Arsenal will go four points clear at the top of the Premier League if they extend their winning run to eight games at Southampton on Tuesday.
Arsene Wenger's side have found remarkable consistency since the 6-3 loss at title rivals Manchester City in December, claiming seven consecutive triumphs in all competitions.
That run has left the London club fighting for silverware on three fronts, and has also silenced the doubters, who suggested that Arsenal's Etihad mauling would spell the end of their championship challenge.
Arsenal were ruthless in the 4-0 FA Cup thrashing of League One Coventry City on Friday and, while much is made of the threat they carry going forward, they have conceded only two goals in the last eight matches.
Wenger's charges have not lost to Southampton since November 2002, but can expect a stern test at St Mary's as they attempt to stretch their lead at the top of the table, with City and Chelsea not in action until Wednesday.
Alex Oxlade-Chamberlain made his first Arsenal start since August following against Coventry following a long injury lay-off.
The forward could be back on the substitutes' bench against his former club, but he is relishing the prospect of returning to the south coast once again.
He told the club's official website: "To go back there in any sense is always really nice, especially when we go to play them.
"Last season I went back there and it was a surreal feeling for me, warming up on the opposite side of the pitch and being in the opposite dressing room.
"It was the first time I went back there to play so it was a bit weird for me. I'm looking forward to going back this season, obviously they're doing really well so it's a tough game for us."
Lukas Podolski staked his claim by scoring twice against Coventry, but the Germany international could also return to the bench.
Mikel Arteta (calf), Aaron Ramsey (thigh), Tomas Rosicky (broken nose) and Thomas Vermaelen (knee) are set to be back in contention.
The likes of Wojciech Szczesny, Santi Cazorla, Olivier Giroud and Bacary Sagna are expected to be restored to the starting line-up.
Abou Diaby and Theo Walcott (both knee) are long-term absentees.
Southampton have won their last three home games and striker Guly do Prado warned Arsenal not to expect an easy ride after scoring in Saturday's FA Cup win over Yeovil Town.
"We get confidence from these wins," the striker told the club's official website. "We play for a win in every game, whether it’s in the FA Cup or the Premier League.
"The win today will give us confidence for Tuesday night against Arsenal. Now we have to think about that because it's going to be another big, hard game – but we are going to play to win."
Rickie Lambert (hamstring) and Artur Boruc (back) are expected to return after missing the clash with Yeovil and Victor Wanyama (calf) could feature for the first time since early last month.
Pablo Daniel Osvaldo is still suspended following a training ground incident, while Dejan Lovren and Gaston Ramirez (both ankle) remain sidelined.
|Coach: M. Pochettino|
for S. Gallagher 70'
for S. Davis 89'
|Moyes watches Sunderland win, Ibe opens account in six-goal Bournemouth thriller|
|Messi cuts short holiday for Barcelona training camp|
|Ranieri still confident of keeping Mahrez|
|Toure to complete Celtic move on Sunday, says Rodgers|
|Vietto sends Simeone a reminder amid Barcelona links|
|Celtic 1 Leicester City 1 (5-6 on penalties): Mahrez magic the highlight as Ranieri´s side triumph i|
|Ribery, Alaba on target in Bayern win|
|Neymar hails Micale ahead of Olympic tilt|
|Ronaldo wants Real Madrid renewal|
|Ochoa joins Granada from Malaga|
|Heidel quashes Meyer to Liverpool as ´nonsense´|
|Scholes challenges Allardyce to change England mentality|
|Tenerife star Crosas investigated for killing endangered shark|
|De Gea: Manchester United can win title under Mourinho|
|Marseille replace Batshuayi with brother Leya Iseka|
|Cristiano Ronaldo: Best season of my career|
|Scholes: Pogba is not worth £100million|
|Gotze has not forgotten how to play football - Riedle|
|Delph learning more than ever under Guardiola|
|Jovetic ´not worried´ about Juventus|
