Millwall host Charlton Athletic in a London derby that could have big implications in the battle for Championship survival.
Charlton began life under new manager Jose Riga with a goalless draw at home to Huddersfield Town in midweek - a result that means the division's bottom club have won only six times in 31 league outings this season.
But the beaten FA Cup quarter-finalists are just three points behind fourth-bottom Millwall and have four games in hand.
That puts Millwall manager Ian Holloway under notable pressure heading into Saturday's meeting after he presided over a third defeat in four matches at former club Blackpool on Tuesday.
The stand-out tie at the top of the league is a meeting between play-off incumbents Reading and Derby County at the Madejski Stadium.
Reading lie sixth after a 4-2 triumph at crisis club Leeds United ended a three-match winless run, similar to the slump Steve McClaren's Derby are currently experiencing.
That has allowed Burnley to open up an eight-point advantage with 11 games remaining in the second automatic promotion spot and Sean Dyche's men will look to inflict further misery on Leeds at Turf Moor after Federico Macheda's last-minute equaliser pegged them back to a dramatic 3-3 draw at Birmingham City on Wednesday.
Leaders Leicester City extended their unbeaten run to 15 matches with a 12th win during that period at Barnsley, and Blackpool will be the latest team to try to halt their seemingly inevitable march to the Premier League.
QPR once appeared to be Leicester's main rivals but their bid for an instant return to the top flight has subsided badly in recent weeks. Harry Redknapp's team suffered a fourth defeat in six games against Brighton and Hove Albion and must look to recover at home to struggling Yeovil Town.
Fifth-placed Nottingham Forest welcome fifth-bottom Doncaster Rovers to the City Ground searching for their first win in a month, a run that has left them and the other play-off teams fearing in-form Wigan Athletic.
Uwe Rosler's side lie seventh on goal difference with games in hand owing to their run to the FA Cup semi-finals. Jordi Gomez netted a penalty in last weekend's sensational quarter-final triumph over Manchester City and the midfielder repeated the trick from 12 yards to sink Sheffield Wednesday in midweek.
Athletic now face a long trip to face an Ipswich Town outfit with similar league ambitions to their own.
Fellow play-off chasers Brighton head north to Bolton Wanderers, while second-bottom Barnsley travel in the opposite direction to face Watford.
Sheffield Wednesday and Birmingham meet at Hillsborough, where a win for either side would considerably ease their relegation fears.
Elsewhere, Huddersfield meet Blackburn Rovers and Bournemouth welcome Middlesbrough.
|Coach: I. Holloway|
for E. Upson 51'
for S. Jackson 56'
for A. Dunne 72'
|Valencia bag Bakkali|
|BREAKING: New York City FC complete Pirlo capture|
|Panama v Haiti: Collat ready to challenge the best of CONCACAF|
|UEFA Champions League Preview: Harrison eyes TNS progression|
|FIFA sanctions Yemen for fielding ineligible player|
|Toulouse rubbish Ben Yedder exit reports|
|Mourinho ´knows what he´s doing´ with Falcao signing|
|Watford shell out club-record fee for Capoue|
|Braafheid signs Lazio extension|
|Nani finalises Fenerbahce move|
|Liverpool confirm O´Driscoll appointment|
|Liverpool have to start better - Lucas|
|USA simply too good - Sasaki|
|Portland Timbers 1 San Jose Earthquakes 0: Jewsbury wins it in stoppage time|
|No move yet for Van Persie|
|Lloyd wins Golden Ball, Silver Boot awards|
|Mascherano: I never grabbed Banega|
|Dunga requested Brazil not appeal Neymar´s suspension|
|United States 5 Japan 2: Lloyd stars with hat-trick|
|Fiorentina deny Inter criticism|
|Nani relishing Fenerbahce opportunity|
|Newcastle hold talks over Northampton youngster|
|Cuadrado´s agent plays down Chelsea exit rumours|
|Liverpool´s Alberto set for Deportivo loan|
|Leverkusen suffer surprise defeat, Stuttgart hit six|
|Inter ´dismayed´ at Fiorentina vice-president´s Salah Twitter outburst|
|Blaszczykowski ruled out of Dortmund´s Asia tour|
|Gerrard gets the beers in for LA Galaxy fans|
|De Gea coy over Real links|
|Former Brazil star Carlos handed Delhi reins|
|Ciftci will not push through Celtic switch – agent|
|In-demand Mitrovic considering Roma offer|
|Lehmann calls on Cech to ´get over´ Chelsea|
|Marlos double sinks Monaco|
|Mauritius 0 South Africa 2 (agg 0-5): Bafana set up Angola qualifier|
|Keane relishing Gerrard arrival|
|Palace confirm Cabaye interest|
|Hamburg bring in Spahic after head-butt ban|
|Blatter hits out at France and Germany over World Cup votes|
|Sanchez: World Cup exit spurred Chile to Copa glory|
|Jojic makes Cologne switch, Santana move falls through|
|Carrillo keen to get going at Monaco|
|Micronesia thrashed 38-0 as Fiji triumph in Olympic qualifier|
|Schalke stunned by ´machine´ Caicara|
|MLS Review: Keane shines at Gerrard´s Galaxy unveiling|
|Counter-attacking the key for Japan|
|Jimenez happy at Atletico|
|Gerrard predicts ´successful future´ with Galaxy|
|Iniesta can´t see Real selling Ramos|
|Keshi sacked as Nigeria coach|
|Three finals, three defeats for Messi, Mascherano|
|Nani close to Fenerbahce move|
|Sampaoli revels in ´unbelievable joy´|
|Bravo: Copa victory a dream|
|Martino: Argentina should have won|
|Chile 0 Argentina 0 (4-1 on penalties): Hosts end trophy drought|
|Germany 0 England 1 (after extra time): England make World Cup history|
|Kenya 0 Ethiopia 0 (agg 0-2): Hosts sent out of CHAN qualifiers after second penalty miss|
|Dortmund put 17 past Olympians, Bremen hand out thrashing|
|Dinamo Zagreb confirm arrests of coach and club president|
|I didn´t know who Wimbledon guest Klopp was - Brown|
|LeBron James backs Liverpool captain Henderson for FIFA 16 cover.|
|Ramos: I am not negotiating with anyone|
|Valencia complete Mina swoop|
|United States v Japan: US seek final redemption|
|Hanousek consigns Celtic to defeat|
|Roma confirm Dzeko interest|
|Arsenal forward Podolski completes Galatasaray switch|
|Warm Dortmund welcome delights Tuchel|
|Silva vows to fight for Madrid place|
|Mancini hints at Shaqiri and Santon departures|
|Bojan raring to go after return from injury|
|Babel backs Firmino to shine at Liverpool|
|Falcao must wait to impress, warns Chelsea favourite|
|Bartomeu: Deal in place for Turan|
|Parejo re-signs with Valencia|
|MLS Review: Sounders return to winning ways|
|Klinsmann unhappy with USA performance|
|High hopes for Paraguay - Diaz|
|Gareca: More to come from Peru|
|Gerrard had European offers|
|Argentina out to spoil Chile´s party - Martino|
|Sampaoli: Chile won´t change style|
|Di Maria will come good at United - Rojo|
|Peru 2 Paraguay 0: Gareca´s men finish third at Copa|
|United States 4 Guatemala 0: Klinsmann´s men win comfortably|
|´I’d prefer no-one to know my name´ - Bassett|