Neither Tottenham nor Arsenal will feel they can afford to lose the north London derby at White Hart Lane on Sunday.
Arsenal make the short trip to their closest rivals needing three points to ensure they do not lose further ground to Chelsea in the Premier League title race.
Arsene Wenger's side currently trail the leaders by seven points, albeit with a game in a hand, and know a loss this weekend could well represent a fatal blow to their challenge for top spot.
What is more, Wenger will be seeking a response after Arsenal exited the UEFA Champions League in midweek courtesy of a 3-1 aggregate defeat to holders Bayern Munich.
Tottenham head coach Tim Sherwood, meanwhile, has come under increasing pressure in recent days.
A heavy 4-0 loss to Chelsea in the Premier League was followed by a 3-1 reverse at home to Benfica in the UEFA Europa League last 16, a result that has severely hindered their hopes of reaching the quarter-finals.
Sherwood appears to have shown signs of feeling the strain, openly criticising his players in the wake of the Chelsea game and then saying Benfica counterpart Jorge Jesus "lacked class" after Thursday's match.
Securing qualification for next season's Champions League now appears a stiff ask for Tottenham, who still have work to do to ensure they reach the Europa League once again with Manchester United and Everton close behind in the league table.
Encouragingly for Sherwood, Arsenal have failed to win on their previous five league visits to White Hart Lane.
However, Arsenal have triumphed in each of the two meetings between the teams this season, winning the reverse league game 1-0 on September 1 prior to a 2-0 success in the third round of the FA Cup.
After Arsenal were defeated 1-0 by Stoke City in their last top-flight fixture, Wenger has warned his team they can have no more "weak moments" this season.
Referring to his side's poor recent form at Tottenham, he said: "We have played two draws and three losses there (in the last five meetings). It is a difficult ground to go to for everybody.
"After Stoke it was very important that we had a good result against Everton (winning 4-1 in the FA Cup), we had a good result even at Bayern (when drawing the second leg 1-1 in Germany), but (it remains important) that we continue and have no weak moments until the end of the season."
If history is anything to go by then Arsenal and Tottenham fans can expect plenty of action when the duo meet on Sunday.
The fixture has provided 125 goals in 43 Premier League encounters; only Liverpool versus Newcastle United has a higher tally with 126.
Arsenal will be without Germany international Mesut Ozil, who sustained a hamstring injury in the Bayern draw, while Aaron Ramsey misses out after suffering a setback in his recovery from a thigh problem.
Jack Wilshere (foot) also remains sidelined and Kieran Gibbs (calf) is doubtful, but Nacho Monreal (foot) returns and January loan signing Kim Kallstrom could make his long-awaited debut after returning to training following a back injury.
For Tottenham, full-back Kyle Walker and midfielder Sandro are both doubtful after coming off injured against Benfica, while Mousa Dembele (hamstring) could once more miss out.
Etienne Capoue (ankle), Vlad Chiriches (back) and Michael Dawson (hamstring) are also sidelined.
|Coach: T. Sherwood|
for Sandro 68'
for N. Chadli 68'
for C. Eriksen 82'
|Blatter formally submits bid to remain FIFA president|
|Puncheon predicts ´great times´ for Palace|
|Donadoni has no plans to leave Parma and criticises Cassano|
|Mangala: My first season at City could have been better|
|UAE v Iraq: Rare podium finish on offer|
|Ryan spurred on by Australia´s 2011 heartbreak|
|Montella will not sell Cuadrado cheap|
|Mali, Guinea furious with tie-breaking procedure|
|Luis Enrique defends Neymar´s behaviour|
|Gabi: Referee lacked personality|
|Chile 3 USA 2: Gonzalez´s brace extends Americans´ pain|
|Franjic cleared of serious injury|
|Our progression was deserved - Pochettino|
|Ivory Coast´s tournament starts now - Renard|
|Allegri rejects Juve criticism|
|Atletico´s Arda Turan escapes red card after throwing boot at assistant referee|
|Atletico Madrid 2 Barcelona 3 (agg 2-4): Neymar double secures semi-final spot|
