Atletico Mineiro and Velez Sarsfield can take huge steps towards the Copa Libertadores knockout stages on matchday three.
Both teams have claimed two wins from as many games in their groups and a third – halfway through the stage – would set them up nicely.
Mineiro have edged their way to the top of Group 4 and sit three points clear of Santa Fe and Nacional Asuncion ahead of their clash against the Paraguayans on Wednesday.
Paulo Autuori's Mineiro are on a seven-match unbeaten run in all competitions and have been scoring for fun.
The Brazilians have netted 16 goals in their past five matches, sharing the load up front.
Neto Berola has struck twice in his past three outings, including the winning goal in the 2-1 win over Santa Fe in February.
Colombia's Santa Fe need to bounce back from that loss when they travel to Venezuela to take on Zamora, who are bottom of Group 4.
Velez Sarsfield are setting the pace in Group 1 ahead of their clash against The Strongest on Tuesday.
The Argentines are yet to concede in two matches and a win in Bolivia would set them up nicely for a place in the round of 16.
The clash between the top two shapes as an opportunity for Atletico Paranaense and Universitario to close in, with the former going into second with a win if The Strongest fail to claim victory.
Group 2 is even heading into matchday three, but leaders Botafogo have an opportunity to edge further than a point clear when they visit lowly Ecuadorians Independiente del Valle.
San Lorenzo and Union Espanola do battle in Argentina in the other match.
In Group 3, the top two of O'Higgins and Cerro Porteno meet, while Deportivo Cali host Lanus on Thursday.
Undoubtedly the most even group, teams in Group 5 will be hoping to settle into the top two.
Cruzeiro visit Defensor Sporting and Real Garcilaso host Universidad Chile with all four teams locked on three points.
Gremio lead Group 6 by three points ahead of their clash at home to Newell's Old Boys, while Nacional desperately need a win when they visit Atletico Nacional.
In Group 7, Leon visit Emelec and Flamengo host Bolivar with all four teams very much alive in the battle for qualification.
Santos Laguna will be aiming to make it three from three in Group 8 when they visit Deportivo Anzoategui, while Arsenal host Penarol.
|10||P. Escobar||56' 77'|
|Coach: E. Villegas|
for N. Solíz 64'
for R. Castro 86'
for P. Escobar 89'
|Mainz bring in Castillo|
|Villa: Lambert will not be sacked|
|Monk hopeful of adding new faces|
|Sainsbury ready to replace Franjic|
|Beckenbauer hopeful of Guardiola stay|
|Mourinho hits back at Costa critics|
|Rodriguez grateful for ´fundamental´ Ronaldo support|
|La Liga Preview: Real want revenge against Socieded|
|No Dallas move for Essien|
|Bale rubbishes United link, Ronaldo rift|
|Sahin in ´good shape´ for Bundesliga resumption|
|Rodgers slams Costa´s stamp collection|
|Under-fire Inzaghi urges patience|
|Rodgers: Courtois saved Chelsea|
|Mashaba wants lessons to be learnt after AFCON exit|
|Mourinho refuses to wade into Costa incidents after Chelsea win|
|Football League Review: Bent double sends Derby second, Rotherham triumph|
|Chelsea 1 Liverpool 0 (aet, agg 2-1): Ivanovic settles action-packed League Cup semi-final|
|Milan 0 Lazio 1: Inzaghi future plunged into further doubt|
|Neymar dreaming of ending Brazil´s home hoodoo|
|South Africa 1 Ghana 2: Late Ayew winner seals qualification|
|Senegal 0 Algeria 2: Mahrez and Bentaleb dump Senegal out|
|Bocchetti poised to join Milan on loan|
|De Rossi suffers calf injury|
|Montano accuses Oldham of double standards after Evans saga|
|Bojan out for the season with ruptured cruciate|
|Cameroon v Ivory Coast: Renard defends Yaya Toure|
|Yanga-Mbiwa makes Roma move permanent|
|Guinea v Mali: Quarter-final berth on offer in Mongomo|
|Thohir: Inter not reliant on European football|
|Bremen land Vestergaard|
|Allegri refuses to rule out Cassano move|
|Mexes handed four-game ban after Lazio dismissal|
|Joyce reveals Valdes´ inspirational team-talk|
