Record signing Juan Mata is set to make his Manchester United debut against former United striker Ole Gunnar Solskjaer's Cardiff City side.
The Spain midfielder completed his £37.1million move from Chelsea on Saturday and is expected to go straight into the starting line-up on Tuesday.
Mata's arrival is a timely boost for United, who crashed out of the League Cup on penalties in their semi-final against Sunderland last week on the back of a 3-0 top-flight defeat at Chelsea.
Manager David Moyes will be expecting Mata to provide the touch of class that United have been lacking in what has been a disappointing season so far for the Premier League champions.
United's prospects of retaining their title are forlorn, as Moyes' men are seventh in the table and 14 points adrift of leaders Arsenal.
Moyes will still be confident of clinching qualification for the UEFA Champions League, though, as Liverpool are six points better off than the Old Trafford outfit.
United drew 2-2 at Cardiff back in November in the first meeting between the two sides since 1975 and since then Solskjaer replaced Malky Mackay at the Welsh club.
The 40-year-old can expect a rapturous reception on his return to Old Trafford, where he spent 11 years during his playing days and enjoyed a major role in such a successful period in United's history, including scoring the winner in the 1999 Champions League final.
The Norwegian has been charged with the task of keeping Cardiff in the Premier League, but they slipped to the bottom of the table with a 4-2 defeat at Manchester City in their last top-flight match.
Cardiff need to improve their away form if they are to avoid a return to the Championship, as they have won only once on their travels in the top flight.
Solskjaer's side did win at Bolton Wanderers in the fourth round of the FA Cup on Saturday, but Cardiff have taken just a point from their last six Premier League games.
The Cardiff boss will be hoping United strike duo Robin van Persie (thigh) and Wayne Rooney (groin) are not yet ready to return.
Moyes will also assess the fitness of Rio Ferdinand (knee), Nani (hamstring) and Michael Carrick (ankle), but captain Nemanja Vidic will not definitely not feature as he serves the second of a two-match suspension following his red card at Chelsea.
Kenwyne Jones could make his Cardiff debut if a swap deal with Stoke City involving Peter Odemwingie goes through in time and forward Jo Inge Berget could make his bow following his move from Molde last week.
The likes of Fraizer Campbell, Steven Caulker and Craig Noone are expected to return to the starting line-up.
|20||R. van Persie||6'|
|Coach: D. Moyes|
for R. van Persie 63'
for R. Giggs 71'
for Mata 84'
|Mourinho hits out at ´unacceptable´ Loftus-Cheek display|
|Inter an ´option´ for Richards|
|Messi: Off-field relationship with Neymar and Suarez key|
|Remy rifle seals Sydney win for Chelsea|
|Messi could replicate Bilbao goal - Luis Enrique|
|Liverpool mauling a boost in transfer market, says Stoke chairman Coates|
|Adkins: Football can learn a lot from rugby|
|Celtic swoop for City defender Boyata|
|Xavi out to sign off in style at Barca|
|Criscito and Poli leave Italy squad|
|Lacazette plays down ´unfounded´ PSG rumours|
|Lloris: No buy-out clause in Tottenham contract|
|Newcastle released Taylor and Gutierrez in same phone call|
|Alba signs new Barcelona deal|
|Benteke coy on Villa future|
|FIFA denies Valcke involvement in $10million payment|
|Brazil selection never influenced, says technical director|
|Pogba doing ´great things´ and will get better, says Deschamps|
|Bundesliga: Borussia Dortmund season review - Klopp endures rocky farewell|
|Adler ´aged three years´, Labbadia ´extremely proud´ of Hamburg|
|Colombia squad settles in Argentina|
|Balotelli ´a target´ because of Liverpool form - Richards|
|Bosnich: If I´d listened to Terry I would have avoided drugs|
|Luiz Gustavo ruled out of Brazil´s Copa America squad|
|Mexico confirm Copa squad|
