager for Real stay|
|Hazard issues Chelsea warning|
|MLS Review: Injury-time winner buoys Galaxy, Martins shows class for Sounders|
|Pastore talents ´unpredictable´ - Blanc|
|Liverpool much bigger than City - Rodgers|
|AFC Champions League Preview: Evergrande look to progress|
|Clarke expects distraught Federici to bounce back|
|Toure is City´s scapegoat - agent|
|Allegri praises high-flying Juve|
|Athletic Bilbao 4 Getafe 0: Hosts end winless run|
|Depay elated at title success|
|Bale and Modric injuries sour Real win|
|Eredivisie Review: PSV seal title, Dordrecht on the brink of relegation|
|CAF Champions League Review: Kone battle back to hold TP Mazembe as El Merreikh stun ES Tunis|
|Juventus 2 Lazio 0: Tevez inspires win over in-form visitors|
|Ligue 1 Review: Monaco held by late Habibou strike, PSG back on top|
|Bundesliga Review: Bayern win to close in on title, no Klopp distraction for Dortmund|
|Real Madrid 3 Malaga 1: Ramos, Rodriguez and Ronaldo do the business for Real|
|Primeira Liga Review: Jonas double maintains Benfica lead, Porto remain three points back|
|PSV secure Eredivisie title|
|Simeone lauds first-half display|
|Reading motivation ´on a different planet´ - Wenger|
|Mourinho: Title almost secured after United win|
|Sampdoria 0 Cesena 0 : Strugglers frustrate Mihajlovic´s men|
|Fatigue taking its toll – Blanc|
|Van Gaal not convinced by Herrera decision|
|League Two Review: Burton seal promotion, relegation battle down to three|
|Reading 1 Arsenal 2 (aet): Federici left red-faced as holders avoid upset|
|Klopp braced for ´brutally emotional´ farewell|
|Burnley still have belief to beat drop - Dyche|
|Chelsea 1 Manchester United 0: Hazard puts leaders 10 points clear|
|Guardiola focusing on Champions League|
|Bale limps off for Real Madrid with apparent calf injury|
|Championship Review: Wigan keep survival hopes alive, Watford go top|
|Barcelona players ´empty´ after Valencia win, says Luis Enrique|
|Pulis thanks ´first-class´ Palace fans|
|Barkley will become ´an Everton great´ - Martinez|
|Deportivo La Coruna 1 Atletico Madrid 2: Griezmann brace does the damage|
|Monk: Swansea deserved defeat|
|Hughes proud of Stoke comeback|
|Pardew: Defeat will not change Palace approach|
|Penalty hero Bravo plays down role in Barca win|
|Aberdeen 1 Dundee United 0: Prolific Rooney seals European spot|
|League One Review: Bristol City clinch title, MK Dons batter Orient|
|Pearson: Still work to do for Leicester|
|Mirallas happy at Everton|
|Koeman remaining positive after Stoke defeat|
|Magnificent Messi brings up 400 Barca goals|
|Nice 1 Paris Saint-Germain 3: Pastore double sends champions back to top|
|Leicester City 2 Swansea City 0: Hosts´ survival hopes boosted with third win in a row|
|Stoke City 2 Southampton 1: Adam strike snatches victory|
|Barcelona 2 Valencia 0: Suarez and Messi on target as leaders battle to win|
|Everton 1 Burnley 0: Mirallas sends visitors bottom|
|Crystal Palace 0 West Brom 2: Pulis makes winning return to Selhurst Park|
|Hoffenheim 0 Bayern Munich 2: Champions end difficult week with hard-earned win|
|Borussia Dortmund 3 Paderborn 0: Hosts respond to Klopp news with fine display|
|Inter have more to lose than Milan - Mancini|
|A-League Review: Victory on the cusp of premiership|
|Newcastle job hardest in football - Carver|
|Diego Lopez a doubt for Milan derby|
|Tevez agent hits out at Boca|
|Mourinho hails ´consistent´ Hazard|
|Arteta: New contract will take five minutes|
|Lopetegui dismisses Real link|
|Ancelotti has no plans to sign new goalkeeper|
|Blanc backs Cavani to respond|
|New York Red Bulls 2 San Jose Earthquakes 0: Hosts stay unbeaten|
|Marseille cannot win title - Bielsa|
|Mourinho feels for Pellegrini|