Arsenal will go four points clear at the top of the Premier League if they extend their winning run to eight games at Southampton on Tuesday.
Arsene Wenger's side have found remarkable consistency since the 6-3 loss at title rivals Manchester City in December, claiming seven consecutive triumphs in all competitions.
That run has left the London club fighting for silverware on three fronts, and has also silenced the doubters, who suggested that Arsenal's Etihad mauling would spell the end of their championship challenge.
Arsenal were ruthless in the 4-0 FA Cup thrashing of League One Coventry City on Friday and, while much is made of the threat they carry going forward, they have conceded only two goals in the last eight matches.
Wenger's charges have not lost to Southampton since November 2002, but can expect a stern test at St Mary's as they attempt to stretch their lead at the top of the table, with City and Chelsea not in action until Wednesday.
Alex Oxlade-Chamberlain made his first Arsenal start since August following against Coventry following a long injury lay-off.
The forward could be back on the substitutes' bench against his former club, but he is relishing the prospect of returning to the south coast once again.
He told the club's official website: "To go back there in any sense is always really nice, especially when we go to play them.
"Last season I went back there and it was a surreal feeling for me, warming up on the opposite side of the pitch and being in the opposite dressing room.
"It was the first time I went back there to play so it was a bit weird for me. I'm looking forward to going back this season, obviously they're doing really well so it's a tough game for us."
Lukas Podolski staked his claim by scoring twice against Coventry, but the Germany international could also return to the bench.
Mikel Arteta (calf), Aaron Ramsey (thigh), Tomas Rosicky (broken nose) and Thomas Vermaelen (knee) are set to be back in contention.
The likes of Wojciech Szczesny, Santi Cazorla, Olivier Giroud and Bacary Sagna are expected to be restored to the starting line-up.
Abou Diaby and Theo Walcott (both knee) are long-term absentees.
Southampton have won their last three home games and striker Guly do Prado warned Arsenal not to expect an easy ride after scoring in Saturday's FA Cup win over Yeovil Town.
"We get confidence from these wins," the striker told the club's official website. "We play for a win in every game, whether it’s in the FA Cup or the Premier League.
"The win today will give us confidence for Tuesday night against Arsenal. Now we have to think about that because it's going to be another big, hard game – but we are going to play to win."
Rickie Lambert (hamstring) and Artur Boruc (back) are expected to return after missing the clash with Yeovil and Victor Wanyama (calf) could feature for the first time since early last month.
Pablo Daniel Osvaldo is still suspended following a training ground incident, while Dejan Lovren and Gaston Ramirez (both ankle) remain sidelined.
|Coach: M. Pochettino|
for S. Gallagher 70'
for S. Davis 89'
|Van Gaal proud of United work|
|Copa Libertadores Review: Independiente del Valle reach group stage|
|Mauro: Allegri should have Chelsea talks|
|Payet can become West Ham great - Sullivan|
|Rooney a target for Chinese clubs, says Eriksson|
|Klopp expects Liverpool´s Premier League drought to continue|
|Van Gaal: Woodward would tell me if he was speaking to Mourinho|
|Emery urges against Camp Nou final|
|Sagna: Man City still title favourites|
|Trelissac 0 Marseille 2: Fletcher opens account to seal quarter-final spot|
|Arsenal set for US pre-season fixtures|
|Lazio 5 Verona 2: Basement boys routed at Stadio Olimpico|
|Celta Vigo 2 Sevilla 2 (2-6 agg): Aspas brace in vain as Emery´s men reach final|
|Juventus v Napoli: Higuain confident he can handle pressure|
|Tan to write off Cardiff debts|
|Paris Saint-Germain v Lille: Champions seek to celebrate Blanc extension with win|
|Crystal Palace v Watford: Pardew hopes Adebayor can turn season around|
|Allardyce urges Van Gaal to discover Manchester United´s intentions|
|Sunderland terminate Johnson´s contract|
|Payet signs new West Ham contract|
|Oscar: I have no reason to leave Chelsea|
|Chelsea v Newcastle United: Oscar reflects on quest for form at Stamford Bridge|
|Pogba must improve mentality to become like Platini and Zidane - Mauro|
|AFC Bournemouth v Stoke City: Hughes praises Howe´s hard workers|
|Swansea City v Southampton: Koeman needs Wanyama to learn|
|Robinho returns to Brazil with Atletico Mineiro|
|Adidas terminates boot deal with Johnson|
|Sunderland consider Eboue deal|
|Sunderland v Manchester United: Carrick lauds Martial form ahead of key clash|
|Bundesliga record-breaker Nagelsmann replaces Stevens at Hoffenheim|
|Robben: No Manchester City move discussions with Guardiola|
|Borussia Dortmund v Hannover: Milosevic staying positive amid relegation fight|
