Manchester United manager David Moyes has described Sunday's clash with rivals Liverpool as "the biggest game in the Premier League".
As in recent seasons, the fixture does not pit two title rivals against one another, although this time around it is United who have struggled to keep pace at the top rather than their Merseyside visitors.
Due to Moyes' rocky first season in charge, it could be argued his side will be underdogs at Old Trafford this weekend.
Brendan Rodgers' charges have taken 23 points from a possible 27 since the turn of the year and are in the title reckoning thanks, in part, to the fearsome strike duo of Daniel Sturridge and Luis Suarez who have helped Liverpool net 73 league goals this season.
While Liverpool have not won at Old Trafford in their last six attempts in all competitions, Moyes acknowledged on Friday that United could have their work cut out, even on home turf.
"I think it's the biggest game in the Premier League. There has been great history between the two clubs over a long period," he said.
"(Winning on Sunday) would be a big boost. It would be an important three points.
"Their league position suggests they're ahead of us and they possibly do come here as favourites."
While Liverpool require a win to maintain title momentum, three points for the champions would merely serve to keep their faint hopes of UEFA Champions League football alive.
Indeed, the UEFA Europa League looks a more realistic proposition, although even that is not a guarantee in a season that has seen United beaten eight times in the top flight.
They sit five points behind fifth-place Spurs, having played a game less, with Sunday's fixture the first of five in two weeks for Moyes' men.
On Wednesday, they will seek to turn around a two-goal first-leg deficit against Olympiacos in the UEFA Champions League last 16 before facing West Ham and Aston Villa either side of a mouthwatering clash with local rivals Manchester City the following Tuesday.
Rodgers will hope Sturridge can add to his 18 Premier League goals and put a further dent in United's season, but the England international feels the result at Old Trafford is not make or break.
"We have got big games regardless of the Manchester United result, of course we want to do as well as we can in every single game and get maximum points if we can but it is important we keep playing the football we do," he told the club's official website.
"I don't think winning at the weekend is going to change anything in regards to the title race."
Moyes was handed a boost in midweek with Nani's return to training from a hamstring injury while Rafael (ankle), Javier Hernandez (knee) and Jonny Evans (calf) could all return for Sunday's clash.
Rodgers too has been boosted after Lucas Leiva (knee) and Mamadou Sakho (tendon tear) returned to contention following spells on the sidelines.
|15||N. Vidić||71' 77'|
|20||R. van Persie|
|Coach: D. Moyes|
for A. Januzaj 76'
for M. Fellaini 76'
for Mata 87'
|Puel pleased with ´good point´ in Israel|
|Mourinho not ´over the moon´ with United wins|
|Southampton investigating Eric Black allegations|
|Rodgers: Celtic would challenge at the top in England|
|Ibrahimovic expects more from United|
|Manchester United 1 Zorya 0: Ibrahimovic header earns Mourinho´s men narrow win|
|De Boer blasts Inter for lack of focus|
|Zarate reveals message to ill wife after goalscoring return|
|Raffael suffers fresh injury setback|
|Hapoel Be´er Sheva 0 Southampton 0: Saints´ winning run comes to an end|
|Sparta Prague 3 Inter 1: De Boer´s side humbled in Europa League again|
|Police to review corruption allegations after Telegraph sting|
|Brady hails Wenger as ´possibly the best ever´ Gunners boss|
|Yacob signs new West Brom deal|
|Guidolin prioritising Swansea improvement over his future|
|Sakho outburst has been dealt with – Klopp|
|Bilic sorry for Allardyce in ´very sad´ week for English football|
|Laporte saga nears conclusion as defender earns France call-up|
|Everton are exceeding expectations – Koeman|
|Wenger could be tempted by an international offer, says ex-assistant|
|No excuses for Liverpool this time, says Klopp|
|Rashford left out of England Under-21 squad|
|Boro must pick up where they left off - Karanka|
|Matuidi could still join Juventus, says Raiola|
|Pardew anticipates battle of the Belgians|
|Legia Warsaw to face Real Madrid behind closed doors|
|England job would be the pinnacle - Pardew|
|Wright sacked by Barnsley|
|Bilic defends West Ham team night out|
|Ramsey withdrawal was Arsenal´s call - Coleman|
