Group C's early pacesetters meet in Brasilia on Thursday as Colombia and Ivory Coast seek to bolster their hopes of progression.
The nations won their respective opening matches on Saturday and another victory for either would all but secure their place in the knockout stages.
In a group where all four sides will have had high expectations of qualification when the tournament began, Colombia and Ivory Coast struck first as they triumphed over Greece and Japan respectively.
Jose Pekerman's team were in particularly impressive form as they swept aside the Greeks 3-0 while Sabri Lamouchi's men came from behind to beat Japan 2-1.
Ivory Coast started slowly in their opening clash and a repeat could cost them against a Colombia side who were ahead inside six minutes in their first game.
The return of Fredy Guarin following suspension will further bolster Colombia's attacking options and Jackson Martinez, who came off the bench against Greece, expects a tougher test than in their opener.
"Ivory Coast is a team who have grown a lot, they have a lot of experience," Martinez said.
"The match against Japan was a showcase of them being a team. You have to keep controlling the game until the end."
Dider Drogba was at his influential best against Japan - helping to inspire his side's recovery from a goal down after being introduced from the bench.
Lamouchi has hinted Drogba will likely begin Thursday's game on the bench again and the 36-year-old striker is content with a bit part role.
Regardless of whether he is handed a starting berth or not, Martinez still anticipates that the Galatasaray man will be a prominent figure for his country.
"We all know his quality, he's a big forward and he's done a lot of things in his career," the Porto striker added.
"He's a leader on the pitch and can lead his team to victory when things get complicated.
"He's a key player for the Ivory Coast either starting or coming off the bench."
It will be the first meeting between the two nations and the victor can take a huge stride towards wrapping up a last-16 berth, with Japan and Greece hoping to make up ground on the losers, or on both sides if the spoils are shared.
Between them, Colombia and Ivory Coast have reached the knockout stages at the World Cup just once previously but that looks set to change ahead of what promises to be an exciting, attacking affair.
Even without the injured Radamel Falcao and Carlos Bacca, the likes of Martinez, Adrian Ramos and Teofilo Gutierrez can threaten goals for Colombia while Wilfried Bony and Gervinho will hope to add their World Cup goal tallies for the Africans.
|Coach: J. Pekerman|
for V. Ibarbo 53'
for P. Armero 72'
for A. Aguilar 79'
|Wenger: West Ham could take two years to settle|
|River Plate play in green as tribute to Chapecoense|
|Roberto Carlos open to coaching in A-League|
|Wenger confident there is more to come from Arsenal|
|Kane wants to see out career at Tottenham|
|Aguero challenge labelled ´crazy´ by disappointed Cahill|
|Mourinho ´has nothing to hide´ over tax affairs|
|Guardiola happy despite City setback|
|Ibrahimovic: I tried to avoid Coleman|
|Pogba hits out at ´distorted´ holiday claim|
|Nice 3 Toulouse 0: Plea strikes again as hosts go top|
|In-demand Belotti extends Torino stay|
|Mourinho defends decision to bring on Fellaini|
|Man Utd performances much better under me, says Mourinho|
|Draw the least Everton deserved against Manchester United, says Koeman|
|Mourinho fumes at media double standards|
|Mourinho has ´no thoughts´ on Fellaini penalty incident|
|Neville unimpressed by ´idiotic´ Fellaini|
|Manchester United are the Premier League´s worst team for dropping points with late goals|
|Manchester United mocked after Fellaini congratulations|
|´We have to put it right´ - Jones frustrated as United lose another late lead|
|Lulic sparks racism storm with Rudiger insult|
|Everton 1 Manchester United 1: Late Baines penalty denies Mourinho|
|Eto´o prefers Iniesta to Ronaldo and Messi: He deserves four Ballons d´Or|
|Liverpool join unfortunate group after Bournemouth collapse|
|Strootman praises Roma´s mental strength after derby win|
|Comeback win over Liverpool a special day for Bournemouth - Howe|
|Liverpool stopped playing football in Bournemouth collapse - Klopp|
|Lazio 0 Roma 2: Strootman and Nainggolan continue Giallorossi dominance|
|Bournemouth hero Ake hails incredible comeback win over Liverpool|
|Montella hails Lapadula´s ´fairytale´ rise to AC Milan stardom|
|Beautiful football is Guardiola´s Bayern legacy - Rummenigge|
|Bournemouth 4 Liverpool 3: Stunning comeback leaves Klopp´s men reeling|
|Lopes set for several weeks of treatment on ´sound trauma´|
|Lapadula: This is just the start of my Milan journey|
|AC Milan 2 Crotone 1: Lapadula winner spares Niang´s blushes|
|Torres fit for Bayern Munich clash|
|Dortmund´s Sahin fears eased|
|Eto´o: Guardiola still the best coach in the world|
