CAF Champions League holders Al Ahly face an uphill task if they are to qualify for the second round of this year's tournament.
The Egyptian outfit overcame Orlando Pirates 3-1 on aggregate in last year's final to claim the title for the eighth time in their history.
However, Mohamed Youssef's men head into the second leg of their tie with Tanzanian side Young Africans 1-0 down following a disappointing first leg.
Defender Nadir Haroub scored the only goal of the game for Young Africans, and the holders will need to improve markedly on that performance in order to avoid an early elimination when they meet for the return leg on Saturday.
Another side surprisingly behind in the tie after the first leg is Raja Casablanca.
The Moroccan side surprised everybody at the FIFA Club World Cup in December, reaching the final with wins over Monterrey and Atletico Mineiro, before succumbing 2-0 to favourites Bayern Munich.
But Faouzi Benzarti's men will have to come from behind if they are to have any chance of returning to that competition following a 1-0 loss to Horoya of Guinea.
By contrast, five-time champions Zamalek have a 1-0 advantage in their tie with Kabuscorp of Angola, while last-season's semi-finalists, ES Tunis, have the benefit of away goals after a 3-2 win at Kenya's Gor Mahia.
Ivorian side Sewe Sport's prospects of qualifying for the next round hang in the balance on the back of an enthralling 3-3 draw in the first leg clash with Barrack Young Controllers of Liberia.
The winner of that tie faces a meeting with either two-time winners TP Mazembe or Les Astres of Cameroon, who are locked at 1-1 after the first leg.
Meanwhile, ES Setif, Leopards de Dolisie and Kaizer Chiefs all have one foot in the next round thanks to easy first-leg victories over ASFA-Yennenga, Primeiro de Agosto and Liga Muculmana respectively.
Cotonsport reached the last four in 2013 but head into the second leg trailing Flambeau de l'Est 1-0, however, 2006 finalists CS Sfaxien host Dedebit leading 2-1 from the first game.
It is all to play for in the ties between Dynamos and AS Vita club and Stade Malien and Al Hilal Omdurman, which are both goalless ahead of the decisive leg.
Elsewhere, Real Bamako hold a 2-1 lead over Enyimba, Berekum Chelsea and Al-Ahly Benghazi are level at 1-1 and Nkana and Kampala City Council face off again following an entertaining 2-2 draw in the first leg.
|Sporting Kansas City 4 Dallas 0: Nemeth, Zusi destroy 10-man visitors|
|Geferson replaces Marcelo for Copa America|
|PSG captain Silva in doubt for Coupe de France final|
|Valverde: Bilbao to stick to style in Copa final|
|´Another round of indictments´ expected in FIFA case|
|Youngsters promoted to Australia´s squad to face Kyrgyzstan|
|Disappointed FFA, US Soccer still want change|
|Gutierrez: Ashley abandoned me|
|US senator urges Blatter to release Garcia Report|
|Gutierrez, Taylor released by Newcastle|
|Figo calls on re-elected Blatter to resign after ´dark day´ for football|
|Szczesny blasts father over ´idiotic´ comments|
|Blatter vows to leave ´strong´ FIFA|
|Blatter re-elected as FIFA president|
|BREAKING NEWS: FIFA elections set for second round of voting|
|Atsu wings in for Bournemouth campaign|
|Klopp: Pokal final not about me|
|Clement says Real goodbyes|
|Inter v Empoli: Icardi looking for final flourish|
|BREAKING NEWS: Blatter - I will fix FIFA|
|Northern Ireland v Qatar: O´Neill keen to prepare for Romania test|
|Palestine drop proposal for Israel suspension|
|Suarez will only get better, warns Iniesta|
|Martinez keen to recruit quickly|
|Monk keen to build on successful Swansea campaign|
|Fit-again Suarez set to aid Barca´s treble quest|
