Malaga will look to last season's shock win over Real Madrid as they seek to end the leaders' 17-match unbeaten run in La Liga.
The Andalusian club ran out 3-2 winners when the sides met at La Rosaleda in December 2012 - Malaga's first triumph over Real since being promoted back to the top flight in 1999.
Real dished out a 6-2 hammering in the return fixture, when Malaga finished with nine men, and also claimed a 2-0 win in this season's meeting at the Santiago Bernabeu.
But Malaga, who have risen to 13th after a three-match unbeaten run, will be hoping for more home comforts on Saturday.
The task faced by Bernd Schuster's side is undoubtedly a tough one, with Carlo Ancelotti's charges sitting three points clear at the summit, having scored 15 goals in the last five league games.
While title rivals Atletico Madrid and Barcelona have both fallen to defeats in recent weeks, Real have continued their relentless push for a 33rd league title and look well placed with 11 games remaining.
The front three of Cristiano Ronaldo, Karim Benzema and Gareth Bale have been impressive in the last five games, contributing eight goals, and Ancelotti will once again look to them to get the job done.
Real travel south to face a Malaga side who remain embroiled in a relegation scrap, with just a three-point buffer over the bottom three.
Under Manuel Pellegrini they reached the quarter-finals of the UEFA Champions League last season, but the loss of key players and a lack of investment has seen them battling in the bottom half of the table this term.
Monday's 2-0 victory at Osasuna was only Malaga's second this year, and goals have been hard to come by, too; just seven have been scored in their last 10 matches.
Sergio Ramos will miss the trip as he serves a one-match suspension following his booking against Levante, so Pepe is expected to partner Raphael Varane at the heart of the defence, while knee injuries continue to keep Alvaro Arbeloa and Sami Khedira out.
The hosts also have suspensions to contend with as Jesus Gamez and Sergi Darder are currently banned, and the absences of Eliseu (virus), Mounir El Hamdaoui (knee) and Weligton (muscular) only add to Schuster's problems.
Angel Di Maria and Ronaldo were on target when Real beat Malaga on home soil in October.
|9||R. Santa Cruz|
|Coach: B. Schuster|
for F. Tissone 68'
for Samu 68'
for M. Angeleri 86'
|MLS Review: Sounders go top in West, Timbers and Galaxy win|
|AFC stands by Blatter|
|Matheus ´alright´ after collapse - Markevych|
|Copa Libertadores Review: River, Inter through to semis|
|Signing Toni a ´long shot´ for Adelaide|
|Ramsey good enough for Barca - Coleman|
|Bacuna pushing for Benteke stay|
|Evans stunner settles City friendly in Toronto|
|Banega: Emery a great coach|
|Emery tight-lipped on Sevilla future|
|Argentina finalise Copa America squad|
|Nike issues statement following arrest of FIFA officials|
|Hero Bacca grateful for Europa League triumph|
|Markevych rues defensive errors in Dnipro defeat|
|AFC Champions League Review: Naft Tehran fairytale continues|
|Emery: We deserved Europa League success|
|Dnipro 2 Sevilla 3: Bacca brace sees holders make history|
|South Africa 0 Malawi 0 (4-5 on penalties): Harawa heroics send Bafana Bafana out|
|CONCACAF and CONMEBOL respond to arrests in FIFA scandal|
|FIFA president Blatter welcomes investigations as corruption probe rocks world football|
|UEFA calls for FIFA elections to be postponed|
|BREAKING NEWS: Advocaat exits Sunderland and retires from club management|
|La Liga: Real Madrid season review - Ancelotti pays the price for disappointing season|
|Zambia 3 Ghana 0: First-half spree does the damage|
