Arsenal will go four points clear at the top of the Premier League if they extend their winning run to eight games at Southampton on Tuesday.
Arsene Wenger's side have found remarkable consistency since the 6-3 loss at title rivals Manchester City in December, claiming seven consecutive triumphs in all competitions.
That run has left the London club fighting for silverware on three fronts, and has also silenced the doubters, who suggested that Arsenal's Etihad mauling would spell the end of their championship challenge.
Arsenal were ruthless in the 4-0 FA Cup thrashing of League One Coventry City on Friday and, while much is made of the threat they carry going forward, they have conceded only two goals in the last eight matches.
Wenger's charges have not lost to Southampton since November 2002, but can expect a stern test at St Mary's as they attempt to stretch their lead at the top of the table, with City and Chelsea not in action until Wednesday.
Alex Oxlade-Chamberlain made his first Arsenal start since August following against Coventry following a long injury lay-off.
The forward could be back on the substitutes' bench against his former club, but he is relishing the prospect of returning to the south coast once again.
He told the club's official website: "To go back there in any sense is always really nice, especially when we go to play them.
"Last season I went back there and it was a surreal feeling for me, warming up on the opposite side of the pitch and being in the opposite dressing room.
"It was the first time I went back there to play so it was a bit weird for me. I'm looking forward to going back this season, obviously they're doing really well so it's a tough game for us."
Lukas Podolski staked his claim by scoring twice against Coventry, but the Germany international could also return to the bench.
Mikel Arteta (calf), Aaron Ramsey (thigh), Tomas Rosicky (broken nose) and Thomas Vermaelen (knee) are set to be back in contention.
The likes of Wojciech Szczesny, Santi Cazorla, Olivier Giroud and Bacary Sagna are expected to be restored to the starting line-up.
Abou Diaby and Theo Walcott (both knee) are long-term absentees.
Southampton have won their last three home games and striker Guly do Prado warned Arsenal not to expect an easy ride after scoring in Saturday's FA Cup win over Yeovil Town.
"We get confidence from these wins," the striker told the club's official website. "We play for a win in every game, whether it’s in the FA Cup or the Premier League.
"The win today will give us confidence for Tuesday night against Arsenal. Now we have to think about that because it's going to be another big, hard game – but we are going to play to win."
Rickie Lambert (hamstring) and Artur Boruc (back) are expected to return after missing the clash with Yeovil and Victor Wanyama (calf) could feature for the first time since early last month.
Pablo Daniel Osvaldo is still suspended following a training ground incident, while Dejan Lovren and Gaston Ramirez (both ankle) remain sidelined.
|Coach: M. Pochettino|
for S. Gallagher 70'
for S. Davis 89'
|New deals for Moore, Schlupp|
|Litex Lovech 3 Veris 0 (3-0 agg): Bulgarians through to second round|
|Valencia loan Fede to Cordoba|
|Stoke closing in on Bojan|
|Inter still hopeful of Jovetic capture|
|Finalists dominate Golden Ball nominees|
|Celtic end Austria tour unbeaten|
|Rizzoli appointed World Cup final referee|
|Oier joins Granada|
|Escriba extends Elche agreement|
|Newcastle have agreement for Cabella, says Nicollin|
|Scolari: We have to move on|
|Roma complete Emanuelson deal|
|Alex pledges to improve Milan|
|Di Maria doing everything he can, says agent|
|Villa give Richardson a Premier League return|
|Sabella ´to step down´ after World Cup final|
|Van Gaal eyes ´unbeaten´ campaign|
|Suarez to take case to CAS|
|Germany have same spirit as in 1990, says Beckenbauer|
|´Quite clear Suarez wanted to leave´ - Liverpool fanzine|
