Tottenham suffered a humiliating defeat at Manchester City in November, but Manuel Pellegrini's side will expect a tougher test on Wednesday.
Free-scoring City hammered the London club 6-0 at the Etihad Stadium in November to pile the pressure on former head coach Andre Villas-Boas.
The Portuguese was sacked following another thrashing by Liverpool last month and the appointment of Tim Sherwood has sparked an upturn in fortunes at White Hart Lane.
Tottenham have won their last four Premier League games and are unbeaten in the top flight under Sherwood.
Former City striker Emmanuel Adebayor has enjoyed a new lease of life since Villas-Boas' departure, scoring six goals in eight games in all competitions with Sherwood at the helm.
Tottenham beat City 3-1 at White Hart Lane last season and could do with a repeat performance as they challenge for a top-four finish.
Midfielder Paulinho comes back into contention to face City after missing the last four games with an ankle injury.
England winger Andros Townsend (hamstring) is also set to return to the squad along with Jan Vertonghen (ankle), but Sandro (calf) may not be ready to return and Younes Kaboul (thigh) is also not match fit.
City were given a scare by Championship side Watford on Saturday, but fought back from two goals down at half-time to win 4-2 in the fourth round of the FA Cup.
Pellegrini's title contenders have been a joy to watch this season and their ominous form has seen them win 16 and draw three of their last 19 in all competitions.
Tottenham are by no means the only team on the wrong end of a thrashing from second-placed City, who have already scored an astonishing 110 goals in all competitions this season.
Striker Alvaro Negredo, who has scored 23 goals this term, is expected to return against Tottenham after he was not risked against Watford due to a shoulder injury.
The Spaniard is set to continue his partnership with Sergio Aguero, who scored a hat-trick at the weekend to take his tally to nine goals in his last eight games and 25 in total in all competitions.
David Silva (hamstring) is also set to return, while Joe Hart, Pablo Zabaleta, Vincent Kompany and Fernandinho will be expected to start after dropping to the bench against Watford.
|Coach: T. Sherwood|
for M. Dembélé 46'
for G. Sigurðsson 55'
for C. Eriksen 83'
|Ameobi extends Newcastle deal and heads for Cardiff|
|U.S. women celebrate World Cup victory with LA rally|
|Atletico agree Vietto deal|
|Silva appointed Olympiacos head coach|
|Presidential candidates unsure of Turan´s Barca switch|
|Toure keen to bounce back from ´disappointing´ campaign|
|El Salvador v Canada: Floro targets Gold Cup learning curve|
|Juve complete Zaza swoop|
|Costa Rica v Jamaica: Borges confident Wanchope´s men are ready|
|Marseille snare Sarr|
|Italy coach Conte to stand trial in match-fixing case|
|Castan keen to repay Roma´s faith|
|Rami thrilled to reunite with ´best coach´ Emery at Sevilla|
|Lusitans v West Ham: Tomkins seeks to silence minnows|
|Kagawa shines as Dortmund hit six in Japan|
|Alonso tips Gerrard for Galaxy glory|
|Firmino seeks self-improvement with Liverpool|
|Buffon bids farewell to Pirlo|
|Sterling named Europe´s ´most valuable´ young player|
|Casillas´ agent reveals Porto offer|
|Southampton bring in Martina|
|Dundee United accept Celtic´s Ciftci bid|
|McArthur pens new Palace deal|
|Bartomeu rules out Barca move for Pogba this year|
|Spurs have to be better now - Bentaleb|
|Milner expects central role|
|Micronesia thrashed again, this time 46-0|
|Marchisio: I cannot be Pirlo´s heir|
|Inter aiming for Champions League return - Icardi|
|UEFA Europa League Preview: Brondby and Slovan to protect handsome leads|
|Bentaleb pens new long-term deal at Tottenham|
|Barca agree Turan deal|
|FIFA bans Mayne-Nicholls|
|United States v Honduras: Klinsmann demands improvement ahead of Gold Cup opener|
|CONCACAF institutes extensive reforms in wake of FIFA corruption scandal|
|Mauri completes Milan move|
|City sign Turkey striker|
|Women´s World Cup final draws huge US TV ratings|
|My first Chelsea team better than current crop - Drogba|
|Bertrand set for lay-off after knee surgery|
|New five-year Juve deal for Marchisio|
|Allegri extends Juve contract|
|Koeman reiterates Alderweireld interest|
|Valencia bag Bakkali|
|New York City FC complete Pirlo capture|
|Panama v Haiti: Collat ready to challenge the best of CONCACAF|
|UEFA Champions League Preview: Harrison eyes TNS progression|
|FIFA sanctions Yemen for fielding ineligible player|
|Toulouse rubbish Ben Yedder exit reports|
|Mourinho ´knows what he´s doing´ with Falcao signing|
|Watford shell out club-record fee for Capoue|
|Braafheid signs Lazio extension|
|Nani finalises Fenerbahce move|
|Liverpool confirm O´Driscoll appointment|
|Liverpool have to start better - Lucas|
|USA simply too good - Sasaki|
|Portland Timbers 1 San Jose Earthquakes 0: Jewsbury wins it in stoppage time|
|No move yet for Van Persie|
|Lloyd wins Golden Ball, Silver Boot awards|
|Mascherano: I never grabbed Banega|
|Dunga requested Brazil not appeal Neymar´s suspension|
|United States 5 Japan 2: Lloyd stars with hat-trick|
|Fiorentina deny Inter criticism|
|Nani relishing Fenerbahce opportunity|
|Newcastle hold talks over Northampton youngster|
|Cuadrado´s agent plays down Chelsea exit rumours|
|Liverpool´s Alberto set for Deportivo loan|
|Leverkusen suffer surprise defeat, Stuttgart hit six|
|Inter ´dismayed´ at Fiorentina vice-president´s Salah Twitter outburst|
|Blaszczykowski ruled out of Dortmund´s Asia tour|
|Gerrard gets the beers in for LA Galaxy fans|
|De Gea coy over Real links|
|Former Brazil star Carlos handed Delhi reins|
|Ciftci will not push through Celtic switch – agent|
|In-demand Mitrovic considering Roma offer|
|Lehmann calls on Cech to ´get over´ Chelsea|
|Marlos double sinks Monaco|
|Mauritius 0 South Africa 2 (agg 0-5): Bafana set up Angola qualifier|
|Keane relishing Gerrard arrival|
|Palace confirm Cabaye interest|
|Hamburg bring in Spahic after head-butt ban|
|Blatter hits out at France and Germany over World Cup votes|
|Sanchez: World Cup exit spurred Chile to Copa glory|
|Jojic makes Cologne switch, Santana move falls through|
|Carrillo keen to get going at Monaco|
|Micronesia thrashed 38-0 as Fiji triumph in Olympic qualifier|
|Schalke stunned by ´machine´ Caicara|
|MLS Review: Keane shines at Gerrard´s Galaxy unveiling|
|Counter-attacking the key for Japan|
|Jimenez happy at Atletico|
|Gerrard predicts ´successful future´ with Galaxy|
|Iniesta can´t see Real selling Ramos|
|Keshi sacked as Nigeria coach|
|Three finals, three defeats for Messi, Mascherano|
|Nani close to Fenerbahce move|
|Sampaoli revels in ´unbelievable joy´|
|Bravo: Copa victory a dream|
|Martino: Argentina should have won|
|Chile 0 Argentina 0 (4-1 on penalties): Hosts end trophy drought|
|Germany 0 England 1 (after extra time): England make World Cup history|