|Allardyce wants Euro 2016 woes to fire his England|
|Giggs not in a rush to take manager´s job|
|Lopetegui: If not for Spain I would be Wolves boss|
|Shaw one of best left-backs in world - Herrera|
|Injured Sanchez to miss Arsenal tour|
|Melbourne Victory 1 Juventus 1 (Melbourne win 4-3 on pens): Thomas inspires Victory as Juve pay pena|
|Janssen: Ajax and PSV were never going to pay as much as Tottenham|
|Bayern to make Munich shooting tributes|
|Wenger wishes luck to old foe Allardyce|
|United defender Varela joins Frankfurt on loan|
|Sunderland appoint Moyes as Allardyce replacement|
|Javi Martinez devastated by Munich shootings|
|Rooney: I´m desperate to play for Mourinho, just like under Ferguson|
|Godin: Champions League the dream, but LaLiga the focus|
|Klopp hails Wijnaldum´s ´football smartness´|
|Klavan ready to fight for starting spot after completing ´dream´ Liverpool move|
|Real Salt Lake 1 San Jose Earthquakes 1: Mulholland salvages point|
|Madeira airport to be named after Cristiano Ronaldo|
|Villar, Ceferin and Van Praag announce UEFA presidential bid|
|Witsel has offers from England and Italy|
|Tuchel will bring out Gotze´s best - Watzke|
|Swansea confirm interest in Liverpool´s Allen|
|Arsenal´s Coquelin: LeBron v Curry is like Messi v Ronaldo|
|Rooney backs Allardyce appointment|
|Bayern and Ancelotti respond to Munich attacks|
|West Brom friendly cancelled over violence concerns|
|Allardyce ´cannot stop smiling´ after getting England job|
|Rakitic dismisses Barcelona exit talk|
|Oxlade-Chamberlain salvages draw for Arsenal in opening friendly|
|Bruce leaves Hull City by mutual consent|
|Juventus start Serie A title defence against Fiorentina|
|Guardiola already making impact at Manchester City - Clichy|
|Liverpool sign Netherlands international Wijnaldum|
|Ranieri: Chilwell, Ulloa going nowhere|
|Batshuayi: Conte already making me a better player|
|Allardyce determined to be the best - Davies|
|Wolfsburg sign Mayoral from Real Madrid|
|New coaches the attraction in USA/Europe Champions Cup zone|
|´It was like F1 v F3´ - Mourinho not making hasty judgments on United squad|
|Suarez would welcome Vietto with open arms at Barcelona|
|Glenn hails ´ideal candidate´ Allardyce|
|Juventus begin ICC campaign amid Pogba furore|
|Sunderland look to move forward after Allardyce departure|
|Kuyt backs Wijnaldum for Liverpool success|
|No major trophies, fewer goals than Moyes - the stats behind England boss Allardyce´s career|
|Hayden was wasting his career at Arsenal - Wenger|
|New recruits excite Aubameyang after United rout|
|Allardyce the right man to take England back to basics|
|Solve the Rooney puzzle and restore Sterling´s confidence: Five problems for Allardyce to solve|
|England appoint Allardyce as manager|
|Manchester United 1 Borussia Dortmund 4: Classy BVB hand Mourinho first defeat|
|James vows to stay at Real Madrid|
|Caught in a jam - Minnesota ´explain´ goalkeeper gaffe|
|Clarke nominated for FA chairman|
|Gazidis expects more Leicester-style Premier League triumphs|
|Arsenal snap up Bolton defender|
|Alex the Mann for Liverpool as veteran seals Anfield move|
|Dortmund sign Schurrle on five-year deal|
|Balotelli needs right opportunity - Raiola|
|Lukaku undergoes Lazio medical|
|Suarez: Messi better than Ronaldo by far|
|Allegri remains hopeful of Pogba Juve stay|
|Rakitic´s agent questions Barcelona midfield buys|
|Shearer: England players must respect Allardyce or walk|
|Raiola: I don´t give a damn if Pogba costs a world-record fee|
|Mazinho dreams of Thiago-Rafinha reunion at Barca|
|No heart, no gold says ex-Brazil striker Elber|
|There is space for Mata at United - Mourinho|
|Alonso: Guardiola needs time to improve City|
|Argentina approach Bauza to be coach|
|Inter still ´under construction´ - Ranocchia|
|Mourinho: Rooney will be an important player|
|Ganso prepared for the step up to European football|
|Dyke: Brexit could help England|
|Galatasaray confirm Lucas interest|
|Conte targets Champions League with Chelsea|
|Swansea style attracted new owners Kaplan and Levien|
|Mourinho not concerned if United fail to sign Pogba|
|Mourinho teased Ibrahimovic into United move|