Colombia goalkeeper David Ospina compared Uruguay's loss of Luis Suarez to the absence of Radamel Falcao from his team on Friday.
Suarez received a four-month ban from all football on Thursday for biting Italy defender Giorgio Chiellini in Uruguay's final Group D encounter, which means the Liverpool striker will miss the rest of the FIFA World Cup.
Colombia are Uruguay's next opponents with the two South American nations set to clash in the round of 16 on Saturday at the Maracana.
Ospina is convinced Uruguay have enough quality to overcome Suarez's absence, just as Colombia have advanced without star striker Falcao, who has missed the World Cup with a knee injury.
"All national teams have difficulties," the 25-year-old goalkeeper said.
"We had difficulties but that is why it is down to all members of the team to have the ability and skill to overcome any difficulty."
Colombia coach Jose Pekerman warned his players not to get too caught up in the media coverage of Suarez's ban and was not interested in giving an opinion on the severity of the suspension.
"It is a very delicate issue. It seems to me that our concern is Uruguay and we are working hard to deal with them," Pekerman said.
"Uruguay are highly respected. We knew the possibility of playing them, they are always top-notch. We have to be ready.
"Playing them motivates us. We have huge respect for Uruguay's history, we have to continue moving ahead."
While Colombia (eighth) started the World Cup ranked just one position lower than Uruguay (seventh) by FIFA, Pekerman underlined the Uruguayans' superior pedigree and claimed the pressure is on Oscar Tabarez's side.
Uruguay have won two World Cups in their history, while Colombia have only beaten their CONMEBOL rivals twice in nine matches over the past decade.
"The big teams must prove why they are so big, why they have won things and why they are so valued," Pekerman said.
"In countries such as ours, which hasn't competed at the World Cup for so long, we must show our willingness and ambitions.
"We must know how to compete and we are doing quite well.
"This is a huge test for us. For Colombia this is going to be a demanding test. We will have to show that we can compete."
|10||J. Rodríguez||28' 50'|
|Coach: J. Pekerman|
for T. Gutiérrez 68'
for J. Cuadrado 81'
for J. Rodríguez 85'
|Exhausted Keane needs a break, says O´Neill|
|Football League Review: Bristol City bounce back|
|Real Sociedad 3 Elche 0: Vela hat-trick gives Moyes first win|
|Marseille 2 Nantes 0: Bielsa´s men stretch lead to four points|
|Freiburg 1 Stuttgart 4: Harnik secures win on Stevens´ return|
|Dordrecht 0 Willem II 4: Armenteros double inspires visitors|
|Bayern Munich turnover breaks half-a-billion barrier|
|Eintracht Frankfurt v Borussia Dortmund: Gundogan demands winning run|
|Milan v Udinese: Inzaghi out to break winless run|
|Pele showing signs of improvement|
|Prandelli axed by Galatasaray|
|Tottenham v Everton: Martinez expects Tottenham to be a force|
|Valencia v Barcelona: Mathieu eyes triumphant Mestalla return|
|Roma v Inter: Campagnaro eyes first-team chance|
|Estoril 3 PSV 3: Wijnaldum puts visitors through|
|Nesta comes out of retirement to join Chennaiyin|
|Messi ´obviously´ not joining Chelsea, says Mourinho|
|Everton and West Ham fined by FA|
|Romario-like Aguero will be decisive, acknowledges Koeman|
|Southampton v Manchester City: Koeman issues challenge|
|Juventus v Torino: Champions target 25 in a row in derby|
|South Africa v Ivory Coast: Squad players get platform to impress|
|McCarthy´s hamstring issues concerning Martinez|
|Rodgers ignoring talk of the sack|
|Mourinho keen to avoid complacency|
|Tottenham and Legia face disciplinary hearings|
|Klopp convinced Dortmund´s fortunes will turn|
|Dzeko close to City return|
|Real hit back at Platini over Ballon d´Or comments|
|Ancelotti: Tired Kroos will play|
|United defender Shaw out for ´a few weeks´|
|Melbourne Victory 3 Adelaide United 2: Hosts edge five-goal thriller to go top|
|Mexes determined to stay at Milan|
