Coppa Italia holders Lazio can set up a last-four tie against rivals Roma with a quarter-final win at Napoli on Wednesday.
Edoardo Reja's men overcame their city neighbours 1-0 in last year's final at the Stadio Olimpico thanks to a goal from Bosnia-Herzegovina winger Senad Lulic.
And the capital club travel to the Stadio San Paolo knowing that victory in what is a matchup between the last two teams to win the tournament will force a repeat of the 2013 showpiece, but at the semi-final stage this time around.
However, the visitors face a Napoli side who have not suffered defeat in any competitions since a 3-1 UEFA Champions League loss to Borussia Dortmund in November.
That result sparked Napoli's current run of 10 games unbeaten, which began as Gonzalo Higuain's double inspired Rafael Benitez's side to a 4-2 win at Lazio.
And Napoli, who beat Atalanta 3-1 earlier this month to reach the quarter-finals, should be confident of replicating that display against a team who are without a win in their last four visits to Campania.
Defender Pablo Armero is a doubt for the hosts after missing the draw with Chievo due to illness, while Juan Zuniga is likely to miss out with a knee problem.
Long-term absentees Giandomenico Mesto (knee) and Valon Behrami (toe) remain on the sidelines.
Meanwhile, Lazio, 2-1 winners over Parma in the previous round, are without defender Stefan Radu due to hamstring injury.
Emiliano Alfaro (knee) and Ederson (hamstring) are unavailable, along with Stefano Mauri, whose match-fixing ban does not expire until next week.
A win would see Lazio take on bitter foes Roma three times in a week.
Reja's men face Rudi Garcia's side on February 9, a clash that would be sandwiched between a two-legged semi-final should the holders progress.
"We think game by game," Lazio's German striker Miroslav Klose said. "Now we think about Napoli, because we could play three derbies in a week."
|9||G. Higuaín||82' 84'|
|Coach: Rafael Benítez|
for L. Insigne 69'
for M. Hamšík 76'
for Jorginho 90+1'
|Chile v El Salvador: Sampaoli´s men search for form|
|Qatar hit back at Dyke|
|Monreal happy at Arsenal|
|Van Persie hints at United exit|
|Zico may run for FIFA presidency|
|Castro: Emery has Napoli offer|
|Schafer finalises Jamaica squad|
|US Soccer, FFA welcome Blatter resignation|
|Blatter decision unrelated to corruption allegations - daughter|
|CONCACAF ready to help rebuild FIFA|
|Champions League Final: Luis Enrique worried about Juve, Italian fan nears end of Berlin bike ride|
|Essien joins Panathinaikos|
|Blatter in profile: A look back on 17 years at the top of world football|
|Demichelis set for international retirement after Copa|
|Football world reacts to Blatter resignation|
|Blackpool turn to McDonald|
|Blatter resignation: How the FIFA scandal unfolded|
|Ancelotti rejects Milan approach|
|Platini: Blatter resignation ´the right decision´|
|Swiss Attorney General: Blatter not under investigation|
|Blatter resignation can inspire FIFA change - Scala|
|Mohsni faces lengthy SFA ban|
|Sepp Blatter: Resignation speech in full|
|Blatter to resign as FIFA president|
|Adkins named Sheffield United manager|
|Juve talks ongoing - Witsel|
|Costa has no intention of leaving Chelsea|
|Ligue 1: Paris Saint-Germain season review - Blanc´s men make history|
|Luis Enrique ´worried´ by Juve|
|Mourinho: Costa happy at Chelsea|
|Mourinho hits out at ´unacceptable´ Loftus-Cheek display|
|Inter an ´option´ for Richards|
|Messi: Off-field relationship with Neymar and Suarez key|
|Remy rifle seals Sydney win for Chelsea|
|Messi could replicate Bilbao goal - Luis Enrique|
|Liverpool mauling a boost in transfer market, says Stoke chairman Coates|
|Adkins: Football can learn a lot from rugby|
|Celtic swoop for City defender Boyata|
|Xavi out to sign off in style at Barca|
|Criscito and Poli leave Italy squad|
|Lacazette plays down ´unfounded´ PSG rumours|
|Lloris: No buy-out clause in Tottenham contract|
|Newcastle released Taylor and Gutierrez in same phone call|
|Alba signs new Barcelona deal|
|Benteke coy on Villa future|
|FIFA denies Valcke involvement in $10million payment|
|Brazil selection never influenced, says technical director|
|Pogba doing ´great things´ and will get better, says Deschamps|
|Bundesliga: Borussia Dortmund season review - Klopp endures rocky farewell|
|Adler ´aged three years´, Labbadia ´extremely proud´ of Hamburg|
|Colombia squad settles in Argentina|
|Balotelli ´a target´ because of Liverpool form - Richards|
|Bosnich: If I´d listened to Terry I would have avoided drugs|
|Luiz Gustavo ruled out of Brazil´s Copa America squad|
|Mexico confirm Copa squad|
|Pogba ´very happy´ at Juve|
|Pogba can be Europe´s greatest - Pirlo|
|Pinedo stays in Argentina, Bolivia captain Raldes in Copa America squad|
|Quinteros cuts Banguera, Hidalgo for Chile showpiece|
|Injured Gonzalez misses Copa America, Venezuela finalise youthful squad|
|Champions League Final: Buffon plays down Juve hopes, Iniesta doubtful|
|Karlsruher 1 Hamburg 2 (2-3 agg): Muller strike ensures survival|
|CONCACAF official Sanz banned by FIFA|
|Gourvennec shuns admirers with Guingamp extension|
|Pastore signs PSG extension|
|Morel swaps Marseille for Lyon|
|Watford sign Austria defender Prodl|
|Monaco confirm Berbatov departure|
|Peru v Mexico: Herrera confident as Copa preparations continue|
|Injury rules Dost out of Netherlands friendlies|
|Koeman must strengthen attack for Europa League challenge - McMenemy|
|Wilshere apologises for Spurs taunts|
|Marchisio: No fear ahead of Barcelona clash|
|Klopp to take break after leaving Dortmund|
|Champions League win would be ´more than extraordinary´ - Allegri|
|Charity calls for education after Leicester ´racist orgy´ claims|
|Taylor agrees Swansea deal|
|Sevilla snare Krohn-Dehli|
|Coloccini hails Gutierrez after ´perfect´ Newcastle finale|
|Benitez excited by Madrid opportunity|
|Sampaoli confirms final Chile squad for Copa America|
|Clement ready to go it alone at Derby|
|Mihajlovic confirms Sampdoria exit|
|Brentford turn to Dijkhuizen|
|Usami, Moto to lead Japan qualifying threat|
|Vieira ´the best bet´ for Newcastle - Bernard|
|´We´ll see what happens with my future´ - De Gea|
|Klinsmann: Guzan will start at Gold Cup|
|Alves wants Barca extension not PSG - Blanc|
|Derby appoint Paul Clement as head coach|
|Karlsruher ´can only win´ - Kauczinski|
|Ronaldinho causes stir with disallowed goal|
|Szczesny plans Arsenal stay|
|Pioli: Lazio deserve Champions League qualification|
|Pablo Aimar makes River Plate return|
|MLS Review: Seattle leave it late against Red Bulls|
|Wenger: Arsenal won´t spend big|
|Police to investigate Rangers-Motherwell fight|
|´I will definitely stay´ at City - Toure|
|Champagne backs Blatter to reform FIFA|
|Honduras 2 El Salvador 0: Penalty, goal and red card to Lozano|
|Mancini wants Icardi to stay|
|Sampdoria set to speak on Mihajlovic future|