Valencia host Ludogorets on Thursday knowing that they already have one foot in the quarter-finals of the UEFA Europa League.
Juan Antonio Pizzi's men are in command of the last-16 tie heading into the second leg, following a 3-0 win over the Bulgarian outfit last Thursday in a game that saw both sides reduced to 10 men.
Seydou Keita was sent off for Valencia in the 24th minute, but Pizzi's side were still able to wrap up a comfortable victory as Federico Cartabia and Philippe Senderos added to Antonio Barragan's fifth-minute strike.
Forward Juninho Quixada was dismissed in the 80th minute for Ludogorets, who are now in need of a remarkable turnaround against a Valencia side in good form at home if they are to progress to the last eight.
The Spaniards have lost just one of their last 12 games in all competitions at the Mestalla and will be confident of keeping their hopes of winning the tournament alive.
Yet Valencia - who last won the competition in 2004 - do have their weaknesses.
Indeed, the win at Ludogorets in the opening leg was their first in four games and was immediately followed by a disappointing 1-0 La Liga defeat to Real Sociedad.
That setback left Valencia well adrift of the European spots in the Spanish top flight, and Pizzi's side will likely need to win the tournament in order to compete in it again next term.
Pizzi does not have any fresh injury worries to contend with, although a number of first-team players are still on the sidelines.
Keita is banned following his red card in Bulgaria, while captain Ricardo Costa is still unavailable with an ankle injury.
Winger Pablo Piatti (hamstring) and Oriol Romeu (knee) are yet to return to full fitness, but Jeremy Mathieu and Paco Alcacer are available after missing the loss to Sociedad through suspension.
Ludogorets will have to cope without Juninho following his indiscretion in the first leg, and midfielder Fabio Espinho is also banned.
The onus should be on top scorer Roman Bezjak to find the target and give the visitors hope after an outstanding season so far.
Bezjak has scored 17 goals in all competition this term, but crucially missed a penalty in the first leg after Keita had been given his marching orders for a clumsy foul on the Slovenian.
But even with Bezjak's presence victory appears highly improbable for Ludogorets against a team that Pizzi insists are determined to win the Europa League.
"We want to win the Europa League and we have a great advantage, more than we could have expected, but the tie isn't decided," Pizzi said.
"I don't call things until they're actually over. Our opponents will be driven to come back.
"We believe we can win this tournament and we'll try to show that in all our matches."
|Wenger criticism baffles Redknapp|
|Leicester must strengthen in window - Walsh|
|United not title contenders - Docherty|
|Koeman: Southampton youngsters will get a chance|
|Dyche empathises with Liverpool striker crisis|
|Cagliari turn to Zola|
|Rooney thanks Van Gaal for Christmas break|
|Cruzeiro offer Paulinho Tottenham exit chance|
|Carlisle´s wife grateful to Burnley|
|Katebe called up to Zambia AFCON squad|
|Cape Verde name AFCON squad|
|Finke names much-changed Cameroon squad|
|Grant omits World Cup troublemakers for AFCON|
|Blackpool striker Ranger goes AWOL|
|Allardyce relishing Mourinho meeting|
|Ashley fails to increase Rangers stake|
|Crystal Palace v Southampton: Koeman calls for focus|
|Warnock targeting striker in January|
|Chelsea v West Ham: Adrian vows visitors will attack|
|Heskey signs short-term deal at Bolton|
|Everton v Stoke City: Martinez eyes strong form|
|Juninho defends David Luiz|
|Burnley v Liverpool: Dyche defends Rodgers ahead of Turf Moor test|
|Arsenal v QPR: Wenger eyes festive momentum|
|Liverpool are growing in confidence, says Rodgers|
|Redknapp: Austin future could depend on survival|
|Martinez wants Everton consistency|
|Barca want Neymar until 2020, says agent|
|Jones undeterred by pressure of Liverpool starting role|
|Allardyce ´knows how to beat managers´ - Carroll|
|Jones playing for a new contract|
|China select Evergrande spine for Asian Cup|
|A-League Preview: Koren tips City to build|
|Khedira keen to fight for Real spot|
|Southampton confirm Elia deal|
|Cellino to remain as Leeds owner until after appeal|
|Manchester United v Newcastle United: Van Gaal demands domination|
|Van Gaal refuses to dismiss Bale speculation|
|Sunderland v Hull City: Bruce sure of Hull revival|
|Swansea City v Aston Villa: Lambert optimistic of away success|
|Agbonlahor red rescinded|
|Falcao depends on team-mates to perform - Van Gaal|
|Monk dismisses talk of Gomis move|
|West Brom v Manchester City: Pellegrini to experiment again|
|Xavi: I was ready for New York switch|
|Ibrahimovic fumes at awards snub|
|Irvine: No approaches for Berahino|
|Pearson determined to revive Leicester fortunes|
|League Two Preview: First host third as Wycombe meet Luton|
|League One Preview: Buoyant MK Dons eye more glory, Bristol City seek response|
|Championship Preview: Pritchard plotting to end Ipswich run, Bournemouth host Fulham|
|Kaboul place not guaranteed by captaincy - Pochettino|
|Koeman hopeful of Elia deal|
|Atletico president not ruling out Torres return|
|Swansea secure Oliveira signing|
|No excuses for Pellegrini|
|Walcott pace unaffected by injury|
|Former Real Madrid star Roberto Carlos backs Ronaldo for Ballon d´Or|
|Former PFA chairman Carlisle ´stable´ after serious incident|
|Balotelli remorse saved him from longer ban|
|Bayern midfielder Martinez ´on track´ with rehab|
|Pardew ´overjoyed´ at Gutierrez return|
|Spurs confirm Yedlin to join in January|
|Zeman sacked by Cagliari|
|Casillas: I´m going nowhere|
|Bruce demands McShane apology|
|Pulis would welcome Brighton talks|
|Buffon: Juve angry after Supercoppa loss|
|Arteta out until new year|
|Rangnick: Kampl deserves Dortmund switch|
|PFA offers support to Carlisle after serious incident|
|Napoli can mount title bid - Higuain|
|Cech´s agent urges Liverpool and Arsenal to make bid|
|Hart happy to be back to his best|
|Terry thrilled with ´revelation´ Matic|
|Perez rues ´unfair´ Tyne-Wear derby result|
|Khalfan Ibrahim returns from injury|
|Magath slams ´sensitive´ Fulham|
|´Limited´ attacking options inspire Postecoglou´s selections|
|Carlisle reportedly involved in serious incident|
|Primeira Liga Review: Braga leapfrog Guimaraes|
|Hughes upbeat despite Stoke defeat|