|CAF announces AFCON venue switches|
|Alcacer commits future to Valencia|
|Postecoglou calls for Aussie ´energy´|
|Everton confirm Eto´o departure to Sampdoria|
|Pochettino to stick with Vorm despite cup error|
|Barcelona are not favourites against Atletico, says Luis Enrique|
|Allegri wary of Parma backlash in Coppa Italia|
|Zidane urges Real to tie Ancelotti down|
|FIFPro: Transfer system failing football|
|Anderlecht condemn Standard´s Defour banner|
|Australia 2 UAE 0: Socceroos ease into home final|
|Barca overhaul youth system|
|FIFPro demands clubs respect contractual obligations|
|Mahmoud targeting World Cup place with Iraq|
|Fabregas wants Chelsea to show winning mentality|
|Rangers borrow £10m from Ashley´s Sports Direct|
|Lyon face anxious wait over Lacazette|
|Undermanned Lazio recall Perea|
|Ki wants South Korea to prove their superiority|
|Ghana´s Gyan wary of South Africa|
|Mashaba urges South Africa to attack|
|Benitez: Napoli deserved to win|
|Pacos de Ferreira 1 Benfica 0: Leaders fail from the spot|
|Serie A Review: Higuain at the double in controversial Napoli win, Udinese see off Empoli|
|I´m glad Rochdale haven´t made the news - Hughes|
|Getafe 2 Celta Vigo 1: Hosts come from behind for first win in 10|
|Real hit back at media reports over transfer dealings|
|Rochdale 1 Stoke City 4: Joy and angst for Bojan as Premier League side progress|
|Turkish Super Lig Review: Kuyt at the double in Fenerbahce win, Besiktas back on track|
|Senegal v Algeria: Morale is high, insists Gourcuff|
|Cassano leaves beleaguered Parma|
|Copa del Rey Preview: Atleti look to overturn Barca advantage, Espanyol wary|
|Atletico Madrid v Barcelona: Griezmann targets second-leg fightback|
|Sheffield United v Tottenham: Clough expects fired-up Spurs for second leg|
|Cape Verde 0 Zambia 0: Stalemate sends both sides out|
|Democratic Republic of Congo 1 Tunisia 1: Both teams qualify for quarter-finals|
|FA Cup fifth round: Middlesbrough handed Arsenal test|
|South Africa v Ghana: Must-win game for Mashaba´s men|
|Parma v Juventus: Serie A leaders strong favourites to reach semi-finals|
|Van Praag planning to stand for FIFA presidency|
|Inter snap up Brozovic|
|Van Persie unsure of long-term United future|
|Broken metatarsal rules El Shaarawy out for at least six weeks|
|FIFA: No disciplinary proceedings against Real|
|No Plan B if Guardiola goes - Rummenigge|
|Millwall take Hooiveld on loan|
|Chile v United States: Klinsmann has high hopes for young stars|
|Carver to lead Newcastle until end of season|
|Shenaishil taking positives from last-four exit|
|Neymar happy with life at Barca and Messi relationship|
|Lucas Silva ready for life at Real|
|Milan ´always with Inzaghi´ - Menez|
|Rodriguez living the dream at Real|
|Stielike expecting Australia in final|
|Mourinho not dwelling on Bradford defeat|
|Schweinsteiger under no pressure to extend Bayern contract|
|Herd heads to Wigan on loan|
|Inter defensive duo suffer hamstring tears|
|UAE coach Ali eyes Asian Cup final|
|Gattuso dreaming of managing Rangers|
|Fiorentina agree return of Gilardino on loan|
|Sakho hits back at critics|
|South Korea 2 Iraq 0: Kim books sixth Asian Cup final place|
|Sturridge could return against Chelsea|
|Zinnbauer backs Drobny as Hamburg first choice|
|Drogba targeting Chelsea stay|
|Postecoglou confident Australia squad can progress|
|UEFA does not have the courage to run against me - Blatter|
|Foster: Anichebe unplayable|
|Australia v UAE: Japan´s absence a boon for Asian Cup hosts|
|Milan v Lazio: Injury-hit visitors aiming for back-to-back wins|
|Trezeguet confirms retirement|
|No ´major problems´ with Nicolas Frey´s head wound|
|Strootman injury not "serious" - Garcia|
|No Paraguay, USA for retiring Riquelme|
|Saint-Etienne did not try to play football - Blanc|
|Primeira Liga Review: Sporting move within one point of Porto|
|La Liga Review: Parejo downs Sevilla, Resino starts with a point|
|Serie A Review: Juve go seven points clear as Roma draw again|