Nono's penalty miss for Real Betis gifted Sevilla a place in the UEFA Europa League last eight after a stunning second-leg comeback.
The visitors won 2-0 on the night to overturn Betis' first-leg lead and then held their nerve in the penalty shoot-out, winning 4-3 despite Vitolo missing their first kick.
Goals from Jose Antonio Reyes and Carlos Bacca either side of the break on Thursday inflicted Betis' first home defeat of the season in Europe and it was Sevilla who prevailed from 12 yards, as Alfred N'Diaye and Nono let Vitolo off the hook.
The result marked the first time Sevilla have overturned a first-leg home defeat in UEFA competition, leaving the hosts to focus on their battle for La Liga survival.
Having lost the first leg to goals from Leo Baptistao and Salva Sevilla, Unai Emery named a bold starting XI at Benito Villamarin, with Bacca and Kevin Gameiro starting together in attack.
With Betis sitting on the first-leg lead, the visitors were invited forward right from the start and they went close to finding the net in the 11th minute, but Gameiro narrowly failed to reach Bacca's low cross.
Sevilla attacked relentlessly in the opening stages and took a deserved lead 20 minutes in as Reyes slotted Alberto Moreno's left-wing delivery into the bottom-left corner.
Gabriel Calderon's Betis struggled to create any kind of momentum but will count themselves unfortunate not to have been awarded a penalty just after the half-hour mark, with the ball appearing to strike Diogo Figueiras on the arm.
Betis' aggregate lead was almost wiped out three minutes into the second period as Stephane M'Bia played a one-two with Gameiro before shooting straight at Adan from point-blank range.
After a nervous start to the second half, Betis started to show more attacking intent as Ruben Castro headed wide 55 minutes in, before Baptistao struck just wide from 25 yards less than a minute later.
Sevilla goalkeeper Beto kept his side in with a shout thanks to a crucial stop in the 64th minute, parrying Baptistao's half-volley after a clever chipped pass by Nono.
And the away side drew level on aggregate 15 minutes from time as Moreno exploited space down the left before drilling a low cross into the danger area for Bacca to knock past Adan unchallenged.
With the score level after 90 minutes, the match entered extra-time and Sevilla should have clinched the tie.
Adan pulled off an excellent stop when one-on-one with Gameiro, before palming away Bacca's headed effort on the rebound.
The Betis keeper saved from Vitolo to give the hosts the early edge in the shoot-out, but N'Diaye struck the post and Nono dragged wide to give Sevilla a place in the quarter-finals.
|Coach: G. Calderón|
for D. Perquis 15'
for Léo Baptistão 73'
for L. Reyes 90+2'
|Rivaldo backs Ronaldo to lead Portugal to international success|
|Tanzania 0 Nigeria 0: Oliseh indebted to debutant Ikeme|
|Rwanda 0 Ghana 1: Wakaso the hero for Grant´s men|
|Wales warn fans against pitch invasion|
|Republic of Ireland v Georgia: Given wary of confident Georgia|
|Northern Ireland v Hungary: History beckons for O´Neill´s men|
|Albania v Portugal: Winners will be all-but qualified|
|Scotland v Germany: Low expects smarting Scots to attack|
|France v Serbia: Deschamps eyes winning run|
|´Where are the stars of Manchester United?´ - Queiroz hits out at Moyes and Van Gaal|
|Sneijder demands improved display from Netherlands|
|Real Madrid make €1m pledge to help refugees|
|Ings: I can learn from ´fantastic´ Sturridge|
|Ozil: Scotland won´t stop us|
|Portugal will be better than France - Santos|
|Kruse: I am 100 per cent fit|
|Mexico 3 Trinidad and Tobago 3: Herrera the hero for Ferretti´s men|
|FFA expect Tajikistan match to go ahead despite Dushanbe violence|
|Panama 0 Uruguay 1: Stuani´s late header clinches win|
|CONCACAF World Cup Qualifying Review: Jamaica stunned, Canada win|
|Argentina 7 Bolivia 0: Aguero, Messi star in rout|
|Canada 3 Belize 0: Hosts dominate in Toronto|
|Chelsea ´warehousing´ players - PFA chief|
|United States 2 Peru 1: Altidore inspires hosts´ comeback|