|LMA demand ´immediate full disclosure´ of corruption evidence|
|´My answer would be a big fat no´ - Coleman rules out taking England job|
|Leeds dismiss Cellino sting as ´non-story´|
|Gabigol, Rashford and Sanches among Golden Boy nominees|
|Keane slams Arsenal: Half their players will have gloves on soon|
|´Special´ Man City draw a career highlight, says Gordon|
|Southgate admits England situation is ´not ideal´|
|England should have gone for O´Neill, says Shilton|
|PSG´s powers of recovery impress Cavani|
|Howe ´absolutely committed´ to Bournemouth amid England links|
|Man City proved character against Celtic, says Zabaleta|
|Walcott: Sanchez partnership bodes well for Arsenal´s season|
|MLS Review: DC, Impact on track for play-offs|
|CONCACAF Champions League Review: Tigres, Dallas left waiting|
|Central Sanchez pleases Wenger|
|Barca felt Messi absence - Busquets|
|Martino knew Messi would come out of retirement|
|Shilton never convinced by Allardyce|
|Degenek replaced by Giannou for Socceroos|
|Griezmann will still take penalties - Simeone|
|Simeone proud of ´one of the best´ wins|
|Godin suffers sprained ankle ligament|
|West Ham receive positive news over injured duo|
|Robson: Four wins for Southgate and he´s an England contender|
|Gunes rues Besiktas´ inability to see off Dynamo|
|Sarri: Late goals leave bitter taste|
|Borussia Monchengladbach were exceptional against Barcelona, feels Schubert|
|PSG must be patient, says Emery|
|Celtic are lucky to have Dembele - Rodgers|
|I´m completely focused on Arsenal, insists Wenger amid England talk|
|Hasselbaink denies wrongdoing amid impropriety allegations|
|Ancelotti frustrated by slow, toothless Bayern|
|Barcelona deserved their win - Luis Enrique|
|I want Celtic atmosphere at City – Guardiola|
|Rebrov defends Yarmolenko after ´difficult´ match|
|Rostov draw is two points dropped for PSV, says De Jong|
|Torres eyeing ´magical´ year for Atletico|
|Celtic 3 Manchester City 3: Dembele at the double in six-goal thriller|
|Celtic 3 Manchester City 3: Dembele at the double in six-goal thriller|
|Rostov 2 PSV 2: Propper´s penalty miss costs visitors|
|Besiktas 1 Dynamo Kiev 1: Tsygankov stuns wasteful Turks|
|Napoli 4 Benfica 2: Mertens bags two as Napoli run riot|
|Arsenal 2 Basel 0: Walcott´s capital gains tax Swiss visitors|
|Borussia Monchengladbach 1 Barcelona 2: Pique grabs the winner|
|Atletico Madrid 1 Bayern Munich 0: Carrasco gives Ancelotti first taste of defeat|
|Ludogorets 1 Paris Saint-Germain 3: Cavani inspires comeback win|
|Premier League, FA and EFL to investigate transfer allegations|
|Vardy reveals matchday energy drink and port routine|
|Everton coping without Stones, says Jagielka|
|Sacked Jemez admits to ´great sadness´ at Granada exit after worst start in over 70 years|
|Wenger has so much to offer English football - Schmeichel|
|No truth to England rumours, says Klinsmann|
|Spalletti demands end to damaging Roma ´games´|
|De Boer: Brozovic was punished and forgiven|
|Allardyce paid price for lack of privacy - McClaren|
|Milik can match Lewandowski - Reina|
|LMA ´extremely concerned´ about manager bribe allegations|
|Iwobi: I nearly left Arsenal|
|Mata has found a ´natural habitat´ at United|
|Higuain slowly approaching top form|
|´Stupid´ Allardyce driven by money - Dyke|
|Wijnaldum vows to improve|
|Renato Sanches needs time at Bayern - Hitzfeld|
|Ibrahimovic nurturing United talent - Lingard|
|Mourinho feels sorry for Allardyce|
|United boss primed for ´must-win´ Europa League tie|
|Mourinho keen to protect under-fire Rooney|
|Jeonbuk Motors 4 Seoul 1: Leonardo brace puts hosts in the driving seat|
|Maloney returns to Scotland squad|
|Van Persie: Kids will decide my future|
|Entrapment won on this occasion - Allardyce|
|Ibra-Rashford pairing the answer for United - Neville|
|Tevez hints at imminent retirement|
|England in safe hands with Southgate - Glenn|
|Holman talks up A-League quality|
|CONCACAF Champions League Review: Red Bulls progress, Timbers win|
|Januzaj blow for Sunderland|
|Navas accepts blame for Dortmund equaliser|
|Sporting assistant Raul Jose pleased with win|
|Nuno left to regret slow start as Porto fail on English soil again|
|Vardy rejected Arsenal due to style|
|Simeone: I am not Griezmann´s mentor|
|Schmidt bemoans ´brutal´ Monaco equaliser|
|Ranieri doesn´t trust bookies over England job|
|Genesio worried wastefulness will cost Lyon in long run|
|Preud´homme admits Champions League too much for Club Brugge|
|Telegraph passes findings to FA after further corruption claims|
|Zidane: Draw difficult to accept|