FA Cup semi-finalists Sheffield United will aim to maintain their outstanding recent form when hosting Carlisle United in League One.
Nigel Clough's side have enjoyed a remarkable resurgence since suffering a 3-0 defeat at Crewe Alexandra on February 1, winning nine consecutive matches in all competitions and conceding just one goal.
Having struggled for much of the season, United are now comfortably clear of the relegation zone in 11th.
And the mood around Bramall Lane will be euphoric after Sunday's 2-0 FA Cup win over Charlton Athletic set up a last-four tie with Premier League Hull City at Wembley next month.
United will be confident of continuing their rise up the table on Wednesday against a side that have lost six of their last seven away matches.
The other form team in the division are leaders Wolves, who have won eight straight league matches and visit a Swindon Town outfit who are winless in six.
Leyton Orient will be hoping to close the two-point gap to Wolves when they travel to Port Vale, while third-placed Brentford welcome struggling Tranmere Rovers to Griffin Park.
At the wrong end of the table, rock-bottom Notts County desperately need to start picking up points if they are to climb away from danger, but they can expect a stern test when play-off chasing MK Dons visit.
Crewe are third from bottom and also face a club hunting for a top-six finish in Walsall, who have hit a bad run of form at the wrong time with a sequence of four successive defeats.
After a dreadful run, Stevenage have picked up in recent weeks with 10 points from their past four games and Graham Westley faces old club Preston North End hoping to climb out of the relegation zone.
Preston are fourth and aiming to maintain their hopes of automatic promotion, while fifth-placed Rotherham United will look to further cement their play-off berth when they travel to Oldham Athletic.
Sixth-placed Peterborough United host Bristol City, while second-from-bottom Shrewsbury Town welcome Crawley Town, who have five games in hand over some of the teams around them following multiple postponements.
Elsewhere, Coventry City travel to Gillingham and Colchester United host Bradford City.
|Coach: N. Clough|
for S. Scougall 68'
for J. Baxter 69'
for R. Flynn 86'
|Nacional Asuncion 2 Defensor Sporting 0: Hosts surge towards Libertadores final|
|Garcia eyeing Serie A title|
|Father against Vlasic´s move abroad|
|Rodgers welcomes Gerrard´s international retirement|
|Cruzeiro, Atletico Mineiro bid for Robinho|
|Inzaghi not drawn into Balotelli speculation|
|Dunga ´not going to sell a dream´|
|City´s Fofana allegedly racially abused|
|Carroll ruled out of NZ friendlies|
|Rodgers excited by new arrivals|
|Zeljeznicar 2 Metalurg Skopje 2 (agg 2-2): Visitors advance on away goals|
|Gibson returns as Tranmere hold Everton|
|UEFA Champions League Review: Celtic coast through, BATE given scare|
|Gomez and Jones feature in Sunderland win|
|Leicester hit Ilkeston for six|
|Austin fires QPR to narrow victory|
|Guardiola: No trophies and I may be sacked|
|Dortmund held as Immobile makes debut|
|Rodriguez´s dream becomes Real|
|Garcia: Benatia and Ljajic going nowhere|
|Stoke secure Bojan on four-year deal|
|FA: No World Cup bids for England|
|Kroos commits to Bremen|
|Caulker makes QPR move|
|Forest agree Hunt loan deal with Palace|
|Bartra ready to prove himself at Barca|
|Southampton looking to sell Osvaldo|
|Marveaux loaned to Guingamp|
|Mourinho eyes success on two fronts|
|Sammer encouraged by Lewandowski start|
|PSG punished for abuse of Chelsea fans|
|Dunga unveiled as Brazil coach|
|Shakhtar CEO: Focus is on players´ safety|
|Foster agrees new West Brom deal|
|Real Madrid sign Rodriguez|
|Mustafi eyes Bundesliga switch|
|Klopp laughs off Hummels, Reus speculation|
|Campana makes Sampdoria switch|
|Leicester seal Ulloa deal|
|Morata sidelined for seven weeks with knee injury|
|Riviere on target in comfortable Newcastle win|
|Advocaat set for Serbia role|
|Wisdom joins West Brom on loan|
|Bundesliga to consider vanishing foam|
|Five-man shortlist for Ivory Coast|
|´Personal issues´ keep Gervinho away from Roma tour|
|Jedinak raring to go|
|Borini set for Liverpool stay, claims agent|
|Koeman: No bids for Lovren|
|Livermore: England hopes shouldn´t hinge on club side|
|MLS Preview: Tough tests for Conference leaders, Revolution still struggling|
|Mathieu not Barca material, says Marquez|
|West Brom claim unimpressive win in Sacramento|
|Neymar: Brazil behind Germany, Spain|
|Vietnamese police confirm match-fixing players|
|Lucescu blames Joorabchian for AWOL players|
|Robinho undecided on future|
|Rush: Still years left in Gerrard|
|Tiago re-signs with Atletico|
|Puyol against Spain overhaul|
|Agger considering his Liverpool future|
|Peruvian Primera Division Review: Juan Aurich bounce back, Melgar draw with Inti Gas|
|Bayern deny interest in Cuadrado|
|New signings on show in Hull double-header|
|Hooiveld strike sinks Swindon|
|Costa departs Valencia|
|Morata suffers knee injury in training|
|K.League Preview: Seoul, Sangju aim to close gap to sixth, Ulsan host Jeonbuk|
|Lewandowski off the mark on Bayern bow|
|Gerrard retirement will boost Liverpool - Carragher|
|World Cup bidding report due in September|
|Evra bids emotional farewell to United fans|
|J.League Preview: Ventforet Kofu look to escape drop zone, Sagan Tosu battle Kawasaki Frontale|
|Salah spared military service|
|Garcia would welcome Torres return|
|Livermore understands Ince decision|
|Cole happy to get away from English press|
|Evra seals Juve switch|
|Bayern stay was Kroos´ ´priority´|
|Scuffet: Udinese right place to continue developing|
|Gerrard retires from England duty|
|Ambitious Pochettino targets title|
|Aspas eager to put ´bad season´ behind him|
|Atletico Mineiro v Lanus: Visitors out to recover from first-leg loss|
|UEFA Europa League Preview: Sligo, Inter Baku out to finish shocks|
|Hughes expects Bojan decision soon|
|Cech on the mend - Holland|
|Pardew eager to honour crash victims|
|Prandelli hits back at critics|
|Negredo breaks metatarsal|
|Rooney eager to impress Van Gaal|
|Palacios´ Qatar move falls through|
|Wenger rules out striker signing|
|Six Shakhtar players refuse to return|
|Six Vietnamese footballers arrested for match fixing|
|Copa Libertadores Preview: Nacional Asuncion, San Lorenzo to host first legs|
|Mata hopeful of title|
|Napoli bullish about Scudetto chances|
|Colombian Primera A Review: Patriotas Boyaca, Deportes Tolima start with wins|
|Subotic thrilled to be back|
|Germain: Monaco can replace Rodriguez|
|Sullivan confident of Carroll improvement|
|Callejon staying put|
|DC United 3 Chivas USA 1: DC end Chivas´ winning run|
|Liga MX Review: Goalkeeping howler costs champions Leon, Monterrey move top|
|Chilean Primera Division Review: Huachipato, Santiago Wanderers opening-day winners|
|Brazilian Serie A Review: Internacional rout Flamengo, Cruzeiro win again|
|Prosinecki keen on South Korea job|