|Parma 0 Juventus 1: Morata late show wins it for visitors|
|Sheffield United 2 Tottenham 2 (agg 2-3): Pochettino books Wembley final|
|Ecuador dismiss Vizuete|
|Championship Preview: Middlesbrough out to continue run, Bournemouth seek response|
|Guinea 1 Mali 1: Lots to decide Group D runners-up|
|Cameroon 0 Ivory Coast 1: Gradel strike sends Renard´s men through|
|Lots to be drawn to decide AFCON qualifiers|
|Eredivisie Preview: De Boer warning for Ajax, leaders PSV host Willem II|
|Bundesliga Preview: Leaders Bayern and Wolfsburg kick off Ruckrunde|
|Howard boost for Everton|
|Ligue 1 Preview: Jardim plays down Monaco title hopes ahead of Lyon showdown|
|Costa charged by FA for alleged Can stamp|
|O´Keefe joins Cardiff|
|Dons teenager Alli in demand|
|Gabriel seals Arsenal switch|
|Wolfsburg v Bayern Munich: Guardiola eyes ´big step´ to Bundesliga title|
|Paris Saint-Germain v Rennes: Montanier seeks another upset in French capital|
|Martinez rules out panic buys|
|Gilardino targets Fiorentina goals|
|Milan agree Bocchetti loan|
|League Two Preview: Cambridge and Luton prepare to renew rivalries|
|Ronaldo hit with two-match ban|
|West Brom complete McManaman deal|
|Sullivan hits back in Sakho row|
|Richards: Cuadrado suited to Premier League|
|Figo to challenge for FIFA presidency|
|Inzaghi out to freshen up struggling Milan|
|Wigan agree a fee for Mckay|
|Carver eyes strong finish|
|Bowen cools talk of Stoke swoop for Sandro and Traore|
|Lazio-bound Morrison lands in Rome|
|Mourinho fined £25k for ´campaign´ claims|
|Mainz bring in Castillo|
|Villa: Lambert will not be sacked|
|Monk hopeful of adding new faces|
|Sainsbury ready to replace Franjic|
|Beckenbauer hopeful of Guardiola stay|
|Mourinho hits back at Costa critics|
|Rodriguez grateful for ´fundamental´ Ronaldo support|
|La Liga Preview: Real want revenge against Socieded|
|No Dallas move for Essien|
|Bale rubbishes United link, Ronaldo rift|
|Sahin in ´good shape´ for Bundesliga resumption|
|Rodgers slams Costa´s stamp collection|
|Under-fire Inzaghi urges patience|
|Rodgers: Courtois saved Chelsea|
|Mashaba wants lessons to be learnt after AFCON exit|
|Mourinho refuses to wade into Costa incidents after Chelsea win|
|Football League Review: Bent double sends Derby second, Rotherham triumph|
|Chelsea 1 Liverpool 0 (aet, agg 2-1): Ivanovic settles action-packed League Cup semi-final|
|Milan 0 Lazio 1: Inzaghi future plunged into further doubt|
|Neymar dreaming of ending Brazil´s home hoodoo|
|South Africa 1 Ghana 2: Late Ayew winner seals qualification|
|Senegal 0 Algeria 2: Mahrez and Bentaleb dump Senegal out|
|Bocchetti poised to join Milan on loan|
|De Rossi suffers calf injury|
|Montano accuses Oldham of double standards after Evans saga|
|Bojan out for the season with ruptured cruciate|
|Cameroon v Ivory Coast: Renard defends Yaya Toure|
|Yanga-Mbiwa makes Roma move permanent|
|Guinea v Mali: Quarter-final berth on offer in Mongomo|
|Thohir: Inter not reliant on European football|
|Bremen land Vestergaard|
|Allegri refuses to rule out Cassano move|
|Mexes handed four-game ban after Lazio dismissal|
|Joyce reveals Valdes´ inspirational team-talk|
|CAF announces AFCON venue switches|
|Alcacer commits future to Valencia|
|Postecoglou calls for Aussie ´energy´|
|Everton confirm Eto´o departure to Sampdoria|
|Pochettino to stick with Vorm despite cup error|
|Barcelona are not favourites against Atletico, says Luis Enrique|
|Allegri wary of Parma backlash in Coppa Italia|
|Zidane urges Real to tie Ancelotti down|
|FIFPro: Transfer system failing football|
|Anderlecht condemn Standard´s Defour banner|
|Australia 2 UAE 0: Socceroos ease into home final|
|Barca overhaul youth system|
|FIFPro demands clubs respect contractual obligations|
|Mahmoud targeting World Cup place with Iraq|
|Fabregas wants Chelsea to show winning mentality|
|Rangers borrow £10m from Ashley´s Sports Direct|
|Lyon face anxious wait over Lacazette|
|Undermanned Lazio recall Perea|
|Ki wants South Korea to prove their superiority|
|Ghana´s Gyan wary of South Africa|
|Mashaba urges South Africa to attack|
|Benitez: Napoli deserved to win|
|Pacos de Ferreira 1 Benfica 0: Leaders fail from the spot|
|Serie A Review: Higuain at the double in controversial Napoli win, Udinese see off Empoli|