|Argentina 7-0 Bolivia: Aguero, Messi & Lavezzi net doubles in rout|
|Del Bosque unmoved by calls for two strikers|
|Deschamps praise for beautiful France|
|Fekir ruptures knee ligaments|
|Italy v Bulgaria: Conte warns against complacency|
|Euro 2016 Qualifiers Review: Germany top Group D, Northern Ireland edge closer|
|Low: Three points most important|
|Northern Ireland on the verge of a ´magnificent achievement´ - O´Neill|
|Scotland need something against Germany - Strachan|
|Portugal 0 France 1: Late Valbuena set-piece clinches deserved win|
|Faroe Islands 1 Northern Ireland 3: O´Neill´s men edge closer|
|Germany 3 Poland 1: Gotze sends world champions top|
|Gibraltar 0 Republic of Ireland 4: Irish hopes reignited|
|Djibouti 0 Togo 2: Saintfiet´s side make it two wins from two|
|Cyprus v Belgium: Benteke boost for Wilmots´ men|
|Roma youngster faces lengthy lay-off|
|United hit back at Perez barb over De Gea saga|
|Georgia 1 Scotland 0: Strachan´s men succumb to Tbilisi hoodoo|
|Hodgson prepared to blood new players|
|Porto invite Euro elite to help raise millions for migrants|
|Dortmund legend Dede backs Tuchel to succeed|
|Robben out for four weeks|
|Turkey v Netherlands: Terim expecting hostile atmosphere for crunch clash|
|Portugal 0-1 France: Valbuena strikes late to sink Ronaldo & Co|
|Wales v Israel: Euro 2016 beckons for Coleman´s history boys|
|Gala: No extra payment for Grosskreutz|
|Increase Bundesliga´s TV rights or be left behind - Rummenigge|
|Kane: I´m no flash in the pan|
|Perez: United showed inexperience in De Gea saga|
|Milligan: Socceroos wary of Tajikistan|
|Conte wants more players like Pelle|
|OFC World Cup Qualifying Review: Samoa to meet Tahiti in next round|
|Krychowiak stayed at Sevilla because of Emery|
|I never considered Bayern exit - Gotze|
|Balotelli ´not in good condition´, Milan must improve - Mihajlovic|
|Robben slams ´stupid´ Martins Indi|
|Robben laments injury blow|
|Euro 2016 Qualifiers Review: Bale edges Wales closer, Iceland dent Netherlands´ qualification hopes|
|De Bruyne relieved to ´boss´ Bosnia-Herzegovina|
|Blind furious after nightmare debut|
|Coleman sees shades of Charles in Bale winner|
|Conte only concerned about Italy winning|
|Mauritania v South Africa: SAFA to investigate Masilela no-show|
|AFC World Cup Qualifying Review: Qatar hit 15 in Bhutan rout|
|Belgium 3 Bosnia-Herzegovina 1: De Bruyne shines in straightforward victory|
|Cyprus 0 Wales 1: Bale winner takes Wales one step closer|
|Netherlands 0 Iceland 1: Sigurdsson winner caps difficult first game for Blind|
|Italy 1 Malta 0: Pelle spares wasteful Azzurri|
|Balotelli stars in Milan friendly win|
|Bhutan thrashed 15-0 by Qatar in qualifier|
|Rwanda v Ghana: Gyan doubt gives hosts hope|
|Tanzania v Nigeria: Enyeama out of AFCON qualifier|
|Valdes and Berahino included in Premier League squads|
|Costa Rica v Brazil: Dunga´s men return after Copa disappointment|
|Spain v Slovakia: Azpilicueta eyeing important revenge|
|Adebayor left out of Tottenham squad list for league and Europe|
|San Marino v England: Place in history books beckons for Rooney|
|Germany can cope with Reus absence - Low|
|Bayern offer aid to refugees in ´training camp´|
|BREAKING NEWS: Welbeck ruled out for months after knee surgery|
|South Korea 8 Laos 0: Son leads the way in rout|
|Australia 5 Bangladesh 0: Socceroos surge to emphatic win|
|Japan 3 Cambodia 0: Hosts pick up first qualifying win|
|Rudiger aiming to nail down Euros spot after Roma move|
|Melo happy to join Inter at last|
|Hernandez thanks Ferguson after United departure|
|Chung: AFC has compromised FIFA election|
|Wales the new best of British|
|Reus out of Germany qualifiers|
|Chile v Paraguay: Vidal missing for Copa champions|
|Ghedin: Anything is possible for Malta|
|Pogba will be worth €100m - Marotta|
|England can win Euro 2016 - Hodgson tells players|
|Conte unsure over Balotelli future|
|Argentina - Bolivia Preview: Mascherano backs 'very special' Messi|
|Portugal - France Preview: Deschamps aiming to correct mistakes|