MLS Cup holders Sporting Kansas City face a marathon start to the season with Saturday's trip to Seattle their first of five games in 15 days.
Sporting will begin the 2014 MLS season away to Seattle Sounders before hosting the first leg of their CONCACAF Champions League quarter-final against Mexico's Cruz Azul on Wednesday, followed by matches against FC Dallas, the Liga MX leaders and San Jose Earthquakes.
Kansas City's star midfielder Graham Zusi believes Sporting are ready to go, however, having played two games a week for the past fortnight.
"We played an awful lot of games (during pre-season)," Zusi said on Tuesday.
"We set up the schedule so we'd play every Wednesday-Saturday, like we will be in the coming weeks.
"So I think we'll be up for it. We'll be ready."
Sporting played seven pre-season matches since the start of February and won four of their past five before losing 4-1 to Columbus Crew last week.
But the reigning champions will take a significant step up on Saturday, playing in front of one of the loudest stadiums in the MLS, before another big challenge against Cruz Azul, who have won their past eight matches.
Kansas City coach Peter Vermes conceded he will have to use his entire squad to get through the opening fortnight of the new season.
"We're definitely going to have to manage minutes for the players, and then also take into consideration that going up to Seattle we're going to be playing on (artificial) turf," Vermes said.
"So there are a lot of variables you have to add into the equation. At the end, there's no doubt that there's a strategy per game, and also looking long term at what we want to do."
While Sporting enter the new season with confidence after their success in 2013, the Sounders will be keen to improve after finishing fourth in the Western Conference last campaign, before they were eliminated from the play-offs in the second round.
Seattle will welcome United States international Clint Dempsey back on Saturday with the 30-year-old having spent the off-season on loan at Fulham but Sounders coach Sigi Schmid said his other players needs to make the difference this season.
"I think everyone should just back off a little bit and not put so much pressure on him," Schmid said.
"All of a sudden there's this expectation that he'll be this magic man every time he steps on the field.
"He doesn't have to be a magic man every time he steps on the field; he has to be Clint Dempsey."
Portland Timbers - who won the Western Conference last season, eliminated arch-rivals Seattle and then lost to MLS Cup runners-up Real Salt Lake - will begin their new campaign at home against Philadelphia Union, while the East's top team from 2013, the New York Red Bulls, will travel to take on the Vancouver Whitecaps.
Real will travel south to face the Los Angeles Galaxy in a rematch of the West's semi-finals, DC United will host Columbus, while Houston Dynamo and Dallas will welcome New England Revolution and Montreal Impact to Texas respectively.
On Sunday, Chivas USA will host Chicago Fire in Los Angeles.
|Coach: B. Arena|
for G. Zardes 69'
for Samuel 77'
for Juninho 88'
|Mourinho tells Ronaldo: Team honours come first|
|Khedira returns to Juve training|
|Celtic v Qarabag: Champions League return of utmost importance, says Collins|
|Pellegrini: Jovetic had to go|
|Manquillo completes Marseille move|
|Schalke reject Juve´s Draxler bid|
|Blanc: Di Maria deal ´close´|
|Di Santo debut ends in stalemate|
|Fire sign Drogba, trade him to Montreal Impact|
|FIFA and UEFA welcome ruling on third-party ownership|
|Juve kick off title defence against Udinese|
|Stoke sign free agent Afellay|
|Benitez confident Ramos will stay|
|Fenerbahce issue warning to fans|
|UEFA Champions League Preview: De Boer confident Ajax are ready for Vienna test|
|Bility: I am the favourite for FIFA presidency|
|Pienaar to miss start of season|
|Vietnam 1 Manchester City 8: Sterling shines as tourists run riot|
|All-Star Keane relishing Spurs clash|
|Shaun Wright-Phillips joins brother Bradley at Red Bulls|
|Inter 0 Real Madrid 3: Rodriguez stunner caps comfortable win|
|Villa sign Ayew|
|Watford complete Berghuis transfer|
|Robben returns to Bayern training|
|Pulis anxious to make West Brom additions|
|David Luiz eager to welcome ´fantastic´ Di Maria|
|Fernando injury free ahead of new campaign|
|Hummels blames weight issues for poor season|
|Defoe hoping for early Sunderland goals|
|Depay hints at identity of ´surprise´ United striker|
|Tigres UANL v River Plate: Hosts look to bounce back and make history|
|Crespo set for Villa move|
|Terry: I would never join a Premier League rival|
|Van Gaal coy on United future|
|Romero to cover potential De Gea exit - Van Gaal|
|Uruguay win men´s football gold at Pan Am Games|
|Pirlo thanks New York City fans for ´beautiful´ welcome|
|Mexico capitalised on ´the mistakes we made´ - Schafer|
|Herrera delighted with Mexico display|
|MLS Review: Whitecaps build happy home, Pirlo debuts|
|Guardado wins Golden Ball at Gold Cup|
|NZF confirms Olympics disqualification appeal|
|Jamaica 1 Mexico 3: CONCACAF giants complete form turnaround|
|New York Red Bulls 2 Benfica 1: Another scalp for MLS side|
|Romero signs with United|
|Moghreb Tetouan 1 Al Hilal Omdurman 1: Visitors go top|
|Van Gaal rules out Ronaldo bid|
|Pique open to Barca captaincy|
|Pirlo makes MLS bow in thrilling NYC victory|
|Coutinho and Can return for Liverpool U21s|
|Walcott deal ´closer´, says Wenger|
|Arsenal 1 Wolfsburg 0: Walcott the match-winner in Emirates Cup finale|
|Di Santo links up with Schalke squad|
|Lukaku treble sinks Hearts|
|Benitez again refutes Ronaldo rift rumours|
|Pepe sure Ramos will stay at Real|
|City target De Bruyne named Germany´s Player of the Year|
|Montero spoils McCarthy´s Palace debut|
|Lyon 0 Villarreal 2: Soriano, Baptistao seal comfortable win in Emirates Cup|
|Wijnaldum on target as Newcastle are held|
|Mourinho: Rivals trying to buy the title|
|Jovetic set for Inter medical|
|RFS in ´denial´ over racism issue, claims Football Against Racism in Europe|
|Salah not staying at Chelsea - Mourinho|
|Mbemba closes in on Newcastle switch|
|Ibrahimovic: Di Maria will take PSG to another level|
|Delph: Don´t compare me to Pogba|
|Dundee United sign Sneijder|
|Morata relishing new-look Juve strikeforce|
|Strachan "not scared" of England after World Cup qualifying draw|
|Brazil claim football, basketball, handball gold in Toronto|
|Lampard´s debut delayed again, Pirlo ready to play|
|Mourinho open to Premier League matches in US|
|MLS Review: Texas unites to hurt Galaxy|
|Luis Enrique: United can emulate Barca revival|
|Van Gaal singles out Januzaj, hails United´s forwards|
|Blanc still hopeful PSG will sign Di Maria|
|Irish international Cunningham seeks Bristol City exit|
|Italy embracing Spain challenge in World Cup qualifying|
|Dos Santos brothers in doubt for Gold Cup final|
|PSG 1 Chelsea 1 (aet, 5-6 on penalties): Courtois clinches victory for Mourinho´s men|
|United States 1 Panama 1 (aet, 2-3 on penalties): Mejia denies hosts third|
|ES Setif 1 Al Merreikh 1: Sudanese deny title-holders at home|
|CONCACAF admit referee errors in Gold Cup semi-final|
|Dutch favourites in Group A - Deschamps|
|Barcelona 1 Manchester United 3: Rooney, Lingard and Januzaj maintain winning start|