Bayern Munich's canter towards the Bundesliga title takes them to Wolfsburg on Saturday, while Hannover host Bayer Leverkusen.
Pep Guardiola's side are 20 points clear atop the league table with 15 matches to play, having won 21 of 23 fixtures this season in a dominant performance.
Wolfsburg sit fifth in the table, just two points outside of a UEFA Champions League spot, however, they would be concerned at shipping six goals to mid-table Hoffenheim at their last start ahead of a date with the ever-strong Bayern.
Leverkusen are third in the table, 22 points behind Bayern, but have severe concerns after dropping their past three matches ahead of their trip to Hannover.
Sami Hyypia's men have the chance to steady their form, though, as Hannover are winless in four, including three losses.
Schalke, fourth, host the in-form Hoffenheim on Saturday, which should prove to be an entertaining contest.
Despite their standing in 10th, Hoffenheim have been one of the most aggressive sides in the league, scoring 52 goals - the third highest tally in the German top flight.
In their past five matches, Markus Gridol's men have scored 16 goals, and will further test the defence of Schalke, who had five put past them last time out against Bayern.
In other Saturday fixtures, Borussia Monchengladbach host Augsburg, while Stuttgart - on a seven-match losing streak - are at home to bottom club Eintracht Braunschweig and Hamburg welcome Eintracht Frankfurt.
The late kick-off sees Nuremburg at home to Werder Bremen.
On Sunday, second side Borussia Dortmund travel to relegation-placed Freiburg.
Dortmund, who bounced back from a 3-0 loss to Hamburg by beating Nuremburg by the same margin last week, have beaten Freiburg seven times in a row, averaging over 3.5 goals in that run.
Later on Sunday, Hertha Berlin - who remain well in the race for European honours in their promotion season - are away at Mainz.
Hertha sit two points behind the sixth-placed Mainz, and a win could catapult Jos Luhukay's men into a Europa League spot.
1 - 0
1 - 1
1 - 2
1 - 3
1 - 4
1 - 5
1 - 6
|14||K. De Bruyne|
|Coach: D. Hecking|
for D. Caligiuri 79'
for M. Arnold 79'
for K. De Bruyne 85'
|Matheus ´alright´ after collapse - Markevych|
|Copa Libertadores Review: River, Inter through to semis|
|Signing Toni a ´long shot´ for Adelaide|
|Ramsey good enough for Barca - Coleman|
|Bacuna pushing for Benteke stay|
|Evans stunner settles City friendly in Toronto|
|Banega: Emery a great coach|
|Emery tight-lipped on Sevilla future|
|Argentina finalise Copa America squad|
|Nike issues statement following arrest of FIFA officials|
|Hero Bacca grateful for Europa League triumph|
|Markevych rues defensive errors in Dnipro defeat|
|AFC Champions League Review: Naft Tehran fairytale continues|
|Emery: We deserved Europa League success|
|Dnipro 2 Sevilla 3: Bacca brace sees holders make history|
|South Africa 0 Malawi 0 (4-5 on penalties): Harawa heroics send Bafana Bafana out|
|CONCACAF and CONMEBOL respond to arrests in FIFA scandal|
|FIFA president Blatter welcomes investigations as corruption probe rocks world football|
|UEFA calls for FIFA elections to be postponed|
|BREAKING NEWS: Advocaat exits Sunderland and retires from club management|
|La Liga: Real Madrid season review - Ancelotti pays the price for disappointing season|
|Zambia 3 Ghana 0: First-half spree does the damage|
|Barnes suffers double knee ligament injury|
|Balotelli to stay at Liverpool - agent|
|Kane at the double in friendly win|
|Norwich make Dorrans switch permanent|
|Ings unsure of next move|
|Bournemouth snap up Federici|
|FIFA ´crisis´ cannot continue - Prince Ali|
|Barton headlines QPR exits|
|Juan demands more from Inter|
|Stoke snap up Haugaard|
|Subotic commits to Dortmund|
|Warner pleads innocence after US indictment|
|Napoli to refuse questions on Benitez´s future|
|USDoJ names indicted FIFA officials|
|Wenger coy over Vidal and Benzema moves|
|Suarez back in training ahead of Copa final|
|Pique: I´ll retire at Barca|
|Gerrard ´blown away´ by Liverpool send-off|
|FIFA ´very happy´ with Zurich arrests|
|Liverpool defender Toure targeting trophies|
|Ramsey eyeing title assault|
|Welbeck out of FA Cup final and England matches|
|FIFA the ´injured party´ as Swiss prosecutors open criminal proceedings|
|Prince Ali saddened by FIFA arrests|
|Pellegrini to make City defence a priority|
|Labbadia giving Lasogga, Olic, Jiracek time|
|Ramsey confident on Wembley chances|
|Swiss authorities confirm FIFA arrests|
|El Shaarawy open to Premier League move - agent|
|Reports: FIFA officials set to be arrested|
|Tigres UANL 2 Emelec 0 (2-1 agg): Mexicans through to Libertadores semis|
|Valencia ruled out of Copa America|
|Coleman: Bale being ignored by Real team-mates|
|Ruddy eyes England recall|
|Benteke will strike fear into Arsenal - Westwood|
|Howe named LMA Manager of the Year|
|Casillas reiterates desire to stay in Madrid|
|Dnipro players pay for fans´ tickets, transport|
|Galliani: I want Ancelotti back at Milan|
|Premier League: Manchester City season review - Frustrations as latest title defence falters|
|Injured Benfica star Salvio not for sale|
|AFC Champions League Review: Al Sadd suffer last-16 exit|
|Emery targeting historic victory|
|Toure and Wisdom pen new Liverpool deals|
|Stadium facilities drive Van Gaal potty|
|Blatter brushes off Figo´s ´dictatorship´ claims|
|Mavuba to end career at Lille after extending contract|
|Ipswich´s Bishop charged over betting breaches|
|Markevych admits to Dnipro nerves|
|Relegated Almeria to be deducted three points|
|Reims retain Guegan on one-year deal|
|Di Matteo departure could hinder Schalke swoop for Khedira|
|Bale planning Real Madrid stay|
|Del Bosque not prepared to risk Costa|
|West Ham earn Europa League berth|
|Pellegrini sure City will win title back|
|Low calls Herrmann into Germany squad|
|Gerrard will win trophies with Galaxy - Carragher|
|Frankfurt agree to let Schaaf leave|
|Hernandez hit with violent conduct charge|
|Bale set for 50th Wales cap against Belgium|
|Baines hoping for pre-season return|
|Bournemouth sign Boruc|
|Sevilla duo Rico and Vidal handed Spain calls|
|Premier League: Chelsea season review - Mourinho´s men canter to title|
|Speroni hints at possible Palace exit|
|Kane states Tottenham commitment|
|Boruc, Hooiveld leave Southampton|
|Oxlade-Chamberlain desperate to make FA Cup final|
|Roar turn to Aloisi|
|Di Matteo resigns as Schalke coach|
|Hughes hints at Moses return|
|Wenger hits out at scheduling|
|Terry backs Chelsea to dominate|
|Jets part ways with coach Stubbins|
|Kewell would love to manage Liverpool|
|Janmaat: Newcastle players failed Carver|
|Adelaide step up interest in Toni|
|Chelsea´s Drogba interested in MLS move|
|Otamendi wants to leave Valencia - agent|
|Benitez almost certain for Real job|
|Schneiderlin will leave for Champions League club|
|Kane planning to come back bigger and better|
|Moyes staying at Sociedad|
|Neil revels in Norwich promotion|
|Drogba interested in MLS move|