Gueida Fofana scored twice to help hosts Lyon to a commanding 4-1 first-leg win over Viktoria Plzen in the UEFA Europa League last 16.
Plzen drew first blood on Thursday at the Stade de Gerland after just three minutes through Tomas Horava's low header, but Lyon soon hit back as Fofana's knee diverted a corner kick past Petr Bolek.
Stanislav Tecl shot wide late in the first half and was made to pay for his miss as Lyon overwhelmed Plzen after the restart.
Alexandre Lacazette drove home Steed Malbranque's inviting through-ball before the veteran midfielder set up Arnold Mvuemba to give Lyon breathing space.
And Fofana popped up after 69 minutes to make the game safe and leave Plzen facing a huge task to reach the quarter-finals when the sides clash again in the second leg next week.
The result stretches Lyon's impressive Europa League record to one defeat in their last 17 games, but they had to dig deep.
The Czech champions enjoyed a great start and took the lead after three minutes when Jan Kovarik's left-wing cross was perfect for Horava to nod past Anthony Lopes.
Remi Garde's Lyon, though, responded well and were back on level terms after 12 minutes when Malbranque's corner was directed in off the knee of Fofana.
Tecl weaved through the home defence and fired a low effort that easily dealt with by Anthony Lopes as Plzen went in search of a second.
Lacazette flashed a volley wide of Bolek's near post as the game flowed from end to end before Fofana saw his speculative effort saved after 25 minutes.
Bolek had to be alert again when Mvuemba's swerving free-kick bounced in front of him but he managed to claw it away.
Despite being on the back foot, Plzen ought to have regained the lead when Tecl robbed Milan Bisevac, but failed to hit the target.
And the visitors went closer a minute before half-time through David Limbersky's rasping effort that Anthony Lopes did well to tip behind.
Plzen were punished for missed chances early in the second half when Malbranque stole the ball in midfield and, after exchanging passes, slipped the ball to Lacazette, who drove home convincingly.
That goal gave Lyon the opportunity to defend deep and hit on the break, which they did to devastating effect on the hour mark.
Malbranque was again influential, lifting an inch-perfect ball to the onrushing Mvuemba and controlled superbly with his chest before lashing home emphatically.
And Lyon made it four after 69 minutes when Fofana ran onto Lacazette's ball to slam home via a deflection on the edge of the area.
|6||G. Fofana||12' 70'|
|Coach: R. Garde|
for S. Malbranque 69'
for A. Lacazette 83'
for M. Dabo 85'
|No shame in second place - Pellegrini|
|Humble Hazard thrilled with PFA honour|
|La Liga Preview: Real continue Barca pursuit against Almeria|
|Serie A Preview: Roma eye much-needed win|
|MLS Review: Toronto end drought, Red Bulls stay unbeaten|
|Chelsea to face Sydney in June|
|Liverpool can attract players - Rodgers|
|Bayern celebrate three-peat|
|Hernandez form forces Ancelotti´s hand|
|Hazard crowned PFA Players´ Player of the Year|
|Weidenfeller ruled out of Dortmund-Bayern semi-final|
|Weidenfeller ruled out of Dortmund-Bayern semi-final|
|Ligue 1 Review: Lens´ fate all but sealed, Lyon return top|
|La Liga Review: Hernandez rescues Real, Sevilla up to fourth|
|Paris Saint-Germain v Metz: Injuries prove a frustration for Blanc|
|Serie A Review: Juve made to wait as Parma fight another day|
|Celta Vigo 2 Real Madrid 4: Hernandez to the rescue again|
|Barcelona v Getafe: Iniesta keen to maintain momentum|
|Milan players in ´retreat´|
|United have opened the door for Liverpool - Van Gaal|
|Mourinho hits back at Arsenal fans´ ´boring´ jibes|
|Juve were own worst enemy in derby defeat – Allegri|
|Bundesliga Review: Gladbach victory ends title race|
|Udinese v Inter: Mancini braced for crucial week|
|Primeira Liga Review: O Classico tie leaves Benfica on the brink|
|Bayern Munich v Borussia Dortmund: Klopp prepares for final Klassiker|
|Russian Premier League Review: Zenit edge closer to glory, Amkar Perm off the bottom|
|Arsenal played with handbrake on - Wenger|
|Mourinho swerves Oscar discussion to hail Terry display|
|Bayern´s title confirmed as Wolfsburg stumble at Gladbach|
|Eredivise Review: Late leveller see Ajax secure Champions League berth|
|Arsenal 0 Chelsea 0: Oscar decision in the spotlight after stalemate|
|Van Gaal bemoans lack of fighting spirit|
|Van Gaal: United to assess Rooney injury|
|Torino 2 Juventus 1: First derby defeat since 1995 puts title celebrations on hold|
