Real Betis beat Sevilla 2-0 in the first Seville derby in UEFA competition to seize the upper hand in their Europa League last-16 tie.
For Betis, the Europa League offers momentary respite from a domestic relegation battle and La Liga's basement club looked to be relishing the stage as they took a 15th-minute lead at Estadio Ramon Sanchez Pizjuan.
Atletico Madrid-owned forward Leo Baptistao headed in an inviting cross from Juanfran, but the hosts generally controlled the remainder of the first period, with goalkeeper Antonio Adan keeping Betis ahead.
Sevilla dominated proceedings after the break but still struggled to find a way past Adan, and Baptistao wasted a glorious chance to double Betis' lead in the 54th minute.
A few moments after Kevin Gameiro had headed over from close range, Salva Sevilla netted against his former side to secure only Betis' third win at their bitter rivals since 1996.
Most of the build-up to the fixture focused on Betis' last two trips to Sevilla - in which they conceded a total of nine goals - and the visitors almost suffered a nightmare start.
Just 17 seconds in, Carlos Bacca burst past Jordi Figueras and into the penalty area, but his left-footed effort was saved by the feet of Adan.
The visitors capitalised on that let-off and took the lead after quarter of an hour. Baptistao produced an expertly timed run to get in front of Federico Fazio at the near post to power home a header from Juanfran's right-wing cross.
Sevilla nearly hit back five minutes later as Ivan Rakitic picked out Bacca with a precise lofted pass into the area, but Adan denied the Colombian again, palming his header away.
Both sides spurned glorious chances within one minute just after the hour mark as Cedrick saw his header well saved by Beto, before Vitolo poked Jose Antonio Reyes' cross agonisingly wide.
Betis should have doubled their lead in the 54th minute as Baptistao pounced on Fernando Navarro's slip before shooting straight at Beto.
Half-time substitute Gameiro nearly restored parity two minutes later after a clever turn in the area, but his effort went narrowly wide of the bottom-right corner.
With Sevilla pressing for an equaliser, Betis looked threatening on the break and a last-ditch tackle by Fazio prevented Baptistao from doubling his tally, before Gameiro headed over an open goal from just a few yards out.
Salva silenced the home fans with just over 10 minutes left as he turned on the edge of the Sevilla area before rifling an unstoppable shot past Beto, rounding off an historic win for Betis.
|19||José Antonio Reyes|
|Coach: Unai Emery|
for Coke 46'
for S. Cristóforo 46'
for Vitolo 66'
|Klopp delighted by Liverpool display|
|Youthful Atletico suffer defeat to Melbourne Victory|
|Paris Saint-Germain 4 Leicester City 0: French champions impress|
|Origi confident of big season|
|LAFC´s Hollywood co-owner Will Ferrell hopes MLS can match Europe|
|Liverpool 2 AC Milan 0: Origi stars for Klopp´s men|
|Lamela not listening to Tottenham exit rumours|
|Green: Scoring goals is my job|
|Mancini: Icardi is Inter´s captain|
|Lucescu: Witsel wants to leave|
|Balotelli unwanted by Besiktas coach|
|Conte: Chelsea will struggle again if there´s no improvement|
|Rashford wants to learn from Ibrahimovic|
|NYC star Lampard revels in historic hat-trick|
|Milner willing to cover at full-back|
|Gameiro: Griezmann and I will score lots of goals|
|Wenger: I won´t buy for the sake of it|
|Inter 1 Bayern Munich 4: Hat-trick hero Green enjoys happy homecoming|
|Ibrahimovic keen for ´interesting´ Pogba deal|
|Conte unsure over Costa´s Chelsea future|
|Zidane: Morata will remain a Madrid player|
|Sergi Roberto ´more than a player´ - Luis Enrique|
|New York City 5 Colorado Rapids 1: Lampard hits hat-trick in MLS rout|
|Mourinho hints at United future for Mata and Fellaini|
|Real Madrid 3 Chelsea 2: Hazard show too late for Blues|
|Penalty woes for Everton, Gray treble inspires Burnley at Ibrox|