|Guardiola positive despite City defeat|
|Hull striker Hernandez out of United clash|
|River Plate 1 Boca Juniors 0 (agg 1-0): Pisculichi goal sends hosts into final|
|Wenger confirms Arteta lay-off|
|Negredo not ´obsessed´ with ending barren run|
|Kroos admits fatigue|
|Keane quits Villa role|
|Henry vows to help Arsenal after retirement|
|Everton can go far in Europe - Jagielka|
|Pardew expects Carroll return|
|Michu undergoes ankle surgery|
|Brandao sentenced to prison|
|Allardyce slams ´rather silly´ Tomkins|
|Rodgers similar to Wenger - Toure|
|J.League Preview: Flying Gamba chasing Urawa|
|Benitez happy to progress|
|Montella: Fiorentina have ´impressive mentality´|
|Pele ´doing fine´, receiving kidney treatment|
|Ausilio praises Handanovic´s ´remarkable statistics´|
|We need to improve - Stambouli|
|Estoril versus PSV postponed due to rain|
|UEFA Europa League Review: Feyenoord and Everton qualify in style|
|Martinez hails Everton perfection|
|Tottenham 1 Partizan 0: Stambouli settles it for Spurs|
|Inter 2 Dnipro 1: Osvaldo strikes as 10-man hosts earn hard-fought win|
|Tottenham-Partizan clash temporarily suspended due to pitch invasions|
|McKinlay named Moyes´ assistant|
|Poyet issues Chelsea challenge|
|Wolfsburg 0 Everton 2: Martinez´s men secure top spot|
|Lambert defends Bent loan move|
|Sunderland v Chelsea: Johnson eyes next major scalp|
|Riera released by Udinese|
|QPR v Leicester City: Pearson aiming to build on positives|
|Galatasaray and Anderlecht face disciplinary proceedings|
|Liverpool v Stoke City: Hughes plotting Anfield success|
|Vermaelen out for four to six months|
|Swansea City v Crystal Palace: Monk looking for positive response|
|Printant to remain Bastia head coach|
|Irvine knew nothing of Berahino drink-driving case|
|Pele admitted to special care unit|
|West Ham v Newcastle United: Allardyce pinpoints vital phase|
|Skripnik agrees three-year extension at Werder|
|Monk rubbishes talk of Michu return|
|FA charges Whelan over comments|
|Burnley v Aston Villa: Lambert laments list of absentees|
|Manchester United v Hull City: Bruce wary of in-form Rooney|
|Hughes hopeful over unwell trio|
|Grant named as Ghana coach|
|Bielsa expecting tough Nantes challenge|
|Basel charged by UEFA following pitch invasion|
|West Brom v Arsenal: Mertesacker refocusing attention after midweek win|
|Colaco banned by FIFA|
|Championship Preview: Derby head to happy hunting ground|
|Hertha Berlin v Bayern Munich: Hosts out to take advantage|
|Taylor injury ´not as bad as first feared´|
|Wilshere out for three months|
|Torosidis suffers calf strain|
|Malaga v Real Madrid: Ancelotti´s men in search of sweet 16|
|England climb FIFA rankings, Germany remain number one|
|Bolasie staying put - Warnock|
|Sewe Sport v Al Ahly: Ivorians eye more history|
|Schalke lose Matip with broken foot|
|Paris Saint-Germain v Nice: Ibrahimovic looks to end Ligue 1 goal drought|
|K. League Preview: Seoul, Steelers tussle for third|
|No complaints over FA charge for Allardyce|
|Redknapp ready for crucial run|
|Zapata targets regular first-team role at Milan|
|Fabregas revels in career-best form|
|Eriksen claims Tottenham struggling to ´connect´|
|MLS Preview: Schmid labels Galaxy ´physical´|
|Costa Rican Primera Division Review: Cartagines secure semi-finals berth|
|Serie A Preview: Roma out to stay in touch with Juve|
|The Strongest 1 Bolivar 1: Capdevila strike saves leaders|
|Sao Paulo 1 Atletico Nacional 0 (agg 1-1, 1-4 on penalties): Colombians reach final|
|Cruzeiro 0 Atletico Mineiro 1 (agg 0-3): Culpi´s men win first Copa do Brasil|
|Malmo´s Hareide furious with referee´s injustice|
|Dermendzhiev elated with Ludogorets display|
|Defour withdrawal stalled Anderlecht|
|Atletico achievement delights Simeone|
|Atletico did ´many´ things well - Michel|
|Raul Garcia promises no let-up from Atletico|
|Missed chances disappoint Rolfes|
|La Liga Preview: Real out to break club record at Malaga|
|Ancelotti praises defence after record-equalling win|