|Martinez hails Everton´s ´incredible mentality´ after beating United|
|Everton 3 Manchester United 0: Martinez outwits Van Gaal in comprehensive win|
|Dundee United 0 Celtic 3: Griffiths´ hat-trick edges champions closer to title|
|Alderweireld reveals he has broken shoulder bone|
|Hull City v Liverpool: Lovren expecting another test of patience|
|Leverkusen dealt Papadopoulos blow|
|Five in a row for Champions League winners Auckland|
|Vermaelen cleared to play in Barca run-in|
|Hughes buoyed by Odemwingie return|
|Allardyce hails Adrian heroics|
|Villa confident of staying up - Sherwood|
|Zorc rejects talk of Gundogan departure|
|´Happy´ Hazard rejects talk of Chelsea exit|
|A-League Review: Victory claim Premiers´ Plate|
|Pochettino hoping to strengthen|
|Pjanic critical of Roma spirit|
|Rodgers: No room for error now|
|MLS Review: Revolution win big as Dynamo, Kansas City draw|
|Garcia rues sloppy build-up play|
|Jokanovic eyes title for Watford|
|Blanc: PSG have moved on|
|Hazard worth ´£100m each leg´ - Mourinho|
|Ferguson: United boss can break my trophy record|
|Levante leap clear of La Liga drop zone|
|Primeira Liga Review: Gil Vicente claim vital win, Estoril and Rio Ave held|
|Icardi destined for the top - Mancini|
|Eredivisie Review: Depay inspires 10-man PSV, wins for Heracles and Utrecht|
|Simeone applauds Atletico´s response to European exit|
|Ligue 1 Review: PSG hit Lille for six, Bastia late show stuns Evian|
|Inter 2 Roma 1: Late Icardi strike puts Juve on brink of title|
|Bundesliga Review: Bayern all but champions, Hamburg claim long-awaited win|
|Guardiola focusing elsewhere with Bundesliga almost secure|
|Pellegrini salutes City spirit in Villa win|
|Inzaghi apologies to Milan fans after Udinese defeat|
|Matuidi hails PSG´s best|
|Sherwood lambasts Benteke decision as Villa miss out in late drama|
|League Two Review: Tranmere and Cheltenham lose League status, Shrewsbury promoted|
|Dyche bemoans ´cruel´ defeat|
|Manchester City 3 Aston Villa 2: Fernandinho concludes Etihad drama in City´s favour|
|League One Review: Colchester take survival battle to last day with victory|
|Pardew questions refereeing decisions|
|Bayern Munich 1 Hertha Berlin 0: Schweinsteiger strike all but seals title|
|Ramsey slams referee Jones after disallowed goal|
|Luis Enrique not looking towards title yet|
|Pearson: The win is all that matters|
|Bruce hails improved Hull display|
|Pulis hails ´great point´ for resilient West Brom|
|Udinese 2 Milan 1: Disappointing visitors´ European hopes dented|
|Atletico Madrid 3 Elche 0: Griezmann nets brace as Champions respond to European exit|
|Allardyce laments lack of squad depth|
|Advocaat still confident of survival|
|No loss of belief at Liverpool, insists Rodgers|
|Carver rues ´mad five minutes´|
|Hughes rues Stoke´s missed opportunities|
|Scottish Premiership Review: Aberdeen secure second as St Mirren fight on|
|Championship Review: Watford promoted as Fulham beat Boro|
|Monk revels in new points record|
|Klopp positive ahead of Bayern battle|
|Paris Saint-Germain 6 Lille 1: Lavezzi nets hat-trick as Blanc´s men go top|
|Newcastle United 2 Swansea City 3: Carver´s men continue worrying slide|
|Crystal Palace 0 Hull City 2: N´Doye at the double to give Bruce´s men vital win|
|Watford seal promotion to the Premier League|
|Stoke City 1 Sunderland 1: Adam strike piles pressure on Advocaat|
|Burnley 0 Leicester City 1: Vardy punishes Taylor´s penalty miss|
|West Brom 0 Liverpool 0: Landmark Gerrard appearance ends goalless|
|QPR 0 West Ham 0: Strugglers rue saved Austin penalty|
|Espanyol 0 Barcelona 2: Messi, Suarez and Neymar star for 10-man visitors|
|Koeman rues missed chances|
|Borussia Dortmund 2 Eintracht Frankfurt 0: Aubameyang inspires Klopp´s men|
|Pochettino thanks Spurs supporters|
|Fellaini contemplated leaving Man United|
|Southampton 2 Tottenham 2: Point for Pochettino on St Mary´s return|
|Ankle surgery ends Routledge´s season|
|Lopetegui hoping for Porto reaction|
|A-League Review: Glory end on a high, Adelaide hammer City|
|Howedes ´concerned´ by Schalke form|
|Ancelotti hopeful on injured trio´s fitness|
|Bernabeu return a possibility for Pogba|
|Marseille in crisis, claims Bielsa|
|Van Gaal tips Giggs as his successor|
|De Gea the boss in contract talks - Van Gaal|
|Mourinho hits out at Wenger|
|Shaqiri not going anywhere - Mancini|
|MLS Review: Goalkeeping blunder sees Chicago burn NYC|
|Ancelotti confident in Real´s chances|
|No Messi, no Barca claims ex-Bayern ´keeper Pfaff|
|Hamilton Academical 2 Motherwell 0: Canning gets first win as player-manager|