|Atleti to present Gameiro on Sunday|
|Ibrahimovic nets debut goal as United put five past Galatasaray|
|Barcelona 3 Celtic 1: Messi, Suarez in action as Catalans cruise to victory|
|WATCH: Zlatan open his Man Utd account with acrobatic goal|
|Alba: It would be foolish not to respect Ronaldo, but Messi on another level|
|Lahm hails ´sensational guy´ Schweinsteiger following Germany retirement|
|Stones´ professionalism praised amid City reports|
|Roma suffer Rui blow|
|Inter complete Ansaldi move|
|Nainggolan confident of Roma challenge despite Juve investment|
|Rummenigge tells off Ribery over Guardiola dig|
|Meli makes Sporting loan switch|
|No repeat of slow start, vows Allegri|
|Mourinho desperately wanted Embolo at Manchester United, claims Heidel|
|Dembele can do anything - Tuchel|
|Pogba arrival would boost Rooney - Yorke|
|Ben Yedder makes Sevilla move|
|De Jong signs PSV renewal until 2020|
|Kovacic to fight for his place at Real Madrid|
|Sturridge out to improve goals-per-game ratio|
|Mourinho hails ´humble´ Ibrahimovic ahead of United debut|
|Schweinsteiger will not leave Manchester United for Bundesliga return - Rummenigge|
|Benatia on target again in Juve win|
|Atletico set to sign Gameiro|
|Zenga appointed Wolves boss|
|Flattered Verratti not seeking Madrid move|
|Ancelotti: Growing transfer fees nothing special|
|Eriksson: Ibrahimovic and Mourinho combo enough to win Premier League|
|Meunier: I could not reject PSG|
|Klopp: I didn´t want Mkhitaryan|
|Anything could happen before transfer window shuts - Zidane|
|Montoya leaves Barca base, nears Valencia switch|
|Wijnaldum: I´m happy to play anywhere|
|Klopp backs Mignolet after Karius injury|
|Liverpool suffer Karius injury blow|
|Ranieri confident Mahrez will stay as contract talks continue|
|Emery confirms interest in Jese|
|Higuain´s Juventus move not about money - agent|
|Wolves sack head coach Jackett|
|Zidane: Ronaldo unlikely to play Madrid La Liga opener|
|Ibrahimovic: United fans are waiting for me|
|Deulofeu shines for Everton, Cook opens Bournemouth account|
|Higuain out to emulate Del Piero|
|Kante does his talking on the pitch - Conte|
|Mourinho explains Fosu-Mensah snub|
|Klopp: No more unwanted players at Liverpool|
|Inter want more than €60m for Icardi - Thohir|
|Leicester can replace Kante - Ranieri|
|Lazio complete Wallace signing|
|Gueye set to join Everton, confirms Di Matteo|
|Tuchel: Transfer market has gone cash crazy|
|Leicester hand King new four-year deal|
|No deal done for Pogba, says Raiola|
|Rooney: Mourinho impact already huge|
|Lafferty hit with FA betting charge|
|Top-four finish never enough for Arsenal, insists Wenger|
|Partey hoping to make his mark on Atletico squad|
|Ibrahimovic in, Schweinsteiger out as United head for Galatasaray friendly|
|Vietto set for Sevilla after completing medical|
|I rejected Besiktas to fight for Barcelona spot, reveals Mathieu|
|De Laurentiis fumes at Higuain´s ´lack of respect´|
|Promising Janssen boosts Tottenham´s title hopes|
|Besiktas sign Adriano on three-year contract|
|Tottenham 0 Atletico Madrid 1: Godin grabs the winner|
|Gomis completes Marseille loan move|
|Iniesta surprised at Casillas-Del Bosque spat|
|New Juve signings do not guarantee success - Allegri|
|New Juve signings do not guarantee success - Allegri|
|Middlesbrough snap up goalkeeper Guzan|
|Guardiola still loves Ribery despite jibes|
|West Ham worry over Tore injury|
|Serie A could be another one-horse race, says Eriksson|
|Schweinsteiger retires from Germany duty|
|Iniesta welcomes Barca´s midfield competition|
|Drogba: No luck in Arsenal scoring record|
|Wenger seeks ´experienced´ striker to bolster Arsenal attack|
|Eriksson and Shanghai SIPG still fighting|
|MLS All-Stars 1 Arsenal 2: Premier League giants win late as Xhaka makes debut|
|Conte: I want aggression and intensity|
|Wimmer backs physical Janssen for Tottenham success|
|Klopp: I wouldn´t spend £100m on one player|