Gueida Fofana scored twice to help hosts Lyon to a commanding 4-1 first-leg win over Viktoria Plzen in the UEFA Europa League last 16.
Plzen drew first blood on Thursday at the Stade de Gerland after just three minutes through Tomas Horava's low header, but Lyon soon hit back as Fofana's knee diverted a corner kick past Petr Bolek.
Stanislav Tecl shot wide late in the first half and was made to pay for his miss as Lyon overwhelmed Plzen after the restart.
Alexandre Lacazette drove home Steed Malbranque's inviting through-ball before the veteran midfielder set up Arnold Mvuemba to give Lyon breathing space.
And Fofana popped up after 69 minutes to make the game safe and leave Plzen facing a huge task to reach the quarter-finals when the sides clash again in the second leg next week.
The result stretches Lyon's impressive Europa League record to one defeat in their last 17 games, but they had to dig deep.
The Czech champions enjoyed a great start and took the lead after three minutes when Jan Kovarik's left-wing cross was perfect for Horava to nod past Anthony Lopes.
Remi Garde's Lyon, though, responded well and were back on level terms after 12 minutes when Malbranque's corner was directed in off the knee of Fofana.
Tecl weaved through the home defence and fired a low effort that easily dealt with by Anthony Lopes as Plzen went in search of a second.
Lacazette flashed a volley wide of Bolek's near post as the game flowed from end to end before Fofana saw his speculative effort saved after 25 minutes.
Bolek had to be alert again when Mvuemba's swerving free-kick bounced in front of him but he managed to claw it away.
Despite being on the back foot, Plzen ought to have regained the lead when Tecl robbed Milan Bisevac, but failed to hit the target.
And the visitors went closer a minute before half-time through David Limbersky's rasping effort that Anthony Lopes did well to tip behind.
Plzen were punished for missed chances early in the second half when Malbranque stole the ball in midfield and, after exchanging passes, slipped the ball to Lacazette, who drove home convincingly.
That goal gave Lyon the opportunity to defend deep and hit on the break, which they did to devastating effect on the hour mark.
Malbranque was again influential, lifting an inch-perfect ball to the onrushing Mvuemba and controlled superbly with his chest before lashing home emphatically.
And Lyon made it four after 69 minutes when Fofana ran onto Lacazette's ball to slam home via a deflection on the edge of the area.
|6||G. Fofana||12' 70'|
|Coach: R. Garde|
for S. Malbranque 69'
for A. Lacazette 83'
for M. Dabo 85'
|Terry thrilled with ´revelation´ Matic|
|Perez rues ´unfair´ Tyne-Wear derby result|
|Khalfan Ibrahim returns from injury|
|Magath slams ´sensitive´ Fulham|
|´Limited´ attacking options inspire Postecoglou´s selections|
|Carlisle reportedly involved in serious incident|
|Primeira Liga Review: Braga leapfrog Guimaraes|
|Hughes upbeat despite Stoke defeat|
|Mourinho: Victory at Stoke means more than three points|
|Postecoglou picks attacking Australia squad|
|Allegri disappointed by wasteful Juve|
|Benitez revels in Napoli´s Supercoppa Italiana win|
|Stoke City 0 Chelsea 2: Fabregas fires visitors to festive number one spot|
|Juventus 2 Napoli 2 (aet, 5-6 on pens): Rafael´s shootout heroics seal victory|
|Ki has mixed feelings over Asian Cup|
|Lafita set for six-month lay-off with ligament injury|
|Dyche dismisses Ings exit speculation|
|Turkish Super Lig Review: Balikesirspor record rare win, Carlos bows out at Sivasspor|
|Freibug agree deals for Daehli and Petersen|
|Kampl set to join Dortmund|
|Al Shabab 1 Al Ain 1: Ahmad rescues late point for visitors|
|Blackpool chairman Oyston apologises for supporter spat|
|Flamini expects Arsenal to kick on|
|Brighton accept Hyypia resignation|
|FA charge Leeds defender Bellusci for alleged racist abuse|
|Uncapped Lee named in South Korea squad|
|Gutierrez makes Newcastle comeback|