|Southampton closing in on Pelle deal - Koeman|
|Suarez, Ronaldo, Bale and more: The Premier League talent drain|
|Augsburg capture Caiuby|
|Gerrard lauds departing Suarez|
|Andrade delighted at Benfica return|
|No Bony talks with Liverpool - Swansea|
|Lahm: Experience will be key|
|FIFA World Cup Preview: Brazil v Netherlands|
|Suarez departs Liverpool with ´heavy heart´|
|Liverpool did everything to keep Suarez - Rodgers|
|Suarez to sign for Barca|
|Boyce: Referees not told to be lenient|
|Sanchez reveals Wenger admiration|
|Flick staying secretive on Messi plans|
|Determined Dyche aims to complete more deals|
|Matri joins Genoa on loan|
|Valderrama talks up James potential|
|Aguero: Argentina are World Cup underdogs|
|Everton in talks over Traore return|
|Lambert tipped to prise open defences|
|Thauvin hails Bielsa impact at Marseille|
|Zico: Time for Scolari to go|
|Klopp eager for defensive improvement|
|Arsenal to run the rule over Fathi|
|Chamakh signs news Palace deal|
|Neville set to learn United fate|
|Fiorentina swoop for Brillante|
|Navas set to join Bayern|
|Neymar rejects agent´s anti-Scolari Twitter tirade|
|Allegri undecided on Italy job|
|Fernando idolises City team-mate Toure|
|Arteta: FA Cup will inspire Arsenal´s Premier League tilt|
|Evergrande confirm Gilardino signing|
|Howedes calls for team effort to stop Messi|
|Kuyt: Van Gaal can succeed at United|
|Argentina fined for player no-show|
|Neymar: ´I could be in a wheelchair´|
|Mascherano: I tackled doubts to block Robben|
|Zaccheroni: I leave Japan in a good spot|
|Aguero: Argentina ready to give everything|
|UEFA Europa League Review: Gothenburg leave it late, Sillamae stun Honka|
|Klose lauds Ronaldo after scooping record|
|Iran refute Susic claims|
|Fernandez named Deportivo boss|
|Argentina have no chance, says Robben|
|Hierro to replace Zidane as Real first-team coach|
|Rhodes signs new Rovers deal|
|Arsenal complete Sanchez swoop|
|Inzaghi backs under-fire Balotelli|
|Defeat has overshadowed display - Vlaar|
|Maradona: Germany full of themselves|
|Barry hoping for England recall|
|Green extends QPR stay|
|Shanghai Shenhua 1 Guangzhou Evergrande 2: Rong leaves it late in dramatic win|
|Germany hope for Brazilian support|
|Torino striker Cerci in demand|
|FIFA critcised following Mascherano incident|
|Bernat happy at Bayern despite bad memories|
|Giggs backs Van Gaal to thrive at Old Trafford|
|Tadic can fill Lallana void - Koeman|
|New five-year deal for Nasri|
|Barcelona release injury-hit Cuenca|
|Suarez appeal rejected|
|La Decima a reflection of Di Stefano - Perez|
|Buoyant Mazzarri eager for Inter success|
|Mandzukic joins Atletico|
|Van Gaal criticises third-place play-off|
|Halilhodzic yet to decide future|
|Mandzukic eager for Simeone link-up|
|Davies hoping for Hull deal|
|Poyet hopeful over Altidore fitness|
|Diego close to ´dream´ Fenerbahce move|
|Inter loan out youngsters|
|Fired-up Cole can inspire Villa, claims Lambert|
|Hughes hailed for winning over Brit doubters|
|Hajrovic signs for Bremen|
|Hull can buck Europa League trend, says Meyler|
|Mertesacker talks up German chances|
|Swansea reveal Tottenham contact over Davies, Sigurdsson|
|Lloris pens five-year deal at Tottenham|
|Fernandinho: ´The pain is big´|
|MLS Preview: Portland aim for swift revenge against Seattle|
|Sabella: Germany have an advantage|
|Second Argentine journalist dies in Brazil|
|Aguero: Argentina defied critics|
|Impressive Mascherano thrilled with final´s berth|
|Zuniga offered protection by Colombia|
|Germany vowed not to ´humiliate´ Brazil|
|Hong resigns from South Korea post|
|Third-choice Vlaar ´wasn´t nervous´|
|Van Gaal: I wanted Krul in the shootout|
|Argentina: Key factors in reaching the final|
|Sabella revels in semi-final win|
|Proud Robben feels pain of World Cup exit|
|FIFA World Cup: Netherlands 0 Argentina 0 (after extra time, 2-4 on penalties)|
|Susic signs two-year extension with Bosnia-Herzegovina|