Arsenal can return to the summit of the Premier League for at least 24 hours with a home win over Crystal Palace on Sunday.
Arsene Wenger's side slipped to second in the table after they drew 2-2 at Southampton on Tuesday, enabling Manchester City to move a point clear by hammering Tottenham 5-1 the following day.
That result at St Mary's Stadium ended Arsenal's five-game winning run in the top flight, but three points against Tony Pulis' men would mean them taking advantage of the fact City do not play until Monday by reclaiming top spot.
Indeed, Arsenal are in something of a no-lose situation as long as they beat Palace, as City host third-placed Chelsea at the Etihad Stadium, meaning at least one of their main title rivals will drop points this weekend.
Wenger's team go into the clash in fine form having lost just one of their last 12 Premier League matches, but face a Palace side buoyed by consecutive top-flight wins.
The Selhurst Park outfit now sit four points clear of the Premier League relegation zone after successive 1-0 home victories over Stoke City and Hull City respectively.
Jason Puncheon scored the winning goal in both of those fixtures and Pulis signed the 27-year-old winger permanently on Friday after an impressive spell on loan from Southampton.
Goalkeeper Wayne Hennessey also joined Palace from Wolves on deadline day and could go straight into the squad at the Emirates Stadium, while Pulis is also said to be close to securing a deal for Blackpool winger Tom Ince.
Wenger, meanwhile, appears set to bring in Sweden international Kim Kallstrom on loan from Spartak Moscow as cover for injured midfield duo Aaron Ramsey (thigh) and Jack Wilshere (ankle).
Mathieu Flamini will also be unavailable after being sent off at Southampton, although Tomas Rosicky is back in contention following a broken nose. Theo Walcott (knee) remains a long-term absentee.
Kagisho Dikgacoi (calf) and Jerome Thomas (groin) could return for Palace, but Jonathan Parr is doubtful with a neck problem.
Arsenal won the reverse fixture at Selhurst Park 2-0 in October, thanks to Mikel Arteta's penalty and a late strike from Olivier Giroud.
However, Wenger is anticipating a tough test on Sunday after watching Palace lose 2-0 at Tottenham earlier in the month - a game in which Puncheon missed a penalty with the scores still level.
"I saw them play (at White Hart Lane) - they were absolutely impressive in that game. That is a good warning for us," said the Frenchman.
|15||A. Oxlade-Chamberlain||47' 73'|
|Coach: A. Wenger|
for L. Podolski 72'
for O. Giroud 84'
for M. Özil 84'
|Lemina rejects Gabon call-up|
|Toure a doubt for Sunderland clash|
|Millen ´ready´ to manage Palace|
|Carver urges Newcastle to kick on|
|Bellarabi extends Leverkusen deal|
|Wenger hails ´committed´ Arsenal|
|Diouf will be missed - Hughes|
|Millen elated at resolute Palace performance|
|Lambert: Big point for Villa|
|Martinez rues Cisse decision|
|Dyche delighted by Burnley character|
|Allardyce: Officials got it horribly wrong|
|Poyet rues dropped points at Villa|
|Bruce frustrated as dominant display yields no points|
|Pellegrini laments key turning points in Burnley setback|
|Newcastle United 3 Everton 2: Pardew´s men impress at St James´ Park|
|League One Review: Swindon climb into second, MK Dons suffer surprise defeat|
|Championship Review: Bournemouth go four points clear, Boro held|
|Koeman hails Southampton spirit|
|Inverness Caledonian Thistle 0 Aberdeen 1: Pawlett strikes sends McInnes´ men second|
|Mourinho fumes at ´campaign´ against Chelsea|
|Manchester City 2 Burnley 2: Barnes claims a point to deny champions|
|West Ham 1 Arsenal 2: Wenger´s men climb above hosts|
|Hull City 0 Leicester City 1: Mahrez fires Pearson´s men to victory|
|QPR 0 Crystal Palace 0: Millen makes solid start as temporary Palace boss|
|Aston Villa 0 Sunderland 0: Delph sees red in stalemate|
|Stoke 2 West Brom 0: Diouf brace secures back-to-back wins|
|Southampton 1 Chelsea 1: Mourinho´s men end 2014 on top|
|Van Gaal frustrated with wasteful finishing|
|Pochettino content with goalless draw|
|Tottenham 0 Manchester United 0: Honours even at White Hart Lane|
|Klose vows to fight for Lazio place|
|Hughton admits interest in Palace and Brighton roles|
|Injuries not behind retirement plans, says Rolfes|
|Podolski: Arsenal exit not a formality|
|Wellington Phoenix 1 Western Sydney Wanderers 0: Krishna wins it|
|Taylor wary of ´beast´ Lukaku|
|Al Habsi to lead Oman at Asian Cup|
|Lacazette will stay at Lyon - Aulas|
|Southampton like Atletico, says Alderweireld|
|World Cup held PSG back - Blanc|
|Everton facing ´pivotal´ moment - Martinez|
|Zamora urges QPR to tie down Austin|
|Badstuber, Alaba set for New Year return|
|Burgos: Atletico will get the best out of Torres|
|Chelsea to offer Terry new deal - Mourinho|
|Rodgers excited by Sterling development|
|Strinic close to finalising Napoli switch|
|Torres to join Milan on permanent deal|
|Scottish Premiership Review: Celtic held to shock draw, rivals fail to capitalise|
|Wenger sings Song´s praises|
|Pochettino calls for bravery|
|West Ham could lose Allardyce - Sullivan|
|League One Preview: Saunders takes charge for Colchester clash|
|Aguirre denies any involvement in La Liga match-fixing scandal|
|Mourinho impressed by Koeman´s Southampton|
|QPR v Crystal Palace: Millen recast in familiar role|
|West Ham v Arsenal: Allardyce eyes further home comfort|
|Elusive Coppa Italia on Juventus´ wish list - Marotta|
|Jones eyes swift response|
|Millen focused on QPR clash|
|League Two Preview: Shrewsbury, Wycombe and Burton vie for year-end top spot|
|Mancini not expecting big-money signings at Inter|
|Tottenham v Manchester United: Carrick expects tough return|
|Pearson eager to see Leicester resolve|
|Newcastle United v Everton: Martinez demands clinical touch|
|Liverpool v Swansea City: Rodgers backs returning Mignolet|
|Bayern can still improve - Sammer|
|Warnock sacked by Palace|
|Aston Villa v Sunderland: No club too big to go down, says Lambert|
|Hull City v Leicester City: Pearson vows to keep going|
|Stoke City v West Brom: Hughes targets elusive back-to-back wins|
|Rodgers dismisses Balotelli exit rumours|
|Modric will not rush Madrid return|
|Dyche pleased with Vokes return|
|Southampton v Chelsea: Koeman vows to go on the offensive|
|A-League Review: Six-goal Gosford thriller, Victory leave it late|
|Manchester City v Burnley: Pellegrini warns against complacency|
|Dortmund can fight on two fronts - Watzke|
|Sterling hails improved Liverpool belief|
|Rosicky eager to build on QPR winner|
|Wenger: ´We made it hard for ourselves´|
|Kane: Spurs eye top four|
|Di Maria in doubt for Spurs clash|