DC United will play host to the Seattle Sounders in a blockbuster clash as the MLS resumes after a two-week break.
The FIFA World Cup in Brazil has taken centre stage recently but the United States' premier competition returns with Saturday's fixture at the Robert F. Kennedy Memorial Stadium in Washington pitting the Eastern Conference's leaders against the Western Conference's high-flyers.
Ben Olsen's DC United have tasted defeat just once in their past seven league games to sit atop the standings on 25 points after 15 games, two points clear of nearest rivals the New England Revolution.
In the West, the Sounders (32 points) are seven points clear at the summit after back-to-back wins, with Real Salt Lake (25 points) in second position.
Nigerian forward Obafemi Martins has played a big part in the Sounders' rise, scoring four goals in his past four games in MLS.
Seattle have enjoyed success against the capital franchise in recent memory, with the Sounders unbeaten in their four most recent meetings in all competitions, having won two (2-0, 3-0) and drawn two (2-2, 0-0).
The Sounders' hopes of maintaining that run of form against DC United has been boosted by the news that star forward Fabian Espindola will miss the next six weeks due to knee ligament damage.
Espindola has scored seven goals and assisted eight for DC United this season - no player has been involved in more goals thus far - and the pressure will be on Luis Silva to step up in his absence after he netted a hat-trick in the final game before the World Cup break.
In other fixtures over the weekend, out-of-sorts New England will be out to arrest a two-game losing streak when they entertain the eighth-placed Philadelphia Union on Saturday.
After five wins on the bounce, New England have suffered back-to-back defeats to the Montreal Impact (2-0) and New York Red Bulls (2-0).
New York and Toronto will go head-to-head in a mid-table clash in the East on Friday.
The Red Bulls were 3-1 winners against Real Salt Lake last time out, while Toronto edged the San Jose Earthquakes 1-0.
The Vancouver Whitecaps and Montreal Impact have a busy week ahead of themselves, with two games in the space of four days.
Vancouver and Montreal will do battle on Thursday, before the Whitecaps travel to the Colorado Rapids on Saturday, while the Impact are in action against the Houston Dynamo the following day.
The Portland Timbers face Sporting KC at Providence Park on Friday.
On Saturday, the Crew welcome Dallas to Columbus and the Los Angeles Galaxy travel to San Jose to play the Earthquakes.
Meanwhile, Real Salt Lake take on Western Conference cellar-dwellers Chivas USA.
|Coach: B. Olsen|
for L. Neal 46'
for L. Silva 76'
for S. Franklin 87'
|Hamstrung Clasie in doubt for Southampton league opener|
|West Ham goalscorer Zarate bemoans Astra comeback|
|Negredo quashes Valencia exit rumours|
|´This is not my Sampdoria´ - president Ferrero|
|Criscito could join Inter - agent|
|CBF endorse Zico´s FIFA presidency campaign|
|Hawit to handle CONCACAF´s referee review|
|Falcao is a ´top, top player´ - Terry|
|Tuchel pleased by Dortmund fighting qualities|
|Premier League rules out schedule changes for Champions League clubs|
|UEFA Europa League Review: Southampton stroll as Sampdoria are humiliated|
|Koeman confident of Southampton progress|
|Bilic frustrated with Collins´ red card, Valencia injury|
|Bamford hits hat-trick in Bromley friendly|
|Southampton 3 Vitesse 0: Play-offs in sight for Koeman’s men|
|Wolfsberger 0 Borussia Dortmund 1: Tuchel begins tenure with narrow win|
|West Ham 2 Astra 2: Collins red allows visitors back in|
|Kukesi - Legia match abandoned|
|Joining Roma an ´easy decision´ - Szczesny|
|Chiriches joins Napoli from Spurs|
|Mihajlovic pleased with Milan improvements|
|Injured Chiellini to miss Supercoppa|
|Newcastle complete Mbemba swoop|
|Blackpool protest incurs FA fine|
|Scottish Premiership Preview: Dons seek to run Celtic closer|
|Paris Saint-Germain v Lyon: Ibrahimovic ready for season opener|
