Atletico Mineiro and Velez Sarsfield can take huge steps towards the Copa Libertadores knockout stages on matchday three.
Both teams have claimed two wins from as many games in their groups and a third – halfway through the stage – would set them up nicely.
Mineiro have edged their way to the top of Group 4 and sit three points clear of Santa Fe and Nacional Asuncion ahead of their clash against the Paraguayans on Wednesday.
Paulo Autuori's Mineiro are on a seven-match unbeaten run in all competitions and have been scoring for fun.
The Brazilians have netted 16 goals in their past five matches, sharing the load up front.
Neto Berola has struck twice in his past three outings, including the winning goal in the 2-1 win over Santa Fe in February.
Colombia's Santa Fe need to bounce back from that loss when they travel to Venezuela to take on Zamora, who are bottom of Group 4.
Velez Sarsfield are setting the pace in Group 1 ahead of their clash against The Strongest on Tuesday.
The Argentines are yet to concede in two matches and a win in Bolivia would set them up nicely for a place in the round of 16.
The clash between the top two shapes as an opportunity for Atletico Paranaense and Universitario to close in, with the former going into second with a win if The Strongest fail to claim victory.
Group 2 is even heading into matchday three, but leaders Botafogo have an opportunity to edge further than a point clear when they visit lowly Ecuadorians Independiente del Valle.
San Lorenzo and Union Espanola do battle in Argentina in the other match.
In Group 3, the top two of O'Higgins and Cerro Porteno meet, while Deportivo Cali host Lanus on Thursday.
Undoubtedly the most even group, teams in Group 5 will be hoping to settle into the top two.
Cruzeiro visit Defensor Sporting and Real Garcilaso host Universidad Chile with all four teams locked on three points.
Gremio lead Group 6 by three points ahead of their clash at home to Newell's Old Boys, while Nacional desperately need a win when they visit Atletico Nacional.
In Group 7, Leon visit Emelec and Flamengo host Bolivar with all four teams very much alive in the battle for qualification.
Santos Laguna will be aiming to make it three from three in Group 8 when they visit Deportivo Anzoategui, while Arsenal host Penarol.
|10||P. Escobar||56' 77'|
|Coach: E. Villegas|
for N. Solíz 64'
for R. Castro 86'
for P. Escobar 89'
|Hero Bacca grateful for Europa League triumph|
|Markevych rues defensive errors in Dnipro defeat|
|AFC Champions League Review: Naft Tehran fairytale continues|
|Emery: We deserved Europa League success|
|Dnipro 2 Sevilla 3: Bacca brace sees holders make history|
|South Africa 0 Malawi 0 (4-5 on penalties): Harawa heroics send Bafana Bafana out|
|CONCACAF and CONMEBOL respond to arrests in FIFA scandal|
|FIFA president Blatter welcomes investigations as corruption probe rocks world football|
|UEFA calls for FIFA elections to be postponed|
|BREAKING NEWS: Advocaat exits Sunderland and retires from club management|
|La Liga: Real Madrid season review - Ancelotti pays the price for disappointing season|
|Zambia 3 Ghana 0: First-half spree does the damage|
|Barnes suffers double knee ligament injury|
|Balotelli to stay at Liverpool - agent|
|Kane at the double in friendly win|
|Norwich make Dorrans switch permanent|
|Ings unsure of next move|
|Bournemouth snap up Federici|
|FIFA ´crisis´ cannot continue - Prince Ali|
|Barton headlines QPR exits|
|Juan demands more from Inter|
|Stoke snap up Haugaard|
|Subotic commits to Dortmund|
|Warner pleads innocence after US indictment|
|Napoli to refuse questions on Benitez´s future|
|USDoJ names indicted FIFA officials|
|Wenger coy over Vidal and Benzema moves|
|Suarez back in training ahead of Copa final|
|Pique: I´ll retire at Barca|
|Gerrard ´blown away´ by Liverpool send-off|
|FIFA ´very happy´ with Zurich arrests|
|Liverpool defender Toure targeting trophies|
|Ramsey eyeing title assault|
|Welbeck out of FA Cup final and England matches|
|FIFA the ´injured party´ as Swiss prosecutors open criminal proceedings|
|Prince Ali saddened by FIFA arrests|
|Pellegrini to make City defence a priority|
|Labbadia giving Lasogga, Olic, Jiracek time|
|Ramsey confident on Wembley chances|
|Swiss authorities confirm FIFA arrests|
|El Shaarawy open to Premier League move - agent|
|Reports: FIFA officials set to be arrested|
|Tigres UANL 2 Emelec 0 (2-1 agg): Mexicans through to Libertadores semis|
|Valencia ruled out of Copa America|
|Coleman: Bale being ignored by Real team-mates|
|Ruddy eyes England recall|
|Benteke will strike fear into Arsenal - Westwood|
|Howe named LMA Manager of the Year|
|Casillas reiterates desire to stay in Madrid|
|Dnipro players pay for fans´ tickets, transport|
|Galliani: I want Ancelotti back at Milan|
|Premier League: Manchester City season review - Frustrations as latest title defence falters|
|Injured Benfica star Salvio not for sale|
|AFC Champions League Review: Al Sadd suffer last-16 exit|
|Emery targeting historic victory|
|Toure and Wisdom pen new Liverpool deals|
|Stadium facilities drive Van Gaal potty|
|Blatter brushes off Figo´s ´dictatorship´ claims|
|Mavuba to end career at Lille after extending contract|
|Ipswich´s Bishop charged over betting breaches|
|Markevych admits to Dnipro nerves|
|Relegated Almeria to be deducted three points|
|Reims retain Guegan on one-year deal|
|Di Matteo departure could hinder Schalke swoop for Khedira|
|Bale planning Real Madrid stay|
|Del Bosque not prepared to risk Costa|
|West Ham earn Europa League berth|
|Pellegrini sure City will win title back|
|Low calls Herrmann into Germany squad|
|Gerrard will win trophies with Galaxy - Carragher|
|Frankfurt agree to let Schaaf leave|
|Hernandez hit with violent conduct charge|
|Bale set for 50th Wales cap against Belgium|
|Baines hoping for pre-season return|
|Bournemouth sign Boruc|
|Sevilla duo Rico and Vidal handed Spain calls|
|Premier League: Chelsea season review - Mourinho´s men canter to title|
|Speroni hints at possible Palace exit|
|Kane states Tottenham commitment|
|Boruc, Hooiveld leave Southampton|
|Oxlade-Chamberlain desperate to make FA Cup final|
|Roar turn to Aloisi|
|Di Matteo resigns as Schalke coach|
|Hughes hints at Moses return|
|Wenger hits out at scheduling|
|Terry backs Chelsea to dominate|
|Jets part ways with coach Stubbins|
|Kewell would love to manage Liverpool|
|Janmaat: Newcastle players failed Carver|
|Adelaide step up interest in Toni|
|Chelsea´s Drogba interested in MLS move|
|Otamendi wants to leave Valencia - agent|
|Benitez almost certain for Real job|
|Schneiderlin will leave for Champions League club|
|Kane planning to come back bigger and better|
|Moyes staying at Sociedad|
|Neil revels in Norwich promotion|
|Drogba interested in MLS move|