|Ji to rejoin Augsburg from Dortmund|
|Holders ES Setif learn Champions League fate|
|Kraft extends Hertha deal|
|FIFA reform process ongoing - Blatter|
|Walsh: Leicester should stick with Pearson|
|Hodgson optimistic for England´s future|
|Milan chief Galliani targets Champions League|
|Hull recall Ince and Figueroa|
|Stranzl extends Gladbach stay|
|Redknapp not ruling out Morrison return|
|Barnes hopeful of keeping his place|
|Lambert hails ´outstanding´ Okore|
|Kramer pens Leverkusen extension|
|Lacazette will not rest on laurels|
|Hughes: Chelsea can win quadruple|
|Liverpool are turning the corner - Lallana|
|Ramos: No rush on contract talks|
|Johnson: Derby winner one of my finest hours|
|Juan credits Mancini for Inter revival|
|Allardyce eyeing London derby success|
|Juanfran targets new-year push|
|Long slams Southampton critics|
|Guidetti out, Griffiths in hints Deila|
|Spurs forward Kane targets 20 goals|
|Lyon fitness key to Bordeaux thrashing - Fournier|
|Santa Fe 1 Medellin 1 (agg 3-2): Hosts win Clausura title|
|Emelec 3 Barcelona 0 (4-1 agg): Bolanos brace seals title defence|
|Pioli: Lazio did not switch off|
|No Park in South Korea´s Asian Cup squad|
|Gignac: Marseille lead ´a huge boost´|
|Simeone applauds Griezmann´s hat-trick|
|Redknapp vows to keep QPR sharpshooter Austin|
|Santiago Wanderers 1 Palestino 6 (agg 2-9): 36-year drought ends for visitors|
|Juan Aurich 2 Sporting Cristal 3 (aet, agg 4-5): Chavez hands visitors Peruvian title|
|Liga del Futbol Profesional Boliviano Review: Bolivar win title|
|Mancini plays down Lennon transfer rumours|
|Ligue 1 Review: Marseille end 2014 top of the table, Lyon leapfrog PSG|
|Kovacic has mixed emotions after Inter draw|
|Serie A Review: Lazio go third despite Inter rally, Sampdoria held|
|La Liga Review: Griezmann the man for Atleti, Villarreal gain fifth straight win|
|Primeira Liga Review: Benfica win six straight|
|Athletic Bilbao 1 Atletico Madrid 4: Griezmann hat-trick seals comeback win|
|Inter 2 Lazio 2: Hosts rally to claim draw|
|McCoist makes Rangers exit|
|Sturridge on course for January return - Rodgers|
|Liverpool getting back on track, says Rodgers|
|Wenger bemoans failure to defend set-pieces|
|Bundesliga Review: Hoffenheim enjoy big win, Freiburg falter late on|
|Zorc: Dortmund to stick with Klopp|
|Liverpool 2 Arsenal 2: Bandaged Skrtel rescues a draw|
|I have no problem with Payet, insists Bielsa|
|Eredivisie Review: Ajax leave it late, Vitesse finally win|
|Pardew rues over-zealous Newcastle approach|
|Benitez hopeful ahead of Supercoppa|
|I nearly took Johnson off - Poyet|
|Johnson revels in derby late show|
|Juventus must maintain focus, warns Allegri|
|Newcastle United 0 Sunderland 1: Johnson settles derby|
|Carlos leaves Sivasspor post|
|Dundee United 2 Celtic 1: Ciftci inspires surprise win|
|Mourinho against use of independent panels|
|Hartlepool not interested in signing Evans|
|Reed delighted with first Southampton start|
|Bremen agree Oztunali loan|
|Irvine backs Ideye to end goal drought|
|Carrick backs Falcao to kick on|
|Dortmund will come back stronger, vows Klopp|
|Bojan senior slams Barcelona|
|Eredvisie title not won yet - Depay|
|Sterling eager to catch Arsenal cold|
|Monk: Ki will be sorely missed|
|Bruce looking to recall Hull duo from loan spells|
|Allardyce: Pearson deserves time|
|Sydney 0 Wellington Phoenix 2: Burns at the double|
|Real Madrid 2 San Lorenzo 0: Spanish giants complete triumphant 2014|
|McCoist: Departures sucking life out of Rangers|
|Hargreaves urges Sterling to stay put|
|Herediano 1 Deportivo Saprissa 1 (agg 3-5): Draw hands visitors consecutive titles|
|Tribulietx basks in Auckland City´s heroics|
|San Lorenzo´s Bauza applauds Ancelotti|
|Wenger: Sanchez a Footballer of the Year candidate|
|Chelsea like United´s treble-winning team - Hargreaves|
|Ancelotti: Copa del Rey victory inspired Real´s stunning run|
|La Liga Review: Catalan clubs triumph|