Chile must be braced for a Spain backlash after the reigning champions were humiliated by the Netherlands in their FIFA World Cup opener.
Vicente del Bosque's men arrived in Brazil as one of the pre-tournament favourites having triumphed in South Africa four years ago, as well as retained their UEFA European Championship title in 2012.
However, Spain's World Cup defence began in a disastrous fashion as Louis van Gaal's side stormed to a shock 5-1 Group B victory in Salvador on Friday.
Xabi Alonso's 27th-minute penalty had appeared to put Spain in a strong position, but Robin van Persie's superb headed equaliser shortly before the break triggered a second-half demolition from the Dutch.
Several Spain stars came in for heavy criticism following the crushing defeat, none more so than Iker Casillas, with some calling for the Real Madrid goalkeeper to be dropped from the starting XI.
Del Bosque may retain faith in his captain, however, as David de Gea is struggling for fitness due to a muscle injury, leaving Pepe Reina as the only alternative.
Central defensive pair Sergio Ramos and Gerard Pique as well as Brazil-born striker Diego Costa also faced scrutiny for their performances, but it remains to be seen if Del Bosque will change his line-up or hand an opportunity to the side that failed so spectacularly last week.
Regardless of who gets the nod at the Maracana in Rio de Janeiro on Wednesday, the result will offer some indication as to whether Spain can mount a challenge to return to the iconic stadium for the final on July 13.
It is the second time in as many World Cups that the teams have faced off, Spain triumphing 2-1 in 2010, although both sides still progressed from Group H.
A repeat victory could re-invigorate Spain - who lost their opener in South Africa before going all the way - and forward Juan Mata believes a strong team bond can help them overcome the poor start.
"We have strong faith in our football, in our ideas and we really believe we can overcome the situation," he said. "This group is like a family since I arrived here.
"I think it's vital this kind of friendship between all of us, this familiar feelings which have made the Spain national team into a successful team."
Chile started their campaign with a 3-1 victory over Australia, but that scoreline somewhat belied the difficulty that Jorge Sampaoli's side faced in Cuiaba.
The South Americans were fluent in attack, with Barcelona forward Alexis Sanchez particularly lively, yet goalkeeper Claudio Bravo was required to make a series of saves to deny Australia at least a draw.
Chile have failed to beat Spain in 10 meetings between the teams and even a point could prove crucial in their bid to qualify for the knockout stages.
However, midfielder Arturo Vidal - who managed 60 minutes against Australia as he continues to recover from knee surgery and has declared himself fit to play Spain - insists Chile are only interested in a maximum haul.
"We're going to push forward looking for the three points," he said. "We have our style and we'll keep to it, we'll keep working in the same way and we're not going to change that."
|Coach: Del Bosque|
for Xabi Alonso 46'
for Diego Costa 64'
for Pedro 76'
|Wenger: Arsenal ´cautious´ in Newcastle win|
|Sevilla can mirror Atletico strengths - Simeone|
|Ibrahimovic and Di Maria in PSG squad for Monaco clash|
|Newcastle United 0 Arsenal 1: Mitrovic off as Coloccini own goal settles it|
|Barca´s Suarez ends Sevilla loan to make Villarreal switch|
|Allegri confirms imminent Coman departure|
|Garcia demands more ahead of Juve clash|
|Knee injury sidelines Ozil|
|Dortmund boost defence with Mainz´s Park|
|Ruddy hoping to impress Hodgson|
|Wolfsburg proved there is life after De Bruyne - Hecking|
|Van Gaal unsure if Romero will replace De Gea long-term|
|Dzeko wants Totti partnership at Roma|
|No excuses for City - Pellegrini|
|San Jose Earthquakes 1 LA Galaxy 0: Salinas´ header levels Cali Clasico tally|
|Koeman plays down expectations|
|Stuttgart´s Langerak suffers surgery setback|
|Rodgers hails Milner´s leadership, mentality|
|Conte hints at Giovinco recall, doesn´t rule out Balotelli|
|Martinez slams Chelsea over Stones pursuit|
|Leverkusen are title contenders - Guardiola|
|Babel in sexism controversy|
|Pellegrini prepared to wait for Otamendi|
|Sevilla v Atletico Madrid: Llorente hoping to repay faith|
|Veloso back for Portugal|
|Kranevitter joins Atletico on five-year deal|
|Maiga leaves West Ham for Al Nassr|
|Blackburn Rovers 0 Bolton Wanderers 0: Lancashire derby ends in stalemate|
|Coutinho, Rafinha called into Brazil squad|
|Guingamp 2 Marseille 0: Privat and Benezet inflict more misery on visitors|
|Wolfsburg 3 Schalke 0: Hosts canter to victory without De Bruyne|
|Villarreal 3 Espanyol 1: Soldado inspires turnaround|
|Carpi v Inter: Mancini demands full focus|
|De Bruyne set to complete City move, reveals Allofs|
|Roma v Juventus: Champions seek to bounce back|
|Motta pens new PSG deal|
|Settled Bale in the hunt for more titles at Real|
|Blind hands Robben Netherlands armband|
|Rodriguez joins Everton from River Plate Montevideo|
|Bolivia appoint Baldivieso|