|Wolfsburg v Bayern Munich: De Bruyne centre of attention|
|Real Madrid 0 Milan 0 (10-9 on pens): Real lift second International Champions Cup|
|De Bruyne a doubt for Supercup clash|
|Reine-Adelaide needs time to blossom, says Walcott|
|Rodgers will not rush Ibe development|
|Napoli not interested in selling Higuain - De Laurentiis|
|Wilson agrees Bournemouth extension|
|Messi makes early Barcelona return|
|Ibrahimovic: My next move will be a very big surprise|
|Van Aanholt backs Lens to shine|
|Besiktas complete loan move for Gomez|
|McClaren: No decision on Coloccini future|
|Kane, Kaka hail goalkeeper Rimando|
|Chung eager to become FIFA president|
|Yedlin open to loan move|
|Tigres not scared of River trip - Ferretti|
|MLS Preview: Wright-Phillips, Lampard set to debut|
|´A draw is good for us´ - River´s Gallardo confident of Libertadores success|
|Di Maria poised for PSG switch - Blanc|
|Franjic: Bring on Bangladesh, Tajikistan|
|Van Gaal bemoans De Gea situation|
|MLS All-Stars 2 Tottenham 1: Kane stunner can´t spare Spurs|
|Manchester United 0 Paris Saint-Germain 2: Van Gaal´s defensive frailties exposed|
|Tigres UANL 0 River Plate 0: Visitors lose Gallardo in Copa Libertadores final first leg|
|Penedo parts ways with Galaxy|
|Benitez backs Mihajlovic, Milan to succeed|
|Barnetta joins Union in MLS|
|Allegri critical of Morata´s attitude|
|Franjic targets more A-League glory with City|
|Beto undaunted by Super Cup clash against Barca|
|Advocaat upbeat despite another Sunderland flop|
|McClaren praises Newcastle recruit Mitrovic|
|Payet will improve West Ham - Bilic|
|Pulis confirms interest in Lambert|
|Deila expects tough test in Baku|
|Drogba mobbed by Montreal Impact fans|
|UEFA Champions League Review: Ajax spurn two-goal lead at 10-man Rapid|
|Sunderland´s struggles continue as Doncaster cruise to win|
|Mahrez and Nugent on target in Leicester win|
|Mitrovic tastes debut defeat for Newcastle|
|Celtic 1 Qarabag 0: Boyata snatches crucial win|
|Jablonec 0 Copenhagen 1: Verbic cracker gives Danes the edge|
|Norwich sign Wisdom on loan from Liverpool|
|UEFA Europa League Preview: Koeman plays down importance of Vitesse links|
|Schneiderlin keen to learn from experienced duo|
|Mandzukic´s maiden Juventus goal seals win in Poland|
|Fofana completes Bastia loan|
|Deila delighted that Gordon pledges future to Celtic|
|Grenier ruled out for four months|
|Rooney: United squad ready for title challenge|
|Messi and Neymar available for start of season|
|Szczesny seals Roma switch|
|Benitez cools Mourinho war of words|
|Filipe Luis vows to win back Atletico fans|
|Besiktas in negotiations over Gomez switch|
|Kishna seals Lazio switch|
|Diaby completes Marseille move|
|Platini is bad for FIFA - Prince Ali|
|Bilic keen to make further additions|
|Brady makes Norwich move|
|Southampton complete Caulker loan|
|Rummenigge feels Muller ´will never leave´ Bayern|
|Platini to stand in FIFA presidential election|
|Howedes to remain Schalke skipper|
|Albion sign Hull defender Chester|
|Lucescu defends Fred selection amid doping allegations|
|Fabregas still in love with Arsenal|
|Luis Enrique ´happy´ with Barca´s US trip|
|Mourinho optimistic over Cahill and Costa|
|River owe Tigres´ Esqueda - Mercado|
|Van Gaal expecting big season from Shaw|
|Begovic keen to challenge Courtois|
|Mourinho launches attack on Benitez|
|CONMEBOL ´knocked on a lot of doors´ to keep half-spot - president|
|America 0 Benfica 0 (3-4 on penalties): Primeira Liga champions finally win|
|Napoli striker Higuain ´untouchable´ - Gabbiadini|
|Arsenal´s friendly form will boost confidence - Wenger|
|Nagatomo-Melo swap possible, says agent|
|Chelsea 2 Barcelona 2 (4-2 on penalties): Courtois stars for Premier League champions|
|Eriksen calls for ruthless Spurs|
|Pulis praises Berahino attitude|
|Alderweireld confident of top-four finish|
|Villa ready for tough Spurs clash|
|West Ham edge win on Carrow Road anniversary|
|Kozak scores twice as Villa draw at Wolves|