|Anonymous ´bomb´ threat received at FIFA Congress|
|Qatar organisers insist World Cup bid met ´highest ethical standards´|
|Wilkinson and Sorensen leave Stoke|
|Blatter: You can´t ask everyone to behave ethically just like that|
|Van Bronckhorst positive about Feyenoord future|
|Australian police to look into FFA-Warner dealings|
|Dardai signs Hertha deal|
|Protester interrupts FIFA Congress|
|Spurs complete Wimmer signing|
|Warner questions charges following release|
|Mexico v Guatemala: Herrera´s men kick off Copa preparations|
|New Zealand no longer supporting Blatter|
|´Post-World Cup trauma´ affected Mertesacker|
|Racing Club 0 Guarani 0 (0-1 agg): Draw sees Paraguayans through|
|Hamburg shocked by Karlsruher attack - Labbadia|
|Serie A Preview: Napoli, Lazio eye Champions League|
|Hodgson will not overstay England welcome|
|Scholes: United must keep Di Maria|
|Leyton Orient appoint Hendon|
|Benteke has a buy-out clause - Sherwood|
|US Soccer will support Prince Ali in FIFA election|
|Dynamo disappointed with officials after City friendly abandoned|
|Calls for Suarez appeal gather momentum|
|Eredvisie Review: Vitesse denied by late Uth goal, NAC Breda boost survival hopes|
|Rangers 1 Motherwell 3: McCall´s men facing uphill struggle|
|Hamburg 1 Karlsruher 1: Bundesliga side escape with draw|
|Blatter vows to lead FIFA clear of trouble as corruption scandal rolls on|
|Bundesliga: Bayern Munich season review - League crown not enough to signal successful campaign|
|Genoa forced to wait for UEFA licence|
|Injured Cardozo out of Paraguay squad|
|CONCACAF provisionally dismisses Webb and Li|
|Klopp: Career highlights of a charismatic coach|
|Verona v Juventus: Ogbonna seeks strong Champions League warm-up|
|FA charges Demetriou over betting breaches|
|Atalanta v Milan: Inzaghi faces last chance to prove worth|
|King joins Bournemouth as QPR rebuild begins|
|Plymouth part ways with Sheridan|
|Hernandez banned for three matches|
|Chelsea star Fabregas has nose surgery|
|Blatter: More bad news may follow|
|Galliani hopeful over Ancelotti deal|
|Frontzeck to continue as Hannover coach|
|Tremmel released as Tate waves goodbye to Swansea|
|Arsenal v Aston Villa: Sherwood out to upset holders|
|UEFA open to boycott of World Cup - Platini|
|Porto activate release clause for Casemiro|
|Athletic Bilbao v Barcelona: Catalans seeking second leg of treble|
|Auxerre v Paris Saint-Germain: History beckons for Ligue 1 champions|
|Cole confirms West Ham departure|
|UEFA elect not to boycott FIFA Congress|
|Borussia Dortmund v Wolfsburg: Klopp aiming for triumphant farewell|
|Flamini hails Coquelin impact at Arsenal|
|South Africa deny wrongdoing in World Cup bid|
|Benitez confirms Napoli exit|
|McShane among six released by Hull|
|Cerci committed to Milan|
|West Ham expect Collins to return for pre-season|
|Real deny Pogba bid|
|Important to keep Chelsea squad together - Mourinho|
|Alonso: Gerrard was magic|
|Pochettino silent on Ings speculation|
|Visa threatens to ´reassess´ sponsorship amid FIFA scandal|
|Blatter skips FIFA Medical Conference|
|MLS Preview: Revs not out for revenge against Galaxy|
|MLS Review: Sounders go top in West, Timbers and Galaxy win|
|AFC stands by Blatter|
|Matheus ´alright´ after collapse - Markevych|
|Copa Libertadores Review: River, Inter through to semis|
|Signing Toni a ´long shot´ for Adelaide|
|Ramsey good enough for Barca - Coleman|
|Bacuna pushing for Benteke stay|
|Evans stunner settles City friendly in Toronto|
|Banega: Emery a great coach|
|Emery tight-lipped on Sevilla future|
|Argentina finalise Copa America squad|
|Nike issues statement following arrest of FIFA officials|