Arsenal can return to the summit of the Premier League for at least 24 hours with a home win over Crystal Palace on Sunday.
Arsene Wenger's side slipped to second in the table after they drew 2-2 at Southampton on Tuesday, enabling Manchester City to move a point clear by hammering Tottenham 5-1 the following day.
That result at St Mary's Stadium ended Arsenal's five-game winning run in the top flight, but three points against Tony Pulis' men would mean them taking advantage of the fact City do not play until Monday by reclaiming top spot.
Indeed, Arsenal are in something of a no-lose situation as long as they beat Palace, as City host third-placed Chelsea at the Etihad Stadium, meaning at least one of their main title rivals will drop points this weekend.
Wenger's team go into the clash in fine form having lost just one of their last 12 Premier League matches, but face a Palace side buoyed by consecutive top-flight wins.
The Selhurst Park outfit now sit four points clear of the Premier League relegation zone after successive 1-0 home victories over Stoke City and Hull City respectively.
Jason Puncheon scored the winning goal in both of those fixtures and Pulis signed the 27-year-old winger permanently on Friday after an impressive spell on loan from Southampton.
Goalkeeper Wayne Hennessey also joined Palace from Wolves on deadline day and could go straight into the squad at the Emirates Stadium, while Pulis is also said to be close to securing a deal for Blackpool winger Tom Ince.
Wenger, meanwhile, appears set to bring in Sweden international Kim Kallstrom on loan from Spartak Moscow as cover for injured midfield duo Aaron Ramsey (thigh) and Jack Wilshere (ankle).
Mathieu Flamini will also be unavailable after being sent off at Southampton, although Tomas Rosicky is back in contention following a broken nose. Theo Walcott (knee) remains a long-term absentee.
Kagisho Dikgacoi (calf) and Jerome Thomas (groin) could return for Palace, but Jonathan Parr is doubtful with a neck problem.
Arsenal won the reverse fixture at Selhurst Park 2-0 in October, thanks to Mikel Arteta's penalty and a late strike from Olivier Giroud.
However, Wenger is anticipating a tough test on Sunday after watching Palace lose 2-0 at Tottenham earlier in the month - a game in which Puncheon missed a penalty with the scores still level.
"I saw them play (at White Hart Lane) - they were absolutely impressive in that game. That is a good warning for us," said the Frenchman.
|15||A. Oxlade-Chamberlain||47' 73'|
|Coach: A. Wenger|
for L. Podolski 72'
for O. Giroud 84'
for M. Özil 84'
|UEFA Europa League Preview: Brondby and Slovan to protect handsome leads|
|Bentaleb pens new long-term deal at Tottenham|
|Barca agree Turan deal|
|FIFA bans Mayne-Nicholls|
|United States v Honduras: Klinsmann demands improvement ahead of Gold Cup opener|
|CONCACAF institutes extensive reforms in wake of FIFA corruption scandal|
|Mauri completes Milan move|
|City sign Turkey striker|
|Women´s World Cup final draws huge US TV ratings|
|My first Chelsea team better than current crop - Drogba|
|Bertrand set for lay-off after knee surgery|
|New five-year Juve deal for Marchisio|
|Allegri extends Juve contract|
|Koeman reiterates Alderweireld interest|
|Valencia bag Bakkali|
|New York City FC complete Pirlo capture|
|Panama v Haiti: Collat ready to challenge the best of CONCACAF|
|UEFA Champions League Preview: Harrison eyes TNS progression|
|FIFA sanctions Yemen for fielding ineligible player|
|Toulouse rubbish Ben Yedder exit reports|
|Mourinho ´knows what he´s doing´ with Falcao signing|
|Watford shell out club-record fee for Capoue|
|Braafheid signs Lazio extension|
|Nani finalises Fenerbahce move|
|Liverpool confirm O´Driscoll appointment|
|Liverpool have to start better - Lucas|
|USA simply too good - Sasaki|
|Portland Timbers 1 San Jose Earthquakes 0: Jewsbury wins it in stoppage time|
|No move yet for Van Persie|
|Lloyd wins Golden Ball, Silver Boot awards|
|Mascherano: I never grabbed Banega|
|Dunga requested Brazil not appeal Neymar´s suspension|
|United States 5 Japan 2: Lloyd stars with hat-trick|
|Fiorentina deny Inter criticism|
|Nani relishing Fenerbahce opportunity|
|Newcastle hold talks over Northampton youngster|
|Cuadrado´s agent plays down Chelsea exit rumours|
|Liverpool´s Alberto set for Deportivo loan|
|Leverkusen suffer surprise defeat, Stuttgart hit six|
|Inter ´dismayed´ at Fiorentina vice-president´s Salah Twitter outburst|
|Blaszczykowski ruled out of Dortmund´s Asia tour|
|Gerrard gets the beers in for LA Galaxy fans|
|De Gea coy over Real links|
|Former Brazil star Carlos handed Delhi reins|
|Ciftci will not push through Celtic switch – agent|
|In-demand Mitrovic considering Roma offer|
|Lehmann calls on Cech to ´get over´ Chelsea|
|Marlos double sinks Monaco|
|Mauritius 0 South Africa 2 (agg 0-5): Bafana set up Angola qualifier|
|Keane relishing Gerrard arrival|
|Palace confirm Cabaye interest|
|Hamburg bring in Spahic after head-butt ban|
|Blatter hits out at France and Germany over World Cup votes|
|Sanchez: World Cup exit spurred Chile to Copa glory|
|Jojic makes Cologne switch, Santana move falls through|
|Carrillo keen to get going at Monaco|
|Micronesia thrashed 38-0 as Fiji triumph in Olympic qualifier|
|Schalke stunned by ´machine´ Caicara|
|MLS Review: Keane shines at Gerrard´s Galaxy unveiling|
|Counter-attacking the key for Japan|
|Jimenez happy at Atletico|
|Gerrard predicts ´successful future´ with Galaxy|
|Iniesta can´t see Real selling Ramos|
|Keshi sacked as Nigeria coach|
|Three finals, three defeats for Messi, Mascherano|
|Nani close to Fenerbahce move|
|Sampaoli revels in ´unbelievable joy´|
|Bravo: Copa victory a dream|
|Martino: Argentina should have won|
|Chile 0 Argentina 0 (4-1 on penalties): Hosts end trophy drought|
|Germany 0 England 1 (after extra time): England make World Cup history|