|Pogba ´very happy´ at Juve|
|Pogba can be Europe´s greatest - Pirlo|
|Pinedo stays in Argentina, Bolivia captain Raldes in Copa America squad|
|Quinteros cuts Banguera, Hidalgo for Chile showpiece|
|Injured Gonzalez misses Copa America, Venezuela finalise youthful squad|
|Champions League Final: Buffon plays down Juve hopes, Iniesta doubtful|
|Karlsruher 1 Hamburg 2 (2-3 agg): Muller strike ensures survival|
|CONCACAF official Sanz banned by FIFA|
|Gourvennec shuns admirers with Guingamp extension|
|Pastore signs PSG extension|
|Morel swaps Marseille for Lyon|
|Watford sign Austria defender Prodl|
|Monaco confirm Berbatov departure|
|Peru v Mexico: Herrera confident as Copa preparations continue|
|Injury rules Dost out of Netherlands friendlies|
|Koeman must strengthen attack for Europa League challenge - McMenemy|
|Wilshere apologises for Spurs taunts|
|Marchisio: No fear ahead of Barcelona clash|
|Klopp to take break after leaving Dortmund|
|Champions League win would be ´more than extraordinary´ - Allegri|
|Charity calls for education after Leicester ´racist orgy´ claims|
|Taylor agrees Swansea deal|
|Sevilla snare Krohn-Dehli|
|Coloccini hails Gutierrez after ´perfect´ Newcastle finale|
|Benitez excited by Madrid opportunity|
|Sampaoli confirms final Chile squad for Copa America|
|Clement ready to go it alone at Derby|
|Mihajlovic confirms Sampdoria exit|
|Brentford turn to Dijkhuizen|
|Usami, Moto to lead Japan qualifying threat|
|Vieira ´the best bet´ for Newcastle - Bernard|
|´We´ll see what happens with my future´ - De Gea|
|Klinsmann: Guzan will start at Gold Cup|
|Alves wants Barca extension not PSG - Blanc|
|Derby appoint Paul Clement as head coach|
|Karlsruher ´can only win´ - Kauczinski|
|Ronaldinho causes stir with disallowed goal|
|Szczesny plans Arsenal stay|
|Pioli: Lazio deserve Champions League qualification|
|Pablo Aimar makes River Plate return|
|MLS Review: Seattle leave it late against Red Bulls|
|Wenger: Arsenal won´t spend big|
|Police to investigate Rangers-Motherwell fight|
|´I will definitely stay´ at City - Toure|
|Champagne backs Blatter to reform FIFA|
|Honduras 2 El Salvador 0: Penalty, goal and red card to Lozano|
|Mancini wants Icardi to stay|
|Sampdoria set to speak on Mihajlovic future|
|Serie A Review: Napoli miss Champions League in Benitez send-off|
|O´Neill: Fitness of players will determine selection against Romania|
|Inter 4 Empoli 3: Icardi brace secures victory|
|Northern Ireland 1 Qatar 1: Irish cough up lead|
|Eredivisie Review: Five-star Vitesse seal Europa berth, NAC Breda relegated|
|Motherwell 3 Rangers 0 (6-1 agg): Miserable return for McCall|
|Wilshere taunts Spurs during FA Cup parade|
|Di Francesco pens Sassuolo extension|
|Klopp thanks Dortmund for emotional farewell|
|Italy call up uncapped duo|
|Walcott expects Arsenal deal|
|Luiz dreaming of Champions League glory|
|Leicester trio issue apology as club investigate alleged ´racist orgy´|
|Gerrard ´a dream to play with´, says Sturridge|
|Clasie a target if Schneiderlin leaves - Koeman|
|Muller appears to pledge future to Bayern in Instagram post|
|Sheikh Mansour wants Toure at City - agent|
|Real vice-president inadvertently ´confirms´ Benitez appointment|
|Pique targeting Barca ´perfection´|
|Malanda helped us a lot - De Bruyne|
|Falcao not focused on transfer speculation|
|Iniesta in doubt for Champions League final|
|Blanc hoping for FFP boost|
|Willian, Filipe Luis, Cuadrado to miss Premier League start|
|Mourinho: Chelsea not playing Sydney ´for fun´|
|MLS Review: Shipp sinks Montreal, Giovinco stars for Toronto|
|Luis Enrique targets ´exemplary treble´, basks in Messi´s magic|
|Iraola: Neymar ´rainbow´ unsporting|
|Mexico 3 Guatemala 0: Herrera brace ensures farewell victory|
|´I´m not going to change the way I play´ - Neymar|
|PSG motivated by historic opportunity - Douchez|
|Wenger hopes Wembley win convinces Walcott to stay|
|Klopp refuses to dwell on departure after cup heartbreak|