|Carvajal apologises for swearing at Barcelona fans|
|MP calls for examination of Mourinho tax avoidance allegations|
|A-League Review: Sydney go six points clear at top as Adelaide clinch first win|
|Referee sorry amid fall-out from Werner dive controversy|
|Pique taking inspiration from 2014-15 turnaround|
|Aulas: Lyon should be awarded win after Metz clash is abandoned|
|Emery: PSG must learn from defeat|
|Marotta: Best to laugh at Pogba comments|
|Mourinho: I´m bringing back Manchester United DNA|
|De Boer: Nobody in charge at Inter|
|Chapecoense to be named Copa Sudamericana champions - Tozzo|
|Bilic: We are in a relegation fight|
|Aubameyang: I don´t know if I´ll be at Dortmund next season|
|Goals will return for Higuain, says Allegri|
|Southgate hopes to convince Zaha to play for England|
|Simeone will go to Inter, says son Giovanni|
|Watford fan dies after falling ill during West Brom clash|
|Simeone marvels at ´almost perfect´ Espanyol defence|
|Gestifute publishes ´Ronaldo tax compliance´|
|Marquinhos urges PSG to forget defeat|
|Tributes paid at Arena Conda memorial after Chapecoense tragedy|
|Juventus 3 Atalanta 1: Alex Sandro stunner helps Allegri´s side return to winning ways|
|Atletico Madrid 0 Espanyol 0: Simeone´s men fail to capitalise on rivals´ slip-ups|
|Metz-Lyon abandoned after Lopes hurt by firecracker|
|Wenger hails ´classy´ Sanchez after 14-minute hat-trick|
|´A big humiliation´ - Bilic slams West Ham´s lack of dedication|
|´Can always count on Serge´ - Bale reacts to El Clasico|
|Modric: Clasico draw feels like a win|
|Record-breaking Leipzig back on top thanks to Kolasinac own goal|
|West Ham 1 Arsenal 5: Sanchez hat-trick sends Gunners second|
|Fellaini: Mourinho more fun than Van Gaal|
|Hughes delighted with Muniesa and Walters impact|
|Goal-shy Messi failing to fire in Clasico clashes|
|Late Clasico draw has little bearing on title race - Zidane|
|Iniesta defends Arda after clumsy foul costs Barca Clasico win|
|Pardew wants Palace to build on Southampton win|
|Mazzarri slams referee Scott after Watford loss|
|´Barca very far off looking like champions´ - Luis Enrique frustrated by Clasico collapse|
|Conte: Chelsea players did well to remain calm|
|Forget Ronaldo - Ramos proves he is Madrid´s ultimate big-game player with Clasico heroics|
|Barcelona were the better team in El Clasico - Suarez|
|Ranieri accepts Leicester face relegation battle|
|Abuse in British football: Chelsea´s statement of apology in full|
|Conte admits Chelsea got lucky|
|Chelsea issue ´profuse apology´ to Johnson following sex abuse claims|
|Reus and Dembele catch Tuchel´s eye in ´complete´ Dortmund performance|
|Montpellier 3 Paris Saint-Germain 0: Visitors miss chance to go top|
|Tottenham needed a big victory - Pochettino|
|´I don´t know if it´s a fair result´ - Ramos accepts Real Madrid rode their luck|
|Barcelona 1 Real Madrid 1: Ramos snatches Clasico point to keep Zidane´s side in control of title ra|
|West Brom 3 Watford 1: Pulis´ men climb into top six|
|Sunderland 2 Leicester City 1: Moyes´ men make it three wins in four|
|Tottenham 5 Swansea City 0: Kane celebrates new deal with brace|
|Crystal Palace 3 Southampton 0: Benteke double and Saints gifts boost Pardew|
|Stoke City 2 Burnley 0: Hughes´ men continue strong run with straightforward win|
|Setback puts Butland injury return on hold|
|Borussia Dortmund 4 Borussia Monchengladbach 1: Aubameyang at the double as Tuchel´s men run riot|
|We had enough chances to win - Guardiola|
|Costa breathes sigh of relief as De Bruyne and Man City misfire|
|Manchester City 1 Chelsea 3: Blues complete brilliant turnaround in Etihad thriller|
|Sevilla miss chance to pile pressure on Clasico rivals with shock loss|
|´It´s not like we´re playing Real Madrid´ - Spalletti confident Roma can beat Lazio|
|Spanish authorities to take ´appropriate´ steps after Ronaldo tax evasion allegations|
|Inter´s Ranocchia sees room for improvement|
|A League Review: City play out feisty Roar draw after FFA Cup exploits|
|Nainggolan has no regrets over failed Chelsea move|
|Arsenal to make decision on Cazorla future in January|
|Bacca has no case to answer for Sevilla trip - Montella|
|Fabregas returns to Chelsea´s XI|
|Ronaldo is no genius like Messi - Capello|
|Everything is wonderful with Boateng - Rummenigge|
|Wenger to drop Jenkinson to protect him from social media taunts|
|Sakho not part of Liverpool´s first-team plans|
|Hughes offers Hitzfeld Stoke invite after Shaqiri comments|
|Roberto Carlos: Ronaldo is the best in the world, still!|
|Robben hopeful of finalising Bayern future|
|Sarri talks up Balotelli to Napoli|
|Everton need time and changes, says Koeman|
|Ancelotti lauds Muller after Bayern win|
|Sterling: I have more freedom under Guardiola|
|Mourinho: Maybe no Premier League title for United this season|
|Bayern laid down a marker - Rummenigge|
|Conte ´maybe the best in the world´ - Guardiola|
|Pioli laments Inter´s ´step backwards´|