|Norwich City v West Ham: Bilic eyes chance to build momentum|
|United poised for more heavy spending after record revenue|
|Pardew, Palace ´jealous´ of Leicester´s romantic title bid|
|Everton v West Brom: Martinez wants Goodison fortress|
|Allardyce confirms Johnson omission|
|Real Madrid not on Spalletti´s mind|
|Real Madrid v Athletic Bilbao: Valverde´s men out to improve shocking Bernabeu record|
|Angry Afobe hits back at Wolves after ´not trying´ accusations|
|Bojan agrees Stoke extension|
|Celina demanded international game-time - Norwegian FA|
|Manchester United profits surge after Champions League return|
|Prince Ali: FIFA is in crisis and needs to change|
|Aguero eyes further goal joy against Spurs|
|Deeney the perfect partner for Vardy and Kane with England, says Flores|
|Sirigu wanted PSG exit|
|Bordeaux suspend Prior and Sane|
|Saul in no rush to leave Atletico|
|Bilic: West Ham close to Payet deal|
|Martinez rubbishes Jagielka exit talk|
|Tomkins to miss five weeks with calf injury|
|Sunderland to drop Johnson for United match|
|Martinez: Title Leicester´s to lose|
|Xhaka tempted by Premier League switch|
|Carragher proud of Liverpool ticket-price U-turn|
|Mourinho and United a perfect match - McCarthy|
|Blanc extends PSG contract|
|Pulis heaps praise on Peterborough|
|Toranzo did not lose toes - Huracan president|
|Willian expects Terry to depart Chelsea|
|Mexico 2 Senegal 0: Duenas, Pizarro inspire win|
|Copa Libertadores Review: Sao Paulo, Racing qualify for group stages|
|Liverpool should be transparent with Sturridge injuries - Owen|
|FFA hands Wanderers fine and suspended points deduction|
|Luis Enrique: I had to give my voice a rest|
|Silva: I was not kicked off Marseille team bus|
|Blanc could sign PSG renewal by end of week|
|PSG drawn against familiar foes Saint-Etienne in Coupe de France|
|Neville confident Valencia fans will be back|
|Guardiola praises beaten Bochum|
|Coupe de France Review: Ibrahimovic sends PSG through, Nantes win thriller|
|I love penalties - West Brom´s shootout hero Foster|
|Ross County 0 Hearts 3: Dauda dazzles in valuable victory|
|Bayern Munich avoid Borussia Dortmund in DFB-Pokal semi-finals|
|FC Heidenheim 2 Hertha Berlin 3: Ibisevic at the double in DFB-Pokal|
|Hart: We will fight for Pellegrini all the way|
|Peterborough United 1 West Brom 1 (aet, 3-4 on pens): Foster spares Premier League team´s blushes|
|Paris Saint-Germain 3 Lyon 0: Ibrahimovic fires holders into last eight|
|Valencia 1 Barcelona 1 (1-8 agg): Kaptoum breaks record with late leveller|
|Bochum 0 Bayern Munich 3: Lewandowski double helps book semi-final spot|
|Colour clash forces Stoke to produce new kit|
|Hernandez to miss Darmstadt match with muscle injury|
|Stoichkov backs ´smart guy´ Neymar to stay at Barcelona|
|FSG´s letter of apology to Liverpool fans in full|
|Huracan bus overturns following Copa Libertadores clash|
|Liverpool scrap ticket price increases following fan backlash|
|Oviedo hopeful of new Everton contract|
|Zoff: Juventus-Napoli a Scudetto match|
|Bolton chairman Phil Gartside dies aged 63|
|Palermo turn to Bosi after Barros Schelotto exit|
|Ben Arfa considered retirement from football during exile|
|Bilic: We paid the price for cup progress|
|Griezmann happy to stay at Atletico|
|Wales to face Sweden in final Euro 2016 warm-up|
|Varela hopeful of long United career|
|Ki: I had ice on my face for two days|
|Niasse settling in well, could face West Brom - Martinez|
|Stevens leaves Hoffenheim on health grounds and retires|
|Diaby nearing return after near 18-month lay-off|
|Nasri would love to finish career at Manchester City|
|Captain Howedes extends Schalke stay|
|M´Vila keen to stay if Sunderland survive|
|Johnson admits child sex and grooming charges|
|Amazing Mahrez is one of Premier League´s best - Ulloa|
|Ronaldo, Messi rivalry good for football - Zidane|
|Barros Schelotto leaves Palermo|
|Age is just a number - Ilori defends Klopp´s team selection|
|Messi, Suarez and Neymar rested for Copa second leg|
|Madrid can dream of trophies under Zidane - Raul|
|Ancelotti: Italy job is a decade away|
|Reus will become a monster, says Dortmund boss Tuchel|
|Young Tottenham stars don´t know their limits - Lloris|
|Niang happy at Milan despite Leicester interest|
|Ticket price rise means more tourist fans, warns football supporters chairman|
|Ogbonna revels in first West Ham goal|
|Copa Libertadores Review: Huracan, River Plate advance to group stages|
|Klopp backs Benteke to rediscover goalscoring form|
|Turan will not leave Barca for China - agent|
|Beating Chelsea more difficult without Mourinho - Motta|
|Tuchel praises Dortmund for ´perfect game´|
|Klopp rues Liverpool wastefulness in FA Cup loss|
|Allegri: Chelsea rumours unfounded|
|Bilic feels weight of history after Liverpool win|
|Coupe de France Review: Second tier Sochaux stun Ligue 1 Monaco|