Valencia took a huge step towards the UEFA Europa League quarter-finals with a 3-0 away win over unfancied Ludogorets.
The Bulgarian side went into the tie with confidence after beating Lazio to reach the last 16 for the first time, but their Spanish visitors got off to a flyer and overcame having to play more than half of the game with 10 men.
Right-back Antonio Barragan fired Valencia into the lead after only five minutes as he blasted a low half-volley past the helpless Vladislav Stoyanov for his first goal since November 2010.
Ludogorets were given a great chance to restore parity with a penalty as Seydou Keita received a straight red card, but Diego Alves palmed Roman Bezjak's 26th-minute effort away and Fede Cartabia grabbed Valencia's second soon after.
Philippe Senderos headed in a third with 31 minutes to go, before Juninho Quixada was dismissed to compound the misery for a Ludogorets side suffering their first Europa League defeat of the season.
Valencia coach Juan Antonio Pizzi spent the build-up to the game talking up his side's chances of winning the competition and they got off to a perfect start in Sofia, over 300 kilometres from Ludogorets' usual Razgrad home.
The hosts partially cleared Eduardo Vargas' free-kick from the left, but Barragan latched on to the loose ball on the edge of the area and drilled a low half-volley into the bottom-left corner.
Ludogorets were handed a lifeline 24 minutes in as Keita was controversially sent off for clumsily denying Bezjak a goal-scoring opportunity in the area, but Alves - a goalkeeper boasting an excellent record when it comes to saving penalties - kept out the subsequent spot-kick.
Valencia narrowly escaped again just after the half-hour mark as Virgil Misidjan hit the post after cutting in from the left, and Pizzi's men capitalised by doubling their lead almost immediately despite Ludogorets' numerical advantage.
Alcacer saw his chipped pass deflect into the area and Cartabia met it with a first-time volley, directing the ball into the bottom-right corner.
Ludogorets finished the half well as Marcelinho and Misidjan both went close from outside the area.
Stoycho Stoev's men also began the second period in determined fashion, putting Valencia under intense pressure, but the La Liga side defended well and restricted Ludogorets to long-range efforts before putting the tie beyond all doubt.
Vargas headed a corner from Cartabia back across the face of goal and Senderos was left unmarked to nod the ball into the bottom-right corner.
Ludogorets' day got even worse with 10 minutes to go as Quixada picked up a red card for seemingly kicking out at the theatrical Joao Pereira, allowing Valencia to see out the closing stages with consummate ease.
|Coach: S. Stoev|
for A. Barthe 46'
for T. Mäntylä 62'
for R. Bezjak 73'
|Canada 3 Belize 0: Hosts dominate in Toronto|
|Chelsea ´warehousing´ players - PFA chief|
|United States 2 Peru 1: Altidore inspires hosts´ comeback|
|Del Bosque unmoved by calls for two strikers|
|Deschamps praise for beautiful France|
|Fekir ruptures knee ligaments|
|Italy v Bulgaria: Conte warns against complacency|
|Euro 2016 Qualifiers Review: Germany top Group D, Northern Ireland edge closer|
|Low: Three points most important|
|Northern Ireland on the verge of a ´magnificent achievement´ - O´Neill|
|Scotland need something against Germany - Strachan|
|Portugal 0 France 1: Late Valbuena set-piece clinches deserved win|
|Faroe Islands 1 Northern Ireland 3: O´Neill´s men edge closer|
|Germany 3 Poland 1: Gotze sends world champions top|
|Gibraltar 0 Republic of Ireland 4: Irish hopes reignited|
|Djibouti 0 Togo 2: Saintfiet´s side make it two wins from two|
|Cyprus v Belgium: Benteke boost for Wilmots´ men|
|Roma youngster faces lengthy lay-off|
|United hit back at Perez barb over De Gea saga|
|Georgia 1 Scotland 0: Strachan´s men succumb to Tbilisi hoodoo|
|Hodgson prepared to blood new players|
|Porto invite Euro elite to help raise millions for migrants|
|Dortmund legend Dede backs Tuchel to succeed|
|Robben out for four weeks|
|Turkey v Netherlands: Terim expecting hostile atmosphere for crunch clash|
|Portugal 0-1 France: Valbuena strikes late to sink Ronaldo & Co|
|Wales v Israel: Euro 2016 beckons for Coleman´s history boys|
|Gala: No extra payment for Grosskreutz|
|Increase Bundesliga´s TV rights or be left behind - Rummenigge|
|Kane: I´m no flash in the pan|
|Perez: United showed inexperience in De Gea saga|
|Milligan: Socceroos wary of Tajikistan|
|Conte wants more players like Pelle|
|OFC World Cup Qualifying Review: Samoa to meet Tahiti in next round|
|Krychowiak stayed at Sevilla because of Emery|
|I never considered Bayern exit - Gotze|
|Balotelli ´not in good condition´, Milan must improve - Mihajlovic|
|Robben slams ´stupid´ Martins Indi|
|Robben laments injury blow|
|Euro 2016 Qualifiers Review: Bale edges Wales closer, Iceland dent Netherlands´ qualification hopes|
|De Bruyne relieved to ´boss´ Bosnia-Herzegovina|
|Blind furious after nightmare debut|
|Coleman sees shades of Charles in Bale winner|
|Conte only concerned about Italy winning|
|Mauritania v South Africa: SAFA to investigate Masilela no-show|
|AFC World Cup Qualifying Review: Qatar hit 15 in Bhutan rout|
|Belgium 3 Bosnia-Herzegovina 1: De Bruyne shines in straightforward victory|
|Cyprus 0 Wales 1: Bale winner takes Wales one step closer|
|Netherlands 0 Iceland 1: Sigurdsson winner caps difficult first game for Blind|
|Italy 1 Malta 0: Pelle spares wasteful Azzurri|
|Balotelli stars in Milan friendly win|
|Bhutan thrashed 15-0 by Qatar in qualifier|
|Rwanda v Ghana: Gyan doubt gives hosts hope|
|Tanzania v Nigeria: Enyeama out of AFCON qualifier|
|Valdes and Berahino included in Premier League squads|
|Costa Rica v Brazil: Dunga´s men return after Copa disappointment|
|Spain v Slovakia: Azpilicueta eyeing important revenge|
|Adebayor left out of Tottenham squad list for league and Europe|
|San Marino v England: Place in history books beckons for Rooney|
|Germany can cope with Reus absence - Low|
|Bayern offer aid to refugees in ´training camp´|
|BREAKING NEWS: Welbeck ruled out for months after knee surgery|
|South Korea 8 Laos 0: Son leads the way in rout|
|Australia 5 Bangladesh 0: Socceroos surge to emphatic win|
|Japan 3 Cambodia 0: Hosts pick up first qualifying win|
|Rudiger aiming to nail down Euros spot after Roma move|
|Melo happy to join Inter at last|
|Hernandez thanks Ferguson after United departure|
|Chung: AFC has compromised FIFA election|
|Wales the new best of British|
|Reus out of Germany qualifiers|
|Chile v Paraguay: Vidal missing for Copa champions|
|Ghedin: Anything is possible for Malta|
|Pogba will be worth €100m - Marotta|
|England can win Euro 2016 - Hodgson tells players|
|Conte unsure over Balotelli future|
|Argentina - Bolivia Preview: Mascherano backs 'very special' Messi|
|Portugal - France Preview: Deschamps aiming to correct mistakes|