The Premier League's top three have been unstoppable of late and third-placed Chelsea will want to maintain that form against West Ham.
Jose Mourinho's men currently share a run of five consecutive league victories with leaders Arsenal, while second-placed Manchester City have won seven in a row, meaning just two points separate the sides in the race for the title.
Chelsea should be full of confidence ahead of Wednesday's meeting with a West Ham outfit who have just one win from their last nine fixtures in all competitions.
The men from east London have not won at Stamford Bridge since 2002, losing seven of the subsequent eight encounters, and suffered a 3-0 reverse when the sides met at Upton Park in November.
Former West Ham favourite Frank Lampard scored a double against his old club on that occasion, breaking the deadlock with a 21st-minute spot-kick before finding the net again late on after Oscar had doubled the advantage.
Chelsea marked Mourinho's 51st birthday with progression to the fifth round of the FA Cup on Sunday, while West Ham should be fresh having had a weekend off thanks to being eliminated by Nottingham Forest in the third round.
And West Ham manager Sam Allardyce knows the magnitude of the task that lies ahead of his side, who are third bottom in the Premier League.
"Stopping Oscar, (Eden) Hazard, (Samuel) Eto'o is one of the elements for us which we have to be very careful of," he said. "When those players get the ball we have to make sure we're very sharp and that we close them down, otherwise their skills and abilities will make life difficult for us."
Fernando Torres (knee) remains sidelined for Chelsea, who could hand a first league start to Nemanja Matic since he returned to the club from Benfica and a debut to Mohamed Salah, signed from Basel on Sunday.
Allardyce, meanwhile, has a near fully-fit squad to choose from, with former Chelsea midfielder Joe Cole and Winston Reid the only players guaranteed to miss out.
As well as his returning players, Allardyce's ranks will be boosted by the arrivals of new signings Marco Borriello and Antonio Nocerino, who could go straight into the squad for Wednesday's match.
|12||J. Obi Mikel|
|Coach: José Mourinho|
for Azpilicueta 63'
for J. Obi Mikel 63'
for Oscar 80'
|Ozil: Scotland won´t stop us|
|Portugal will be better than France - Santos|
|Kruse: I am 100 per cent fit|
|Mexico 3 Trinidad and Tobago 3: Herrera the hero for Ferretti´s men|
|FFA expect Tajikistan match to go ahead despite Dushanbe violence|
|Panama 0 Uruguay 1: Stuani´s late header clinches win|
|CONCACAF World Cup Qualifying Review: Jamaica stunned, Canada win|
|Argentina 7 Bolivia 0: Aguero, Messi star in rout|
|Canada 3 Belize 0: Hosts dominate in Toronto|
|Chelsea ´warehousing´ players - PFA chief|
|United States 2 Peru 1: Altidore inspires hosts´ comeback|
|Argentina 7-0 Bolivia: Aguero, Messi & Lavezzi net doubles in rout|
|Del Bosque unmoved by calls for two strikers|
|Deschamps praise for beautiful France|
|Fekir ruptures knee ligaments|
|Italy v Bulgaria: Conte warns against complacency|
|Euro 2016 Qualifiers Review: Germany top Group D, Northern Ireland edge closer|
|Low: Three points most important|
|Northern Ireland on the verge of a ´magnificent achievement´ - O´Neill|
|Scotland need something against Germany - Strachan|
|Portugal 0 France 1: Late Valbuena set-piece clinches deserved win|
|Faroe Islands 1 Northern Ireland 3: O´Neill´s men edge closer|
|Germany 3 Poland 1: Gotze sends world champions top|
|Gibraltar 0 Republic of Ireland 4: Irish hopes reignited|
|Djibouti 0 Togo 2: Saintfiet´s side make it two wins from two|
|Cyprus v Belgium: Benteke boost for Wilmots´ men|
|Roma youngster faces lengthy lay-off|
|United hit back at Perez barb over De Gea saga|
|Georgia 1 Scotland 0: Strachan´s men succumb to Tbilisi hoodoo|
|Hodgson prepared to blood new players|
|Porto invite Euro elite to help raise millions for migrants|
|Dortmund legend Dede backs Tuchel to succeed|
|Robben out for four weeks|
|Turkey v Netherlands: Terim expecting hostile atmosphere for crunch clash|
|Portugal 0-1 France: Valbuena strikes late to sink Ronaldo & Co|
|Wales v Israel: Euro 2016 beckons for Coleman´s history boys|
|Gala: No extra payment for Grosskreutz|
|Increase Bundesliga´s TV rights or be left behind - Rummenigge|
|Kane: I´m no flash in the pan|
|Perez: United showed inexperience in De Gea saga|
|Milligan: Socceroos wary of Tajikistan|
|Conte wants more players like Pelle|
|OFC World Cup Qualifying Review: Samoa to meet Tahiti in next round|
|Krychowiak stayed at Sevilla because of Emery|
|I never considered Bayern exit - Gotze|
|Balotelli ´not in good condition´, Milan must improve - Mihajlovic|
|Robben slams ´stupid´ Martins Indi|
|Robben laments injury blow|
|Euro 2016 Qualifiers Review: Bale edges Wales closer, Iceland dent Netherlands´ qualification hopes|
|De Bruyne relieved to ´boss´ Bosnia-Herzegovina|
|Blind furious after nightmare debut|
|Coleman sees shades of Charles in Bale winner|
|Conte only concerned about Italy winning|
|Mauritania v South Africa: SAFA to investigate Masilela no-show|
|AFC World Cup Qualifying Review: Qatar hit 15 in Bhutan rout|
|Belgium 3 Bosnia-Herzegovina 1: De Bruyne shines in straightforward victory|
|Cyprus 0 Wales 1: Bale winner takes Wales one step closer|
|Netherlands 0 Iceland 1: Sigurdsson winner caps difficult first game for Blind|
|Italy 1 Malta 0: Pelle spares wasteful Azzurri|
|Balotelli stars in Milan friendly win|
|Bhutan thrashed 15-0 by Qatar in qualifier|
|Rwanda v Ghana: Gyan doubt gives hosts hope|
|Tanzania v Nigeria: Enyeama out of AFCON qualifier|
|Valdes and Berahino included in Premier League squads|
|Costa Rica v Brazil: Dunga´s men return after Copa disappointment|
|Spain v Slovakia: Azpilicueta eyeing important revenge|
|Adebayor left out of Tottenham squad list for league and Europe|
|San Marino v England: Place in history books beckons for Rooney|
|Germany can cope with Reus absence - Low|
|Bayern offer aid to refugees in ´training camp´|
|BREAKING NEWS: Welbeck ruled out for months after knee surgery|
|South Korea 8 Laos 0: Son leads the way in rout|
|Australia 5 Bangladesh 0: Socceroos surge to emphatic win|
|Japan 3 Cambodia 0: Hosts pick up first qualifying win|
|Rudiger aiming to nail down Euros spot after Roma move|
|Melo happy to join Inter at last|
|Hernandez thanks Ferguson after United departure|
|Chung: AFC has compromised FIFA election|
|Wales the new best of British|
|Reus out of Germany qualifiers|
|Chile v Paraguay: Vidal missing for Copa champions|
|Ghedin: Anything is possible for Malta|
|Pogba will be worth €100m - Marotta|
|England can win Euro 2016 - Hodgson tells players|
|Conte unsure over Balotelli future|
|Argentina - Bolivia Preview: Mascherano backs 'very special' Messi|
|Portugal - France Preview: Deschamps aiming to correct mistakes|