|Southampton v Norwich City: Neil holds south-coast club up as inspiration|
|Monaco v Paris Saint-Germain: Rabiot wants champions to send a message|
|Barca face tough group - Luis Enrique|
|Swansea City v Manchester United: Van Gaal celebrates 50th game in charge|
|Herrera pushing for United start, says Van Gaal|
|Borussia Dortmund v Hertha Berlin: Tuchel puts perfect record on the line|
|Michu still not part of my plans if he stays – Monk|
|Hughes not expecting late transfer deals at Stoke|
|FIFA or bust in Platini´s presidency bid|
|Cuadrado struggles to explain Chelsea snub|
|Atletico seal Borre deal|
|Schalke loan Hojbjerg from Bayern|
|Sissoko in contention to face Arsenal|
|Advocaat confident of more signings, but De Guzman not among them|
|Berahino ´not just a lump of meat´ - Pulis|
|Ajax set to face Champions League quality - Van der Sar|
|Pellegrini quiet on intense De Bruyne speculation|
|Van Persie and Nani offer cause for Celtic excitement - Hawthorn|
|Lopes seals Monaco switch|
|Mourinho silent on Stones saga|
|Milan snap up Kucka|
|Can earns first Germany call-up|
|Dortmund get kind draw, Sousa takes Fiorentina back to Basel|
|Costa and Mata return for Spain qualifiers, De Gea gets the nod|
|Rodriguez omission not personal - Benitez|
|Allofs frustrated by Premier League´s financial muscle|
|Sherwood hopeful over Traore fitness|
|Leverkusen sign Kampl from Dortmund|
|Toivonen joins Sunderland on loan from Rennes|
|Markovic has Liverpool future, says Rodgers|
|Martinez insists Stones in perfect environment at Everton|
|Tottenham wrap up Son deal|
|Schmeichel wants Real target De Gea to re-sign with United|
|Cech is one of the best - Cudicini|
|Rodwell hoping for more goals|
|Thauvin needs time to settle at Newcastle – Haidara|
|Kennedy takes blame for Celtic´s loss, stands by zonal marking|
|CONCACAF Champions League Review: Comunicaciones, Motagua off the mark|
|Rooney´s contribution undervalued - Schmeichel|
|Jedinak ruled out as Socceroos make changes|
|Sampdoria not a ´discount store´ - president Ferrero|
|Montolivo: No issue with Mihajlovic|
|Gilardino signs for Palermo|
|Chelsea target ´China´s Sergio Ramos´|
|Striker search like looking for love - Pochettino|
|Hecking ´sick´ of De Bruyne talk|
|Deschamps calls up Martial, leaves out Sakho|
|´The only thing they can is long balls´ - Midtjylland´s skipper slams Southampton|
|UEFA Europa League Review: Reus leads Dortmund rout, AZ complete late comeback|
|Messi should win Ballon d´Or - Bartomeu|
|Koeman rues refereeing decisions after Europa League defeat|
|Tottenham deal for Son not complete, say Leverkusen|
|Tuchel thrilled with aggressive Dortmund display|
|Midtjylland 1 Southampton 0 (2-1 agg): Premier League side crash out|
|Borussia Dortmund 7 Odd 2 (11-5 agg): Reus hat-trick highlights hammering|
|Cudicini tips Mourinho to avoid Porto upset|
|Anything is possible with Neymar´s future - Belletti|
|Burnley bring in Barton|
|Bayern Munich v Bayer Leverkusen: Vidal putting friendships on hold|
|De Bruyne edges closer to City move after further Wolfsburg talks|
|Real Madrid v Real Betis: Benzema back as Real look to hit the goal trail|
|Barcelona v Malaga: Rosales hopes for another upset|
|West Brom hit out at Tottenham´s Berahino pursuit|
|Stoke City v West Brom: Pulis set for Britannia return|
|Tottenham v Everton: Pochettino´s men eye first win|
|Everton reject Stones´ transfer request|
|Messi named UEFA Player of the Year|
|Pocehttino quiet on Berahino bids|
|Real Madrid to meet PSG in Champions League, Barca drawn with Leverkusen|
|Bournemouth v Leicester City: Howe eager to entertain|
|Ranieri coy on Gray link|
|Newcastle United v Arsenal: Wenger hopes for sharper shooting|
|PSG snap up Kurzawa from Monaco|
|Aston Villa v Sunderland: Sinclair aims to replicate cup form|
|Grabban a silly boy - Neil|
|Chelsea v Crystal Palace: Pardew braced to face stronger champions|
|Manchester City v Watford: Flores heads to Etihad with confidence|
|Marseille loan Real Madrid youngster Lucas Silva|
|Howe surprised by Harte´s retirement|
|Liverpool v West Ham: History counts for nothing, says Bilic|
|Bolasie set for Palace comeback|
|De Bruyne to City not a done deal - Allofs|
|Sevilla complete Llorente swoop|
|Wenger supports video technology|
|Milan v Empoli: Zapata sets sights on ´must-win´ fixture|
|Watford boss Flores ´not happy´ with transfer situation|
|Balotelli: I am no longer a kid|
|Bilic has no issue with Valencia|
|Arsenal ´not close´ to any late deals|
|Balotelli finalises return to Milan on loan|
|West Ham confirm Nolan departure|
|Thiago signs new Bayern deal|
|Schmidt saddened as Son nears exit|
|CONCACAF Champions League Review: Sounders lose in Honduras|
|Van Gaal considered early Herrera substitution|
|MLS Review: Fire stun Red Bulls|
|Carroll nears West Ham return|
|Rodriguez hoping for England recall|
|Leverkusen can challenge best - Schmidt|
|Ozil defends United recruit Schweinsteiger|
|Sporting ´better over two legs´ - Jesus|
|Stoilov revels in historic Astana triumph|
|Pioli: Lazio not ready for Champions League|
|UEFA Champions League Review: Rooney nets treble and Astana make history|
|Everton to reject Stones´ transfer request - Martinez|