|Barnes suffers double knee ligament injury|
|Balotelli to stay at Liverpool - agent|
|Kane at the double in friendly win|
|Norwich make Dorrans switch permanent|
|Ings unsure of next move|
|Bournemouth snap up Federici|
|FIFA ´crisis´ cannot continue - Prince Ali|
|Barton headlines QPR exits|
|Juan demands more from Inter|
|Stoke snap up Haugaard|
|Subotic commits to Dortmund|
|Warner pleads innocence after US indictment|
|Napoli to refuse questions on Benitez´s future|
|USDoJ names indicted FIFA officials|
|Wenger coy over Vidal and Benzema moves|
|Suarez back in training ahead of Copa final|
|Pique: I´ll retire at Barca|
|Gerrard ´blown away´ by Liverpool send-off|
|FIFA ´very happy´ with Zurich arrests|
|Liverpool defender Toure targeting trophies|
|Ramsey eyeing title assault|
|Welbeck out of FA Cup final and England matches|
|FIFA the ´injured party´ as Swiss prosecutors open criminal proceedings|
|Prince Ali saddened by FIFA arrests|
|Pellegrini to make City defence a priority|
|Labbadia giving Lasogga, Olic, Jiracek time|
|Ramsey confident on Wembley chances|
|Swiss authorities confirm FIFA arrests|
|El Shaarawy open to Premier League move - agent|
|Reports: FIFA officials set to be arrested|
|Tigres UANL 2 Emelec 0 (2-1 agg): Mexicans through to Libertadores semis|
|Valencia ruled out of Copa America|
|Coleman: Bale being ignored by Real team-mates|
|Ruddy eyes England recall|
|Benteke will strike fear into Arsenal - Westwood|
|Howe named LMA Manager of the Year|
|Casillas reiterates desire to stay in Madrid|
|Dnipro players pay for fans´ tickets, transport|
|Galliani: I want Ancelotti back at Milan|
|Premier League: Manchester City season review - Frustrations as latest title defence falters|
|Injured Benfica star Salvio not for sale|
|AFC Champions League Review: Al Sadd suffer last-16 exit|
|Emery targeting historic victory|
|Toure and Wisdom pen new Liverpool deals|
|Stadium facilities drive Van Gaal potty|
|Blatter brushes off Figo´s ´dictatorship´ claims|
|Mavuba to end career at Lille after extending contract|
|Ipswich´s Bishop charged over betting breaches|
|Markevych admits to Dnipro nerves|
|Relegated Almeria to be deducted three points|
|Reims retain Guegan on one-year deal|
|Di Matteo departure could hinder Schalke swoop for Khedira|
|Bale planning Real Madrid stay|
|Del Bosque not prepared to risk Costa|
|West Ham earn Europa League berth|
|Pellegrini sure City will win title back|
|Low calls Herrmann into Germany squad|
|Gerrard will win trophies with Galaxy - Carragher|
|Frankfurt agree to let Schaaf leave|
|Hernandez hit with violent conduct charge|
|Bale set for 50th Wales cap against Belgium|
|Baines hoping for pre-season return|
|Bournemouth sign Boruc|
|Sevilla duo Rico and Vidal handed Spain calls|
|Premier League: Chelsea season review - Mourinho´s men canter to title|
|Speroni hints at possible Palace exit|
|Kane states Tottenham commitment|
|Boruc, Hooiveld leave Southampton|
|Oxlade-Chamberlain desperate to make FA Cup final|
|Roar turn to Aloisi|
|Di Matteo resigns as Schalke coach|
|Hughes hints at Moses return|
|Wenger hits out at scheduling|
|Terry backs Chelsea to dominate|
|Jets part ways with coach Stubbins|
|Kewell would love to manage Liverpool|
|Janmaat: Newcastle players failed Carver|
|Adelaide step up interest in Toni|
|Chelsea´s Drogba interested in MLS move|
|Otamendi wants to leave Valencia - agent|
|Benitez almost certain for Real job|
|Schneiderlin will leave for Champions League club|
|Kane planning to come back bigger and better|
|Moyes staying at Sociedad|
|Neil revels in Norwich promotion|
|Drogba interested in MLS move|